Article
Oncology
Analena Handke, Claudia Kesch, Wolfgang Peter Fendler, Tugce Telli, Yang Liu, Alexander Hakansson, Elai Davicioni, Jason Hughes, Hong Song, Katharina Lueckerath, Ken Herrmann, Boris Hadaschik, Robert Seifert
Summary: Higher PD-L2 signature may be associated with a better response to 177Lu-PSMA therapy and further studies on additional immunotherapy are needed. In contrast, PD-L1 is not associated with outcome. The protective effect of PD-L2 signature may only exist in men with lower LDH levels.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Urology & Nephrology
Justin D. Oake, Benjamin Shiff, Oksana Harasemiw, Navdeep Tangri, Thomas W. Ferguson, Bimal Bhindi, Jeff W. Saranchuk, Rahul K. Bansal, Darrel E. Drachenberg, Jasmir G. Nayak
Summary: The study compared outcomes of patients with nonmetastatic prostate cancer treated with radical prostatectomy or radiation therapy. It found that radical prostatectomy was associated with higher overall survival and lower prostate cancer specific mortality compared to radiation therapy.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Justin D. Oake, Benjamin Shiff, Oksana Harasemiw, Navdeep Tangri, Thomas W. Ferguson, Bimal Bhindi, Jeff W. Saranchuk, Rahul K. Bansal, Darrel E. Drachenberg, Jasmir G. Nayak
Summary: This study compared the outcomes of radiation therapy (RT) and radical prostatectomy (RP) for nonmetastatic prostate cancer patients. The findings showed that RT was associated with higher all-cause mortality and prostate cancer specific mortality rates compared to RP.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Francesco Claps, Nicola Pavan, Paolo Umari, Michele Rizzo, Fabio Barbone, Manuela Giangreco, Giovanni Liguori, Carmen M. Mir, Rossana Bussani, Carlo Trombetta
Summary: The study found that incidental prostate cancer (iPCa) is common in patients undergoing radical cystectomy (RC) for bladder cancer, with most cases being organ-confined and well differentiated. Regardless of clinical relevance, iPCa does not impact survival outcomes as bladder cancer drives the prognosis of these patients.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Urology & Nephrology
Aaron Brant, Patrick Lewicki, Xian Wu, Christina Sze, Jeffrey P. Johnson, Spyridon P. Basourakos, Camilo Arenas-Gallo, Daniel Shoag, Christopher E. Barbieri, Nicholas G. Zaorsky, Jonathan E. Shoag
Summary: An increase in left-digit age from 69 to 70 is associated with disproportionately increased recommendations for radiation therapy and decreased recommendations for radical prostatectomy in patients with localized prostate cancer.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Neal Andruska, Benjamin W. Fischer-Valuck, Michael Waters, Elizabeth Juarez Diaz, Temitope Agabalogun, Eric H. Kim, Zachary L. Smith, Randall J. Brenneman, Hiram A. Gay, Gerald L. Andriole, Jeff M. Michalski, Brian C. Baumann
Summary: This study showed that men with higher LN risk scores and Gleason grade benefited from WPRT. WPRT correlated with improved overall survival in men with Gleason 9 and 10 disease or risk of LN involvement >= 10%.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Francesco Chierigo, Mike Wenzel, Christoph Wuernschimmel, Rocco Simone Flammia, Benedikt Horlemann, Zhe Tian, Fred Saad, Felix K. H. Chun, Markus Graefen, Michele Gallucci, Shahrokh F. Shariat, Guglielmo Mantica, Marco Borghesi, Nazareno Suardi, Carlo Terrone, Pierre Karakiewicz
Summary: This study compared the survival rates between hormone therapy and hormone therapy plus chemotherapy in high-risk patients. The results showed that hormone therapy had a better cancer-specific survival rate in the overall NCCN high-risk cohort and the JH high-risk and very high-risk subgroup.
JOURNAL OF UROLOGY
(2022)
Review
Oncology
Ariane Lapierre, Christophe Hennequin, Amandine Beneux, Sarah Belhomme, Nicolas Benziane Ouaritini, Marie-Claude Biston, Gilles Crehange, Renaud de Crevoisier, Jean-luc Dumas, Maher Fawzi, Albert Lisbona, David Pasquier, Sandra Pelissier, Pierre Graff-Cailleaud, Pascal Pommier, Paul Sargos, Jean-Marc Simon, Stephane Supiot, Florence Tantot, Olivier Chapet
Summary: Stereotactic body radiotherapy (SBRT) is a feasible treatment option for localized prostate cancer, but the evidence base is incomplete. The French Genito-Urinary Group (GETUG) suggests that SBRT can be considered as an option for patients after appropriate information and counseling.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Cell Biology
Fei Wang, Yuanming Fan, Xiaojian Yin, Lian-Wen Qi, Gaoxiang Ma, Qinbo Yuan
Summary: A comparison of RP and RT for PCa patients found that RT patients had a worse prognosis. The choice between RT and RP should be guided by TNM stage and age, with different outcomes depending on these factors.
Article
Oncology
Daniel J. Herr, David A. Elliott, Gillian Duchesne, Kristian D. Stensland, Megan E. V. Caram, Christina Chapman, Jennifer A. Burns, Brent K. Hollenbeck, Jordan B. Sparks, Chris Shin, Alexander Zaslavsky, Alexander Tsodikov, Ted A. Skolarus
Summary: This study aims to examine the 10-year clinical outcomes of patients with localized prostate cancer undergoing radiation therapy within a national healthcare system. The results showed improved survival rates for high-risk disease, providing important benchmarks for clinical decision-making.
Article
Oncology
Willeke Danckaert, Mathieu Spaas, Nora Sundahl, Aurelie De Bruycker, Valerie Fonteyne, Ellen De Paepe, Carlos De Wagter, Lynn Vanhaecke, Piet Ost
Summary: Radiation therapy has limited effects on the microbiome and metabolome fingerprints, and no distinctive signature for toxicity status could be established. There is an ongoing need for toxicity risk stratification tools for diagnostic and therapeutic purposes, but the translation of metabolic and microbial biomarkers into routine clinical practice remains challenging.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Urology & Nephrology
Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G. Schultz, Chiara Lonati, Agostino Mattei, R. Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F. Shariat, Marco Moschini
Summary: The study found that patients with variant histology bladder cancer have a higher risk of recurrence, requiring extended surveillance time, and different histological types have different risks of recurrence and metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Sung Uk Lee, Kwan Ho Cho, Jin Ho Kim, Young Seok Kim, Taek-Keun Nam, Jae-Sung Kim, Jaeho Cho, Seo Hee Choi, Su Jung Shim, Jin Hee Kim, Ah Ram Chang
Summary: SRT for locoregional CR after RP can achieve favorable outcomes with acceptable long-term toxicities. Higher Gleason's scores and pre-radiotherapy PSA level are unfavorable prognostic variables. Combined ADT may decrease the risks of metastases.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Danielle Rodin, Bouchra Tawk, Osama Mohamad, Surbhi Grover, Fabio Y. Moraes, Mei Ling Yap, Eduardo Zubizarreta, Yolande Lievens
Summary: The study demonstrates significant variations in the adoption of hypofractionation across different geographic regions and treatment purposes, with greater consistency in palliative care. Lack of long-term data and concerns about local control and toxicity are major barriers identified.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Urology & Nephrology
Michele Marchioni, Piergustavo De Francesco, Riccardo Campi, Umberto Carbonara, Matteo Ferro, Luigi Schips, Juan Gomez Rivas, Rocco Papalia, Roberto M. Scarpa, Francesco Esperto
Summary: This article provides a summary of current literature on the treatments of radiation cystitis, aiming to guide physicians in choosing appropriate management options. The review includes studies on various treatments such as hyperbaric oxygen therapy, cranberry compounds, and intravesical instillation. The effectiveness of different treatments varies.
MINERVA UROLOGY AND NEPHROLOGY
(2022)
Article
Urology & Nephrology
Otto O. Ettala, Tarja Saaresranta, Kari T. Syvanen, Antti J. Kaipia, Tero J. Vahlberg, Pertti T. Aarnio, Peter J. Bostrom, Paivi E. Korhonen
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ileana Montoya Perez, Ivan Jambor, Tapio Pahikkala, Antti Airola, Harri Merisaari, Jani Saunavaara, Saeid Alinezhad, Riina-Minna Vaananen, Terhi Tallgren, Janne Verho, Aida Kiviniemi, Otto Ettala, Juha Knaapila, Kari T. Syvanen, Markku Kallajoki, Paula Vainio, Hannu J. Aronen, Kim Pettersson, Peter J. Bostrom, Pekka Taimen
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amogh Hiremath, Rakesh Shiradkar, Harri Merisaari, Prateek Prasanna, Otto Ettala, Pekka Taimen, Hannu J. Aronen, Peter J. Bostrom, Ivan Jambor, Anant Madabhushi
Summary: The study evaluated the short-term test-retest repeatability of a deep learning architecture (U-Net) in detecting and segmenting clinically significant prostate cancer. The results showed that the two CNN models had good repeatability in detecting csPCa at the slice-level, but were somewhat affected in lesion-level segmentation.
EUROPEAN RADIOLOGY
(2021)
Article
Urology & Nephrology
Ugo Falagario, Ivan Jambor, Pekka Taimen, Kari T. Syvanen, Esa Kahkonen, Harri Merisaari, Ileana Montoya Perez, Juha Knaapila, Aida Steiner, Janne Verho, Ashutosh Tewari, Hannu J. Aronen, Giuseppe Carrieri, Peter J. Bostrom, Otto Ettala
Summary: The developed nomogram based on MRI volumetric parameters and clinical information has the potential to assist in determining when SBx should be performed in men with suspicious prostate MRI, providing a potential benefit in addition to TBx.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Juha Knaapila, Ivan Jambor, Otto Ettala, Pekka Taimen, Janne Verho, Ileana Montoya Perez, Aida Kiviniemi, Tapio Pahikkala, Harri Merisaari, Tarja Lamminen, Jani Saunavaara, Hannu J. Aronen, Kari T. Syvanen, Peter J. Bostrom
Summary: This study demonstrated that IMPROD bpMRI has a high negative predictive value for excluding CSPCa, and patients with IMPROD bpMRI Likert score 1-2 can be excluded from having Gleason > 7 prostate cancer.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pietari Makela, Mikael Anttinen, Visa Suomi, Aida Steiner, Jani Saunavaara, Teija Sainio, Antero Horte, Pekka Taimen, Peter Bostrom, Roberto Blanco Sequeiros
Summary: The study evaluated acute and subacute MRI findings after TULSA treatment in six men with newly diagnosed MRI-visible and biopsy-concordant clinically significant prostate cancer. TULSA-related hemorrhage was detected as subtle T1 hyperintensity and more apparent T2 hypointensity in MRI. Prostate volume and non-perfused volume (NPV) increased significantly after TULSA at one week and three weeks after treatment, respectively. Lesion apparent diffusion coefficient values increased one week after treatment and decreased nearing the baseline values at the three-week MRI follow-up. The optimal timing of MRI follow-up seems to be at the earliest at three weeks after treatment, when the post-procedural edema has decreased and the NPV has matured. Diffusion-weighted imaging has little or no added diagnostic value in the subacute setting.
Article
Urology & Nephrology
Stefanie Korsgaard Korner, Thomas Dreyer, Erik Skaaheim Haug, Tomas Jerlstrom, Peter J. Bostrom, Sigurdur Gudjonsson, Jorgen Bjerggaard Jensen
Summary: This study aimed to provide a collective overview of available data sources on bladder cancer patients in the Nordic countries, revealing that detailed information on diagnostics, treatment, and outcomes could be retrieved for most aspects of bladder cancer from population-based, non-selected patient cohorts, despite varying completeness and coverage in different databases.
SCANDINAVIAN JOURNAL OF UROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simona Malaspina, Vesa Oikonen, Anna Kuisma, Otto Ettala, Kalle Mattila, Peter J. Bostrom, Heikki Minn, Kari Kalliokoski, Ernst J. Postema, Matthew P. Miller, Mika Scheinin
Summary: This study evaluated the uptake kinetics of F-18-rhPSMA-7.3 for imaging prostate cancer lesions, with optimal visual detection starting from 60 minutes post-injection. The radiopharmaceutical showed high uptake in prostate cancer lesions, with increasing lesion-to-reference ratios over time. The results suggest that F-18-rhPSMA-7.3 is a promising PET radiopharmaceutical for diagnostic imaging of prostate cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Multidisciplinary Sciences
Kalle E. Mattila, Teemu D. Laajala, Sara V. Tornberg, Tuomas P. Kilpelainen, Paula Vainio, Otto Ettala, Peter J. Bostrom, Harry Nisen, Laura L. Elo, Panu M. Jaakkola
Summary: The study aimed to develop a prognostic model for predicting metastasis-free survival after surgery of localized clear cell RCC, identifying key features such as tumor size, grade and microvascular invasion. The model demonstrated high accuracy, with concordance indices comparable to existing prediction models.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Ilkka Nikulainen, Antti P. Salminen, Ivan Jambor, Harri Merisaari, Ville Tammilehto, Pekka Taimen, Heikki Seikkula, Peter J. Bostrom
Summary: The study evaluated the performance of mpMRI for muscle-invasion detection in bladder cancer patients, showing that both the subjective MRI visual T-category and VI-RADS score had low to moderate accuracy for detecting muscle-invasion with no significant difference between the reporting systems. The agreement between radiologists was substantial.
SCANDINAVIAN JOURNAL OF UROLOGY
(2021)
Article
Oncology
Heikki Seikkula, Antti Kaipia, Peter J. Bostrom, Nea Malila, Janne Pitkaniemi, Karri Seppa
Summary: This study evaluated the variation in prostate cancer incidence and mortality rates in different regions of Finland. The results showed significant differences in incidence and mortality rates between municipalities, with variations over time. Additionally, municipalities with higher education levels had lower prostate cancer-specific mortality rates.
Article
Engineering, Biomedical
Cameron Wright, Pietari Makela, Alexandre Bigot, Mikael Anttinen, Peter J. Bostrom, Roberto Blanco Sequeiros
Summary: This study aimed to develop a deep learning model capable of predicting the non-perfused volume (NPV) immediately after prostate ablation therapy without the need for MRI contrast agents. The model was trained and tested using MRI imaging data from 95 patients, and the results showed the feasibility of predicting NPV without the use of MRI contrast agents, which could improve patient treatment outcomes.
BIOMEDICAL ENGINEERING LETTERS
(2023)
Article
Medicine, General & Internal
Alisa Salmivalli, Otto Ettala, Pertti Nurminen, Pekka Kinnala, Peter J. Bostrom, Ville Kyto
Summary: This study aims to compare the short- and long-term risks of PVP and TURP in the treatment of benign prostate enlargement. Retrospective study on consecutive patients in 20 hospitals in Finland showed that PVP had lower postoperative bleeding risk but higher long-term reoperation risk.
ANNALS OF MEDICINE
(2023)
Article
Oncology
Gregory J. Nason, Michael A. S. Jewett, Peter J. Bostrom, Hanan Goldberg, Aaron R. Hansen, Philippe L. Bedard, Jeremy Sturgeon, Padraig Warde, Peter Chung, Lynn Anson-Cartwright, Joan Sweet, Eshetu G. Atenafu, Martin O'Malley, Robert J. Hamilton
Summary: Surveillance is a safe and effective strategy for patients who achieve a complete response following chemotherapy for metastatic testis cancer.
EUROPEAN UROLOGY ONCOLOGY
(2021)
Letter
Oncology
Ivan Jambor, Ugo G. Falagario, Alberto Martini, David Eldred-Evans, Hashim U. Ahmed, Peter J. Bostrom
EUROPEAN UROLOGY ONCOLOGY
(2020)