Article
Virology
Imene Ben Dhifallah, Kaouther Ayouni, Haifa Jmel, Wafa Kammoun, Kamel Hamzaoui, Amel Sadraoui, Henda Triki
Summary: The study revealed that the IL-12B gene polymorphism is significantly associated with an increased risk of chronic hepatitis B (CHB) in patients, particularly in males under the age of 50.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Julio Ramirez, Ruth Carrico, Ashley Wilde, Alan Junkins, Stephen Furmanek, Thomas Chandler, Paul Schulz, Robin Hubler, Paula Peyrani, Qing Liu, Sonali Trivedi, Sonal Uppal, Warren V. V. Kalina, Ann R. Falsey, Edward E. E. Walsh, Kari Yacisin, Luis Jodar, Bradford D. D. Gessner, Elizabeth Begier
Summary: Current estimates of respiratory syncytial virus (RSV) incidence are mainly based on real-time polymerase chain reaction (RT-PCR) testing of nasal or nasopharyngeal swabs. This study compared RSV diagnosis using RT-PCR of nasal or nasopharyngeal swabs alone versus when additional specimen types (saliva, sputum, and serology) were included.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Virology
Xin Long, Jun Xie, Luo Ren, Guangyuan Yu, Enmei Liu, Yu Deng, Xiaoru Long
Summary: IL-17A has a significant role in respiratory syncytial virus (RSV) infection and is associated with respiratory system diseases in children and mice. CD3(+)CD4(+)T cells are its major cellular sources, and the IL-6/IL-21-IL-23R-ROR gamma t signaling pathway might participate in its regulation.
Article
Medicine, General & Internal
Shimon Amar, Yonat Shemer Avni, Norm O'Rourke, Tal Michael
Summary: The study examines the incidence rates of infectious diseases after a successful COVID-19 vaccination campaign and the lifting of social restrictions in Israel. The results suggest that the rates of respiratory and gastrointestinal infections have increased, indicating that similar trends could occur in other countries.
Article
Immunology
Zaid Haddadin, Stockton Beveridge, Kailee Fernandez, Danielle A. Rankin, Varvara Probst, Andrew J. Spieker, Tiffanie M. Markus, Laura S. Stewart, William Schaffner, Mary Lou Lindegren, Natasha Halasa
Summary: Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections (ARIs) in hospitalized children. RSV-positive children were more likely to be hospitalized, require intensive care unit admission, and receive oxygen compared with children positive for other viruses. Higher viral load, White race, younger age, and higher severity score were independently associated with hospitalization in RSV-positive children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Ruslan Kalendar, Alexandr V. Shustov, Ilyas Akhmetollayev, Ulykbek Kairov
Summary: This article introduces a bioinformatic tool for PCR-based genotyping assays, which allows design of probe sequences, discrimination of allelic variants, and enhances reaction specificity and discriminative power, offering greater likelihood of research success.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Immunology
Marina Luise Viola Azevedo, Aline Cristina Zanchettin, Caroline Busatta Vaz de Paula, Jarbas da Silva Motta Junior, Mineia Alessandra Scaranello Malaquias, Sonia Mara Raboni, Plinio Cezar Neto, Rafaela Chiuco Zeni, Amanda Prokopenko, Nicolas Henrique Borges, Thiago Mateus Godoy, Ana Paula Kubaski Benevides, Daiane Gavlik de Souza, Cristina Pellegrino Baena, Cleber Machado-Souza, Lucia de Noronha
Summary: By comparing post-mortem lung samples from patients who died of severe COVID-19 and H1N1pdm09 infection, it was found that the H1N1 group showed an increase in tissue expression of IL-8/IL-17A and a higher number of neutrophils. There was no significant difference in the distribution of genotype frequencies in the IL17A gene between the two groups. However, in SNP rs3819025 (G/A), the G allele may be considered a risk allele in patients who died from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Pierre Bay, Cloe Loegel, Arnaud Ly, Alexandre Soulier, Melissa N'Debi, Sarah Seng, Christian Kassasseya, Christophe Rodriguez, Jean-Michel Pawlotsky, Nicolas de Prost, Slim Fourati
Summary: A study investigating the clinical phenotypes and genetic diversity of respiratory syncytial virus (RSV) found no clustering by severity. Patients infected with RSV-B at risk for severe pneumonia had higher fusion protein diversity. No substitutions conferring resistance to nirsevimab were detected.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Microbiology
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose
Summary: Understanding the interaction between RSV and the host is crucial for developing effective interventions. This study identifies the RSV nonstructural protein NS2 as the key component in activating autophagy by modulating the ISGylation of Beclin1.
Article
Biochemistry & Molecular Biology
Jae Woo Lee, Mi Na Kim, Eun Gyul Kim, Ji Su Leem, Seung Min Baek, Min Jung Kim, Kyung Won Kim, Myung Hyun Sohn
Summary: Viral respiratory infections can cause lung diseases with inflammation. CHI3L1 protein may be involved in regulating inflammatory responses through the MAPK pathways in airway epithelial cells following viral infections.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Microbiology
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose
Summary: Paramyxoviruses like RSV are a leading cause of viral pneumonia in infants. This study identified the viral protein NS2 as mediating autophagy induction by RSV, providing a potential target for interventions against RSV.
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Based on a study in South African children, the burden of RSV-associated illness was estimated, with newborns and infants being the most affected group. Implementing maternal vaccination and monoclonal antibody products for this group can help reduce the disease burden.
Article
Medicine, General & Internal
Laura L. Hammitt, Ron Dagan, Yuan Yuan, Manuel Baca Cots, Miroslava Bosheva, Shabir A. Madhi, William J. Muller, Heather J. Zar, Dennis Brooks, Amy Grenham, Ulrika Wahlby Hamren, Vaishali S. Mankad, Pin Ren, Therese Takas, Michael E. Abram, Amanda Leach, M. Pamela Griffin, Tonya Villafana
Summary: A single injection of nirsevimab administered before the RSV season protected healthy late-preterm and term infants from medically attended RSV-associated lower respiratory tract infection.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Jason R. Gantenberg, Robertus van Aalst, Nicole Zimmerman, Brendan Limone, Sandra S. Chaves, William V. La Via, Christopher B. Nelson, Christopher Rizzo, David A. Savitz, Andrew R. Zullo
Summary: RSV is a major cause of infant hospitalization in the United States. While preterm infants and those with specific comorbidities are at high risk, 80% of RSV infections occur in term infants without comorbidities. Future prevention efforts should target all infants.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Alaa Ahmad, Kingsley Eze, Nicolas Noulin, Veronika Horvathova, Bryan Murray, Mark Baillet, Laura Grey, Julie Mori, Nathalie Adda
Summary: The study demonstrated that EDP-938 was superior to placebo in reducing RSV viral load, total symptom scores, and mucus weight, with a favorable safety profile.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
