Article
Surgery
Puja D. Patel, Mark Broadwin, Tara Stansbury, Jeffrey B. Brown, Hope Kincaid, Shae Duka, Justin Pasquale, Mark Cipolle, Kamalesh Shah
Summary: Community centers often transfer patients with traumatic intracranial hemorrhage (ICH) to higher-level trauma centers for neurosurgical evaluation, regardless of the severity of the injury. Identifying risk factors associated with neurosurgical intervention (NSI) may help reduce morbidity and mortality of traumatic ICH and unnecessary transfers. This retrospective study found that male gender, warfarin use, subdural hemorrhage, larger subdural hemorrhage size, worsening repeat head CT scan, confusion, hemiparesis, midline shift, and shift size were significantly associated with NSI. These clinical factors and patient characteristics can help predict the likelihood of requiring NSI and facilitate appropriate transfers.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Clinical Neurology
Janne Kinnunen, Jarno Satopaa, Mika Niemela, Jukka Putaala
Summary: The study aimed to assess the prevalence of coagulopathy in patients with traumatic intracranial hemorrhage, their clinical features, and the effect of coagulopathy on treatment and mortality. Results showed that coagulopathy patients had larger hemorrhage volumes and higher 30-day mortality, but coagulopathy was not independently associated with higher mortality. Surgical treatment was associated with lower mortality in both patients with and without coagulopathy.
ACTA NEUROCHIRURGICA
(2021)
Review
Clinical Neurology
Marc Maegele
Summary: TBI can lead to hemorrhagic progression and coagulopathy, affecting morbidity and mortality, with potential associations with preinjury use of antithrombotic agents and changes in coagulation function. Further research suggests the presence of both hyper- and hypocoagulable states after TBI, requiring more comprehensive hemostatic analysis.
Article
Critical Care Medicine
M. Victoria P. Miles, R. Chace Hicks, Hunter Parmer, Caroline Brown, Abigail Edwards, Kathryn Stewart, Lani Gao, Robert Maxwell
Summary: This study suggests that platelet dysfunction occurs in patients with TBI, and transfusion of platelets can correct this dysfunction and prevent hemorrhagic progression. Thromboelastography with platelet mapping can be used to evaluate platelet dysfunction and provide prognostic information to guide treatment in patients with TBI.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Medical Laboratory Technology
Hannes Warmuth, Kai Zacharowski, Volker Seifert, Juergen Konczalla, Christian F. Weber, Haitham Mutlak
Summary: The study found that nearly one-third of patients with acute intracranial bleeding have decreased platelet function, with 12% diagnosed with acute acquired platelet dysfunction. Hemotherapy algorithms for treating this cohort's coagulopathy should incorporate aggregometric measures for rapid goal-directed therapy.
CLINICAL LABORATORY
(2021)
Article
Clinical Neurology
Sebastiaan M. Bossers, Stephan A. Loer, Frank W. Bloemers, Dennis Den Hartog, Esther M. M. Van Lieshout, Nico Hoogerwerf, Joukje van der Naalt, Anthony R. Absalom, Saskia M. Peerdeman, Lothar A. Schwarte, Christa Boer, Patrick Schober
Summary: The study suggests that prehospital administration of tranexamic acid is associated with increased mortality in patients with isolated severe traumatic brain injury, indicating caution in its use when there is no evidence of extracranial hemorrhage.
Article
Cell Biology
Paul Vulliamy, Lucy Z. Kornblith, Matthew E. Kutcher, Mitchell J. Cohen, Karim Brohi, Matthew D. Neal
Summary: Platelets play a crucial role in the initial response to tissue injury, with altered responsiveness observed in both acutely injured patients and survivors. Aside from their role in coagulation, platelets contribute to the sterile inflammatory response to injury and can impact multiple-organ dysfunction syndromes.
Article
Cardiac & Cardiovascular Systems
Pil Hyung Lee, Sojeong Park, Hyewon Nam, Do-Yoon Kang, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Cheol Whan Lee
Summary: The study found that the incidence of ICH is highest in the early period after PCI and is closely associated with a high risk of early death. Careful implementation of antithrombotic strategies is needed for patients at increased risk for ICH, particularly in the peri-PCI period.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Surgery
Darla K. Eastman, Sarah K. Spilman, Kelly Tang, Richard A. Sidwell, Carlos A. Pelaez
Summary: The study investigated the use of platelet reactivity testing (PRT) to guide platelet transfusion for traumatic intracranial hemorrhage (tICH) patients suspected of taking aspirin. Results showed that some patients with suspected aspirin use did not require platelet transfusion based on PRT, suggesting that PRT can detect platelet inhibition related to aspirin and should guide transfusion decisions for head injured patients in the initial hours after trauma.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Surgery
Taylor E. Wallen, Matthew R. Baucom, Dennis Hanseman, Yao-Wei W. Wang, Charles E. Wade, John B. Holcomb, Timothy A. Pritts, Michael D. Goodman
Summary: This study examines the relationship between platelet dysfunction and 30-day survival in massively transfused, traumatically injured patients. The results indicate that platelet dysfunction is significantly associated with poor prognosis.
Article
Oncology
Johannes Wach, Stefanos Apallas, Matthias Schneider, Johannes Weller, Patrick Schuss, Hartmut Vatter, Ulrich Herrlinger, Erdem Gueresir
Summary: The MPV/PC ratio may independently predict the progression-free survival rates of patients with glioblastoma multiforme.
FRONTIERS IN ONCOLOGY
(2021)
Article
Neurosciences
Jean-Nicolas Tourigny, Veronique Paquet, Emile Fortier, Christian Malo, Eric Mercier, Jean-Marc Chauny, Gregory Clark, Pierre-Gilles Blanchard, Valerie Boucher, Pierre-Hugues Carmichael, Jean-Luc Gariepy, Marcel Emond
Summary: This study identified subdural hemorrhage >= 4 mm width and midline shift as predicting factors for neurosurgical intervention in patients with complicated mild traumatic brain injury. Conversely, subarachnoid hemorrhage was associated with a lower risk of neurosurgical intervention. Radiological deterioration did not necessarily lead to neurosurgical intervention.
Article
Critical Care Medicine
Peng Zhang, Qi Tu, Zhihui Ni, Zezheng Zheng, Yu Chen, Lin Yan, Han Bao, Qichuan Zhuge, Haoqi Ni
Summary: This study found that serum calcium levels are associated with coagulopathy and hemorrhagic progression contusion (HPC) in patients with traumatic intraparenchymal hemorrhage (tIPH). Low calcium is an independent risk factor for HPC in these patients, with part of the association being mediated by coagulopathy.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Biotechnology & Applied Microbiology
Yexiang Jiang, Meng Hao, Fenglin Jiang, Jiwu Li, Kunkun Yang, Can Li, Lan Ma, Shiyu Liu, Xiaoxing Kou, Songtao Shi, Xin Ding, Xiao Zhang, Jianxia Tang
Summary: This study presents a novel method for rapid hemostasis using dried apoptotic vesicles and adhesive hydrogel sponge. The method demonstrates high yield, stability, and fast clotting ability, and shows promising therapeutic effects in experimental models.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Emergency Medicine
Cecilia Tran, Hannah Frederick, Hammad Baqai, Matthew Fairchild, Julianna Solomon, Ayah Aligabi, Joshua Olexa, Uttam Bodanapally, Gary Schwartzbauer, Quincy K. Tran
Summary: This study demonstrates that blood pressure variability (BPV) is associated with the progression of hemorrhagic contusion or intraparenchymal hemorrhage (HPC) and worse outcomes in patients with traumatic intraparenchymal hemorrhage or contusion (tIPH). The coefficient of variation in systolic blood pressure (SBPCV) is significantly associated with HPC among patients requiring external ventricular drain (EVD). Additionally, the difference between the highest and lowest systolic blood pressure (SBPmax-min) is associated with hospital mortality.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Transplantation
Fasih Ali Ahmed, Yong K. Kwon, Shannon Zielsdorf, Jeffrey T. Cooper, Hassan Aziz
Summary: Liver transplant has emerged as a potential treatment option for isolated colorectal liver metastasis, providing prolonged overall survival compared to other therapeutic modalities. Selecting appropriate patients, including those with less aggressive biology, good performance status, at least 6 weeks of chemotherapy, low clinical risk scores, and negative nodal disease, is crucial.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
Article
Surgery
Hassan Aziz, Gavin Drumm, Augustus Gleason, Sam M. Han, Saba Alvi, Miklos Palotai
Summary: This study surveyed general surgery residents in the USA on their opinions about receiving formal radiology didactics. The results showed that most residents favored having radiological assessments as part of the competency evaluation and suggested the implementation of a curriculum and training structure to enhance residents' clinical image interpretation abilities.
WORLD JOURNAL OF SURGERY
(2022)
Editorial Material
Oncology
Diamantis Tsilimigras, Hassan Aziz, Timothy M. Pawlik
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hassan Aziz, Ye In Christopher Kwon, Saba Alvi, Shahzaib Ahmad, Sangrag Ganguli, Martin Goodman, Yong K. Kwon
Summary: Patients on chronic preoperative steroids undergoing liver resections have higher morbidity rates but no differences in mortality.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Editorial Material
Surgery
Cherilyn Song, Faisal S. Jehan, Alan I. Reed, Hassan Aziz
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Faisal S. Jehan, Sangrag Ganguli, Cherilyn Song, Hassan Aziz
Summary: This study analyzed the association of chronic steroid use with outcomes after hepatobiliary and pancreatic surgery. The results showed that in patients undergoing pancreatic surgery, chronic steroid use was associated with higher rates of pneumonia, unplanned intubation, readmission, transfusions, prolonged ventilator use, and greater mortality. In patients undergoing hepatobiliary surgery, chronic steroid use was associated with higher rates of sepsis, unplanned intubation, transfusions, and readmission.
AMERICAN JOURNAL OF SURGERY
(2023)
Review
Gastroenterology & Hepatology
Ahmad Hamad, Hassan Aziz, Ihab R. Kamel, Dayssy Alexandra Diaz, Timothy M. Pawlik
Summary: Radioembolization (RE) with 90Yttrium (Y90) has shown promising results for patients with HCC, regardless of stage. It can be used as a downstaging treatment for advanced HCC patients and has comparable outcomes to other standard treatments. Radiation lobectomy (RL) can be used to treat the liver lobe with HCC and induce compensatory hypertrophy of the future liver remnant (FLR).
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Surgery
Hassan Aziz, Zachary J. Brown, Seyedeh Panid Madani, Ihab R. Kamel, Timothy M. Pawlik
Summary: This review article discusses the latest advancements in diagnosing, imaging, and managing fibrolamellar hepatocellular carcinoma (FLC). Surgical resection is the mainstay of therapy, but systemic therapies are also crucial due to the high incidence of metastasis and relapse. However, there is a lack of proven effective systemic therapies, and further research is needed to define their role in managing this disease.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Article
Gastroenterology & Hepatology
Fasih A. Ahmed, Sameer A. Khan, Apoorve Nayyar, Hassan Aziz
Summary: The expansion of Medicaid under the Affordable Care Act has positively impacted the treatment and outcomes of intrahepatic cholangiocarcinoma (ICC) by increasing access to care processes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Faisal S. Jehan, Niklas E. Hase, Sangrag Ganguli, Areeba Saif, Apoorve Nayyar, Hassan Aziz
Summary: This study found that accounting for Pre-Admission Time of Surgery (PATOS) is important for estimating unadjusted postoperative complication rates, particularly in pancreatic surgery. By considering PATOS, the observed postoperative complication rates decreased, with varying reductions across different types of complications. Risk adjustment is essential in quality assessment, as failure to account for PATOS may unfairly penalize surgeons.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Hassan Aziz, Sangrag Ganguli, John R. Potts Iii
Summary: This study examined the trends in resident pancreatic operative experience since 1990 and found a significant decline in the number of pancreatic operations performed by residents over the past decade.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Kamil Hanna, Bardiya Zangbar, Jordan Kirsch, Matthew Bronstein, Kenji Okumura, Shekhar Gogna, Ilya Shnaydman, Kartik Prabhakaran, Jorge Con
Summary: This study compared the outcomes of cholecystectomy and nonoperative management in cirrhotic patients with acute calculous cholecystitis. The results showed a higher failure rate of nonoperative management, longer length of stay, and higher mortality in these patients.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Hassan Aziz, Alyssa C. Brown, Saba Alvi, Manish Karamchandani, Monica Majumdar, Maura E. Sullivan, Mohammed A. Bawazeer
Summary: The incorporation of a dedicated research sabbatical during general surgery residency is becoming increasingly common, but there is inconsistency in its structure and definition. This survey-based study aimed to understand the perceptions of program directors and residents regarding research sabbaticals. Findings showed that 44.1% of residents felt that research time delayed their surgical training. Regarding funding, 46.7% of residents reported program funding, while 30.9% acquired funding independently.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Surgery
Hannan A. Maqsood, Laura Somppi-Montgomery, Lawrence Feng, Saba Alvi, Nicole Segalini, Muneera R. Kapadia, Hassan Aziz
Summary: This study examines the research pathways, opportunities, and academic productivity of different general surgery residency programs in the United States. The data collected reveals that 41% of the programs offer dedicated research years, with 8% being mandatory and 32% being optional. Additionally, 23% of the programs require residents to start the dedicated research year after postgraduate year 2 or 3, and about 7% provide examples of resident publications and presentations. There is a need to expand the available research opportunities and information for various general surgery residency programs.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Surgery
Hassan Aziz, Taylor Nordan, Lawrence R. Feng, Yong K. Kwon, Mohammad Khreiss, Raffi Karagozian, Thomas Schnelldorfer
Summary: This study aimed to evaluate the difference in liver resection outcomes in patients with benign tumors based on the utilization of preoperative angioembolization (AE). A retrospective cohort study was conducted using the National Surgical Quality Improvement Program database (2014-2019). The results showed that preoperative AE was not associated with bleeding complications or blood transfusions within 72 hours after surgery.
JOURNAL OF SURGICAL RESEARCH
(2023)