Journal
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
Volume 74, Issue 2, Pages 371-376Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TA.0b013e31827e1d40
Keywords
Transfusion; oxygenation; red blood cells; storage
Categories
Funding
- 711th Human Performance Wing, Air Force Research Laboratory [FA8650-09-2-6035, FA8650-10-2-6143]
Ask authors/readers for more resources
BACKGROUND: During preservation, donated liquid red blood cells (RBCs) experience multiple functional and structural changes known as the storage lesion. Increased RBC age is associated with increased infection rates, organ failure, and mortality. METHODS: This prospective, randomized, double-blinded pilot study enrolled stable trauma patients who required RBC transfusion. Patients were randomly assigned to receive standard or cryopreserved RBCs. Continuous tissue oxygenation (StO(2)) monitoring was performed during the peritransfusion period. Hematocrit and thrombelastography before and after transfusion were evaluated. Patients were monitored for transfusion reactions and clinical outcomes. RESULTS: Fifty-seven patients were randomized, and groups were well matched for demographics and Injury Severity Score (ISS). No statistically significant differences were noted in hematocrit change, thrombelastography parameters, transfusion reactions, or clinical outcomes. StO(2) was found to be higher in the cryopreserved group. CONCLUSION: Cryopreserved RBCs are equally safe and efficacious to refrigerated RBCs. This storage technique extends the life span of RBCs to 10 years, potentially preserving a precious resource and preventing the storage lesion. StO2 was superior in patients receiving cryopreserved RBCs. This finding has the potential to drive a paradigm shift in transfusion practices. (J Trauma Acute Care Surg. 2013;74: 371-377. Copyright (C) 2013 by Lippincott Williams & Wilkins)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available