Article
Oncology
Kai-Ling Lee, Tsung-Ching Lai, Wei-Jiunn Lee, Yu-Chieh Chen, Kuo-Hao Ho, Wen-Yueh Hung, Yi-Chieh Yang, Ming-Hsien Chan, Feng-Koo Hsieh, Chi-Li Chung, Jer-Hwa Chang, Ming-Hsien Chien
Summary: Non-small-cell lung cancer (NSCLC) is a typical inflammation-associated cancer, and epidermal growth factor (EGF) receptor (EGFR) mutations are the most common driver mutations of NSCLC. This study aimed to evaluate the effects of interleukin (IL)-17A, a proinflammatory cytokine, on EGFR-mediated progression of NSCLC. The results showed that the IL-17A/IL-17RC axis promoted proliferation and resistance to EGFR-tyrosine kinase inhibitors (TKIs) in NSCLC cells with mutant EGFR, and enhanced EGF-induced EGFR activation and cell proliferation in NSCLC cells with wild-type (WT) EGFR by impairing EGFR lysosomal degradation. Developing therapeutic strategies against IL-17A/IL-17RC could be valuable for NSCLC treatment.
Article
Oncology
Bo Zhang, Yao Zhang, Xizi Jiang, Hongbo Su, Qiongzi Wang, Muli Wudu, Jun Jiang, Hongjiu Ren, Yitong Xu, Zongang Liu, Xueshan Qiu
Summary: JMJD8 functions as an oncogenic regulator in non-small-cell lung cancer (NSCLC), promoting carcinogenic activity by stabilizing EGFR and activating the downstream PI3K/AKT signaling pathway. High expression of JMJD8 is associated with the malignancy and staging of NSCLC patients.
Article
Oncology
Sze-Ching Wong, Chun-Chieh Yeh, Xun-Yu Zhang, Chih-Ying Hsieh, Chia-Chien Lo, Ting-Ting Kuo, Ching-Chan Lin, Chih-Hua Chao, Jing-Pei Liu, Ling-Chu Chang, Lu-Hai Wang, Yuh-Pyng Sher
Summary: CUB domain-containing protein 1 (CDCP1) contributes to EGFR TKI resistance in lung cancer, and this study identified a CDCP1 reducer called 8-isopentenylnaringenin (8PN) that synergistically improves TKI treatment. 8PN treatment reduced CDCP1 protein levels and malignant features, and in TKI-resistant lung cancer cells, the combination of 8PN and TKI had additive effects on cell death and reduced the downstream EGFR pathway signaling. Mechanistically, 8PN increased IL6 and IL8 expression, induced neutrophil infiltration, and enhanced neutrophil-mediated cytotoxicity. Combination therapy effectively reduced tumor growth and necrosis in vivo.
MOLECULAR ONCOLOGY
(2023)
Article
Biophysics
Parimala Devi Ganthala, Sateesh Alavala, Naveen Chella, Sai Balaji Andugulapati, Nagendra Babu Bathini, Ramakrishna Sistla
Summary: Erlotinib-based EGFR targeted therapy has shown significant clinical improvement against non-small cell lung cancer. However, the development of drug resistance limits its effectiveness. In this study, the combination of Erlotinib and Quercetin was found to be more synergistic against certain lung cancer cells compared to other natural products. By preparing drug-loaded nanoparticles, the encapsulation efficiency and release performance of the drugs were improved. The nanoparticles could reduce the expression of drug-resistant proteins, increase drug uptake, and induce apoptosis in drug-resistant cells. In vivo experiments also showed increased uptake of nanoparticles in lung tissue and decreased expression of cancer-related genes.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Shinan Li, Thi Thinh Nguyen, Trong Thuan Ung, Dhiraj Kumar Sah, Seon Young Park, Vinoth-Kumar Lakshmanan, Young Do Jung
Summary: The study demonstrated that piperine blocked LCA-induced IL-8 expression by inhibiting Src and EGFR in human CRC HCT-116 cells, leading to a significant reduction in tube formation of endothelial EA.hy926 cells.
Article
Cell Biology
Ming-Na Zhao, Ling-Fei Zhang, Zhen Sun, Li-Hua Qiao, Tao Yang, Yi-Zhe Ren, Xian-Zhou Zhang, Lei Wu, Wen-Li Qian, Qiao-Mei Guo, Wan-Xing Xu, Xue-Qing Wang, Fei Wu, Lin Wang, Yutong Gu, Mo-Fang Liu, Jia-Tao Lou
Summary: Bone metastasis is a significant complication in lung cancer patients, leading to poor quality of life and low survival rates. The regulatory mechanisms of lung cancer bone metastasis are not well understood. A study found that miR-182 plays a critical role in promoting osteoclastic metastasis of lung cancer cells. Mechanistically, miR-182 enhances the secretion of Interleukin-8 (IL-8) by NSCLC cells, which in turn activates STAT3 signaling in osteoclast progenitor cells to promote osteoclastogenesis. Inhibition of IL-8 with antibodies effectively suppresses NSCLC bone metastasis in animal models. These findings highlight the importance of the miR-182/IL-8/STAT3 axis as a potential therapeutic target for interrupting lung cancer bone metastasis.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Marina Luise Viola Azevedo, Aline Cristina Zanchettin, Caroline Busatta Vaz de Paula, Jarbas da Silva Motta Junior, Mineia Alessandra Scaranello Malaquias, Sonia Mara Raboni, Plinio Cezar Neto, Rafaela Chiuco Zeni, Amanda Prokopenko, Nicolas Henrique Borges, Thiago Mateus Godoy, Ana Paula Kubaski Benevides, Daiane Gavlik de Souza, Cristina Pellegrino Baena, Cleber Machado-Souza, Lucia de Noronha
Summary: By comparing post-mortem lung samples from patients who died of severe COVID-19 and H1N1pdm09 infection, it was found that the H1N1 group showed an increase in tissue expression of IL-8/IL-17A and a higher number of neutrophils. There was no significant difference in the distribution of genotype frequencies in the IL17A gene between the two groups. However, in SNP rs3819025 (G/A), the G allele may be considered a risk allele in patients who died from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiao-Ping Zhao, Xiao-Li Zheng, Min Huang, Ya-Jia Xie, Xiao-Wen Nie, Ali Adnan Nasim, Xiao-Jun Yao, Xing-Xing Fan
Summary: Despite advances in clinical and diagnostic techniques, the treatment of non-small cell lung cancer (NSCLC) remains unsatisfactory in terms of cure and survival rates. Epidermal growth factor (EGFR) is recognized as a key driver of NSCLC and a target for pharmacological intervention. DMU-212, an analog of resveratrol, has shown inhibitory effects on various types of cancer, but its effect on lung cancer is unclear. This study aimed to investigate the effects and underlying mechanism of DMU-212 on EGFR-mutant NSCLC cells. The results showed that DMU-212 had higher cytotoxicity on EGFR-mutant NSCLC cell lines compared to normal lung epithelial cells. Further analysis revealed that DMU-212 induced G2/M phase arrest in H1975 and PC9 cells by regulating cell cycle-related proteins and modulating the expression of EGFR and key signaling molecules. In conclusion, this study suggests that DMU-212 inhibits NSCLC growth by targeting AMPK and EGFR.
Review
Immunology
Ding-Yu Rao, De-Fa Huang, Mao-Yan Si, Hua Lu, Zhi-Xian Tang, Zu-Xiong Zhang
Summary: As an important mediator of information transfer between cells, exosomes play a unique role in regulating tumor growth, supporting vascular proliferation, tumor invasion, and metastasis. Exosomes can be used as a potential tool for non-invasive liquid biopsy due to their presence in various body fluids. This study reviews the role of exosomes in liquid biopsy, tumor microenvironment formation, and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC). It also discusses the occurrence of EGFR+ exosomes and the role of exosomes and their contents in non-invasive detection and potential therapeutic targets in EGFR-mutated lung cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Wei Wang, Xinhang Xia, Kuifei Chen, Meng Chen, Yinnan Meng, Dongqing Lv, Haihua Yang
Summary: PHLPP, a potential tumor suppressor, is found to be a key regulator of sensitivity to EGFR-TKIs in NSCLC. Loss of PHLPP function leads to activation of survival pathways, reducing sensitivity to EGFR-TKIs. Enhancing PHLPP expression may be a valuable strategy for delaying or overcoming EGFR-TKIs drug resistance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shike Yan, Bing Zhang, Jingwen Feng, Haigang Wu, Namin Duan, Yamin Zhu, Yueliang Zhao, Shuang Shen, Kai Zhang, Wenhui Wu, Ning Liu
Summary: FGFC1 selectively suppressed the growth of NSCLC cells with EGFR mutation, induced apoptosis of erlotinib-resistant NSCLC cells via mitochondrial dysfunction and ROS accumulation, and inhibited EGFR and its downstream PI3K/Akt/mTOR pathway by directly binding to EGFR. Additionally, FGFC1 inhibited the migration and invasion of NSCLC cells and effectively inhibited tumor growth in a xenograft model, indicating its potential as a candidate for erlotinib-resistant NSCLC therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mogammad Baaghith Hamid, Antonio Mendes Serafin, John Mbabuni Akudugu
Summary: This study found that breast cancer cell lines were more sensitive to X-ray irradiation, while cervical and lung cancer cell lines were more sensitive to EGFR and PI3K/mTOR inhibitor therapy. These results provide some guidance for the treatment options of patients with different types of cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Chia-Hsiang Li, Ya-Chen Yang, Te-Chun Hsia, Te-Chun Shen, Yi-Cheng Shen, Wen-Shin Chang, Yun-Chi Wang, Chia-Wen Tsai, Da-Tian Bau
Summary: The interleukin-8 rs4073 genotypes are associated with lung cancer susceptibility, especially for smokers. The study found that the homozygous variant AA genotypes had a lower percentage in lung cancer patients compared to healthy controls, and there was a statistical difference in allele frequencies distribution.
ANTICANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Fei Wang, Chong Yuan, Bo Liu, Yan-Fang Yang, He-Zhen Wu
Summary: This study isolated Syringin and demonstrated its anti-breast cancer effects. Bioinformatics analysis revealed the target genes and potential mechanisms of Syringin against breast cancer. In vitro experiments confirmed that Syringin inhibits proliferation and migration and promotes apoptosis in breast cancer cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Shigeki Nanjo, Wei Wu, Niki Karachaliou, Collin M. Blakely, Junji Suzuki, Yu-Ting Chou, Siraj M. Ali, D. Lucas Kerr, Victor R. Olivas, Jonathan Shue, Julia Rotow, Manasi K. Mayekar, Franziska Haderk, Nilanjana Chatterjee, Anatoly Urisman, Jia Chi Yeo, Anders J. Skanderup, Aaron C. Tan, Wai Leong Tam, Oscar Arrieta, Kazuyoshi Hosomichi, Akihiro Nishiyama, Seiji Yano, Yuriy Kirichok, Daniel S. W. Tan, Rafael Rosell, Ross A. Okimoto, Trever G. Bivona
Summary: This study investigates the impact of co-occurring genetic alterations on mutant EGFR and identifies the deficiency of RNA-binding factor RBM10 as a factor that decreases the efficacy of EGFR inhibitors in lung cancer treatment. The study reveals that RBM10 modulates tumor cell apoptosis by regulating the alternative splicing of Bcl-x and its deficiency diminishes EGFR inhibitor-mediated apoptosis. The findings suggest that co-occurring genetic alterations and splicing factor deficiency play a role in determining the sensitivity to targeted kinase inhibitor therapy.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Environmental Sciences
Fenghua Li, Xianqi Zhao, Yanni Jiao, Xinglan Duan, Lianlong Yu, Fengjia Zheng, Xiaolin Wang, Lin Wang, Jia-Sheng Wang, Xiulan Zhao, Tianliang Zhang, Wei Li, Jun Zhou
Summary: This study analyzed the exposure level and health risks of aflatoxins (AFs) and zearalenone (ZEA) through cooking oil consumption in Shandong, China. The findings showed that children are facing the highest health risk, and liver cancer incidence is associated with exposure to aflatoxins.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Electrical & Electronic
Dehui Wu, Shibin Lin, Hongfu Chen, Xiaohong Wang
Summary: An analytical model for calculating the mutual inductance between coplanar rectangular spiral coils was developed in this study. The model is applicable to PCB-based spiral coils in eddy-current testing probes and can simplify the calculation process while maintaining accuracy.
INTERNATIONAL JOURNAL OF NUMERICAL MODELLING-ELECTRONIC NETWORKS DEVICES AND FIELDS
(2023)
Article
Polymer Science
Xin-Xin Zhi, Hua-Sen Wang, Jie Jia, Xiao-Lei Wang, Yan-Shuang Ga, Shu-Jing Chen, Jin-Gang Liu
Summary: In this study, alignment agents derived from different poly(amic acid)s (PAAs) were prepared and applied to the fabrication of liquid crystal (LC) minicells. The polyimides (PI) alignment layers obtained from the thermal dehydration reaction of the PAA precursors showed good alignment effects to the LC molecules and exhibited good optoelectronic features.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Obstetrics & Gynecology
Linli Hu, Jieqiang Lv, Qianhong Ma, Xiujuan Chen, Xiaohong Wang, Xiaoyan Liang, Dingfei Xu, Yanping Li, Yuanhua Huang, Lina Hu, Xiaohui Deng, Jing Wei, Feng Zhou, Songying Zhang, Jie Wang, Fang Ma, Yingpu Sun
Summary: The study aimed to compare the equivalence of QL1012 and Gonal-f((R)) in ovarian stimulation for assisted reproductive technology. The results showed that there were no significant differences between QL1012 and Gonal-f((R)) in the primary endpoint of oocytes retrieved, and they had similar safety profiles.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Psychiatry
Yu Gu, Huijuan Guo, Jiansong Zhou, Xiaoping Wang
Summary: This study investigated the socio-demographic, clinical, and offense-related characteristics of mentally ill offenders in a forensic psychiatric hospital in China. The majority of the participants were male, unmarried, and had sought medical help for their mental illnesses prior to their offenses. Schizophrenia was the most common diagnosis, and homicide offenses were prevalent, with family members being the most common victims.
Article
Biochemistry & Molecular Biology
Hao Liu, Jingxuan Wang, Mei Liu, Xia Zhang, Ying Liang, Jinshui Wang
Summary: Self-assembled fibrillation of wheat gluten is a common phenomenon in the production and processing of wheat flour products. The breakage of hydrogen bonds, strengthening of hydrophobic interactions, and SH-SS exchange reactions play important roles in fibrillation. Wheat gluten with higher degrees of hydrolysis show a greater propensity for worm-like aggregation.
Article
Genetics & Heredity
Liangcheng Yu, Lu Wang, Lijin Wang, Song Yan, Shuqiang Chen, Qian Xu, Danjie Su, Xiaohong Wang
Summary: This study aims to identify the association between immune cell types, immune-related genes, and recurrent implantation failure (RIF) through bioinformatics analysis. Differentially expressed genes (DEGs) were screened, and enrichment analysis and protein-protein interaction (PPI) analysis were conducted. The RIF-associated immune cell types were clarified, and differentially expressed immune cell types-related modules were identified. Three immune-related hub genes were identified and validated, and a ceRNA network was constructed.
FRONTIERS IN GENETICS
(2023)
Article
Chemistry, Medicinal
Baiyang Xu, Mengxue Yao, Zilu Liu, Shanshan Zhang, Bin Wang, Yanquan Han, Jiarong Gao, Deling Wu, Xiaoli Wang
Summary: The combination of Stephania tetrandra and Astragalus membranaceus has positive effects on the treatment of nephrotic syndrome by reducing renal injury and improving the condition. It achieves this by inhibiting the IL-13/STAT6 signal pathway, regulating endogenous metabolic pathways, and inhibiting the expression of AQP2 and AVP genes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaohong Wang, Guiying Du, Yao Liu
Summary: The study found that lateral meniscal body extrusion (LMBE) is associated with progression of OA-related knee structural damage over 4 years, and identified thresholds for predicting this progression.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Elena-Codruta Cozma, Laura Madalina Banciu, Cristina Soare, Sanda-Maria Cretoiu
Summary: Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer originating from keratinocytes. Multiple risk factors have been identified for the development of cSCC, including UV/ ionizing radiation, chemical carcinogens, immunosuppression, chronic inflammation, viral infections, and genetic alterations. Due to its socio-economic impact and treatment challenges, extensive research has been conducted to understand the molecular mechanisms and advance the therapies for cSCC. This review provides an overview of the molecular, genetic, and epigenetic aspects of cSCC, as well as the treatment methods from conventional to targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qiong Wang, Xiao-Hong Wang, Qing Pan, Hai Chang, Hong-Jian Yu, Wei-Qiang Pang
Summary: The thermal behaviors of nano-scale composite energetic materials composed of ADN and NC were studied using various instruments. The results showed that the interaction mechanism between ADN and NC is crucial for the design and safety of these materials. The mixture of NC and ADN exhibited different thermal decomposition characteristics compared to NC or ADN alone. ADN initiated the interaction with NC, leading to the formation of oxidative gases. The thermal decomposition process of ADN dominated the initial stage of the mixture, followed by the oxidation of NC and the cation of ADN.
Article
Immunology
Genwei Zhang, Guodong Niu, Diana Hooker-Romera, Sadeq Shabani, Julian Ramelow, Xiaohong Wang, Noah S. Butler, Anthony A. James, Jun Li
Summary: In this study, antibodies against human alpha-tubulin were found to significantly reduce the number of P. falciparum oocysts in mosquito midguts. Further investigation revealed that antibodies specifically against P. falciparum alpha-tubulin-1 also limited the transmission of P. falciparum to mosquitoes. Mouse monoclonal antibodies against recombinant P. falciparum alpha-tubulin-1 were generated, and two of them, A3 and A16, effectively blocked parasite transmission.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lingze Yang, Lei Bao, Tong Dong, Honghao Xie, Xiaohong Wang, Huili Wang, Jingbo Wu, Chen Hao
Summary: In this study, Typha angustifolia was chemically modified with potassium permanganate to obtain modified Typha angustifolia (MTC), and then compounded with carboxymethyl cellulose (CMC) and guar gum (GG) to prepare the CMC/GG/MTC composite hydrogel. The optimal adsorption conditions were determined, and the maximum adsorption capacity for Cu2+, Co2+, and methylene blue (MB) were calculated. The results showed that the main mechanism of removing pollutants by the adsorbent is surface complexation and electrostatic attraction. The CMC/GG/MTC adsorbent exhibited good adsorption and regeneration capacity after five cycles.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Proceedings Paper
Energy & Fuels
Fan Yang, Xiaohong Wang, Haishan Guo, Hemin Yang, Zhixin Huo, Youzong Jian, Jing Hu
Summary: This paper proposes a direct AC-AC modular multilevel converter called Hexverter, which is based on cascaded full-bridge sub-modules and is suitable for connecting two systems operating at different frequencies. However, the operating range of Hexverter is limited by the capacitor voltage of the sub-modules. To address this issue, a strategy based on optimal neutral voltage and circulating current is proposed to limit the capacitor voltage within a specific range and minimize switching loss. Simulation results confirm that this strategy effectively suppresses the magnitude of the capacitor ripple voltage and reduces switching loss.
PROCEEDINGS OF THE 3RD INTERNATIONAL SYMPOSIUM ON NEW ENERGY AND ELECTRICAL TECHNOLOGY
(2023)
Review
Materials Science, Biomaterials
Dongxu Xu, Qian Duan, Hui Yu, Wenyue Dong
Summary: Porphyrins and their derivatives have excellent properties that make them attractive for various applications, but their limitations hinder their use in biomedicine. Metal-organic frameworks (MOFs) have emerged as a promising solution by combining the unique properties of porphyrins and MOFs. This article reviews the synthetic strategies and recent research achievements in forming porphyrin-based MOFs and their applications in photodynamic therapy (PDT) and tumor therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
