Article
Medicine, General & Internal
Giulia Pivetta, Chiara Coluccio, Emanuele Dilaghi, Edith Lahner, Emanuela Pilozzi, Marilia Carabotti, Vito Domenico Corleto
Summary: Iron-deficiency anemia in the elderly may be caused by various gastrointestinal conditions. The use of routine duodenal biopsies for diagnostic purposes in elderly patients is debated. A cross-sectional study analyzing 7968 gastroscopies was conducted to determine the diagnostic value of routine duodenal biopsies in adult and elderly patients with no bleeding anemia. The study found limited diagnostic yield of routine duodenal biopsies in this population.
Article
Gastroenterology & Hepatology
Marianna Calabretto, Daniele Di Carlo, Francesca Falasca, Laura Mazzuti, Arianna Meacci, Giuseppe Donato, Nicoletta Greco, Laura Mezzatesta, Anna Morrone, Ombretta Turriziani, Antonio Picarelli
Summary: This study investigated the presence of Adenovirus, Epstein-Barr virus (EBV), HHV-6, and cytomegalovirus (CMV) in gastrointestinal biopsies from patients with active celiac disease (CD). The results showed that HHV-6B was present in 62.5% of CD patients and 65% of non-CD individuals, while the prevalence of EBV-positive samples was 20% and 10% respectively. However, no nucleic acids from HHV-6A, CMV, or adenovirus were detected in any group. These findings suggest that these viruses may not directly contribute to the development of acute CD, but they do not exclude the possibility that viruses can act as triggers for the onset of celiac disease.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Veterinary Sciences
Lars Beedgen, Andreas Huellen, Sevinc Guecuem, Thomas Thumberger, Jochen Wittbrodt, Christian Thiel
Summary: The use of animal models allows for detailed studies on disease development and potential therapies, reducing the risk of therapeutic side effects for patients. Developing alternative test systems can help in reducing the number of experimental animals used in research, with cell culture systems showing promising potential.
LABORATORY ANIMALS
(2022)
Article
Biochemistry & Molecular Biology
Sebastian Stricker, Jan de Laffolie, Klaus-Peter Zimmer, Silvia Rudloff
Summary: This study found that PX-12 is an effective inhibitor of TG2, reducing the cross-linking reaction of PTG in cells. ERW1041 showed weaker inhibitory effect compared to PX-12. In addition, ERW1041 also inhibited the absorption of P56-88 by Caco-2 cells. In conclusion, TG2 inhibitors have potential therapeutic effects in the treatment of celiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Leqian Yu, Yulei Wei, Jialei Duan, Daniel A. Schmitz, Masahiro Sakurai, Lei Wang, Kunhua Wang, Shuhua Zhao, Gary C. Hon, Jun Wu
Summary: The study developed an effective three-dimensional culture strategy to generate blastocyst-like structures in vitro which resemble human blastocysts. These structures, termed 'human blastoids', are readily accessible, scalable, versatile, and perturbable alternative to blastocysts for studying early human development, understanding early pregnancy loss, and gaining insights into early developmental defects.
Article
Biochemistry & Molecular Biology
Johannes Wolf, Edith Willscher, Henry Loeffler-Wirth, Maria Schmidt, Gunter Flemming, Marlen Zurek, Holm H. Uhlig, Norman Handel, Hans Binder
Summary: This study provides a high-resolution analysis of the transcriptomes extracted from duodenal biopsies of children and adolescents with active CD, revealing three distinct CD patient groups. The persistence of symptoms was weakly associated with subgroups, with the CD-high group showing the highest marsh stages and cell cycle rates, indicating virtually complete villous atrophy. Inflammation-level differences between subgroups were further deciphered into immune cell types using cell type de-convolution. The application of self-organizing maps provided high-resolution landscapes of the CD-transcriptome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Victorine H. Roos, Barbara A. Bastiaansen, Frank G. J. Kallenberg, Arthur S. Aelvoet, Patrick M. M. Bossuyt, Paul Fockens, Evelien Dekker
Summary: This study evaluated the safety and effectiveness of endoscopic duodenal interventions in patients with FAP. Prophylactic duodenal polypectomies were relatively safe, while papillectomies showed substantial adverse events. Both interventions were effective in preventing duodenal cancer.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Nutrition & Dietetics
Rakel Nurmi, Ilma Korponay-Szabo, Kaija Laurila, Heini Huhtala, Onni Niemela, Jukka Mustonen, Satu Makela, Katri Kaukinen, Katri Lindfors
Summary: IgA-tTG deposits were found in the kidney biopsies of IgAN patients with celiac disease and non-celiac IgAN patients consuming gluten, suggesting limited specificity to celiac disease.
Article
Immunology
Robin D. Wright, Thais F. Bartelli, Seyda Baydogan, James Robert White, Michael P. Kim, Manoop S. Bhutani, Florencia Mcallister
Summary: In this feasibility study, the tumor microbiome (TM) of pancreatic adenocarcinoma was characterized using Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA) biopsy and sequencing techniques. The results showed that it is possible to characterize the TM in biopsies with proper decontamination strategies and by comparing it to non-matched tumor.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xavier Suarez-Calvet, Esther Fernandez-Simon, Patricia Pinol-Jurado, Jorge Alonso-Perez, Ana Carrasco-Rozas, Cinta Lleixa, Susana Lopez-Fernandez, Gemma Pons, Laura Soria, Anne Bigot, Vincent Mouly, Isabel Illa, Eduard Gallardo, Jyoti K. Jaiswal, Jordi Diaz-Manera
Summary: The study presented a method to isolate and grow SCs and FAPs from frozen human skeletal muscle biopsies, demonstrating their multipotency and interactions.
Article
Pathology
Vikarm Narang, Akriti Jindal, Aminder Singh, Bhavna Garg Varun Mehta, Neena Sood, Ajit Sood
Summary: The study suggests that conducting multiple duodenal biopsies, including D3 region biopsies, can increase the diagnostic accuracy of adult celiac disease, especially for patients whose biopsies in D1 and D2 regions appear normal.
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Popp Alina, Taavela Juha, Graziano Paolo, Parente Paola, Covelli Claudia, Lamacchia Carmela, Andriulli Angelo, Maki Markku, Isola Jorma
Summary: A new IHC method has been developed to reliably detect and quantify gamma delta-IELs in FFPE duodenal biopsies, showing excellent specificity and sensitivity for celiac disease. This new method is a promising addition to the routine histopathologic assessment of celiac disease.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Surgery
Mickael Chevallay, Florian Lorenz, Philippe Bichard, Jean-Louis Frossard, Thomas Schmidt, Tobias Goeser, Christiane Josephine Bruns, Stefan P. Monig, Seung-Hun Chon
Summary: This retrospective study examined the successful application of endoscopic vacuum therapy (EVT) for duodenal leaks. EVT was successfully applied in all interventions and led to definitive closure of the defects in eight out of ten patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Public, Environmental & Occupational Health
H. Callaby, K. Emery, M. Killip, T. Rampling, K. S. Richards, C. F. Houlihan
Summary: Monkeypox virus is a DNA virus that causes monkeypox. Symptoms include fever, lymphadenopathy, and vesicular lesions. This study used cell culture as a proxy for infectivity and found that infectious mpxv could be recovered from clinical samples up to 25 days after illness onset.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Pharmacology & Pharmacy
Tom de Waal, Joachim Brouwers, Philippe Berben, Talia Flanagan, Jan Tack, Wim Vandenberghe, Tim Vanuytsel, Patrick Augustijns
Summary: Parkinson's disease may not only impact the motor system but also the physiology of the gastrointestinal tract. The composition of intestinal fluids in PD patients is generally similar to healthy controls, with only minor differences. These differences may be attributed to slower gastric emptying and altered intestinal bacterial metabolism.
Article
Chemistry, Multidisciplinary
Alice Scricciolo, Karla A. Bascunan, Magdalena Araya, David S. Sanders, Nick Trott, Luca Elli, Maria Teresa Bardella, Luisa Doneda, Vincenza Lombardo, Nicoletta Nandi, Maurizio Vecchi, Leda Roncoroni
Summary: The gluten-free diet is a restrictive diet, but it can be balanced and healthy by correctly consuming vitamins and minerals and following a Mediterranean gluten-free diet. Monitoring the diet through urine testing and online nutritional questionnaires, as well as providing guidance through telemedicine, can be beneficial.
APPLIED SCIENCES-BASEL
(2022)
Letter
Gastroenterology & Hepatology
Andrea Sorge, Gian Eugenio Tontini, Lucia Scaramella, Nicoletta Nandi, Flaminia Cavallaro, Maurizio Vecchi, Luca Elli
Article
Gastroenterology & Hepatology
Andrea Sorge, Luca Elli, Emanuele Rondonotti, Marco Pennazio, Cristiano Spada, Sergio Cadoni, Renato Cannizzaro, Carlo Calabrese, Roberto de Franchis, Carlo Maria Girelli, Riccardo Marmo, Maria Elena Riccioni, Clelia Marmo, Salvatore Oliva, Giuseppe Scarpulla, Marco Soncini, Maurizio Vecchi, Gian Eugenio Tontini
Summary: This study used the Delphi process to establish a consensus on the definitions of bleeding entities and the role of enteroscopy in managing small bowel bleeding. After three rounds of voting, 33 statements were approved, providing clear definitions and a unified strategy for standardizing the management of small bowel bleeding.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Luca Elli, Pietro Soru, Leda Roncoroni, Francesca Gaia Rossi, Valeria Ferla, Luca Baldini, Nicoletta Nandi, Lucia Scaramella, Alice Scricciolo, Alessandro Rimondi, Nicola Fuscoi, Giorgio Alberto Croci, Umberto Gianelli, Lilla Crog, Marzia Barbierig, Vincenza Lombardob, Andrea Costantinoa, Valentina Vairaa, Stefano Ferrero, Gian Eugenio Tontini, Giulio Barigellettih, Sabrina Fabianoh, Luisa Doneda, Maurizio Vecchi
Summary: This study describes the clinical and histological features of a cohort of patients with refractory celiac disease (RCeD) at diagnosis, after therapy, and at lymphoma onset, as well as evaluates the rate and causes of death over a 17-year follow-up. The results show differences in clinical severity, response to therapy, and mortality between RCeD-I and RCeD-II, with atrophy extension being associated with disease severity and mortality.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Francesco Valitutti, Maureen M. Leonard, Victoria Kenyon, Monica Montuori, Pasqua Piemontese, Ruggiero Francavilla, Basilio Malamisura, Lorenzo Norsa, Angela Calvi, Maria Elena Lionetti, Mariella Baldassarre, Chiara Maria Trovato, Michela Perrone, Tiziana Passaro, Naire Sansotta, Marco Crocco, Annalisa Morelli, Lidia Celeste Raguseo, Federica Malerba, Luca Elli, Fernanda Cristofori, Carlo Catassi, Alessio Fasano, CD-GEMM Team
Summary: The purpose of this study was to identify potential serum biomarkers predicting the onset of celiac disease (CD) in at-risk children. The results showed that 73.6% of the children had an increase in anti-deamidated gliadin peptides (DGPs) IgG levels before their first seroconversion of anti-tissue transglutaminase (anti-tTG) IgA antibodies, indicating that anti-DGPs IgG may serve as an early preclinical biomarker predicting CD onset in children.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Elisa Farina, Paolo Cantu, Flaminia Cavallaro, Veronica Iori, Erik Rosa-Rizzotto, Maurizio Cavina, Gian Eugenio Tontini, Nicoletta Nandi, Lucia Scaramella, Romano Sassatelli, Roberto Penagini, Maurizio Vecchi, Luca Elli
Summary: The effectiveness of double-balloon enteroscope-assisted retrograde cholangiopancreatography (DBE-ERCP) in patients with surgically altered anatomy (SAA) was investigated. The study found that DBE-ERCP was successful in these challenging patients, and there has been improvement in the results over the years, suggesting the need for adequate training and centralization of patients in specialized centers.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Marco Vincenzo Lenti, Nicola Aronico, Paola Ilaria Bianchi, Carmela Cinzia D'Agate, Matteo Neri, Umberto Volta, Maria Gloria Mumolo, Marco Astegiano, Antonino Salvatore Calabro, Fabiana Zingone, Giovanni Latella, Antonio Di Sario, Antonio Carroccio, Carolina Ciacci, Francesco Luzza, Carmela Bagnato, Massimo Claudio Fantini, Luca Elli, Giovanni Cammarota, Antonio Gasbarrini, Piero Portincasa, Mario Andrea Latorre, Clarissa Petrucci, Claudia Quatraccioni, Chiara Iannelli, Nicoletta Vecchione, Carlo Maria Rossi, Giacomo Broglio, Gianluca Ianiro, Ilaria Marsilio, Stefano Bibbo, Beatrice Marinoni, Donatella Tomaselli, Ludovico Abenavoli, Riccardo Pilia, Giovanni Santacroce, Erica Lynch, Antonella Carrieri, Pasquale Mansueto, Margherita Gabba, Giacomo Alunno, Chiara Rossi, Francesca Onnis, Konstantinos Efthymakis, Nicola Cesaro, Marta Vernero, Federica Baiano Svizzero, Francesco Paolo Semeraro, Marco Silano, Alessandro Vanoli, Catherine Klersy, Gino Roberto Corazza, Antonio Di Sabatino
Summary: This study investigated the diagnostic delay in coeliac disease (CD) and identified patient-dependent and physician-dependent factors that contribute to the delay. It highlights the importance of implementing a proper screening strategy for CD.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Marco Pennazio, Emanuele Rondonotti, Edward J. Despott, Xavier Dray, Martin Keuchel, Tom Moreels, David S. Sanders, Cristiano Spada, Cristina Carretero, Pablo Cortegoso Valdivia, Luca Elli, Lorenzo Fuccio, Begona Gonzalez Suarez, Anastasios Koulaouzidis, Lumir Kunovsky, Deirdre McNamara, Helmut Neumann, Enrique Perez-Cuadrado-Martinez, Enrique Perez-Cuadrado-Robles, Stefania Piccirelli, Bruno Rosa, Jean-Christophe Saurin, Reena Sidhu, Ilja Tacheci, Erasmia Vlachou, Konstantinos Triantafyllou
Summary: According to the recommendations from ESGE, small-bowel capsule endoscopy is the recommended first-line examination for suspected small-bowel bleeding due to its excellent safety profile and patient tolerability. In cases of overt suspected small-bowel bleeding, small-bowel capsule endoscopy should be conducted as soon as possible, ideally within 48 hours after the bleeding episode to maximize diagnostic and therapeutic benefits. Routine second-look endoscopy before small-bowel capsule endoscopy is not recommended for patients with suspected small-bowel bleeding or iron-deficiency anemia. Conservative management is recommended for patients with suspected small-bowel bleeding and negative small-bowel capsule endoscopy. If lesions are identified, device-assisted enteroscopy can be used for confirmation and possibly treatment. Small-bowel capsule endoscopy is recommended as the first-line examination for patients with iron-deficiency anemia when small bowel evaluation is indicated. Small-bowel capsule endoscopy is also recommended in patients with suspected Crohn's disease and negative ileocolonoscopy findings, as well as in patients with unremarkable or nondiagnostic findings from dedicated small-bowel cross-sectional imaging if it is likely to influence patient management. A patency capsule should be used before small-bowel capsule endoscopy in patients with established Crohn's disease to decrease the capsule retention rate. Device-assisted enteroscopy can be used as an alternative to surgery for retrieving foreign bodies in the small bowel in patients without acute intestinal obstruction. Additionally, DAE-endoscopic retrograde cholangiopancreatography (DAE-ERCP) is recommended as a first-line endoscopic approach to treat pancreaticobiliary diseases in patients with surgically altered anatomy, except for Billroth II patients.
Editorial Material
Gastroenterology & Hepatology
Gian Eugenio Tontini, Alessandro Rimondi, Flaminia Cavallaro, Nicoletta Nandi, Lucia Scaramella, Maurizio Vecchi, Luca Elli
Letter
Gastroenterology & Hepatology
Andrea Sorge, Luca Elli
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Gastroenterology & Hepatology
Alessandro Rimondi, Andrea Sorge, Alberto Murino, Nicoletta Nandi, Lucia Scaramella, Maurizio Vecchi, Gian Eugenio Tontini, Luca Elli
Summary: This study conducted a systematic review of treatment options for Blue rubber bleb nevus syndrome (BRBNS), and found that endoscopy, surgery, and systemic drug therapy are feasible choices. Compared to endoscopy and surgery, endoscopic treatment requires more sessions to achieve complete eradication, and systemic drug therapy is favored as a second-line treatment after treatment failure or recurrence, but with more reported adverse events.
DIGESTIVE ENDOSCOPY
(2023)
Review
Nutrition & Dietetics
Chris J. J. Mulder, Luca Elli, Benjamin Lebwohl, Govind K. Makharia, Kamran Rostami, Alberto Rubio-Tapia, Michael Schumann, Jason Tye-Din, Jonas Zeitz, Abdulbaqi Al-Toma
Summary: For patients with celiac disease, a gluten-free diet is necessary to resolve symptoms and minimize long-term morbidity. Follow-up care should involve a multidisciplinary approach, improved access through telemedicine, and adherence to guidelines informed by evidence-based research. However, data is lacking on optimal clinic visit intervals and outcomes, as well as quality indicators and resource utilization.
Editorial Material
Gastroenterology & Hepatology
Nicoletta Nandi, Gian Eugenio Tontini, Lucia Scaramella, Andrea Sorge, Tommaso Pessarelli, Matilde Topa, Luca Elli
Article
Gastroenterology & Hepatology
Matilde Topa, Nicoletta Nandi, Lucia Scaramella, Michele Puricelli, Marco Pennazio, Reena Sidhu, David S. Sanders, Gian Eugenio Tontini, Roberto Penagini, Maurizio Vecchi, Luca Elli
Summary: This study assessed the clinical impact of videocapsule endoscopy (VCE) and double-balloon enteroscopy (DBE) in patients with indications other than suspected small bowel bleeding (OSBB), and compared them to a control group of suspected small bowel bleeding (SSBB) patients. The results showed that VCE and DBE are effective and safe in patients with indications other than suspected small bowel bleeding, similar to their role in suspected small bowel bleeding patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Nutrition & Dietetics
Vincenza Lombardo, Alice Scricciolo, Andrea Costantino, Luca Elli, Giorgia Legnani, Angel Cebolla, Luisa Doneda, Federica Mascaretti, Maurizio Vecchi, Leda Roncoroni
Summary: The aim of this study was to evaluate the clinical efficacy of urinary gluten immunogenic peptides (uGIP) in the follow-up of celiac disease (CD). The results showed that uGIP test can accurately assess the adherence to gluten-free diet and correlated significantly with duodenal biopsy results.