Article
Oncology
Catherine Sarre-Lazcano, Sinziana Dumitra, Marco Fiore
Summary: Pelvic soft tissue sarcomas (PSTS) are a rare and heterogeneous group of tumors that differ from retroperitoneal sarcomas (RPS). Adequate imaging and preoperative biopsy are crucial for differential diagnosis and treatment planning. Surgical approach and multidisciplinary teamwork are essential due to anatomic constraints and potential complications. Early referral to specialized centers is recommended for optimal resection and improved survival. International consensus on PSTS treatment is needed, similar to recent efforts for RPS.
Review
Oncology
Changkai Zhou, Xue Chen, Ying Huang, Qi Zhang, Shu Zhu, Wei Fu
Summary: This article discusses the progress made in the use of nanotechnology for the diagnosis and treatment of soft tissue sarcomas (STS) and highlights the future prospects of STS multimodality therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
William G. J. Kerrison, Alexander T. J. Lee, Khin Thway, Robin L. Jones, Paul H. Huang
Summary: Immunotherapy in soft tissue sarcoma has become a popular and promising therapeutic strategy, with immune checkpoint inhibitors showing effectiveness in certain subtypes. Combination therapies have also shown enhanced response rates.
Article
Biochemistry & Molecular Biology
Yin-Ying Wang, Hongen Kang, Tianyi Xu, Lili Hao, Yiming Bao, Peilin Jia
Summary: CeDR Atlas is a knowledgebase reporting computational inference of cellular drug response for various cell types, fine mapping drug response at cellular resolution and providing insights for the design of effective treatments. Through the use of high-throughput profiling of drug-induced gene expression and single-cell RNA sequencing data, it presents results for hundreds of cell types from different tissues and diseases, allowing exploration and search by keywords for drugs, cell types, tissues, diseases, and signature genes.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Yanlin An, Xiaozeng Mi, Xiaobo Xia, Dahe Qiao, Shirui Yu, Huayan Zheng, Tingting Jing, Feng Zhang
Summary: In this study, the PYL gene family in tea plants was analyzed, and it was found that the PYL genes play important roles in plant growth, development, and stress response. The results provided important clues for further exploring the functions of the PYL genes in tea plant's growth, development, and stress resistance.
Editorial Material
Oncology
Antoine Italiano
Summary: This article reports two early-phase studies investigating the use of different TP53-MDM2 antagonists to treat patients with soft-tissue sarcomas and other solid tumors. These inhibitors are a potential therapeutic approach to target solid tumors with wild-type TP53, especially sarcomas with consistent amplification of the MDM2 gene.
Article
Genetics & Heredity
Minchao Lv, Feixiong He, Jinku Guo, Zhenxin Zheng, Wei Wang, Jun Xie
Summary: This study identified the key genes associated with M1-like macrophage infiltration in soft tissue sarcomas (STS) cells. The LCK gene was found to be positively related to the level of M1-like macrophage infiltration and positively regulated the expression of genes involved in macrophage polarization and chemotaxis.
FRONTIERS IN GENETICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amandine Crombe, Frederic Bertolo, David Fadli, Michele Kind, Francois Le Loarer, Raul Perret, Vanessa Chaire, Paolo Spinnato, Carlo Lucchesi, Antoine Italiano
Summary: This study highlights the convergence of radiomics and transcriptomics in soft tissue sarcomas (STS), showing that the most rapidly evolving STS on consecutive imaging exhibit hyper-activation of proliferation and immune response inhibition.
EUROPEAN RADIOLOGY
(2023)
Review
Cell Biology
Shadi Hames-Fathi, Steven W. G. Nottley, Nischalan Pillay
Summary: This article reviews recent advances in the diagnosis and treatment of undifferentiated soft tissue sarcoma (USTS), including genomic sequencing, cancer evolution and heterogeneity studies, and immunotherapy. The critical role of pathologists in the diagnosis and treatment of USTS patients is emphasized.
Review
Oncology
Shyam Srinivasan, Swaminathan Keerthivasagam, Shathish Kumar, Ajay Puri
Summary: This meta-analysis challenges the routine use of imaging for diagnosing local relapse, while supporting the use of chest imaging for surveillance. Further studies are needed to determine the optimal surveillance strategy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Roberto Carmagnani Pestana, Cesar Serrano
Summary: This study found that histology-agnostic therapies may be of interest for patients with soft tissue and bone sarcoma. Molecular alterations that could lead to currently approved histology-agnostic therapy were identified, as well as potential future indications. Next-generation sequencing can guide treatment strategies for advanced sarcoma.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Mohamed Kelany, Thomas F. E. Barth, Dina Salem, Marwa M. Shekweer
Summary: PD-L1 expression ranged from 19% to 92% in different cancer subtypes. Positive PD-L1 expression was observed in 24% of soft tissue sarcomas, with rhabdomyosarcoma and desmoid tumors showing the highest prevalence. Patients with positive PD-L1 expression tended to have worse survival outcomes, but the results did not reach statistical significance. Larger clinical trials are needed to validate PD-L1 as a poor prognostic biomarker.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Oncology
Markus Albertsmeier, Annelore Altendorf-Hofmann, Lars H. Lindner, Rolf D. Issels, Eric Kampmann, Hans-Roland Duerr, Martin K. Angele, Frederick Klauschen, Jens Werner, Achim A. Jungbluth, Thomas Knoesel
Summary: This study demonstrates that VISTA is broadly expressed across subtypes of soft tissue sarcoma and is associated with increased tumor-infiltrating lymphocytes, PD-1, PD-L1, and CD3 expression. Patients with VISTA(+) tumors exhibit improved survival.
Article
Multidisciplinary Sciences
Beibei Ru, Jinlin Huang, Yu Zhang, Kenneth Aldape, Peng Jiang
Summary: Spatial transcriptomics technology enables topographical gene expression profiling of tumor tissues, but cell type deconvolution in tumor ST data remains challenging. We develop SpaCET, a method that accurately infers cell identities from tumor ST data and reveals intercellular interactions at the tumor-immune interface.
NATURE COMMUNICATIONS
(2023)
Review
Medicine, General & Internal
Grace C. Blitzer, Poonam Yadav, Zachary S. Morris
Summary: Soft tissue sarcomas are rare tumors that primarily occur in the extremities, trunk, and retroperitoneum. Surgical resection with clear margins is the main treatment option for localized tumors, while radiation therapy can be used to reduce local recurrence. MRI-guided radiotherapy offers advantages in target delineation and differentiation from normal tissues, particularly for unresectable tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Rolf Muller, Fay Betsou, Michael G. Barnes, Keith Harding, Jacques Bonnet, Olga Kofanova, John H. Crowe
BIOPRESERVATION AND BIOBANKING
(2016)
Article
Medicine, Research & Experimental
Keith M. Skubitz, Kate Geschwind, Wayne W. Xu, Joseph S. Koopmeiners, Amy P. N. Skubitz
JOURNAL OF TRANSLATIONAL MEDICINE
(2016)
Article
Oncology
Kristin L. M. Boylan, Petra C. Buchanan, Rory D. Manion, Dip M. Shukla, Kelly Braumberger, Cody Bruggemeyer, Amy P. N. Skubitz
Article
Oncology
M. Felices, S. Chu, B. Kodal, L. Bendzick, C. Ryan, A. J. Lenvik, K. L. M. Boylan, H. C. Wong, A. P. N. Skubitz, J. S. Miller, M. A. Geller
GYNECOLOGIC ONCOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Petra C. Buchanan, Kristin L. M. Boylan, Bruce Walcheck, Rachel Heinze, Melissa A. Geller, Peter A. Argenta, Amy P. N. Skubitz
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemical Research Methods
Kristin L. M. Boylan, Kate Geschwind, Joseph S. Koopmeiners, Melissa A. Geller, Timothy K. Starr, Amy P. N. Skubitz
CLINICAL PROTEOMICS
(2017)
Article
Multidisciplinary Sciences
Somaieh Afiuni-Zadeh, Kristin L. M. Boylan, Pratik D. Jagtap, Timothy J. Griffin, Joel D. Rudney, Marnie L. Peterson, Amy P. N. Skubitz
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Locke D. Uppendahl, Martin Felices, Laura Bendzick, Caitlin Ryan, Behiye Kodal, Peter Hinderlie, Kristin L. M. Boylan, Amy P. N. Skubitz, Jeffrey S. Miller, Melissa A. Geller
GYNECOLOGIC ONCOLOGY
(2019)
Article
Biophysics
Todd Klein, Wei Wang, Lina Yu, Kai Wu, Kristin L. M. Boylan, Rachel Isaksson Vogel, Amy P. N. Skubitz, Jian-Ping Wang
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Oncology
Amy P. N. Skubitz, Kristin L. M. Boylan, Kate Geschwind, Qing Cao, Timothy K. Starr, Melissa A. Geller, Joseph Celestino, Robert C. Bast, Karen H. Lu, Joseph S. Koopmeiners
CANCER PREVENTION RESEARCH
(2019)
Article
Medicine, Research & Experimental
Keith M. Skubitz, Jon D. Wilson, Edward Y. Cheng, Bruce R. Lindgren, Kristin L. M. Boylan, Amy P. N. Skubitz
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Kristin L. M. Boylan, Rory D. Manion, Heena Shah, Keith M. Skubitz, Amy P. N. Skubitz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Erin Wesley, Locke D. Uppendahl, Martin Felices, Carly Dahl, Audrey Messelt, Kristin L. M. Boylan, Amy P. N. Skubitz, Rachel Vogel, Heather H. Nelson, Melissa A. Geller
Summary: The study found that previous exposure to CMV and high CRP levels at surgery indicate worse recurrence-free survival and overall survival compared to those who tested negative. The group with CMV+/CRP- had the longest overall survival, suggesting that CMV status alone, without inflammation, may be protective.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Biochemical Research Methods
Kristin L. M. Boylan, Somaieh Afiuni-Zadeh, Melissa A. Geller, Peter A. Argenta, Timothy J. Griffin, Amy P. N. Skubitz
Summary: This study aimed to determine the feasibility of using liquid-based Pap test or cervical swab for the detection of ovarian cancer protein biomarkers. Protein samples from different sources expressed various ovarian cancer biomarkers, indicating the similarity between Pap test fixative, cervical swab proteins, and tumor extract.
CLINICAL PROTEOMICS
(2021)
Article
Oncology
Kristin L. M. Boylan, Ashley Petersen, Timothy K. Starr, Xuan Pu, Melissa A. Geller, Robert C. Bast, Karen H. Lu, Ugo Cavallaro, Denise C. Connolly, Kevin M. Elias, Daniel W. Cramer, Tanja Pejovic, Amy P. N. Skubitz
Summary: This study aimed to develop a multiprotein classifier for detecting early stages of ovarian cancer by analyzing the levels of 92 cancer-related proteins in the blood. The combination of four proteins successfully detected over 90% of women with ovarian cancer and improved sensitivity and specificity compared to using CA125 alone. These findings suggest potential new biomarkers for early stage ovarian cancer detection.