Article
Endocrinology & Metabolism
Daniela Gallo, Antonino Bruno, Matteo Gallazzi, Simona Antonia Maria Cattaneo, Giovanni Veronesi, Angelo Genoni, Maria Laura Tanda, Luigi Bartalena, Alberto Passi, Eliana Piantanida, Lorenzo Mortara
Summary: This study suggests that supplementation with vitamin D and selenium in patients with Graves' disease receiving MMI treatment can modulate the frequency of Treg and NK cells, leading to better control of hyperthyroidism symptoms.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Jacob N. Kisiolek, Victoria A. Flores, Arjun Ramani, Blake Butler, James M. Haughian, Laura K. Stewart
Summary: This clinical study found that daily oral intake of 50 mg CBD can improve sleep quality and NK immune cell function in healthy, younger adults, with no significant effects on body weight, BMI, body fat percentage, mental health measures, or sleep quantity.
Article
Biotechnology & Applied Microbiology
Peter J. J. Chockley, Jorge Ibanez-Vega, Giedre Krenciute, Lindsay J. J. Talbot, Stephen Gottschalk
Summary: In this study, researchers aimed to enhance the function of CAR immune cells by tuning the CAR immune synapses using an intracellular scaffolding protein binding site. The results showed that the synapse-tuned CAR immune cells exhibited increased effector cell functionality both in vitro and in vivo, leading to enhanced killing of tumor cells.
NATURE BIOTECHNOLOGY
(2023)
Article
Immunology
Juliet Chepngeno, Joshua O. Amimo, Husheem Michael, Sergei A. A. Raev, Kwonil N. Jung, Marcia V. V. Lee, Debasu Damtie, Alfred Omwando, Anastasia N. N. Vlasova, Linda J. J. Saif
Summary: The effects of vitamin A deficiency/supplementation and rotavirus A (RVA) exposure on immune responses in pregnant and lactating sows and passive protection of piglets were evaluated. Vitamin A deficiency impaired innate and T cell responses in sows, while supplementation restored some of the responses. This highlights the importance of maintaining adequate vitamin A levels and RVA immunization in pregnant and lactating mothers for optimal immune responses and passive protection of piglets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Soo-yeon Park, Kyeong Jin Kim, So Min Jo, Jin-Young Jeon, Bo-Ra Kim, Ji Eun Hwang, Ji Yeon Kim
Summary: Euglena supplementation improved immune function through enhanced natural killer cell activity, without any significant safety concerns in healthy individuals.
NUTRITION RESEARCH
(2023)
Article
Veterinary Sciences
Tomislav Speranda, Valentina Pavic, Zdenko Loncaric, Marcela Speranda, Maja Popovic, Vesna Gantner, Mislav Didara
Summary: The study demonstrates that supplementing slightly higher levels of organic selenium, combined with natural zeolite, can increase selenium deposition in tissues of growing pigs, enhance antioxidant status, and strengthen the immune system.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Shuting Wu, Shanshan Wang, Lili Wang, Hongyan Peng, Shuju Zhang, Qinglan Yang, Minghui Huang, Yana Li, Shuzhen Guan, Wenjuan Jiang, Zhaohui Zhang, Qinghua Bi, Liping Li, Yuan Gao, Peiwen Xiong, Zhaoyang Zhong, Bo Xu, Yafei Deng, Youcai Deng
Summary: DHA supplementation represses the early response to CMV infection but preserves NK cell effector functions by improving mitochondrial activity, which may play critical roles in subsequent MCMV clearance.
Article
Immunology
Jingjing Liu, Menghao You, Yingpeng Yao, Ce Ji, Zhao Wang, Fang Wang, Di Wang, Zhihong Qi, Guotao Yu, Zhen Sun, Wenhui Guo, Juanjuan Liu, Shumin Li, Yipeng Jin, Tianyan Zhao, Hai-Hui Xue, Yuanchao Xue, Shuyang Yu
Summary: Invariant natural killer T (iNKT) cells, originating from CD4(+)CD8(+) thymocytes, are regulated by serine/arginine splicing factor 1 (SRSF1) through direct targeting of Myb and balance of isoform abundance. SRSF1 deficiency leads to defects in iNKT cell development, particularly in the iNKT2 subset, and resistance to acute liver injury induction. This study highlights the essential post-transcriptional regulatory role of SRSF1 in iNKT cell development and functional differentiation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Benjamin Wolfson, Michelle R. Padget, Jeffrey Schlom, James W. Hodge
Summary: This study demonstrates that ER targeting drugs can enhance NK cell killing of ER+ and ER- breast cancer cells, with GPR30 signaling activation playing a key role. The mechanism remains effective in populations resistant to 4-OHT, and in vivo studies show the combination of fulvestrant and N-803 is effective in triple-negative breast cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, Research & Experimental
Priyanka Rawat, Asmita Das
Summary: NK cells play important immune functions in autoimmune diseases and successful pregnancies, providing immunity against viral infections and tumors. They are distributed in various organs and exhibit functional differences due to the regulation of transcription factors.
Article
Immunology
Junqi Wang, Xiaolin Liu, Tianqiang Jin, Yuqing Cao, Yu Tian, Feng Xu
Summary: NK cells have potential in tumor immunotherapy, but their metabolism in the liver cancer microenvironment is not fully understood. The interaction between immune checkpoints and metabolic checkpoints in NK cells plays a role in their development and function. Understanding NK cell metabolic reprogramming is important for improving the efficacy of liver cancer therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Annelisa M. Cornel, Ester Dunnebach, Damon A. Hofman, Sanjukta Das, Satyaki Sengupta, Femke van den Ham, Judith Wienke, Josephine G. M. Strijker, Denise A. M. H. van den Beemt, Anke H. W. Essing, Bianca Koopmans, Sem A. G. Engels, Vania Lo Presti, Celina S. Szanto, Rani E. George, Jan J. Molenaar, Sebastiaan van Heesch, Miranda P. Dierselhuis, S. Nierkens
Summary: This study explores the potential of combining immunotherapy with histone deacetylase inhibitors (HDACi) to enhance T cell-driven and NK cell-driven immune responses in high-risk neuroblastoma (HR-NBL). Screening drug repurposing libraries, the researchers identified compounds that upregulated major histocompatibility complex class I (MHC-I) surface expression in NBL cells. Treatment with HDACi enhanced the cytotoxic capacity of tumor-specific T cells against NBL in vitro and increased the expression of factors regulating T cell and NK cell cytotoxicity. The findings suggest a promising strategy to enhance immune responses in patients with HR-NBL through (immuno)therapy and HDACi.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Matteo Caforio, Cristina Sorino, Ignazio Caruana, Gerrit Weber, Antonio Camera, Loredana Cifaldi, Biagio De Angelis, Francesca Del Bufalo, Alessia Vitale, Bianca Maria Goffredo, Rita De Vito, Doriana Fruci, Concetta Quintarelli, Maurizio Fanciulli, Franco Locatelli, Valentina Folgiero
Summary: IDO1 plays a crucial role in immune escape of neuroblastoma, inhibiting the activity of anti-GD2 CAR T cells and NK cells. Combination therapy with IDO1 inhibitors could enhance the long-term efficacy of immunotherapeutic approaches.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Xiaobo Cheng, Jing Wang, Chenli Qiu, Yanling Jin, Bili Xia, Ran Qin, Huiliang Hu, Jia Yan, Xiaoyan Zhang, Jianqing Xu
Summary: This study is an ongoing single-arm exploratory clinical trial that used iNKT cells, PD-1+CD8+ T cells, and dendritic cells as treatment for patients. Preliminary results showed manageable tolerance and positive tumor response for this immunotherapy.
CLINICAL IMMUNOLOGY
(2022)
Article
Microbiology
Yongwei Qin, Qinglan Wang, Jiahai Shi
Summary: The down-regulated expression of immune-activating receptors and enhanced expression of immune-inhibitory receptors play a role in chronic infectious diseases and cancer. However, the impact of Mycobacterium tuberculosis infection on the expression of immune checkpoint molecules on natural killer (NK) cells and their functions has been poorly studied. Understanding the function of NK cells during Mtb infection is crucial for a comprehensive understanding of the immune mechanism and evaluation of immunotherapies for treating tuberculosis.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sadia Anjum, Hamile Ali, Faiza Naseer, Maisa S. Abduh, Halima Qadir, Salik Kakar, Yasir Waheed, Tahir Ahmad
Summary: This study demonstrates that avocado and papaya fruit juices can reduce the accumulation of cadmium in the liver, kidney, and hippocampal tissues, and upregulate the expression of antioxidant enzymes while reducing lipid peroxidation. Compared to avocado, papaya has a stronger potential for improving memory and learning, as well as reducing lipid peroxidation in various tissues.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Celio Junior da C. Fernandes, Gerson Santos de Almeida, Patricia Fretes Wood, Anderson M. Gomes, Fabio J. Bezerra, Jose C. S. Vieira, Pedro M. Padilha, Willian F. Zambuzzi
Summary: This study demonstrates the role of mechanosignaling in the promotion of an osteoblastic phenotype in response to zirconia exposure. The release of angiocrine factors modulated by mechanosignaling is crucial in creating a microenvironment that promotes wound healing and osseointegration. These findings highlight the importance of considering endothelial cell mechanosignaling in bone healing and osseointegration in the context of blood vessel effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Rehab I. Abdel-Karim, Rania K. Hashish, Dahlia I. Badran, Sally S. Mohammed, Noha A. Salem
Summary: The study found that chlorpyrifos has hepatotoxicity, while cerium oxide nanoparticles can alleviate this toxicity. Cerium oxide nanoparticles can protect the liver by reducing the expression of inflammatory and apoptotic proteins and increasing the activity of antioxidant enzymes.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tahani El Ayari, Raja Ben Ahmed, Zaineb Hammemi, Abdessalem Kouki, Emna Chelb, Salwa Nechi, Najoua Trigui El Menif
Summary: This study assessed the effects of samarium doped zinc oxide nanoparticles (Sm doped ZnO NPs) on the edible mussel Mytilus galloprovincialis and found that it led to a decrease in filtration rates and histopathological alterations in the gills, digestive glands, and gonads.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shanshan Niu, Zhangmin Wang, Xuebin Yin, Xiaodong Liu, Liqiang Qin, Muhammad Raza Farooq, Ofori Prince Danso, Zezhou Zhang, Qin Luo, Chenlu Sun, Jiaping Song
Summary: This study investigated the transport of selenium through the soil-crop-human chain in regions with different selenium levels. It found that the residents' dietary selenium intake was related to the selenium content in soil, with one village within the WHO recommended intake range while the other village was at risk of selenium deficiency. There were significant positive correlations between residents' dietary selenium intake and the three selenium biomarkers.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Sanaz Salaramoli, Hamid Reza Joshaghani, Ali Shoeibi, Seyed Isaac Hashemy
Summary: The study suggests that serum levels of selenium and selenoprotein P may serve as biomarkers or risk factors for Parkinson's disease. Additionally, there is a correlation between alpha-synuclein levels and disease stage. Further research is needed to understand the role of selenoprotein S in reducing alpha-synuclein aggregation.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Motozumi Ando, Keiko Suzuki, Riko Kitamoto, Ayako Nakayama, Norio Watanabe, Masami Kawahara
Summary: C57BL/6 mice and BALB/c mice showed different expression profiles of selenoprotein P after a high-fat diet (HFD). C57BL/6 mice in the HFD group had higher body weight, fasting plasma glucose levels, and plasma selenoprotein P levels compared to the ND group. However, BALB/c mice did not show significant differences in fasting plasma selenoprotein P levels between the HFD and ND groups.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ruihan Song, Huanhuan Chen, Runqing Zhan, Miaomiao Han, Longzhu Zhao, Xiaoli Shen
Summary: This study aims to investigate the protective effects of Vitamin E (Vit E) on manganese (Mn)-induced nigrostriatal system lesions. The results demonstrate that Vit E improves behavioral disorders, attenuates the loss of nigral dopaminergic neurons, and restores mitochondrial function. Additionally, the protective effect of Vit E may be associated with the upregulation of CHRM1 and KCNJ4 mRNA.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jose Luan da Paixao Teixeira, Ana Paula Rebellato, Maria Isabel Andrekowisk Fioravanti, Raquel Fernanda Milani, Marcelo Antonio Morgano
Summary: The study aimed to determine the total Se content and bioaccessibility in commercial plant-based beverages, with results showing that only one beverage made from organic cashew nuts could meet the recommended Se intake for different populations. High bioacessibility percentages were observed in the beverages.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Andreas F. Lehner, Sarah Rebolloso, Paul P. Calle, Karen Ingerman, Gregory A. Lewbart, Juan Pablo Munoz-Perez, Carlos A. Valle, John P. Buchweitz
Summary: The dried blood spot (DBS) technology is useful for storing blood samples from wildlife, and this study developed methods for measuring several important elements in DBS and used them for health assessments of Galapagos land iguanas. The results showed that the DBS samples accurately reflected the concentrations of various elements compared to plasma samples, with some divergences observed between different species.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Zhou, Chunbei Zhou, Jun Xie, Fei Luo, Ning Yao
Summary: The study illustrates the changes in iodized salt usage, goiter rate, and median urinary iodine concentration in school-aged children in Chongqing over the past 21 years. Adequate iodized salt consumption can eliminate iodine deficiency disorders in children, but excessive iodine intake from salt can lead to high urinary iodine excretion and even goiter. Continuous monitoring and adjustment of iodine fortification levels in household table salt is crucial.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Agustin B. Actis Dato, Valeria R. Martinez, Jorge O. Velez Rueda, Enrique L. Portiansky, Veronica De Giustu, Evelina G. Ferrer, Patricia A. M. Williams
Summary: The zinc coordination complex ZnMD, synthesized in this study, showed promising effects in treating hypertension and cardiac hypertrophy. It was more effective than the antihypertensive drug MD in reducing blood pressure and preventing myocardial hypertrophy. ZnMD also exhibited protective effects on the heart by reducing oxidative damage and regulating the expression of oxidative enzymes. These findings suggest that ZnMD has the potential to be developed as a therapeutic drug for hypertension and cardiac dysfunction.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mina Sarani, Maryam Roostaee, Mahboubeh Adeli-Sardou, Davood Kalantar-Neyestanaki, Seyed Amin Ayatollahi Mousavi, Azam Amanizadeh, Mahmood Barani, Alireza Amirbeigi
Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mona Abdel-Rahman, Heba M. Elmasry, Omar A. Ahmed-Farid, Sherein M. Hegazy, Mohamed M. Rezk
Summary: This study investigates the neuro effects of lanthanides on different brain areas in rats and finds that they can distribute and accumulate in various brain regions. Treatment with cerium nanoparticles or lanthanum causes a significant decrease in norepinephrine, dopamine, serotonin, and GABA, accompanied by a significant increase in 5-hydroxyl indoleacetic acid levels. Moreover, cerium nanoparticles exhibit high activity in scavenging free radicals.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian
Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)