New Perspectives for in Vitro Risk Assessment of Multiwalled Carbon Nanotubes: Application of Coculture and Bioinformatics

In Vitro - In Vivo Correlation of Gene Expression Alterations Induced by Liver Carcinogens

(2012) T. Heise et al.   CURRENT MEDICINAL CHEMISTRY

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study

(2012) Russell S. Thomas et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Evaluation of genotoxicity of multi-walled carbon nanotubes in a battery of in vitro and in vivo assays

(2012) Makoto Ema et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity

(2012) Anke Van Summeren et al.   TOXICOLOGY IN VITRO

Characterization of Translocation of Silver Nanoparticles and Effects on Whole-Genome Gene Expression Using an In Vitro Intestinal Epithelium Coculture Model

(2011) Hans Bouwmeester et al.   ACS Nano

Determinants of the thrombogenic potential of multiwalled carbon nanotubes

(2011) Andrew R. Burke et al.   BIOMATERIALS

Health impact and safety of engineered nanomaterials

(2011) Yiwei Teow et al.   CHEMICAL COMMUNICATIONS

Multiwalled Carbon Nanotubes Induce a Fibrogenic Response by Stimulating Reactive Oxygen Species Production, Activating NF-κB Signaling, and Promoting Fibroblast-to-Myofibroblast Transformation

(2011) Xiaoqing He et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Overview of Current Toxicological Knowledge of Engineered Nanoparticles

(2011) Vincent Castranova   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Toxicoproteomic evaluation of carbon nanomaterials in vitro

(2011) Hisao Haniu et al.   Journal of Proteomics

In vitro transcriptomic prediction of hepatotoxicity for early drug discovery

(2011) Feng Cheng et al.   JOURNAL OF THEORETICAL BIOLOGY

Influence ofBifidobacterium bifidumon Release of Minerals from Bread with Differing Bran Content

(2011) Beata Nalepa et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Cell Permeability, Migration, and Reactive Oxygen Species Induced by Multiwalled Carbon Nanotubes in Human Microvascular Endothelial Cells

(2011) M. Pacurari et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Evaluation of the Interactions Between Multiwalled Carbon Nanotubes and Caco-2 Cells

(2011) Katherine A. Clark et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Pulmonary Endpoints (Lung Carcinomas and Asbestosis) Following Inhalation Exposure to Asbestos

(2011) Brooke T. Mossman et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Toxicology of Nanomaterials Used in Nanomedicine

(2011) Jinshun Zhao et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells

(2011) Tamotsu Tsukahara et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes

(2011) Robert R Mercer et al.   Particle and Fibre Toxicology

Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: Comparison with conventional monocultures

(2011) Jennifer Kasper et al.   Particle and Fibre Toxicology

Nanoparticle exposure at nanotechnology workplaces: A review

(2011) Thomas AJ Kuhlbusch et al.   Particle and Fibre Toxicology

Coating carbon nanotubes with a polystyrene-based polymer protects against pulmonary toxicity

(2011) Lyes Tabet et al.   Particle and Fibre Toxicology

Comparison of MeHg-induced toxicogenomic responses across in vivo and in vitro models used in developmental toxicology

(2011) Joshua F. Robinson et al.   REPRODUCTIVE TOXICOLOGY

Multi-walled carbon nanotube-induced gene expression in the mouse lung: Association with lung pathology

(2011) M. Pacurari et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Quantitative Techniques for Assessing and Controlling the Dispersion and Biological Effects of Multiwalled Carbon Nanotubes in Mammalian Tissue Culture Cells

(2010) Xiang Wang et al.   ACS Nano

Physiologically Based Pharmacokinetic Modeling of Nanoparticles

(2010) Mingguang Li et al.   ACS Nano

Toxicity assessment of nanomaterials: methods and challenges

(2010) Alok Dhawan et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In vitro gene regulatory networks predict in vivo function of liver

(2010) Youping Deng et al.   BMC Systems Biology

Application of Genomics for Identification of Systemic Toxicity Triggers Associated With VEGF-R Inhibitors

(2010) Hisham K. Hamadeh et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The carcinogenic potential of nanomaterials, their release from products and options for regulating them

(2010) Heidi Becker et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Concept of Assessing Nanoparticle Hazards Considering Nanoparticle Dosemetric and Chemical/Biological Response Metrics

(2010) Erik K. Rushton et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Determination of Cytotoxicity Attributed to Multiwall Carbon Nanotubes (MWCNT) in Normal Human Embryonic Lung Cell (WI-38) Line

(2010) Jin Sik Kim et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Single- and Multi-Wall Carbon Nanotubes Versus Asbestos: Are the Carbon Nanotubes a New Health Risk to Humans?

(2010) Maricica Pacurari et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Identification of deregulated genes by single wall carbon-nanotubes in human normal bronchial epithelial cells

(2010) Anas Alazzam et al.   Nanomedicine-Nanotechnology Biology and Medicine

Rationale of genotoxicity testing of nanomaterials: Regulatory requirements and appropriateness of available OECD test guidelines

(2010) David B. Warheit et al.   Nanotoxicology

Potential pulmonary effects of engineered carbon nanotubes:in vitrogenotoxic effects

(2010) Linda M. Sargent et al.   Nanotoxicology

Multi-walled carbon nanotubes induce oxidative stress and apoptosis in human lung cancer cell line-A549

(2010) Ritesh K Srivastava et al.   Nanotoxicology

A critical review of the biological mechanisms underlying thein vivoandin vitrotoxicity of carbon nanotubes: The contribution of physico-chemical characteristics

(2010) Helinor J. Johnston et al.   Nanotoxicology

Asbestos, carbon nanotubes and the pleural mesothelium: a review and the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma

(2010) Ken Donaldson et al.   Particle and Fibre Toxicology

Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes

(2010) Robert R Mercer et al.   Particle and Fibre Toxicology

Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies

(2010) Liying Wang et al.   Particle and Fibre Toxicology

Hybrid Models Identified a 12-Gene Signature for Lung Cancer Prognosis and Chemoresponse Prediction

(2010) Ying-Wooi Wan et al.   PLoS One

Automated Dose-Response Analysis and Comparative Toxicogenomic Evaluation of the Hepatic Effects Elicited by TCDD, TCDF, and PCB126 in C57BL/6 Mice

(2010) Anna K. Kopec et al.   TOXICOLOGICAL SCIENCES

Application of Transcriptional Benchmark Dose Values in Quantitative Cancer and Noncancer Risk Assessment

(2010) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

The Evolution of Bioinformatics in Toxicology: Advancing Toxicogenomics

(2010) C. A. Afshari et al.   TOXICOLOGICAL SCIENCES

Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications

(2009) Bengt Fadeel et al.   ADVANCED DRUG DELIVERY REVIEWS

ROS and NF-κB are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes

(2009) She-Fang Ye et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Detection of Treatment-Induced Changes in Signaling Pathways in Gastrointestinal Stromal Tumors Using Transcriptomic Data

(2009) M. F. Ochs et al.   CANCER RESEARCH

Nanoscale and Fine Zinc Oxide Particles: Can in Vitro Assays Accurately Forecast Lung Hazards following Inhalation Exposures?

(2009) D. B. Warheit et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A role for nanoparticle surface reactivity in facilitating pulmonary toxicity and development of a base set of hazard assays as a component of nanoparticle risk management

(2009) David B. Warheit et al.   INHALATION TOXICOLOGY

Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology

(2009) G. Oberdörster   JOURNAL OF INTERNAL MEDICINE

Oxidative stress and inflammation response after nanoparticle exposure: differences between human lung cell monocultures and an advanced three-dimensional model of the human epithelial airways

(2009) L. Muller et al.   Journal of the Royal Society Interface

An impaired alveolar-capillary barrier in vitro: effect of proinflammatory cytokines and consequences on nanocarrier interaction

(2009) M. I. Hermanns et al.   Journal of the Royal Society Interface

Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats

(2009) Yoshimitsu Sakamoto et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Whole Genome Expression Analysis Reveals Differential Effects of TiO2Nanotubes on Vascular Cells

(2009) Lily Peng et al.   NANO LETTERS

A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles

(2009) Anke Lenz et al.   Particle and Fibre Toxicology

Transcriptional responses to oxidative stress: Pathological and toxicological implications

(2009) Qiang Ma   PHARMACOLOGY & THERAPEUTICS

Putting Chemicals on a Path To Better Risk Assessment

(2009) E. Stokstad   SCIENCE

Tubulin Encapsulation of Carbon Nanotubes into Functional Hybrid Assemblies

(2009) Cerasela Zoica Dinu et al.   Small

Use of Short-term Transcriptional Profiles to Assess the Long-term Cancer-Related Safety of Environmental and Industrial Chemicals

(2009) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Absence of Carcinogenic Response to Multiwall Carbon Nanotubes in a 2-Year Bioassay in the Peritoneal Cavity of the Rat

(2009) Julie Muller et al.   TOXICOLOGICAL SCIENCES

Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes®) relative to α-quartz following a single 6h inhalation exposure of rats and a 3 months post-exposure period

(2009) Heidrun Ellinger-Ziegelbauer et al.   TOXICOLOGY

Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes

(2009) Dale W. Porter et al.   TOXICOLOGY

Size-dependent effects of tungsten carbide–cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells

(2009) M. Ding et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Proteomics-based safety evaluation of multi-walled carbon nanotubes

(2009) Hisao Haniu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects and uptake of gold nanoparticles deposited at the air–liquid interface of a human epithelial airway model

(2009) C. Brandenberger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo

(2009) Anne S. Kienhuis et al.   TOXICOLOGY IN VITRO

Assessment of the dermal and ocular irritation potential of multi-walled carbon nanotubes by using in vitro and in vivo methods

(2009) A. Sairam Kishore et al.   TOXICOLOGY LETTERS

Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis

(2008) A. A. Shvedova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells

(2008) Julie Muller et al.   CARCINOGENESIS

Confirmation of Gene Expression-Based Prediction of Survival in Non-Small Cell Lung Cancer

(2008) N. L. Guo et al.   CLINICAL CANCER RESEARCH

Co-cultures of multiple cell types mimic pulmonary cell communication in response to urban PM10

(2008) E. Alfaro-Moreno et al.   EUROPEAN RESPIRATORY JOURNAL

In vitromodels of the human epithelial airway barrier to study the toxic potential of particulate matter

(2008) Barbara Rothen-Rutishauser et al.   Expert Opinion on Drug Metabolism & Toxicology

Monitoring Multiwalled Carbon Nanotube Exposure in Carbon Nanotube Research Facility

(2008) Jeong Hee Han et al.   INHALATION TOXICOLOGY

Design and Testing of Electrostatic AerosolIn VitroExposure System (EAVES): An Alternative Exposure System for Particles

(2008) K. de Bruijne et al.   INHALATION TOXICOLOGY

Induction of mesothelioma in p53+/− mouse by intraperitoneal application of multi-wall carbon nanotube

(2008) Atsuya Takagi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area

(2008) Tina M Sager et al.   Particle and Fibre Toxicology

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE

Automated Quantitative Dose-Response Modeling and Point of Departure Determination for Large Toxicogenomic and High-Throughput Screening Data Sets

(2008) Lyle D. Burgoon et al.   TOXICOLOGICAL SCIENCES

Nonnegative Matrix Factorization: An Analytical and Interpretive Tool in Computational Biology

(2008) Karthik Devarajan   PLoS Computational Biology

Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model

(2007) R. R. Mercer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY