Article
Environmental Sciences
Huan Chen, Wenxin Zhang, Yanqiu Zhou, Jiufeng Li, Hongzhi Zhao, Shunqing Xu, Wei Xia, Zongwei Cai, Yuanyuan Li
Summary: The study aimed to determine the patterns of exposure to environmental chemicals over three trimesters among pregnant women, identifying different exposure patterns and main chemical components. Various physiological, socio-demographic factors, and behavior patterns were found to be related to different exposure clusters and principal components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Andrea Rodriguez-Carrillo, Sylvie Remy, Shereen Cynthia D'Cruz, Elena Salamanca-Fernandez, Fernando Gil, Pablo Olmedo, Vicente Mustieles, Fernando Vela-Soria, Kirsten Baken, Nicolas Olea, Fatima Smagulova, Mariana F. Fernandez, Carmen Freire
Summary: This study found that kisspeptin serum protein and DNA methylation levels in adolescent males were associated with exposure to environmental chemicals and serum reproductive hormone levels. This suggests that kisspeptin may be a promising effect biomarker.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Pharmacology & Pharmacy
Melanie H. Jacobson, Akhgar Ghassabian, Andrea C. Gore, Leonardo Trasande
Summary: Women are more likely than men to develop mood disorders, especially during reproductive transitions. Exposure to environmental toxicants may impact maternal psychopathology during the perinatal period. Previous studies have shown that exposure to environmental tobacco smoke has a positive effect on antenatal depression, while persistent organic pollutants such as polybrominated diphenyl ethers have been associated with perinatal depression. The results for exposure to heavy metals and non-persistent chemicals are mixed, but studies in animal models support the association between bisphenols and phthalates and reduced maternal behavior and care after parturition.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Environmental Sciences
Huan Chen, Wenxin Zhang, Xiaojie Sun, Yanqiu Zhou, Jiufeng Li, Hongzhi Zhao, Wei Xia, Shunqing Xu, Zongwei Cai, Yuanyuan Li
Summary: This study evaluates the association between prenatal exposure to chemical mixtures and birth size. The findings suggest that exposure to multiple chemical mixtures during pregnancy is associated with variations in birth weight, length, and ponderal index.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Review
Environmental Sciences
Maricel V. Maffini, Swati D. G. Rayasam, Daniel A. Axelrad, Linda S. Birnbaum, Courtney Cooper, Shari Franjevic, Patrick M. MacRoy, Keeve E. Nachman, Heather B. Patisaul, Kathryn M. Rodgers, Mark S. Rossi, Ted Schettler, Gina M. Solomon, Tracey J. Woodruff
Summary: Chemical risk assessment and management can be made more efficient by grouping chemicals into categories or classes. This manuscript evaluates different approaches to grouping chemicals and proposes a decision tree approach based on the decision context and scientific considerations. The use of a class-based approach can result in a more efficient process to reduce exposure to hazardous chemicals and health risks.
ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Kurunthachalam Kannan, Alexa Stathis, Matthew J. Mazzella, Syam S. Andra, Dana Boyd Barr, Stephen S. Hecht, Lori S. Merrill, Aubrey L. Galusha, Patrick J. Parsons
Summary: A consortium of laboratories under CHEAR used a multifaceted quality assurance program to ensure reliable and reproducible data quality for trace organics analyses. Participation in external quality assurance programs and the use of a common quality control pool for each project sample batch improved organic chemical analysis capabilities and accuracy. The laboratories' methods were verified through NIST SRMs, demonstrating acceptable analytical precision and excellent reliability across various batches.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Review
Chemistry, Analytical
Zhizhen Zhang, Shenghong Wang, Li Li
Summary: This review highlights the importance of understanding how chemical properties and human behavior interact to determine human exposure to environmental chemicals, emphasizing the variability in intake patterns among chemicals with different properties. Future research should focus on gaining more mechanistic insights into human exposure processes, improving techniques for characterizing and predicting chemical properties, expanding experimental data diversity, and describing interactions between chemical properties and human behavior.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2021)
Article
Engineering, Environmental
Michiel A. van den Dries, Kelly K. Ferguson, Alexander P. Keil, Anjoeka Pronk, Suzanne Spaan, Akhgar Ghassabian, Susana Santos, Vincent W. V. Jaddoe, Leonardo Trasande, Henning Tiemeier, Monica Guxens
Summary: Prenatal exposure to nonpersistent chemical mixtures is associated with lower nonverbal IQ in children, but not emotional and behavioral problems. This exposure is universal and may impact neurodevelopment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Environmental Sciences
Etienne Babin, German Cano-Sancho, Evelyne Vigneau, Jean-Philippe Antignac
Summary: The aim of this study was to critically review the current state-of-the-science about statistical approaches used to integrate endogenous biomarkers in environmental-health studies linking chemical exposures with health outcomes. Multivariate regression models were the most predominant statistical method reported in the published workflows, however some studies applied latent based methods or multipollutant models to overcome the specific constraints of omic or exposure data. A minority of studies used formal mediation analysis to characterize the indirect effects mediated by the endogenous biomarkers.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Lauren E. Koval, Kathie L. Dionisio, Katie Paul Friedman, Kristin K. Isaacs, Julia E. Rager
Summary: This study focused on identifying environmental chemicals that co-occur and share properties with chemicals associated with breast cancer, highlighting exposure combinations that may alter disease risk. Through in silico chemical database querying and analysis, the study prioritized understudied chemicals with physicochemical similarities to known carcinogens, emphasizing the need for further evaluation in clinical, epidemiological, and toxicological studies.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Chris S. Elcombe, Ana Monteiro, Matthew R. Elcombe, Mohammad Ghasemzadeh-Hasankolaei, Kevin D. Sinclair, Richard Lea, Vasantha Padmanabhan, Neil P. Evans, Michelle Bellingham
Summary: This study using a BTP sheep model found that gestational exposure to environmental chemical mixture led to decreased germ cells and increased Sertoli-cell-only seminiferous tubules in ram lambs' testes. Comparison with human TDS patients revealed common gene changes related to apoptosis and mTOR signaling. The activation and nuclear localization of HIF1 alpha were also observed in Leydig cells of BTP exposed animals, potentially disrupting testosterone synthesis.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Environmental Sciences
John D. Hader, Taylor Lane, Alistair B. A. Boxall, Matthew MacLeod, Antonio Di Guardo
Summary: European agricultural development in the 21st century will be influenced by global changes, including climate change, technological advancements, and a shift towards a circular economy. This review identifies key research areas and proposes scenarios to forecast chemical exposure in European agriculture, supporting sustainable practices.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Public, Environmental & Occupational Health
Farin Fatemi, Alireza Dehdashti, Mohammadreza Jannati
Summary: This study aimed to develop and implement a chemical risk assessment method to determine and prioritize more hazardous chemicals in academic laboratories. The study found that laboratory activities may pose risks to health, safety, and the environment, and measures need to be strengthened for risk management and mitigation.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Abdullahi, Jiarui Zhou, Vignesh Dandhapani, Anurag Chaturvedi, Luisa Orsini
Summary: This study investigates the transgenerational effect of environmentally relevant concentrations of chemicals on a keystone species, Daphnia magna. The results show that historical exposure to chemical stress leads to reduced genome-wide diversity and lower cross-generational tolerance to novel chemical stress. The genes affected by historical chemical stress are conserved and potential targets in other species, including humans.
Article
Engineering, Environmental
Deming Xia, Jingwen Chen, Zhiqiang Fu, Tong Xu, Zhongyu Wang, Wenjia Liu, Hong-bin Xie, Willie J. G. M. Peijnenburg
Summary: This paper summarizes the recent progress in machine learning-based quantum chemical methods (ML-QCMs) and discusses their potential applications in environmental chemical studies. The ML-QCMs have potential applications and challenges in predicting degradation networks of chemical pollutants, searching global minima for atmospheric nanoclusters, discovering heterogeneous or photochemical transformation pathways of pollutants, as well as predicting environmentally relevant end points.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Sheena E. Martenies, Joshua P. Keller, Sherry WeMott, Grace Kuiper, Zev Ross, William B. Allshouse, John L. Adgate, Anne P. Starling, Dana Dabelea, Sheryl Magzamen
Summary: Researchers developed a spatiotemporal prediction model for black carbon (BC), collected over 700 weekly BC samples, and successfully predicted air pollution levels in Denver, improving upon typical land use regression models that only capture spatial gradients.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Jaime Butler-Dawson, Katherine A. James, Lyndsay Krisher, Diana Jaramillo, Miranda Dally, Natalie Neumann, Daniel Pilloni, Alex Cruz, Claudia Asensio, Richard J. Johnson, John Adgate, Lee S. Newman
Summary: The study found that higher levels of cadmium and arsenic in the urine of sugarcane cutters in Guatemala may contribute to kidney dysfunction, increasing the risk of chronic kidney disease.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
S. E. Martenies, L. Hoskovec, A. Wilson, W. B. Allshouse, J. L. Adgate, D. Dabelea, S. Jathar, S. Magzamen
Summary: The study found that wildfire smoke could bias traffic exposure measures in a spatially-dependent way, potentially leading to larger health effect estimates for simulated outcomes.
Article
Endocrinology & Metabolism
Lizan D. Bloemsma, Dana Dabelea, Deborah S. K. Thomas, Jennifer L. Peel, John L. Adgate, William B. Allshouse, Sheena E. Martenies, Sheryl Magzamen, Anne P. Starling
Summary: After studying maternal exposure to environmental pollution and traffic during pregnancy, limited evidence was found for associations with indicators of adiposity in children aged 4-6. However, inconsistent results were observed. Further investigation is needed to explore the suggestive relationship between residential proximity to a highway during pregnancy and greater adiposity.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Public, Environmental & Occupational Health
Kelsey E. Barton, Lauren M. Zell-Baran, Jamie C. DeWitt, Stephen Brindley, Carrie A. McDonough, Christopher P. Higgins, John L. Adgate, Anne P. Starling
Summary: This study found preliminary evidence of altered inflammatory profiles among adults with elevated serum concentrations of PFASs due to contaminated drinking water. Some PFAS concentrations in the sample were higher than a nationally representative US sample, and higher concentrations of multiple PFASs were significantly associated with lower odds of detectable IL-113. Weak associations were observed with other cytokines.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
M. Van Dyke, B. King, E. Esswein, J. Adgate, M. Dally, M. Kosnett
Summary: This study evaluated the effects of selected ventilation measures on air change rates in school buses. The results showed that practical ventilation protocols can achieve air change rates capable of reducing viral transmission in school buses.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
(2022)
Article
Environmental Sciences
Anne P. Starling, Cheyret Wood, Cuining Liu, Katerina Kechris, Ivana V. Yang, Chloe Friedman, Deborah S. K. Thomas, Jennifer L. Peel, John L. Adgate, Sheryl Magzamen, Sheena E. Martenies, William B. Allshouse, Dana Dabelea
Summary: Prenatal exposure to ambient air pollution, such as PM2.5 and O3, can lead to changes in DNA methylation in umbilical cord blood cells, which are associated with various health outcomes in offspring. This study identified differentially methylated regions (DMRs) in cord blood cells associated with maternal exposure to PM2.5 and O3. The significant sites were annotated to genes involved in cardiometabolic disease, immune function and inflammation, and neurologic disorders. However, limited evidence was found for the mediation of the association between O3 exposure and infant adiposity by DNA methylation.
ENVIRONMENTAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Lauren M. Zell-Baran, Anne P. Starling, Deborah H. Glueck, Traci A. Bekelman, Jill M. Norris, John L. Adgate, Jared M. Brown, Dana Dabelea
Summary: This study aims to assess family-level factors associated with childhood immunization schedule adherence. The results show that factors such as in-utero exposure to cigarette smoke, single parent household, children identified as non-White, mothers not working outside the home, and lower household income are associated with not completing the vaccination series.
AMERICAN JOURNAL OF HEALTH PROMOTION
(2022)
Article
Health Care Sciences & Services
Kylie K. Harrall, Keith E. Muller, Anne P. Starling, Dana Dabelea, Kelsey E. Barton, John L. Adgate, Deborah H. Glueck
Summary: This paper discusses the methods for conducting power analyses for longitudinal studies of environmental exposures. It provides a roadmap for aligning data analysis and power analysis plans and emphasizes the importance of considering sensitivity in power values. It also offers a template and checklist for describing power and sample size analysis in grant applications.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Environmental Sciences
Sheena E. Martenies, Lauren Hoskovec, Ander Wilson, Brianna F. Moore, Anne P. Starling, William B. Allshouse, John L. Adgate, Dana Dabelea, Sheryl Magzamen
Summary: The study indicates that prenatal exposures to ozone and temperature may affect birth weight, with potentially greater impact on mothers who identify as a race or ethnicity other than non-Hispanic White. While NPB models have limitations, they can assist in studying nonlinear effects.
ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Dylan J. Wallis, Kelsey E. Barton, Detlef R. U. Knappe, Nadine Kotlarz, Carrie A. McDonough, Christopher P. Higgins, Jane A. Hoppin, John L. Adgate
Summary: Per-and polyfluoroalkyl substances (PFASs) are synthetic chemicals widely present in the environment and biological systems, including human serum, and are associated with various health effects. This study assessed the effectiveness of three source apportionment methods in identifying contributors to PFAS concentrations in highly exposed populations, and found that these methods successfully identified potential exposure sources. Future research should focus on expanding the PFAS panel, identifying cohorts with different point source exposures, and combining biological and environmental data for better understanding of source apportionment results.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Chloe Friedman, Dana Dabelea, Deborah H. Glueck, William B. Allshouse, John L. Adgate, Kayleigh P. Keller, Sheena E. Martenies, Sheryl Magzamen, Anne P. Starling
Summary: Higher levels of black carbon in early childhood were associated with increased adiposity and altered insulin homeostasis at around 5 years old. However, there was inconsistent evidence of associations between prenatal black carbon exposure and cardiometabolic health outcomes in early childhood.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Lauren M. Zell-Baran, Carina Venter, Dana Dabelea, Jill M. Norris, Deborah H. Glueck, John L. Adgate, Jared M. Brown, Antonia M. Calafat, Kaci Pickett-Nairne, Anne P. Starling
Summary: Exposure to poly: and perfluoroalkyl substances (PFAS) in early life may increase the risk of childhood asthma, but the associations between maternal serum concentrations of PFAS during pregnancy and clinician-diagnosed asthma incidence in offspring have been inconsistent. In this study, no significant association was found between prenatal PFAS concentrations and the incidence of clinician-diagnosed asthma in children followed to eight years of age.
ENVIRONMENTAL RESEARCH
(2023)
Correction
Environmental Sciences
M. VanDyke, K. Bradley, E. Esswein, J. Adgate, M. Dally, M. Kosnet
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
(2022)
Article
Environmental Sciences
Chloe Friedman, Dana Dabelea, Lizan D. Bloemsma, Deborah S. K. Thomas, Jennifer L. Peel, John L. Adgate, Sheryl Magzamen, Sheena E. Martenies, William B. Allshouse, Anne P. Starling
Summary: This study examined the effects of prenatal air pollution on fetal cardiometabolic outcomes. The results showed that higher prenatal ozone concentrations were associated with elevated cord blood insulin levels. Future studies should investigate the long-term health implications for offspring.
ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Maria Vitoria Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thais Posser, Jeferson Luis Franco
Summary: This study evaluated the toxicity of copper at environmentally relevant concentrations on zebrafish larvae and found adverse effects on morphology, biochemistry, and behavior. Therefore, the permissible copper concentrations in Brazil need to be reevaluated.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2024)
