Article
Pharmacology & Pharmacy
Jian Zhang, Catherine Powell, Sunitha Meruvu, Ravi Sonkar, Mahua Choudhury
Summary: The study demonstrated that PQQ can attenuate metabolic aberrations induced by obesogens and high fat diet, especially in the presence of BBP. However, the effects of PQQ were more pronounced in male mice compared to female mice.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Lang Lang, Angjin Yang, Langxi Lang, Yuanyuan Hu, Pan Xu, Lei Yu, Wenlan Li
Summary: This study found that the reproductive toxicity of Benzyl butyl phthalate (BBP) was directly related to its metabolites. BBP and its metabolites can alter the cell cycle, affect the expression of key proteins, and disrupt the cytoskeleton structure of Sertoli cells.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Engineering, Environmental
Mengyao Yao, Jingran Qian, Xiaoni Chen, Jilong Liu, Xiaoqing Yang, Peng Gao, Cheng Zhang
Summary: Agricultural films are widely used in high-intensity agriculture, but the low recovery rate leads to an accumulation of plastic mulch in agricultural soils. This study focuses on the exposure impact of BBP, a chemical introduced into soil ecosystems through the accumulation of plastic mulch, on earthworms. The study explores the effects of BBP on the digestive system, oxidative stress, and neurotoxicity in earthworms, providing insights into the molecular mechanisms underlying these effects.
Article
Environmental Sciences
Weili Wang, Zhenyu Liu, Yu Zhang, Liu Wang, Dongwei Meng, Xueqin Li, Jingbo Zhang, Yuzhang Wu, Xinyuan Zhou, Guoxiang Liu
Summary: This study investigated the effects of benzyl butyl phthalate (BBP) on lung injury and fibrosis. The findings suggest that BBP exposure can lead to lung injury and fibrosis by disturbing innate immunity through neutrophil extracellular trap (NETs) formation.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biotechnology & Applied Microbiology
R. Kaur, A. Kumari, G. Sharma, D. Singh, R. Kaur
Summary: The study aimed to explore the degradation potential of BBP and DMP by Bacillus marisflavi RR014 isolated from tap water, and to optimize the degradation process using response surface methodology. The results showed that the bacterium can degrade both phthalates under varying environmental conditions, and the degradation rate increases with pH, temperature, and salt concentration.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Environmental Sciences
Xiang Tang, Man Zhou, Changzheng Fan, Guangming Zeng, Rui Gong, Qiuxiang Xu, Biao Song, Zhaohui Yang, Yang Yang, Chengyun Zhou, Xiaoya Ren, Wenjun Wang
Summary: The research demonstrates that high levels of BBP can cause anaerobic digestion upset, leading to deferred cell lysis and rupture, as well as affecting hydrolysis, acetogenesis, and methanogenesis processes. Long-term exposure to BBP can alter the microbial structure in anaerobic digesters and the abundance of functional microorganisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Analytical
Xia Hong, Yin Cui, Ming Li, Yifan Xia, Daolin Du, Chengwu Yi
Summary: A magnetic-based immunoassay (MBI) combined with biotin-streptavidin amplification was proposed for butyl benzyl phthalate (BBP) investigation and risk assessment. The study found that BBP contamination in urban sewage was within a controllable range, but potential harm to the ecology was indicated. The non-carcinogenic risk of BBP exposure from drinking water was higher for females than males, but the non-carcinogenic risk from drinking water and bathing pathways was negligible. This study provides an alternative method for detecting BBP and essential information for controlling BBP contamination.
Article
Engineering, Environmental
Jing Li, Haotian Li, Dongdong Lin, Muyi Li, Quansheng Wang, Song Xie, Yuming Zhang, Fengsong Liu
Summary: BBP has toxic effects on the reproductive and developmental toxicity of D. magna, including reduced survival ratio, decreased body length, increased abnormal ratio, and reduced offspring. BBP exposure inhibits the expression of the vitellogenin gene, leading to embryotoxicity and shortened embryonic development cycle.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Cheng Zhang, Xiaoqing Yang, Zhangjia Wang, Yinglin Liu, Mengyao Yao, Lusheng Zhu, Peng Gao, Zhenyu Wang
Summary: This study assessed the co-exposure effects of butyl benzyl phthalate (BBP) and titanium dioxide nanomaterials (nTiO(2)) on Metaphire guillelmi, a soil organism. The results showed that BBP and nTiO(2) had detrimental effects on the gut and intestinal bacteria of Metaphire guillelmi. This study provides evidence for the sustainable application and scientific management of these compounds.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yongquan Yu, Yucheng Wang, Yu Dong, Shuge Shu, Di Zhang, Jiayi Xu, Ying Zhang, Wei Shi, Shou-Lin Wang
Summary: This study used data from the NHANES 2011-2014 cycles to examine the association between 11 urinary phthalate metabolites and cognitive impairment. The results showed that butyl benzyl phthalate (BBP) was closely associated with cognitive deficits in elderly individuals, possibly through its effects on hippocampal neurons, neuroinflammation, and neuroactive receptors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Yi Jiang, Di Wang, Cheng Zhang, Yangyang Jiao, Yanan Pu, Rong Cheng, Chunyu Li, Yan Chen
Summary: This study investigated the specific influence of benzyl butyl phthalate (BBP) on mouse oocyte maturation using in vivo and in vitro models. The results showed that BBP exposure significantly affected the rate of oocyte exclusion of the first polar body and blastocyst rate. Further analysis revealed that BBP disrupted mitochondrial function and induced oxidative stress-induced early apoptosis, while nicotinamide mononucleotide (NMN) supplementation reduced the adverse effects of BBP.
CELL PROLIFERATION
(2023)
Article
Biochemistry & Molecular Biology
Zhengyi Zhang, Mengqi Zeng, Xiao Han, Zhanwu Hou, Zhen Wang, Tian Su, Wei Zhao, Jiankang Liu, Huadong Liu
Summary: This study revealed the mechanism of pomegranate extract punicalagin (PU) in combating insulin resistance (IR) by investigating the proteomic response of mitochondria. The findings showed that PU promotes the incorporation of newly synthesized protein into mitochondria, enhancing mitochondrial turnover.
Article
Chemistry, Medicinal
Jian Zhang, Mahua Choudhury
Summary: Exposure to BBP may lead to metabolic dysregulation by altering key epigenetic regulators such as lncRNA H19 and its target microRNAs at an earlier stage, which further regulates insulin signaling.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Environmental Sciences
Jian Li, Ying Xu, Yuhao Jiang, Na Li, Zhanjie Li, Dongdong Kong, Xueru Guo, Junbo Zhang, Rui Zuo
Summary: Based on in vitro and in silico assays as well as proteome analysis, this study explored the nongenomic mechanism for BBP-induced thyroid disruption. The results showed that BBP could dock into the RGD domain of integrin α(v)β(3) and activate the MAPK pathway, promoting cell proliferation. Furthermore, BBP perturbed proteins and pathways related to cell communication and signal transduction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Yu Li, Bo Xiong, Yilong Miao, Qian Gao
Summary: This study evaluated the effects of BBP on porcine oocyte meiosis and found that supplementation of 50μM silibinin effectively rescued the meiotic failure induced by BBP exposure.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Maria Vitoria Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thais Posser, Jeferson Luis Franco
Summary: This study evaluated the toxicity of copper at environmentally relevant concentrations on zebrafish larvae and found adverse effects on morphology, biochemistry, and behavior. Therefore, the permissible copper concentrations in Brazil need to be reevaluated.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2024)