Article
Environmental Sciences
Yan Zhang, Linchao Zhang, Jialu Bao, Liantao Liu, Xiaodan Wang
Summary: The study revealed that PFOA can increase liver weight, reduce uterine index, and induce toxic effects on liver and uterine tissues. Additionally, various factors expressed in uterine cells showed dose-dependent changes in response to PFOA exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Wentao Shao, Jin Xu, Cheng Xu, Zhenkun Weng, Qian Liu, Xin Zhang, Jingjia Liang, Wenxiang Li, Yi Zhang, Zhaoyan Jiang, Aihua Gu
Summary: The study revealed that gestational exposure to PFOA may lead to obesity, hepatic inflammation, disorders of lipid metabolism, and disruption of gut barrier integrity in offspring. Additionally, supplementation of chlorogenic acid (CGA) can alleviate these adverse effects.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Jialu Bao, Yan Zhang, Linchao Zhang, Xiaodan Wang
Summary: Exposure of pregnant mice to PFOA was found to have a damaging effect on testicular development in male offspring mice, leading to reduced testosterone content and increased apoptosis. Genes associated with snRNA and THOC were dysregulated after PFOA exposure, indicating potential mechanisms underlying the observed effects.
Article
Environmental Sciences
Yu-Ting Zhou, Rui Li, Si-Hong Li, Xiang Ma, Lu Liu, Dong Niu, Xing Duan
Summary: Perfluorooctanoic acid (PFOA) exposure during gestation was found to have potential toxic effects on ovarian function and resulted in higher meiotic defects in female offspring. PFOA exposure disrupted early embryonic cleavage and blastocyst formation by impacting spindle assembly and chromosome alignment. Moreover, PFOA exposure caused mitochondrial dysfunction, oxidative stress, DNA damage, autophagy, and apoptosis in 2-cell stage embryos.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Venugopalan Rajesh, Pachangattupalayam Karuppusamy Divya
Summary: Neural tube defects are severe congenital disorders of the central nervous system. This study revealed the harmful impact of the DNA methylation inhibitor decitabine on zebrafish neural tube development, supporting the hypothesis that hypomethylation during embryonic development causes neural tube defects.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Engineering, Environmental
Hua Guo, Hongxia Zhang, Nan Sheng, Jinghua Wang, Jiamiao Chen, Jiayin Dai
Summary: PFOA exposure induced splenic atrophy in mice, resulting in decreased spleen weight and relative spleen weight, as well as impacting iron levels and gene expression, leading to alterations in cell cycle, autoimmunity, and anemia. The study also indicated that overactivation of macrophages may be a crucial factor in causing splenic atrophy.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Marine & Freshwater Biology
Tingting Yu, Guangdi Zhou, Zhenzhen Cai, Wei Liang, Yatao Du, Weiye Wang
Summary: Research using zebrafish as a model has found that early-life exposure to PFOA affects dopaminergic neuron development and leads to neurobehavior changes in zebrafish larvae.
AQUATIC TOXICOLOGY
(2021)
Article
Physiology
Denise R. Rodrigues, Kim M. Wilson, Lisa R. Bielke
Summary: This study investigated the impact of early intestinal colonizers on immune processes in chicks. The results showed that probiotic treatment facilitated the activation and balanced function of innate and adaptive immune systems, while exposure to Enterobacteriaceae may lead to dysregulated immunological mechanisms.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Isaac A. Adedara, Oluwatoyin O. Abioye, Gbemisola T. Oyedele, Cynthia N. Ikeji, Blessing A. Afolabi, Joao B. T. Rocha, Ebenezer O. Farombi
Summary: This study evaluated the toxicological impact of PFOA on Nauphoeta cinerea insects. The results showed that PFOA exposure led to reduced locomotory abilities and increased freezing time in the insects, along with changes in several biochemical markers. This indicates that PFOA poses an ecological risk to Nauphoeta cinerea.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Pingping Zhang, Changyong Qi, Zhinan Ma, Yixiong Wang, Lei Zhang, Xiaojing Hou
Summary: This study reveals for the first time that in vivo exposure to PFOA impairs the meiotic maturation of oocytes in female mice, resulting in decreased rates of embryonic foam rupture and first polar body extrusion, disrupted mitochondrial metabolism, increased DNA damage, and abnormal spindle and chromosome arrangements.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Zhe Zhang, Jiao Tian, Wenwen Liu, Jidong Zhou, Yang Zhang, Lijun Ding, Haixiang Sun, Guijun Yan, Xiaoqiang Sheng
Summary: This study investigated the impact of PFOA on ovarian function and discovered that it impairs follicle development and disrupts oxidative phosphorylation. Resveratrol, a mitochondrial nutrient supplement, was found to restore mitochondrial function and promote normal follicular development by activating FoxO1. These findings highlight the potential therapeutic use of resveratrol for PFOA-induced ovarian dysfunction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yaming Ge, Fei Ren, Lingli Chen, Dongfang Hu, Xinrui Wang, Yunli Cui, Yu Suo, Hongli Zhang, Junping He, Zhihong Yin, Hongmei Ning
Summary: The study revealed that BPA exerts toxic effects on the development and behavior of Xenopus embryos, inducing DNA damage, apoptosis, and multiple malformations.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Fengkai Ruan, Changqian Liu, Weiping Hu, Jinpeng Ruan, Xiaoyan Ding, Lu Zhang, Chunyan Yang, Zhenghong Zuo, Chengyong He, Jiyi Huang
Summary: This study reveals the long-term effects of neonatal exposure to polychlorinated biphenyls (PCBs) on uric acid metabolism and kidney health, and uncovers the underlying mechanisms. Early life pollutant exposure may play a significant role in later-life diseases.
ENVIRONMENTAL POLLUTION
(2022)
Article
Food Science & Technology
Yuan Yang, Guoqing Fu, Xueyi Zhao, Xiaoping Wu, Kaili Zhu, Shangyu Liu, Ding Yuan, Jie Wu, Ting Wang, Changcheng Zhang, Haixia Zhao
Summary: PFOA disrupts tight junction function in Sertoli cells by blocking autophagic flux, leading to male reproductive toxicity. This finding provides clues for effective prevention and treatment of PFOA-induced male reproductive toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Ya Wang, Yajie Zhang, Zhaochun Shi, Tingting Di, Wenfeng Yu, Ling Chen
Summary: Exposure to PFOA in male mice enhances CRF expression in BLA neurons by increasing hepatic FGF21 synthesis, which then enhances CRF-R1 mediated presynaptic glutamate release to facilitate NMDAR-dependent BLA-LTP induction, leading to anxiety-like behaviors.
Article
Neurosciences
Adi Pinkas, Gadi Turgeman, Shay Tayeb, Joseph Yanai
NEUROTOXICOLOGY AND TERATOLOGY
(2015)
Article
Chemistry, Medicinal
Adi Pinkas, Michael Aschner
CHEMICAL RESEARCH IN TOXICOLOGY
(2017)
Review
Chemistry, Medicinal
Adi Pinkas, Michael Aschner
CHEMICAL RESEARCH IN TOXICOLOGY
(2016)
Review
Environmental Sciences
Adi Pinkas, Cinara Ludvig Goncalves, Michael Aschner
ENVIRONMENTAL RESEARCH
(2017)
Article
Neurosciences
Adi Pinkas, Kun He Lee, Pan Chen, Michael Aschner
NEUROTOXICITY RESEARCH
(2019)
Article
Neurosciences
Adi Pinkas, Michael Lawes, Michael Aschner
Article
Pharmacology & Pharmacy
Joanna A. Ruszkiewicz, Adi Pinkas, Mahfuzur R. Miah, Rebecca L. Weitz, Michael J. A. Lawes, Ayodele J. Akinyemi, Omamuyovwi M. Ijomone, Michael Aschner
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2018)
Review
Environmental Sciences
Adi Pinkas, Airton Cunha Martins, Michael Aschner
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Article
Neurosciences
Gadi Turgeman, Adi Pinkas, Theodore A. Slotkin, Matanel Tfilin, Rachel Langford, Joseph Yanai
JOURNAL OF NEUROSCIENCE RESEARCH
(2011)
Article
Neurosciences
Sharon Dotan, Adi Pinkas, Theodore A. Slotkin, Joseph Yanai
NEUROTOXICOLOGY AND TERATOLOGY
(2010)
Article
Neurosciences
Joseph Yanai, Yael Brick-Turin, Sharon Dotan, Rachel Langford, Adi Pinkas, Theodore A. Slotkin
NEUROTOXICOLOGY AND TERATOLOGY
(2010)
Article
Neurosciences
Safa Abdul-Ghani, Joseph Yanai, Rula Abdul-Ghani, Adi Pinkas, Ziad Abdeen
NEUROTOXICOLOGY AND TERATOLOGY
(2012)
Review
Toxicology
Joanna A. Ruszkiewicz, Adi Pinkas, Beatriz Ferrer, Tanara V. Peres, Aristides Tsatsakis, Michael Aschner
TOXICOLOGY REPORTS
(2017)
Meeting Abstract
Neurosciences
Joseph Yanai, Adi Pinkas, Asher Ornoy, Itamar Altman, Dana Pulver, Gadi Turgeman
NEUROTOXICOLOGY AND TERATOLOGY
(2016)
Meeting Abstract
Neurosciences
Joseph Yanai, Adi Pinkas, Theodore A. Slotkin, Gadi Turgeman
NEUROTOXICOLOGY AND TERATOLOGY
(2011)
Article
Environmental Sciences
Maria Vitoria Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thais Posser, Jeferson Luis Franco
Summary: This study evaluated the toxicity of copper at environmentally relevant concentrations on zebrafish larvae and found adverse effects on morphology, biochemistry, and behavior. Therefore, the permissible copper concentrations in Brazil need to be reevaluated.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2024)