Article
Endocrinology & Metabolism
Juan Zeng, Nengqing Liu, Yinghong Yang, Yi Cheng, Yuanshuai Li, Xiaoxia Guo, Qian Luo, Lifen Zhu, Hongmei Guan, Bing Song, Xiaofang Sun
Summary: The study found that reducing Pak2 expression in early mouse embryos affected blastocyst formation, spindle assembly, chromosome alignment, oxidative stress, DNA damage, and cell apoptosis. Pak2 may play a crucial role in regulating spindle assembly and DNA repair in early mouse embryos.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Lepeng Gao, Chang Zhang, Yingying Zheng, Deyi Wu, Xinyuan Chen, Hainan Lan, Xin Zheng, Hao Wu, Suo Li
Summary: The addition of glycine in in vitro culture can improve the maturation efficiency of oocytes by maintaining redox balance and blocking reactive oxygen species-induced lipid peroxidation. This study provides a theoretical basis for preventing and improving oxidative damage during oocyte culture in vitro.
JOURNAL OF ANIMAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Maria Nunzia De Luca, Marisa Colone, Riccardo Gambioli, Annarita Stringaro, Vittorio Unfer
Summary: Infertility is a global health problem affecting approximately 187 million couples worldwide, with oxidative stress being a common reason for male infertility. Antioxidant supplementation is considered effective in improving male fertility parameters due to their synergistic effects in decreasing ROS concentration. Additionally, natural molecules such as myo-inositol and d-chiro-inositol play a role in ameliorating sperm quality by regulating various cellular mechanisms.
Article
Biochemistry & Molecular Biology
Yuguo Tompkins, Guanchen Liu, Brett Marshall, Milan Kumar Sharma, Woo Kyun Kim
Summary: The current study aimed to monitor the impact of H2O2-induced oxidative stress on avian bone formation during the early stage of embryonic development. The results showed that H2O2 micro-injection altered the expression pattern of antioxidant enzymes' mRNA during early embryogenesis and decreased the expression of COL1A2 and COL2A1 at 6 h and 24 h post-injection. Decreased expression of BMP, BGLAP, and RUNX2 was observed 48 h post-injection. Additionally, a shorter embryo length was observed in the 100 nM and 300 nM H2O2 treatment groups 72 h post-injection.
Review
Cell Biology
Klaudia Mietkiewska, Pawel Kordowitzki, Chandra S. Pareek
Summary: Heat stress poses a significant threat to cattle reproduction, impacting hormonal balance, oocyte quality, mitochondrial function, DNA integrity, and maternal transcription. It can also lead to blastocyst development disorders. Cows exposed to heat stress in utero experience lower milk yield, immunological disorders, lower birth weight, and shortened lifespan associated with accelerated aging. Understanding the effects of heat stress at the cellular and molecular levels is crucial for protecting cow reproduction.
Article
Obstetrics & Gynecology
Xiangqian Meng, Ximing Dai, Jihua Huang, Tingting Han, Xue Liao, Ke Cheng, Xiaoyue Sun, Qingdong Xie, Pingnan Sun, Xiaoling Zhou
Summary: Male HBV infection does not affect assisted reproductive outcomes, but HBV is capable of impairing human sperm and embryo formation in the early stages following fertilization.
HUMAN REPRODUCTION
(2023)
Article
Biology
Sahar M. Greish, Ghada S. Abdel Kader, Eman Z. Abdelaziz, Dalia A. Eltamany, Hanaa S. Sallam, Noha M. Abogresha
Summary: In an animal model of diet-induced obesity, both Moringa and lycopene show positive effects in improving body weight, oxidative stress, and male fertility markers. Lycopene exhibits better antioxidant and anti-lipidemic effects, possibly improving male fertility parameters by attenuating oxidative stress.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Environmental Sciences
Lei Ge, Yu-Qing Gao, Zhe Han, Shu-Jun Liu, Xing-Yue Wang, Xiao-Jie Zhang, Rui-Hao Tang, Rui-Feng Zhang, Dui Sun, Bo Feng, De-Jian Zhang, Cheng-Guang Liang
Summary: This study demonstrates that Olaquindox (OLA) intake has detrimental effects on sperm quality and offspring survival in male mice. High-dose OLA administration leads to changes in body weight, organ weights, and the morphology of the testis seminiferous tubules. It also reduces sperm count, motility, and viability. Both low and high doses of OLA induce oxidative damage, early apoptosis, and abnormal mitochondrial membrane potential in sperm. While high-dose OLA impairs the development of in vitro fertilized embryos, it does not affect the natural fertility of males, although paternal OLA intake significantly decreases offspring survival rate from the age of 4 weeks.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Medicine, General & Internal
Ashok Agarwal, Saradha Baskaran, Neel Parekh, Chak-Lam Cho, Ralf Henkel, Sarah Vij, Mohamed Arafa, Manesh Kumar Panner Selvam, Rupin Shah
Summary: Infertility affects 8-12% of couples globally, with male factors contributing to around 50%. The causes of male infertility are diverse, requiring thorough evaluation to identify treatable or reversible factors. Semen analysis is key for evaluation, while advanced tests have been developed to investigate sperm quality and function.
Review
Cell Biology
Sutian Wang, Kunli Zhang, Yuchang Yao, Jianhao Li, Shoulong Deng
Summary: Oxidative stress and autophagy play important roles in bacterial infection in the male reproductive system, with moderate oxidative stress helping clear invaders and maintain sperm motility, while excessive stress can lead to host damage. Oxidative stress is often accompanied by autophagy, which helps maintain host homeostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Marion Cheron, David Costantini, Frederic Angelier, Cecile Ribout, Francois Brischoux
Summary: This study investigated the impact of AMPA on tadpole embryonic development, finding non-monotonic effects on oxidative status markers and suggesting that oxidative imbalance may lead to reduced hatching success.
Article
Environmental Sciences
Yuanzhao Wu, Jiawen Wang, Yumei Xia, Kaiqin Tang, Jincheng Xu, Anli Wang, Shundi Hu, Luhong Wen, Binjie Wang, Weixuan Yao, Jiye Wang
Summary: This study demonstrated the developmental and neurotoxic effects of Isofenphos-methyl (IFP) on zebrafish embryos. IFP exposure resulted in abnormal heart development, uninflated swim bladder, and behavioral defects. Furthermore, IFP exposure activated oxidative stress and reduced acetylcholinesterase (AChE) content.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Plant Sciences
Lin Chen, Maomao Yun, Zhenqiang Cao, Zhaojun Liang, Wenrui Liu, Min Wang, Jinqiang Yan, Songguang Yang, Xiaoming He, Biao Jiang, Qingwu Peng, Yu'e Lin
Summary: This study evaluated the changes in male flower development in cucumber under normal and heat stress conditions. It was found that heat stress led to decreased pollen fertility, abnormal tapetum and microspores, and significant changes in gene expression related to carbohydrate metabolism. Additionally, a co-expression network analysis revealed specific hub genes associated with heat stress response.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Environmental Sciences
Rami M. M. Mosaoa, Taha A. A. Kumosani, Soonham S. S. Yaghmoor, Shaimaa Rihan, Said S. S. Moselhy
Summary: This study found that the methanolic extract of Rhus tripartita (RTME), a type of herbal medicine, could protect against reproductive toxicity induced by propylparaben (PrP). The RTME treatment improved hormonal levels, reduced inflammation, and enhanced antioxidant enzymes activities. These findings suggest that the active components of RTME have antioxidative and anti-inflammatory effects, and can mitigate PrP-induced testicular damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biology
Berta Canal Domenech, Claudia Fricke
Summary: Thermal stress has severe ecological and evolutionary consequences, including fertility reduction and threat to species persistence. This study focused on the sensitivity of different developmental stages in males to heat stress. The results showed that the last steps of spermatogenesis were particularly sensitive to heat stress, leading to delayed sperm production and maturation. The findings highlight the impact of heat stress on reproductive organ function and male reproductive potential.
JOURNAL OF THERMAL BIOLOGY
(2023)
