Article
Neurosciences
Lisa Wintzell, Samuel Klemetz, Stefan Lange, Eric Hanse, Caroline Wass, Joakim Strandberg
Summary: The endogenous peptide antisecretory factor (AF) enhances long-term potentiation (LTP) and spatial learning and memory by disinhibiting GABAergic transmission in the rat hippocampus.
Article
Neurosciences
Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasamy
Summary: This study investigated the effect of aspirin on spatial memory in ageing experimental mice. Aspirin was found to enhance working memory, increase the number of new neurons in the hippocampus, reduce the number of microglial cells, and decrease the activity of AChE in the blood.
Article
Pharmacology & Pharmacy
Burak Tan, Umut Bakkaloglu, Meral Ascioglu, Cem Suer
Summary: This study found that thyroid hormone excessiveness during perinatal period can lead to long-lasting effects on hippocampal function, with differences in behavior and molecular indicators between rats treated with l-thyroxine during maternal period and in young adulthood. These effects may contribute to memory problems observed in adolescents with lactational hyperthyroidism.
PHARMACOLOGICAL REPORTS
(2021)
Article
Pharmacology & Pharmacy
Zahra Gholami Mahmoudian, Ali Ghanbari, Iraj Rashidi, Iraj Amiri, Alireza Komaki
Summary: This study investigated the effects of minocycline on cognitive abilities, antioxidant enzyme activities, neuronal loss, and plaque number in rats with Alzheimer's disease induced by Aβ. The results showed that minocycline improved anxiety behavior, restored learning and memory deficits, and had antioxidant and anti-apoptotic effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
David A. Cinalli, Sarah J. Cohen, Mariah Calubag, Goksu Oz, Lylybell Zhou, Robert W. Stackman
Summary: This study used the DREADDs method to investigate the effects of CA1 pyramidal neurons in the hippocampus on the retrieval of long-term memory for nonspatial and spatial information in mice. The results showed that the inhibition of CA1 neuronal activity significantly impaired the memory retrieval in mice. These findings support the use of mice as a model system to study the neurobiological mechanisms of human episodic memory.
Article
Behavioral Sciences
Niklas Lonnemann, Martin Korte, Shirin Hosseini
Summary: Alzheimer's disease is a neurodegenerative disease with no successful treatment. In addition to its features, neuroinflammatory processes, genetic factors, and lifestyle also play important roles. Training in a water maze has shown positive effects on memory formation in AD mice.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mu-Hsuan Chen, Hsiao-Chun Lin, Tzu Chao, Viola Szu-Yuan Lee, Chia-Lung Hou, Tsyr-Jiuan Wang, Jeng-Rung Chen
Summary: Women, especially after menopause, are more susceptible to cognitive impairments and Alzheimer's disease. Estrogen deficiency, particularly estradiol deficiency, plays a key role in this phenomenon. A novel polymeric drug, HA-E2, has been developed to deliver estradiol to the brain, crossing the blood-brain barrier and reducing side effects. In a study using postmenopausal rats, HA-E2 treatment showed improvements in the cholinergic septo-hippocampal innervation system, synaptic transmission, and cognitive function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Laura B. Tucker, Amanda H. Fu, Joseph T. McCabe
Summary: Cognitive dysfunction is a common complaint following acquired traumatic brain injuries, with hippocampal circuits often implicated in resulting deficits. The study aimed to phenotype cognitive deficits in male and female mice following TBI induced by the CHIMERA device, showing significant impairment in spatial learning and memory skills. Differences in injury-induced deficits between male and female mice were observed, with cognitive impairment assessment potentially confounded by motor and visual impairments post-injury.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Behavioral Sciences
Soniya Assudani Patel, Karyn M. Frick, Paul A. Newhouse, Robert S. Astur
Summary: The study examined the role of estradiol in hippocampal-dependent spatial memory in women. Results showed that the high estradiol group demonstrated superior spatial reference memory, while the low estradiol group exhibited the poorest probe trial performance. There were no group differences in performance on the virtual memory tasks.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Neurosciences
Arne D. Ekstrom, Paul F. Hill
Summary: This passage discusses the close relationship between spatial navigation and memory at the cognitive and neural levels. It introduces models that suggest a central role for the medial temporal lobes, including the hippocampus, in both navigation and memory. However, these models have limitations in explaining functional and neuroanatomical differences. The idea of navigation as a dynamically acquired skill and memory as an internally driven process is explored, as well as network models that focus more on connections rather than specific brain regions.
Article
Behavioral Sciences
IbDanelo Cortez, Caterina M. Hernandez, Kelly T. Dineley
Summary: The study found that the insulin-sensitizing drug rosiglitazone can improve age- and AD-related learning and memory deficits, particularly in cognitive domains that rely on the dorsal hippocampus.
BRAIN AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Gregory D. Clemenson, Antonella Maselli, Alexander J. Fiannaca, Amos Miller, Mar Gonzalez-Franco
Summary: GPS navigation has become commonplace in everyday life, but traditional turn-by-turn navigation may promote passive spatial navigation and poor spatial learning. An alternative form of GPS navigation based on sensory augmentation, using a 3D spatial audio system, is proposed to encourage users to take a more active role in their spatial navigation for a better understanding of the explored environment.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Yuxi Chen, Audrey Branch, Cecelia Shuai, Michela Gallagher, James J. Knierim
Summary: The hippocampal formation is vulnerable to normal aging, and Long-Evans rats serve as a valuable model to study aging. This study found individual differences in spatial navigation and episodic-like memory abilities in aged rats, similar to age-related cognitive decline observed in humans. These findings suggest that aged Long-Evans rats can be used to explore the changes in cognitive function during aging.
Article
Physiology
Caitlin S. Mitchell, Elisabeth K. Goodman, Caitlin R. Tedesco, Kathy Nguyen, Lei Zhang, Herbert Herzog, Denovan P. Begg
Summary: This study investigated the effect of disrupted insulin signaling in NPY neurons on diet-induced deficits in hippocampal-dependent memory. The results showed that obesogenic diets can lead to hippocampal insulin resistance and impairments to hippocampal-dependent cognition. However, chronic sucrose intake did not have adverse effects on metabolic outcomes or hippocampal-dependent memory. These findings suggest that the effects of high-fat diet on hippocampal-dependent memory may depend on insulin signaling in hippocampal NPY cells.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Behavioral Sciences
Amanda Dyer, Maxine De Butte
Summary: This study aimed to examine the effects of chronic low-dose vanadium administration on the behavior of young male rats. The findings suggest that vanadium does not significantly affect exploration, locomotion, or anxiety-like behavior in rats, but does affect novel object recognition performance. Additionally, vanadium administration led to lower latency times in the Morris Water maze task.
BEHAVIOURAL BRAIN RESEARCH
(2022)