4.1 Article

Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats

Journal

JOURNAL OF TOXICOLOGICAL SCIENCES
Volume 34, Issue 4, Pages 377-387

Publisher

JAPANESE SOC TOXICOLOGICAL SCIENCES
DOI: 10.2131/jts.34.377

Keywords

Alanine aminotransferase; Aspartate aminotransferase; Induction; Fenofibrate; Rats

Categories

Funding

  1. Torii Pharmaceutical Co., Ltd

Ask authors/readers for more resources

Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels are widely used as sensitive markers of possible tissue damage, particularly liver toxicity. Lipid-lowering drugs, such as fibrates, slightly increase serum tratisaminase levels in humans, but there is little evidence that the phenomenon is related to drug-induced liver injury (DILI). Some in vitro studies have indicated that the elevations of serum transaminase activities after treatment of humans with fenofibrate, one of the fibrates, are related to increased transaminase synthesis ill the hepatocytes rather than to transaminase leakage from the hepatocytes associated with cell lysis. In this Study, male F344/DuCrlCrlj (Fischer) rats were treated once with fenofibrate at a dose level of 400 mg/kg and the relationships between the pharmacological effects, blood and hepatic transaminase activities and the gene expression of the transaminases in the liver were investigated. Fenofibrate treatment slightly increased plasma transaminase activities in rats with the findings directly related to the pharmacological action of the drug. The increases were in parallel with increases in hepatic transaminase activities associated with increases in the transaminase genes ill the liver and were not considered to be a consequence of hepatotoxicity from the drug. The modification in transaminase gene expression is likely to be secondary to the pharmacological action of fenofibrate. The evidence obtained in our study underlines the importance of gene regulation as a possible alternative mechanism for increased blood transaminase activities.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.1
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available