Article
Reproductive Biology
Flavia C. F. Dos Santos, Charles S. da Costa, Jones B. Graceli
Summary: This review summarizes the effects of microcystins on ovarian function, including ovarian morphology, folliculogenesis, hormone production, oxidative stress, and other aspects. Current evidence suggests that microcystin exposure impairs ovarian function, but further research is needed to understand the underlying mechanisms.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Feng Zhou, Lu Lu Zhong, Yang Tan, Li Liu, Gang Pei
Summary: In this study, the reproductive toxicity of Triptolide (TP) and its mechanism were investigated using a metabolomic approach. The results showed that TP induced histopathological changes in the ovaries of rats, leading to follicular apoptosis and damage to the ovarian microstructure. Metabolomics analysis revealed significant differences in small molecule metabolites in the ovaries and serum of TP-treated rats compared to the control group.
Article
Biochemistry & Molecular Biology
Genevieve E. Campbell, Hannah R. Bender, Grace A. Parker, Thomas E. Curry, Diane M. Duffy
Summary: Experimental evidence suggests that NTS is a potential paracrine mediator of ovulation, with NTS inhibition leading to the failure of most follicles to ovulate. NTS also plays a role in vascular remodeling associated with ovulation.
Article
Reproductive Biology
Shinichiro Shirouzu, Naohiro Sugita, Narantsog Choijookhuu, Yu Yamaguma, Kanako Takeguchi, Takumi Ishizuka, Mio Tanaka, Fidya Fidya, Kengo Kai, Etsuo Chosa, Yoshihiro Yamashita, Chihiro Koshimoto, Yoshitaka Hishikawa
Summary: This study revealed the essential role of HMGB2 in ovarian folliculogenesis and fertilization, with its depletion leading to alterations in ovarian morphology and function.
JOURNAL OF OVARIAN RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Catherine Kim, Janet Catov, Pamela J. Schreiner, Duke Appiah, Melissa F. Wellons, David Siscovick, Ronit Calderon-Margalit, Heather Huddleston, Imo Asuquo Ebong, Cora E. Lewis
Summary: The CARDIA study, conducted between 1985 and 1986, collected longitudinal data on women's reproductive milestones and their association with cardiovascular and metabolic risk factors. The study identified differences in age at menarche between Black and White participants and evaluated the impact of adverse pregnancy outcomes and postpartum behaviors on future cardiovascular risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Reproductive Biology
Hong Ye, Min Lin, Ruotong Li, Shuming Qin, Gang Hou, Hongzhi Chen, Xiaomei Li
Summary: The diagnosis and treatment of primary ovarian angiosarcoma is challenging due to lack of specific clinical symptoms, requiring careful observation of morphology and application of immunohistochemistry. In this case, a 47-year-old female with this rare tumor underwent surgery, radiotherapy, targeted therapy, and immunotherapy, resulting in disease-free survival at 9-month follow-up. Targeted therapy and immunotherapy show promise as potential directions for angiosarcoma treatment.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Abdulkarem Alrezaki, Nouf Aldawood, Shamsa Alanazi, Maria Arafah, Zuzana Fabova, Yacine Badjah, Alexander Sirotkin, Saleh Alwasel, Abdel Halim Harrath
Summary: The study found that sage extract has effects on ovarian function, with high doses increasing estradiol concentration levels and promoting follicle development while reducing the number of abnormal follicles.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Cell Biology
Alba M. Polonio, Marta Medrano, Lucia Chico-Sordo, Isabel Cordova-Oriz, Mauro Cozzolino, Jose Montans, Sonia Herraiz, Emre Seli, Antonio Pellicer, Juan A. Garcia-Velasco, Elisa Varela
Summary: The SAMP8 model exhibits signs of ovarian aging and reduced fertility, similar to middle-aged women. Female SAMP8 mice have a shorter lifespan and reduced telomere length and telomerase activity in their ovaries at 7 months old. These mice also produce more morphologically abnormal embryos compared to controls.
Article
Environmental Sciences
Beatriz Piquer, Freddy Ruz, Rafael Barra, Hernan E. Lara
Summary: Exposure to sympathetic stress during gestation has a significant impact on the reproductive capacity, fertility, and ovarian morphology of female offspring. This effect can be seen in the subsequent three generations and may be influenced by intrauterine factors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Wei Liu, Xinyu Wang, Yating Chen, Huiyu Zhang, Jing Chen, Jing Zhang, Tinghe Wu, Jing Li
Summary: The combination DACHAO developed in this study improved ovarian functions in women at advanced maternal age by enhancing mitochondrial functions, blastocyst formation, and fertility, while reducing apoptosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Toxicology
Yuchong He, Ruocheng Yin
Summary: Microplastics and nanoplastics are widely distributed in the environment and have effects on the reproductive capacity and transgenerational toxicity on mammals, especially on humans. For males, microplastics cause abnormalities in testicular and sperm structure, decreased sperm vitality, and endocrine disruption. For females, microplastics cause abnormalities in ovary and uterus structure and endocrine disruption. Transgenerational toxicity studies show that exposure to microplastics can result in premature mortality and various disorders in offspring. Further research is needed to assess the threat of microplastics and nanoplastics to human fertility and reproductive health risks.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei Liu, Jing Zhang, Lu Wang, Shenglian Liang, Boqun Xu, Xiaoyan Ying, Jing Li
Summary: The pretreatment of rapamycin before vitrification has been shown to effectively inhibit the activation of the mTOR signaling pathway, increase follicle survival rate, reduce apoptosis, and promote ovarian survival during the process of ovarian tissue cryopreservation and transplantation, demonstrating important clinical implications.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Abdel Halim Harrath, Maroua Jalouli, Mohamed Habib Oueslati, Mohammad Abul Farah, Anouar Feriani, Waleed Aldahmash, Nouf Aldawood, Khalid Al-Anazi, Fawaz Falodah, Ayman Swelum, Saleh Alwasel
Summary: The study found that KARP has anti-tumor effects on MCF-7 breast cancer cells and can affect estradiol levels in rats.
PHYTOTHERAPY RESEARCH
(2021)
Article
Obstetrics & Gynecology
L. Grin, K. C. T. Vo, Y. Sato, Y. Mizrachi, M. Kohara, T. Sankai, K. Kawamura
Summary: This study revealed that the relative localization of ovarian follicles becomes deeper with aging and certain chronic diseases, resulting in shifts towards the medulla of the ovaries. Additionally, total follicle distance from the ovarian surface increased with age.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
C. B. Bartels, T. F. Uliasz, L. Lestz, L. M. Mehlmann
Summary: The study showed that testosterone injections in female mice caused virilization, but ovaries were still able to produce fertilizable eggs. This research provides insights for future clinical trials on fertility treatment options for transgender men.
HUMAN REPRODUCTION
(2021)