Journal
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Volume 9, Issue 12, Pages E210-E218Publisher
WILEY-BLACKWELL
DOI: 10.1002/term.1701
Keywords
bone; tissue engineering; scaffold; permeability; pore size; porosity
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Funding
- National Basic Research Program of China (973 program) [2011CB710901]
- National Natural Science Foundation of China (NSFC) [11120101001]
- NSFC [10925208]
- 863 High Technology Project
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Pore size and porosity have been widely acknowledged as important structural factors in tissue-engineered scaffolds. In fact, scaffolds with similar pore size and porosity can provide important and varied permeability due to different pore shape, interconnectivity and tortuosity. However, the effects of scaffold permeability on seeded cells remains largely unknown during tissue regeneration in vitro. In this study, we measured the Darcy permeability (K) of tri-calcium phosphate scaffolds by distributed them into three groups: Low, Medium and High. As a result, the effects of scaffold permeability on cell proliferation, cellular activity and growth in the inner pores were investigated in perfused and static cultures in vitro. Results demonstrated that higher permeable scaffolds exhibited superior performance during bone regeneration in vitro and the advantages of higher scaffold permeability were amplified in perfused culture. Based on these findings, scaffold permeability should be considered in future scaffold fabrications. Copyright (C) 2013 John Wiley & Sons, Ltd.
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