Article
Pharmacology & Pharmacy
Meenal Agrawal, Anilkumar Yadav, Sonam Takkar, Ritu Kulshreshtha, Bhanu Nandan, Rajiv K. Srivastava
Summary: Nanocomposite poly (e-caprolactone) scaffolds were fabricated using modified silica nanoparticles as stabilizers. The concentration of nanoparticles and the size of dispersed phase particles were controlled to achieve tunable properties of the scaffolds. Clove oil was used to functionalize the scaffolds, improving their antibacterial effectiveness and inhibiting biofilm formation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Jiongyu Ren, Nupur Kohli, Vaibhav Sharma, Taleen Shakouri, Zalike Keskin-Erdogan, Siamak Saifzadeh, Gary I. Brierly, Jonathan C. Knowles, Maria A. Woodruff, Elena Garcia-Gareta
Summary: The study showed that composites of PCL and FA have the potential to accelerate bone repair due to their angiogenic properties, but long-term bone regeneration may require adjustments to the degradation rate of FA to synchronize with new bone formation.
Article
Biotechnology & Applied Microbiology
Shiva Shariati, Ehsan Seyedjafari, Fatemeh Sadat Mahdavi, Amirhosein Maali, Elaheh Ferdosi-Shahandashti
Summary: In this study, NiFe2O4/ZnO-coated PLLA scaffold was used to evaluate the osteogenic differentiation capability of hAMSCs. The results showed that the NiFe2O4/ZnO-coated PLLA scaffold could enhance the adhesion, proliferation, and differentiation of hAMSCs, as well as promote the expression of osteogenic markers.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Keziban Huner, Baran Sarac, Eray Yuece, Amir Rezvan, Matej Micusik, Maria Omastova, Juergen Eckert, A. Sezai Sarac
Summary: The incorporation of iron and carboxylic acid-functionalized polyaniline into polymeric polycaprolactone structures enhances the electron-donating ability and conductivity of the compound, making it suitable for electrochemical immunosensors.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Engineering, Biomedical
Zhaochuang Wang, Wenhao Zhang, Guo Bai, Qiaohui Lu, Xiaoyu Li, Yan Zhou, Chi Yang, Yan Xiao, Meidong Lang
Summary: Customized elastomeric scaffolds mimicking natural tissues have been used for tissue regeneration. Polyester elastic scaffolds with tunable mechanical properties have shown excellent elasticity and have potential applications in soft tissue regeneration.
BIOACTIVE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Hao Li, Zhiyao Liao, Zhen Yang, Cangjian Gao, Liwei Fu, Pinxue Li, Tianyuan Zhao, Fuyang Cao, Wei Chen, Zhiguo Yuan, Xiang Sui, Shuyun Liu, Quanyi Guo
Summary: This study presents a composite scaffold for meniscus tissue engineering, consisting of a 3D-printed PCL scaffold, injected MECM, and KGN-loaded PLGA microspheres. The combination showed enhanced hydrophilicity, bioactivity, cell adhesion, proliferation, and chondrogenic differentiation. The sustained release of KGN from the scaffold contributed to improved cell affinity and chondrogenic activity, indicating promising application prospects in MTE.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Moloud A. Baghbadorani, Ashkan Bigham, Mohammad Rafienia, Hossein Salehi
Summary: In this study, a novel nanocomposite fibrous scaffold composed of PCL/GT/GLN7% was fabricated through electrospinning method, and its potential for bone tissue regeneration was evaluated through various physical and chemical properties assessments in vitro. The results indicate that the ternary scaffold shows promising performance in accelerating cell attachment, proliferation, and differentiation rate for bone tissue regeneration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Pharmacology & Pharmacy
Wei-Lin Zhang, Zhi-Wen Dai, Si-Yuan Chen, Wei-Xiong Guo, Zhong-Wei Wang, Jin-Song Wei
Summary: In this study, a multifunctional scaffold material, PHBV-mPEG5k (PP5), was prepared and loaded with melatonin (MT) to achieve desired bone tissue repair and anti-tumor properties. The results showed that the MT loaded PP5 scaffold can effectively enhance the anti-tumor effect of melatonin and provide a therapeutic strategy for comprehensive postoperative treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Maria Luisa Leite, Rafael Antonio de Oliveira Ribeiro, Diana Gabriela Soares, Josimeri Hebling, Carlos Alberto de Souza Costa
Summary: The tubular scaffold composed of poly(caprolactone)-aligned nanofibres and fibronectin-loaded collagen hydrogel enhances the migration, proliferation, and gene expression of human apical papilla cells, showing potential for regenerative pulp therapy of teeth with incomplete root formation.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Masoud Arastouei, Mohammad Khodaei, Seyed Mohammad Atyabi, Milad Jafari Nodoushan
Summary: The study demonstrated that PLA/akermanite scaffolds have a positive impact on bone tissue engineering applications, enhancing cell proliferation, growth, and viability, as well as increasing calcium deposition. The release of gentamicin from gelatin microspheres increased over time with longer cross-linking duration. Overall, PLA/akermanite scaffolds are an ideal candidate for bone tissue engineering.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Caroline D. Hoemann, Javier Rodriguez Gonzalez, Jessica Guzman-Morales, Gaoping Chen, Ebrahim Jalali Dil, Basil D. Favis
Summary: This study found that non-inflammatory chitosan coatings promoted cartilage infiltration into and over a bioplastic scaffold, and were compatible with trabecular bone integration. Compared to drill-only defects, the 83-99-PCL scaffold induced angiogenesis and slight bone resorption, with the smallest change in bone volume fraction.
BIOACTIVE MATERIALS
(2022)
Article
Cell & Tissue Engineering
Ahmad Oryan, Shadi Hassanajili, Sonia Sahvieh
Summary: This study tested the effects of a scaffold made of different materials on the regeneration of critical bone defects in rats, finding that the cell-seeded scaffold group showed significantly better regeneration outcomes compared to the untreated group. Additionally, the cell-seeded scaffold group and autograft group demonstrated comparable results on day 80 post-treatment.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Chemistry, Medicinal
Farah Alwani Azaman, Margaret E. Brennan E. Fournet, Suzina Sheikh Ab Hamid, Muhamad Syahrul Fitri Zawawi, Valdemiro Amaro da Silva Junior, Declan M. M. Devine
Summary: The field of bone tissue engineering is developing various bone graft substitute materials to reconstruct new bone tissue while maintaining native bone characteristics. Insufficient scaffold degradation is currently the critical limitation for tailoring bone formation turnover rate. This study examines novel scaffold formulations, and results show that the CS/HAp/FAp 1:1 formulation can improve scaffold degradation and bone regeneration, providing a cost-effective alternative to traditional methods (BMP-2).
Article
Biochemistry & Molecular Biology
Yan Zhu, Shengjun Jiang, Dongdong Xu, Gu Cheng, Bin Shi
Summary: In this study, a core-shell poly(& epsilon;-caprolactone)/chitosan/ polyvinyl alcohol (PCL/CS/PVA) guided bone regeneration (GBR) membrane loaded with resveratrol (RSV) was fabricated. The loaded membrane exhibited superior osteogenic induction ability compared to regular GBR membranes. In vitro and in vivo experiments demonstrated that the PCL/CS/PVA GBR membrane loaded with 0.5% RSV could efficiently release RSV, induce osteogenic differentiation, and promote bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell & Tissue Engineering
Lisa Berntsen, Anoosha Forghani, Daniel J. Hayes
Summary: This study demonstrates the potential of composite cell sheets, fabricated with adipose-derived stem cells, for engineering the tendon-bone interface. By stacking tenogenic and osteogenic cell sheets, the researchers were able to create a composite structure expressing markers of tendon, mineralized fibrocartilage, and bone. This research is an important step towards regenerating the biological gradient of the enthesis and has clinical translation implications.
TISSUE ENGINEERING PART A
(2022)
Article
Materials Science, Multidisciplinary
Sheng Li, Yichen Zhang, Hanlin Wu, Huifei Zhai, Wenhao Liu, Daniel Peirano Petit, Ji Seop Oh, Jonathan Denlinger, Gregory T. McCandless, Julia Y. Chan, Robert J. Birgeneau, Gang Li, Ming Yi, Bing Lv
Summary: The layered ternary selenide BaPt4Se6 features sesqui-selenide Pt2Se3 layers sandwiched by Ba atoms, resulting in a mixed-valence compound with peculiar electrical transport properties and a hidden state below 5 K. Temperature-dependent measurements reveal distinct anomalies, but no dramatic reconstruction of the electronic structure up to 200 K according to angle-resolved photoemission spectroscopy.
NPJ QUANTUM MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Han Wu, Alannah M. Hallas, Xiaochan Cai, Jianwei Huang, Ji Seop Oh, Vaideesh Loganathan, Ashley Weiland, Gregory T. McCandless, Julia Y. Chan, Sung-Kwan Mo, Donghui Lu, Makoto Hashimoto, Jonathan Denlinger, Robert J. Birgeneau, Andriy H. Nevidomskyy, Gang Li, Emilia Morosan, Ming Yi
Summary: The study reports Dirac nodal line crossings in PtPb4, which arise from the nonsymmorphic symmetry of its crystal structure. The results show that the nodal lines remain gapless in the absence of spin-orbit coupling (SOC), but the SOC lifts the band degeneracy everywhere except at a set of isolated points. However, the observed nodal line has a smaller bandwidth than predicted by density functional theory (DFT).
NPJ QUANTUM MATERIALS
(2022)
Article
Chemistry, Physical
Yaojia Wang, Gregory T. McCandless, Xiaoping Wang, Kulatheepan Thanabalasingam, Heng Wu, Damian Bouwmeester, Herre S. J. van der Zant, Mazhar N. Ali, Julia Y. Chan
Summary: The Kagome lattice plays an important role in condensed matter physics for studying the interaction between electron correlation, topology, and frustrated magnetism. Recent research on Kagome metals has revealed various correlation-driven distortions, including charge density waves and superconductivity. The study of a new Kagome metal, Yb0.5Co3Ge3, shows similar behavior to AV(3)Sb(5) compounds, indicating a temperature-dependent kink in resistivity and structural distortion. The findings raise questions about the nature of distortions in Kagome nets and their effects on superconductivity and magnetism.
CHEMISTRY OF MATERIALS
(2022)
Review
Multidisciplinary Sciences
You Lai, Julia Y. Chan, Ryan E. Baumbach
Summary: In this review, information about Ce, Eu, Yb, and U compounds with the ThCr2Si2 structure is aggregated to construct electronic/magnetic state maps and propose structural/chemical regions for accelerating the discovery of the next generation of f-electron quantum materials.
Article
Chemistry, Multidisciplinary
Trent M. Kyrk, Moises Bravo, Gregory T. McCandless, Saul H. Lapidus, Julia Y. Chan
Summary: The recent discovery of the A(n+1)B(n)X(3n+1) homologous series provides a new platform to study the structure-property relationships of highly correlated electron systems. This perspective discusses the motivation for synthesizing Prn+1ConGe3n+1 compounds and presents the structural characterization of n = 3 and n = 4 members. These findings lay the foundation for future investigations and highlight the importance of complementary methods for characterizing new quantum materials.
Article
Chemistry, Multidisciplinary
Wenkai Zheng, Li Xiang, Felipe A. . de Quesada, Mathias Augustin, Zhengguang Lu, Matthew Wilson, Aditya Sood, Fengcheng Wu, Dmitry Shcherbakov, Shahriar Memaran, Ryan E. Baumbach, Gregory T. McCandless, Julia Y. Chan, Song Liu, James H. Edgar, Chun Ning Lau, Chun Hung Lui, Elton J. G. Santos, Aaron Lindenberg, Dmitry Smirnov, Luis Balicas
Summary: Interlayer excitons are studied in hetero-bilayers of metal monochalcogenides, showing adjustable emission spectra and longer lifetimes compared to intralayer excitons. The bound electron-hole pair has a separation close to the calculated interfacial Se separation. These heterostacks have flat interfacial valence bands and are potential candidates for observing magnetism or other correlated electronic phases.
Article
Chemistry, Physical
Alexis Dominguez Montero, Gregory T. McCandless, Olatunde Oladehin, Ryan E. Baumbach, Julia Y. Chan
Summary: In this Perspective, the heuristic methods used to rationalize the stability of extended solids are discussed, with emphasis on the role of Goldschmidt's tolerance factor in perovskite research. The development of a tolerance factor for predicting the stability of intermetallic pseudoperovskites, the Remeika phases, and the correlation between oxidation states and valence fluctuation is also discussed. The feasibility of the Remeika phase tolerance factor is evaluated through the synthesis of a new predicted compound and measurement of its magnetic moment. The importance of determining the factors dictating the stability of Remeika intermetallics is highlighted.
CHEMISTRY OF MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Tyus J. Yeingst, Julien H. Arrizabalaga, Ferdousi S. Rawnaque, Lindsay P. Stone, Amar Yeware, Angelica M. Helton, Aman Dhawan, Julianna C. Simon, Daniel J. Hayes
Summary: This study developed an ultrasound-responsive polymer system that can degrade on demand when exposed to high-intensity focused ultrasound (HIFU). Diels-Alder cycloadducts were used to crosslink polycaprolactone (PCL) polymers and underwent a retro Diels-Alder reaction under HIFU stimulation. The relationship between reverse reaction energy barriers and polymer degradation rates was evaluated for two Diels-Alder polymer compositions. HIFU exposure time and amplitude were found to correlate with an increase in PCL degradation for Diels-Alder-based polymers. The study demonstrated that HIFU is an effective image-guided stimulus to control the degradation of Diels-Alder-based PCL polymers on-demand.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Inorganic & Nuclear
Moises Bravo, Gregory T. McCandless, Ryan E. Baumbach, Yaojia Wang, Mazhar N. Ali, Julia Y. Chan
Summary: There is a growing interest in kagome materials, which provide tunable platforms combining magnetism and electron correlation. In this study, new kagome materials Ln(x)Co(3)(Ge1-ySny)(3) (Ln = Y, Gd; y = 0.11, 0.133) were examined using the Sn flux-growth method. The Y and Gd analogues have a hybrid YCo6Ge6/CoSn structure with Sn substitution. The Gd analogue displays a magnetic moment of 8.48 mu(B), indicating contributions from both Gd and Co, while the Y analogue exhibits temperature-independent paramagnetism. Anisotropic magnetic measurements suggest that the Co magnetism is in plane with the kagome net.
INORGANIC CHEMISTRY
(2023)
Review
Oncology
Debarati Bhanja, Hannah Wilding, Angel Baroz, Mara Trifoi, Ganesh Shenoy, Becky Slagle-Webb, Daniel Hayes, Yasaman Soudagar, James Connor, Alireza Mansouri
Summary: This review focuses on summarizing the potential and shortcomings of photodynamic therapy (PDT) in the treatment of glioblastoma (GBM), analyzing the current challenges that hinder its effectiveness, and highlighting novel investigations in this field. By addressing these barriers and proposing solutions, this review provides a path for optimizing PDT as a paradigm-shifting treatment for GBM.
Article
Nanoscience & Nanotechnology
Julien H. Arrizabalaga, Molly Smallcomb, Mohammad Abu -Laban, Yiming Liu, Tyus J. Yeingst, Aman Dhawan, Julianna C. Simon, Daniel J. Hayes
Summary: This study presents the development of tunable, ultrasound-responsive hydrogels that can release protein payload on-demand when exposed to focused ultrasound. The reversible Diels-Alder linkers were used to achieve this ultrasound response. The results showed that the retro Diels-Alder reaction induced by focused ultrasound can control the release of the payload and enable real-time visualization of the process, suggesting potential therapeutic applications.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Julien H. Arrizabalaga, Molly Smallcomb, Mohammad Abu-Laban, Yiming Liu, Tyus J. Yeingst, Aman Dhawan, Julianna C. Simon, Daniel J. Hayes
Summary: This study describes the development of tunable, ultrasound-responsive hydrogels that can deliver protein payload on-demand when exposed to focused ultrasound. The results demonstrate the correlation between ultrasound response and the rate of protein release.
ACS APPLIED BIO MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Trent M. Kyrk, Ellis R. Kennedy, Jorge Galeano-Cabral, Kaya Wei, Gregory T. McCandless, Mary C. Scott, Ryan E. Baumbach, Julia Y. Chan
Summary: The crystal structure and various measurements of Sn flux grown single crystals of orthorhombic Pr2Co3Ge5 were reported, showing the complex magnetic ordering with a partially spin-polarized state.
JOURNAL OF PHYSICS-MATERIALS
(2022)
Review
Polymer Science
Tyus J. Yeingst, Julien H. Arrizabalaga, Daniel J. Hayes
Summary: Stimuli-responsive hydrogel drug delivery systems that release drugs under external stimuli, such as ultrasound, have gained importance in the field of drug delivery. This review summarizes the current understanding of ultrasound-responsive hydrogels, including mechanisms of drug release, innovative formulations, and applications in cancer treatment and tissue engineering.
