Review
Polymer Science
Hee Sook Hwang, Chung-Sung Lee
Summary: Hydrogel-based bone tissue engineering using hyaluronic acid (HA) has gained popularity as a potential strategy for treating bone abnormalities and fractures. HA-based hydrogels have the ability to mimic the natural extracellular matrix of bone tissue and provide a suitable microenvironment for cell support and tissue regeneration. The physical and chemical properties of HA can be modified to improve its mechanical strength, biocompatibility, and osteogenic potential, making it a promising material for bone tissue engineering.
Article
Biotechnology & Applied Microbiology
Zhiwei Peng, Huai Xue, Xiao Liu, Shuguang Wang, Guodong Liu, Xinghai Jia, Ziqiang Zhu, Moontarij Jahan Orvy, Yin Yang, Yunqing Wang, Dong Zhang, Lei Tong
Summary: Researchers have developed a tough and adhesive biomimetic hydrogel made of hyaluronic acid methacryloyl and poly(N-hydroxyethyl acrylamide). This hydrogel shows high mechanical strength and adhesiveness, and exhibits good biocompatibility and blood compatibility. This study has significant implications for wound repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Huiling Deng, Jiecong Wang, Ran An
Summary: This article summarizes the important role of exosomes in bone regeneration and the problems in their clinical application. It then introduces the use of hydrogels as a solution to these problems, with a focus on the application prospects and challenges of hyaluronic acid-based hydrogels as exosome delivery devices in bone regeneration.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shangzhi Li, Qi Dong, Xiaotong Peng, Yun Chen, Hongjun Yang, Weilin Xu, Yanteng Zhao, Pu Xiao, Yingshan Zhou
Summary: A self-healing nanocomposite hydrogel based on hyaluronic acid has been developed, which exhibits good strength, self-healing ability, and the potential to load platelet-rich plasma (PRP) for promoting skin wound healing.
Article
Chemistry, Applied
Hongjuan Weng, Weibin Jia, Min Li, Zonggang Chen
Summary: Novel NSC-OHA-based hydrogels with self-healing and injectable properties were fabricated, and the mechanical behavior and bioactivities were regulated by the addition of Ca2+ or PEG1. The hydrogels showed improved biocompatibility, hemostasis, and wound healing abilities, making them promising for medical applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Emine Salva, Ahmet Enes Akdag, Saadet Alan, Sema Arisoy, Fatma Julide Akbuga
Summary: The 3D polymeric network structure of chitosan/hyaluronic acid/honey hydrogels, which imitates the extracellular matrix, promotes cell growth and differentiation and exhibits excellent wound-healing abilities. The hydrogels were characterized and their properties, such as water content, water uptake capacities, and porosity, were investigated. The addition of honey altered the interaction between chitosan and hyaluronic acid, resulting in changes in the hydrogel's properties. The honey-containing hydrogels showed decreased porosity and slightly decreased water-uptake capacity, but increased cell adhesion and proliferation. In vivo studies demonstrated that honey addition accelerated wound healing. These findings highlight the potential of honey-loaded chitosan-hyaluronic acid hydrogels in wound healing applications.
Review
Polymer Science
Xu Zhang, Bowen Tan, Yanting Wu, Min Zhang, Jinfeng Liao
Summary: Photothermal hydrogels show potential in antibacterial action, angiogenesis, and osteogenesis, and could be promising in wound healing and bone regeneration applications.
Article
Biochemistry & Molecular Biology
Jun Ho Lee, Yu Jin Won, Hail Kim, Minji Choi, Esther Lee, Bumsik Ryoou, Seok-Geun Lee, Byong Seung Cho
Summary: Exosomes derived from adipose tissue-derived stem cells (ASCs) have shown beneficial effects on cell proliferation, migration, and gene expression related to wound healing. Combining these ASC-derived exosomes (ASC-EXOs) with hyaluronic acid (HA) can enhance wound closure rates, tissue regeneration, and collagen production in animal models. This suggests the potential for their use in clinical and regenerative aesthetic applications for skin repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Huinan Suo, Mubashir Hussain, Hua Wang, Nuoya Zhou, Juan Tao, Hao Jiang, Jintao Zhu
Summary: The study developed an antibiotic-free hydrogel-based biomaterial for the management of chronic bacteria-infected wounds, utilizing an antimicrobial peptide as a cross-linking agent to achieve acidity-triggered release of AMP, along with high biostability and enhanced mechanical strength.
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Review
Polymer Science
Sibusiso Alven, Blessing A. Aderibigbe
Summary: The negative factors that lead to delayed and prolonged wound healing, such as microbial pathogens and excess wound exudates, pose challenges for currently used wound dressings, necessitating improvements. Biopolymers offer interesting properties suitable for the design of wound dressings.
Article
Chemistry, Physical
Yueyue Li, Weifeng Zhong, Junjie Wu, Yuan Jia, Zhonghua Chen, Kaiwen Zhang, Danyang Guo, Yifei Fu, Mengnan Chen, Weiwei Chen, Fan Tian, Xia Li, Hongji Zhang, Xiaojin Zhou, Feng-Lai Yuan
Summary: Recruiting key cells to regeneration sites is a promising strategy for promoting functional wound healing. Papillary fibroblasts, with central regulatory roles in skin appendage regeneration, can be recruited using Grass Carp Fishing multifunctional hydrogels, which deliver Lrig1 antibodies and IGF1 to the surface of these fibroblasts. Injectable self-healing multifunctional hydrogels, with sustained release of Lrig1 antibodies and IGF1, were shown to accelerate the migration and proliferation of Lrig1(+) fibroblasts and promote wound healing and skin regeneration.
Review
Chemistry, Multidisciplinary
Aziz Maleki, Jiahui He, Shayesteh Bochani, Vahideh Nosrati, Mohammad-Ali Shahbazi, Baolin Guo
Summary: Light-based photothermal therapy (PTT) and photo-dynamic therapy (PDT) have great potential in wound healing and infection prevention. Multifunctional photoresponsive hydrogels (MPRHs) combining light and hydrogel advantages are increasingly used in biomedicine, particularly in wound repair. The modulation of bacterial microenvironments to inhibit infection through PTT, PDT, and photothermal/photodynamic synergistic therapy has been discussed.
Article
Chemistry, Multidisciplinary
Yaodong Zhao, Bingcheng Yi, Jilin Hu, Dongjie Zhang, Guotai Li, Yun Lu, Qihui Zhou
Summary: In order to prevent microbial invasion, inhibit scar formation, and promote wound healing, a thermo-responsive and tissue-adhesive hydrogel dressing was developed. This dressing, based on N-dimethylbisacrylamide (NIPAM) and glutaraldehyde (GTA) cross-linked hyaluronic acid (HA), showed self-contraction and tissue adhesiveness, aiding wound closure via mechanical stretch. It also demonstrated hemocompatibility and cytocompatibility, accelerating wound healing. In vivo experiments using a mouse model showed that the hydrogel dressing achieved sutureless closure at the early stage of wound healing and promoted healing by reducing inflammation, promoting angiogenesis, and reducing collagen deposition.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Rong Yang, Xin Liu, Yanhan Ren, Wenliang Xue, Shuai Liu, Penghui Wang, Ming Zhao, Hong Xu, Bo Chi
Summary: The bionic extracellular matrix hydrogels developed in this study possess dynamic covalent network and self-healing capability, showing typical viscoelastic characteristics, degradation property, and free radical scavenging capability. The properties of the hydrogels can be tuned by adjusting polymer content, and they significantly enhance wound healing process by promoting angiogenesis and collagen deposition, demonstrating great application potential in biomedical areas.
ACTA BIOMATERIALIA
(2021)
Article
Computer Science, Interdisciplinary Applications
Ehsan Sarshari, Matteo Mancuso, Alexandre Terrier, Alain Farron, Philippe Mullhaupt, Dominique Pioletti
Summary: This study investigates an alternative method to estimate GH from videogrammetry using a CT/MRI image of the subject's glenohumeral joint without requiring SKMD. The accuracy of GH estimations was within 5 mm, and the reconstructed motion showed good agreement with reported in vivo measurements.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Computer Science, Interdisciplinary Applications
Ehsan Sarshari, Matteo Mancuso, Alexandre Terrier, Alain Farron, Philippe Mullhaupt, Dominique Pioletti
Summary: This study aimed to improve the estimation of muscle co-contractions in an upper limb musculoskeletal model by incorporating EMG data. The results showed that EALS estimated higher muscle co-contractions compared to SLS.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Materials Science, Biomaterials
Jisheng Ran, Yang Fei, Canlong Wang, Dengfeng Ruan, Yejun Hu, Zefeng Zheng, Xiao Chen, Zi Yin, Chenqi Tang, Yangwu Chen, Jiayun Huang, Lingfang Shen, Lidong Wu, Boon Chin Heng, Dominique Pioletti, Weiliang Shen, Hongwei Ouyang
Summary: The study developed a one-step cryopreserved ACI tissue-engineered cartilage that demonstrated strong cartilage repair capacity and convenience through optimized spheroidal CSPCs pellets, showcasing a promising one-step surgical approach.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Oriane Poupart, Riccardo Conti, Andreas Schmocker, Lucio Pancaldi, Christophe Moser, Katja M. Nuss, Mahmut S. Sakar, Tomas Dobrocky, Hansjorg Grutzmacher, Pascal J. Mosimann, Dominique P. Pioletti
Summary: Hydrogels are emerging as a promising intracranial aneurysm embolic agent for their ability to be injected in liquid phase and solidify in situ, providing better filling of an aneurysm sac compared to solid implants. Photopolymerizable poly(ethylene glycol) dimethacrylate (PEGDMA) hydrogels have been demonstrated to be feasible for aneurysm application in vitro, with fine-tuning to match the elastic modulus and compliance of aneurysmal tissue. In a fatigue test under physiological pulsatile flow, these hydrogels showed minimal surface erosion defects and no significant weight loss, indicating their potential for in vivo implant studies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alexis Laurent, Philippe Abdel-Sayed, Aurelie Ducrot, Nathalie Hirt-Burri, Corinne Scaletta, Sandra Jaccoud, Katja Nuss, Anthony S. de Buys Roessingh, Wassim Raffoul, Dominique Pioletti, Brigitte von Rechenberg, Lee Ann Applegate, Salim Darwiche
Summary: Cell therapy approaches, such as bone marrow stimulation and autologous chondrocyte implantation, show promise in managing cartilaginous tissue issues; cultured human epiphyseal chondro-progenitors are considered sustainable, safe, and stable candidates for assisting in cartilage repair or regeneration, offering potential in regenerative medicine.
Article
Orthopedics
Pezhman Eghbali, Fabio Becce, Patrick Goetti, Frederic Vauclair, Alain Farron, Philippe Buchler, Dominique Pioletti, Alexandre Terrier
Summary: The objective of this study was to determine the normative bone mineral density (BMD) of cortical and trabecular bone regions in the adult glenoid and its dependence on the subject's age and sex. The study found that glenoid BMD was higher in males than females and declined with age. These findings are clinically relevant in the diagnosis and management of shoulder disorders and related research.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biology
Naser Nasrollahzadeh, Peyman Karami, Jian Wang, Lida Bagheri, Yanheng Guo, Philippe Abdel-Sayed, Lee Laurent-Applegate, Dominique P. Pioletti
Summary: This study focused on cartilage self-heating and investigated the impact of its coupling with mechanical stimuli on cell behavior. The findings suggest that the co-existence of thermo-mechanical cues has a superior effect on chondrogenic gene expression compared to either signal alone, with the TRPV4 channel identified as a key mediator of the thermo-mechanotransduction process.
Review
Engineering, Biomedical
Peyman Karami, Theofanis Stampoultzis, Yanheng Guo, Dominique P. Pioletti
Summary: The drive to develop cartilage implants for major defects in the musculoskeletal system has led to an increased focus on developing biomaterial devices for cartilage repair. However, there has been limited attention on the preclinical validation process and approval procedures for these devices. This review paper aims to highlight the various considerations regarding preclinical validation of hydrogel devices for cartilage repair, including regulatory requirements, implantation strategies, device performance aspects, and characterizations.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Peyman Karami, Vijay Kumar Rana, Qianyi Zhang, Antoine Boniface, Yanheng Guo, Christophe Moser, Dominique P. Pioletti
Summary: The use of low viscosity photopolymerizable hydrogels for surgical treatment of injured soft tissues can reduce the severity of iatrogenic injury. In this study, near-infrared light was used to cure the hydrogel located behind biological tissues, achieving a minimally invasive approach. The mechanical and adhesive properties of the hydrogel can be modulated by adjusting parameters such as NIR light power and UCNP concentration.
Article
Materials Science, Biomaterials
Theofanis Stampoultzis, Yanheng Guo, Naser Nasrollahzadeh, Peyman Karami, Dominique P. Pioletti
Summary: Articular cartilage is a mechanically sensitive tissue where chondrocytes perceive and react to physical cues. This study explores the role of temperature as a regulatory signal for chondrocyte function and evaluates the effects of thermal and/or mechanical stimulation on chondrocytes in different types of scaffolds. The results suggest that the combination of dynamic thermal and mechanical stimuli has superior effects on chondrogenic genes and proteoglycan accumulation.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Vijay K. Rana, Peyman Karami, Naser Nasrollahzadeh, Dominique P. Pioletti
Summary: Incorporating nanoparticles into polymer matrices can improve the properties of composite materials, but the impact of nanoparticle surface heterostructures on composite systems is not fully understood. By comparing the properties of composite hydrogels containing smooth-surfaced particles and rough-surfaced particles, it is found that the surface roughness of nanoparticles significantly affects the macroscopic properties of the hydrogels.
ADVANCED MATERIALS INTERFACES
(2023)
Meeting Abstract
Cell & Tissue Engineering
Naser Nasrollahzadeh, Lee A. Applegate, Dominique Pioletti
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Lida Bagheri, Ahmad S. A. Ramazani, Naser Nasrollahzadeh, Dominique Pioletti
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Peyman Karami, Celine Wyss, Pierre-Etienne Bourban, Philip Procter, Christophe Moser, Dominique Pioletti
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Endocrinology & Metabolism
Ulrike Kettenberger, Arne Vogel, Dominique Pioletti
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)