Review
Hematology
Flavio Giuseppe Biccire, Alessio Farcomeni, Carlo Gaudio, Pasquale Pignatelli, Gaetano Tanzilli, Daniele Pastori
Summary: In patients with ACS, high D-dimer levels were associated with higher in-hospital and short/long-term complications, as well as with the no-reflow phenomenon. The use of D-dimer may be helpful in identifying patients with residual thrombotic risk after ACS.
THROMBOSIS JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Rajesh Kumar, Ali Ammar, Tahir Saghir, Jawaid Akbar Sial, Kamran Ahmed Khan, Jehangir Ali Shah, Abdul Hakeem Shaikh, Syed Nadeem Hassan Rizvi, Nadeem Qamar, Musa Karim
Summary: In this study, a novel risk stratification model (RK-SF/NR score) was developed to predict the risk of SF/NR during primary PCI. The model showed good discrimination and sensitivity in predicting SF/NR. Therefore, it has good clinical utility for screening high-risk patients for SF/NR during primary PCI.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xue Gong, Xiaoting Lei, Zheyong Huang, Yanan Song, Qibing Wang, Juying Qian, Junbo Ge
Summary: Plasma D-dimer level can independently predict the occurrence of no-reflow in STEMI patients who underwent pPCI within 2-7 days of symptom onset, indicating its potential as a predictive factor.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Review
Medicine, General & Internal
Gianmarco Annibali, Innocenzo Scrocca, Tiziana Claudia Aranzulla, Emanuele Meliga, Francesco Maiellaro, Giuseppe Musumeci
Summary: This review provides a contemporary overview of the pathogenesis, diagnosis, and treatment of no reflow.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Xiangming Hu, Xing Yang, Xida Li, Guang Li, Yingling Zhou, Haojian Dong
Summary: Elevated serum uric acid is associated with a higher incidence of no/slow-reflow phenomenon in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention, especially in those with delayed perfusion or diabetes mellitus. It is related to severe inflammation and worse left ventricular ejection fraction.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Gjin Ndrepepa, Salvatore Cassese, Erion Xhepa, Michael Joner, Hendrik B. Sager, Sebastian Kufner, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati
Summary: The frequency and prognostic value of coronary no-reflow (CNR) was investigated in studies that used stents and antithrombotic drugs in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI).
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Qinyao Zhang, Meirong Hu, Shumei Ma, Tiesheng Niu
Summary: The study evaluated the prognostic validity of the R-2-CHA(2)DS(2)-VASc score for patients with STEMI. The results showed that R-2-CHA(2)DS(2)-VASc>=3 was associated with no-reflow phenomena and poor clinical outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Xiangming Hu, Weimian Wang, Jingguang Ye, Yan Lin, Bingyan Yu, Langping Zhou, Yingling Zhou, Haojian Dong
Summary: This study compared the efficacy and safety of short- and long-term GPI infusion in patients with STEMI and the no-/slow-reflow phenomenon, and found that prolonging the duration of GPI may not significantly improve the clinical outcome in real-world patients.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Ying Sun, Jian Ren, Li Li, Chunsong Wang, Hengchen Yao
Summary: This study investigated the predictive value of red blood-cell distribution width (RDW) on no-reflow phenomenon (NRP) in ST-segment elevation myocardial infarction (STEMI) patients. The results showed that patients with high RDW had a higher likelihood of developing NRP. In patients with diabetes, RDW was found to be an independent predictor of NRP.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Sanjiv Kaul, Carmen Methner, Zhiping Cao, Anusha Mishra
Summary: Pericytes contract during myocardial ischemia leading to capillary constriction and no reflow. Pharmacological reversal of pericyte contraction can reduce no reflow and infarct size. These findings provide a new avenue of research for modifying pericyte function in myocardial ischemia and infarction.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, General & Internal
Marcin Kozuch, Maciej Poludniewski, Emil Julian Dabrowski, Ewa Tarasiuk, Slawomir Dobrzycki
Summary: This study aimed to assess the relationship between GDF-15 concentration on admission and the occurrence of the no-reflow phenomenon. The results showed a negative correlation between GDF-15 concentration and TIMI flow after PCI. Multivariate logistic regression analysis identified higher age, GDF-15 concentration > 1503 pg/mL, lower systolic blood pressure, and higher troponin I concentration on admission as risk factors for no-reflow.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Monica Verdoia, Filippo Viglione, Annalisa Boggio, Daniele Stefani, Nicolo Panarotto, Aurelio Malabaila, Roberta Rolla, Pier Luigi Solda, Alessandro Stecco, Alessandro Carriero, Giuseppe De Luca
Summary: This study aimed to assess the impact of vitamin D on cholesterol levels among patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (pPCI). The results showed that lower levels of vitamin D were independently associated with a more atherogenic lipid profile.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Peripheral Vascular Disease
Ozge Ozcan Abacioglu, Arafat Yildirim, Nermin Yildiz Koyunsever, Salih Kilic
Summary: The study found that ATRIA, especially the m-ATRIA-HS score, can be used to assess the risk of no-reflow in STEMI patients. In addition, age, higher CK-MB, neutrophil-to-lymphocyte ratio, and diabetes mellitus were also identified as other predictors for no-reflow.
Article
Cardiac & Cardiovascular Systems
Carmen Methner, Zhiping Cao, Anusha Mishra, Sanjiv Kaul
Summary: The no reflow phenomenon following treatment of acute myocardial infarction is associated with worse outcomes, with the mechanism remaining unknown. This study demonstrates that GPR39-mediated pericyte contraction during reduced coronary perfusion pressure leads to capillary constriction and subsequent no reflow. Smaller no reflow zones in GPR39-knockout animals and those treated with a GPR39 inhibitor are associated with reduced infarct size, indicating potential therapeutic implications.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yehong Liu, Ting Ye, Ke Chen, Gangyong Wu, Yang Xia, Xiao Wang, Gangjun Zong
Summary: A prediction model that can be quickly referred to before surgery to predict the risk for no-reflow after primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) patients was constructed. This novel nomogram may be useful in identifying STEMI patients at higher risk for no-reflow and may predict prognosis in this patient population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Burak Turan, Ayhan Erkol, Mehmet Gul, Ugur Findikcioglu, Ismail Erden
CARDIORENAL MEDICINE
(2015)
Article
Cardiac & Cardiovascular Systems
Burak Turan, Hakan Demir, Ayhan Mutlu, Tolga Dasli, Ayhan Erkol, Ismail Erden
ANATOLIAN JOURNAL OF CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Ismail Erden, Emine Cakcak Erden, Tolga Aksu, Sukriye Ebru Golcuk, Burak Turan, Ayhan Erkol, Mustafa Akcakoyun, Tulin Saym
ANATOLIAN JOURNAL OF CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Burak Turan, Ayhan Erkol, Fatih Yilmaz, Mehmet Mustafa Can, Ismail Erden
CARDIOLOGY JOURNAL
(2016)
Article
Cardiac & Cardiovascular Systems
Burak Turan, Ayhan Erkol, Ayhan Mutlu, Tolga Dasli, Ismail Erden
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
A. Kalayci, V Oduncu, C. Y. Karabay, A. Erkol, A. C. Tanalp, I. H. Tanboga, O. Candan, C. Gecmen, I. A. Izgi, C. Kirma
Article
Medicine, General & Internal
Ayhan Erkol, Vecih Oduncu, Burak Turan, Alev Kilicgedik, Can Yucel Karabay, Taylan Akgun, Ahmet Guler, Selcuk Pala, Cevat Kirma
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2014)
Article
Hematology
Taylan Akgun, Vecih Oduncu, Atila Bitigen, Can Yucel Karabay, Ayhan Erkol, Gonenc Kocabay, Olcay Ozveren, Abdulmelik Yildiz, Arif Oguzhan Cimen, Cevat Kirma
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2015)
Article
Cardiac & Cardiovascular Systems
Tayyar Gokdeniz, Ayhan Erkol, Ezgi Kalaycioglu, Ahmet Cagri Aykan, Ilker Gul, Faruk Boyaci, Burak Turan, Mehmet Ozkan
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2015)
Article
Cardiac & Cardiovascular Systems
Vecih Oduncu, Ayhan Erkol, Mustafa Kurt, Ibrahim Halil Tanboga, Can Yucel Karabay, Cihan Sengul, Mustafa Bulut, Olcay Ozveren, Hakan Fotbolcu, Taylan Akgun, Erdem Turkyilmaz, Cevat Kirma
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Can Yucel Karabay, Gonenc Kocabay, Ahmet Guler, Vecih Oduncu, Taylan Akgun, Arzu Kalayci, Alev Kilicgedik, Onur Tasar, Sedat Kalkan, Ayhan Erkol, Akin Izgi, Ali Metin Esen, Cevat Kirma
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2014)
Article
Cardiac & Cardiovascular Systems
Burak Turan, Tolga Dasli, Ayhan Erkol, Ismail Erden
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2015)
Article
Cardiac & Cardiovascular Systems
Cihan Dundar, Filiz Kizilirmak, Kursat Tigen, Akin Izgi, Tansu Karaahmet, Selcuk Pala, Vecih Oduncu, Ayhan Erkol, Mustafa Bulut, Cevat Kirma
TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Ayhan Erkol, Selcuk Pala, Vecih Oduncu, Alev Kilicgedik, Filiz Kizilirmak, Can Yucel Karabay, Ahmet Guler, Cevat Kirma
TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
(2013)