Lowering homocysteine levels with folic acid and B-vitamins do not reduce early atherosclerosis, but could interfere with cognitive decline and Alzheimer’s disease

No Effect of Folic Acid Supplementation on Global DNA Methylation in Men and Women with Moderately Elevated Homocysteine

(2011) Audrey Y. Jung et al.   PLoS One

DNA methylation-mediated control of learning and memory

(2011) Nam-Kyung Yu et al.   Molecular Brain

Homocysteine, Another Risk Factor for Alzheimer Disease, Impairs Apolipoprotein E3 Function

(2010) Hirohisa Minagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

(2010) A. David Smith et al.   PLoS One

Hyperhomocysteinemia Increases β-Amyloid by Enhancing Expression of γ-Secretase and Phosphorylation of Amyloid Precursor Protein in Rat Brain

(2009) Chang-E Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Plasma Total Homocysteine Levels are not Associated with Medial Temporal Lobe Atrophy, but with White Matter Changes in Alzheimer's Disease

(2009) Sung Rae Kim et al.   Journal of Clinical Neurology

Hyperhomocysteinemia and Alzheimer's disease: A systematic review

(2008) Floris Van Dam et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-β deposition in mice

(2008) Andrea Fuso et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA