P2Y12 platelet inhibition in clinical practice

Standardized Bleeding Definitions for Cardiovascular Clinical Trials

(2011) Roxana Mehran et al.   CIRCULATION

Standard- vs High-Dose Clopidogrel Based on Platelet Function Testing After Percutaneous Coronary Intervention

(2011) Matthew J. Price   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Incidence of Bradyarrhythmias and Clinical Bradyarrhythmic Events in Patients With Acute Coronary Syndromes Treated With Ticagrelor or Clopidogrel in the PLATO (Platelet Inhibition and Patient Outcomes) Trial

(2011) Benjamin M. Scirica et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clopidogrel–Drug Interactions

(2011) Eric R. Bates et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non–ST-segment elevation myocardial infarction: The TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial

(2010) Chee Tang Chin et al.   AMERICAN HEART JOURNAL

Rationale and design of the dual antiplatelet therapy study, a prospective, multicenter, randomized, double-blind trial to assess the effectiveness and safety of 12 versus 30 months of dual antiplatelet therapy in subjects undergoing percutaneous coronary intervention with either drug-eluting stent or bare metal stent placement for the treatment of coronary artery lesions

(2010) Laura Mauri et al.   AMERICAN HEART JOURNAL

Ticagrelor Versus Clopidogrel in Acute Coronary Syndromes in Relation to Renal Function

(2010) Stefan James et al.   CIRCULATION

Ticagrelor Versus Clopidogrel in Patients With ST-Elevation Acute Coronary Syndromes Intended for Reperfusion With Primary Percutaneous Coronary Intervention

(2010) Philippe Gabriel Steg et al.   CIRCULATION

Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial

(2010) Stefan James et al.   EUROPEAN HEART JOURNAL

Comparison of Platelet Function Tests in Predicting Clinical Outcome in Patients Undergoing Coronary Stent Implantation

(2010) Nicoline J. Breet   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibitory Effects of Ticagrelor Compared With Clopidogrel on Platelet Function in Patients With Acute Coronary Syndromes

(2010) Robert F. Storey et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

5-Year Clinical Outcomes in the ICTUS (Invasive versus Conservative Treatment in Unstable coronary Syndromes) Trial

(2010) Peter Damman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

New P2Y12Inhibitors Versus Clopidogrel in Percutaneous Coronary Intervention

(2010) Anne Bellemain-Appaix et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impact of Cytochrome P450 2C19 Loss-of-Function Polymorphism and of Major Demographic Characteristics on Residual Platelet Function After Loading and Maintenance Treatment With Clopidogrel in Patients Undergoing Elective Coronary Stent Placement

(2010) Willibald Hochholzer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Long-Term Outcome of a Routine Versus Selective Invasive Strategy in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome

(2010) Keith A.A. Fox et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes Undergoing Coronary Artery Bypass Surgery

(2010) Claes Held et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study

(2010) Christopher P Cannon et al.   LANCET

Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial

(2010) Lars Wallentin et al.   LANCET

Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADP-receptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: The Early Rapid ReversAl of Platelet ThromboSis with Intravenous Elinogrel before PCI to Optimize REperfusion in Acute Myocardial Infarction (ERASE MI) pilot trial

(2009) Jeffrey S. Berger et al.   AMERICAN HEART JOURNAL

Effect of prasugrel versus clopidogrel on outcomes among patients with acute coronary syndrome undergoing percutaneous coronary intervention without stent implantation: A TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet inhibitioN with prasugrel (TRITON)–Thrombolysis in Myocardial Infarction (TIMI) 38 Substudy

(2009) Yuri B. Pride et al.   AMERICAN HEART JOURNAL

Assessment, Mechanisms, and Clinical Implication of Variability in Platelet Response to Aspirin and Clopidogrel Therapy

(2009) Itsik Ben-Dor et al.   AMERICAN JOURNAL OF CARDIOLOGY

Prognostic Modeling of Individual Patient Risk and Mortality Impact of Ischemic and Hemorrhagic Complications

(2009) Stuart J. Pocock et al.   CIRCULATION

Cost-Effectiveness of Prasugrel Versus Clopidogrel in Patients With Acute Coronary Syndromes and Planned Percutaneous Coronary Intervention

(2009) Elizabeth M. Mahoney et al.   CIRCULATION

P2Y12 inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use

(2009) L. Wallentin   EUROPEAN HEART JOURNAL

The PLATO trial: do you believe in magic?

(2009) V. L. Serebruany et al.   EUROPEAN HEART JOURNAL

Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

(2009) Alan R. Shuldiner   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabolism and Disposition of the Thienopyridine Antiplatelet Drugs Ticlopidine, Clopidogrel, and Prasugrel in Humans

(2009) Nagy A. Farid et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The Efficacy and Safety of Prasugrel With and Without a Glycoprotein IIb/IIIa Inhibitor in Patients With Acute Coronary Syndromes Undergoing Percutaneous Intervention

(2009) Michelle O'Donoghue et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial

(2009) Gilles Montalescot et al.   LANCET

Intravenous Platelet Blockade with Cangrelor during PCI

(2009) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelet Inhibition with Cangrelor in Patients Undergoing PCI

(2009) Robert A. Harrington et al.   NEW ENGLAND JOURNAL OF MEDICINE

P2Y12 Inhibitors in Cardiovascular Disease: Focus on Prasugrel

(2008) Day Marice Scott et al.   ANNALS OF PHARMACOTHERAPY

Greater Clinical Benefit of More Intensive Oral Antiplatelet Therapy With Prasugrel in Patients With Diabetes Mellitus in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis in Myocardial Infarction 38

(2008) Stephen D. Wiviott et al.   CIRCULATION

Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial

(2008) Stephen D Wiviott et al.   LANCET

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

(2008) Jessica L. Mega et al.   NEW ENGLAND JOURNAL OF MEDICINE