Article
Oncology
Pauline Duerr, Katja Schlichtig, Carolin Kelz, Birgit Deutsch, Renke Maas, Michael J. Eckart, Jochen Wilke, Harald Wagner, Kerstin Wolff, Caroline Preuss, Valeska Brueckl, Norbert Meidenbauer, Christian Staerk, Andreas Mayr, Rainer Fietkau, Peter J. Goebell, Frank Kunath, Matthias W. Beckmann, Andreas Mackensen, Markus F. Neurath, Marianne Pavel, Frank Doerje, Martin F. Fromm
Summary: Treatment with oral anticancer drugs is associated with a wide range of medication errors and side effects. Intensified clinical pharmacological/pharmaceutical care has significant positive effects on reducing medication errors, improving patient treatment perception, and decreasing severe side effects.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Katja Stahl, Oliver Groene
Summary: Routine measurement of patient safety from the patients' perspective is important, and this study found that patients have positive experiences in various aspects of patient safety. However, a small percentage of patients reported experiencing patient safety events in the last 12 months.
Article
Medicine, General & Internal
Nienke E. Dijkstra, Marcia Vervloet, Carolien G. M. Sino, Eibert R. Heerdink, Marjorie Nelissen-Vrancken, Nienke Bleijenberg, Marijn de Bruin, Lisette Schoonhoven
Summary: The study found that most participants were satisfied with nurses' support interventions, with some hoping to receive more support. Nurses' support interventions helped patients improve self-management of medication taking, facilitate communication about adherence problems, and provide practical support. Some patients identified insufficient timing of home visits, rushed appearance of nurses, and lack of expertise as areas in need of improvement.
PATIENT PREFERENCE AND ADHERENCE
(2021)
Article
Psychiatry
Quanjun Liu, Haochen Wang, Anbang Liu, Cheng Jiang, Weiya Li, Huan Ma, Qingshan Geng
Summary: Depression is marginally associated with poor medication adherence in hypertensive patients, and the correlation increases with the severity of depression. Moreover, socioeconomic/demographic factors have an independent impact on medication adherence.
Article
Rheumatology
Swamy Venuturupalli, Amit Kumar, Alden Bunyan, Nikhil Davuluri, Natalie Fortune, Katja Reuter
Summary: This study assessed the feasibility of using public patient-generated health data from Twitter to identify diverse lupus patients and gather their perspectives. The results indicate that lupus patients on Twitter are diverse in gender and race, and their expressions of symptoms and medications vary significantly. This information can be valuable for the medical community to inform patient-centered care, especially for underrepresented patient groups.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Medicine, General & Internal
Abate Wondesen, Alemseged Beyene Berha, Minyahil Woldu, Desalew Mekonnen, Ephrem Engidawork
Summary: This study aimed to assess the impact of medication therapy management on ambulatory heart failure patients. The results indicated that through teamwork, it was possible to reduce DPTs, improve medication adherence, and increase treatment satisfaction among patients with outpatient heart failure.
Article
Medicine, General & Internal
Hanna-Maria E. Gerland, Tino Prell
Summary: Study conducted in primary care settings found that health locus of control (HLC) has a significant impact on medication non-adherence. Forgetting to take medication or lacking knowledge about prescribed medication were common reasons for non-adherence. External HLC was associated with better adherence, while internal HLC was linked to poorer adherence.
FRONTIERS IN MEDICINE
(2021)
Article
Environmental Sciences
Jan D. Hirsch, Nancy Kong, Kevin T. Nguyen, Christine L. Cadiz, Crystal Zhou, Sarah A. Bajorek, Mark Bounthavong, Candis M. Morello
Summary: In a collaborative pharmacist-endocrinologist diabetes clinic, improving medication adherence and patient satisfaction has been found to significantly enhance HbA1c levels, leading to better glycemic control. A personalized treatment approach from a pharmacist provider shows positive impacts on long-term management of diabetes patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Semra Ozdemir, Sharon Wan Jie Yeo, Jia Jia Lee, Adithya Bhaskar, Eric Finkelstein, Louis Tong
Summary: Patients with dry eye disease prioritize the duration of burning/stinging sensation and medication costs when choosing medications, while the duration of blurring is of lesser importance. The predicted uptake of medication is influenced by the duration of burning/stinging sensation.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2022)
Article
Nursing
Reza Hajialibeigloo, Seyed Reza Mazlum, Samira Mohajer, Donald E. Morisky
Summary: The study findings indicate that the self-administration of medication programme can significantly improve medication adherence levels in cardiovascular patients and increase nurse satisfaction.
Article
Medicine, General & Internal
Ivie C. Egiebor, Karl J. McCleary, Jim E. Banta, Ronald Mataya, Wendy Shih
Summary: The study aims to identify multi-level barriers to medication adherence among adults with Sickle Cell Disease (SCD) and examine the relationship between these barriers and medication adherence levels. The study found that barriers at the community, institutional, and individual levels can impact medication adherence. Depression severity and patient concerns about medication were negatively correlated with adherence. Patients with fewer barriers tend to have higher medication adherence.
Article
Clinical Neurology
Julia-Lou Consoloni, Katia M'Bailara, Cyrille Perchec, Bruno Aouizerate, Valerie Aubin, Jean-Michel Azorin, Frank Bellivier, Nadia Correard, Philippe Courtet, Caroline Dubertret, Bruno Etain, Sebastien Gard, Emmanuel Haffen, Marion Leboyer, Pierre-Michel Llorca, Emilie Olie, Mircea Polosan, Paul Roux, Raymund Schwan, Ludovic Samalin, Raoul Belzeaux
Summary: In this study, three distinct trajectories of medication adherence in bipolar disorder patients were identified: deteriorating, improving, and consistently good adherence. Factors such as low depressive symptoms and good tolerance to psychotropic medications were associated with better medication adherence. The study highlights the heterogeneity and variability of medication adherence in BD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Maria Cristina Munoz-Contreras, Ignacio Segarra, Francisco Javier Lopez-Roman, Raul Nieto Galera, Begona Cerda
Summary: This study examined medication adherence and caregiver satisfaction in patients with Alzheimer's disease and other types of dementia. The results showed that married or widowed patients, first-degree relatives as caregivers, and female caregivers had higher medication adherence. Caregivers found the use and administration of treatment easy and rarely interfering with their daily lives. The study suggests educating caregivers about the disease and the importance of medication adherence to ensure optimal treatment for patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Eduardo Gutierrez-Abejon, M. Aranzazu Pedrosa-Naudin, Diego Fernandez-Lazaro, F. Javier Alvarez
Summary: Non-adherence to antidepressants is associated with worse disease outcomes and economic burden. This study found that nearly 20% of patients were non-adherent to antidepressant treatment in 2021. Different types of antidepressants varied in terms of non-adherence rates and costs. Reducing non-adherence to antidepressants is critical for improving clinical and economic outcomes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Thu Pham, Parth Patel, Daniel Mbusa, Alok Kapoor, Sybil Crawford, Hammad Sadiq, Sanjeev Rampam, Joann Wagner, Jerry H. Gurwitz, Kathleen M. Mazor
Summary: Education on high-risk medications is limited in ambulatory care settings, and the role of clinical pharmacists in patient education is often overlooked. This study assessed the impact of an intervention framed around a checklist on patient knowledge and satisfaction, and found little effect on both.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Psychology, Clinical
Danieelle Otten, Mareike Ernst, Antonia M. Werner, Ana N. Tibubos, Iris Reiner, Elmar Braehler, Joerg Wiltink, Matthias Michal, Markus Nagler, Philipp S. Wild, Thomas Muenzel, Jochem Koenig, Karl J. Lackner, Norbert Peiffer, Manfred E. Beutel
Summary: This study aimed to predict the occurrence of chronic diseases based on baseline depressive symptoms and to examine the sex-dependent effects. The results showed that baseline depressive symptoms predicted cardiovascular disease, chronic obstructive lung disease, diabetes, and migraine in both men and women, but not cancer. Additional adjustments for metabolic and lifestyle risk factors increased the risk of chronic obstructive lung disease and migraine for each point of depressive symptoms. There were trends suggesting a relevance of depressive symptoms for cardiovascular disease in men and for diabetes in women.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Ophthalmology
Achim Fiess, Michael S. Urschitz, Markus Nagler, Stefan Nickels, Susanne Marx-Gross, Thomas Muenzel, Philipp S. Wild, Manfred E. Beutel, Karl J. Lackner, Norbert Pfeiffer, Alexander K. Schuster
Summary: This study aimed to analyze the long-term effect of low birth weight on corneal aberrations in adulthood. The results indicated that low birth weight is associated with increased spherical aberration, which may affect optical image quality and visual function.
JOURNAL OF OPTOMETRY
(2023)
Review
Cardiac & Cardiovascular Systems
Lukas Hobohm, Ioannis T. Farmakis, Karsten Keller, Barbara Scibior, Anna C. Mavromanoli, Ingo Sagoschen, Thomas Muenzel, Ingo Ahrens, Stavros Konstantinides
Summary: This study systematically investigated the composition and clinical value of multidisciplinary pulmonary embolism response teams (PERTs). The results showed that PERT implementation led to greater use of advanced therapies and shorter in-hospital stay, but did not show a survival benefit in patients with PE.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Respiratory System
Lukas Hobohm, Ingo Sagoschen, Stefano Barco, Ioannis T. Farmakis, Ugo Fedeli, Sebastian Koelmel, Tommaso Gori, Christine Espinola-Klein, Thomas Muenzel, Stavros Konstantinides, Karsten Keller
Summary: Although the prevalence of pulmonary embolism (PE) has been reported in critically ill patients with coronavirus disease 2019 (COVID-19), nationwide data on the outcome of hospitalised patients with COVID-19 and PE in Germany are limited. This study investigated seasonal trends and predictors of in-hospital death in these patients.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Thomas Muenzel, Andreas Daiber
Summary: Cardiovascular disease and drug-induced health side effects are often associated with an imbalance between reactive oxygen and nitrogen species (RONS) and antioxidants. This review focuses on dysfunctional eNOS caused by RONS in the context of transportation noise exposure or chronic treatment with nitroglycerin (GTN). It also discusses various redox switches involved in the uncoupling process of eNOS.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Psychiatry
Matthias Michal, Andreas Schulz, Philipp S. Wild, Thomas Koeck, Thomas Muenzel, Alexander K. Schuster, Konstantin Strauch, Karl Lackner, Sigurd D. Suessmuth, Heiko G. Niessen, Andreas Borta, Kelly A. Allers, Daniela Zahn, Manfred E. Beutel
Summary: Previous studies have shown altered tryptophan catabolite concentrations in major depression, suggesting their potential as biomarkers and treatment targets. However, these studies had small sample sizes, limiting their generalizability. In this population-based study with 3,389 participants, we found that clinically significant depression was associated with lower levels of kynurenine and kynurenic acid. However, the correlation between tryptophan catabolites and depression severity was very small, and they could not be used to diagnose depression.
Article
Cardiac & Cardiovascular Systems
Michael Molitor, Maria T. Bayo-Jimenez, Omar Hahad, Claudius Witzler, Stefanie Finger, Venkata S. Garlapati, Sanela Rajlic, Tanja Knopp, Tabea K. Bieler, Melania Aluia, Johannes Wild, Jeremy Lagrange, Recha Blessing, Steffen Rapp, Andreas Schulz, Hartmut Kleinert, Susanne Karbach, Sebastian Steven, Wolfram Ruf, Philipp Wild, Andreas Daiber, Thomas Muenzel, Philip Wenzel
Summary: The study found that aircraft noise may have a significant impact on the development and deterioration of ischaemic heart disease. Exposure to noise before myocardial infarction (MI) can induce cardiovascular dysfunction and inflammation, leading to worsened cardiac function and increased inflammation in the vascular and cardiac tissues. The findings suggest that reducing environmental noise exposure may improve the clinical outcomes of patients with MI.
CARDIOVASCULAR RESEARCH
(2023)
Article
Medicine, General & Internal
Berit Hackenberg, Julia Doege, Karoline O'Brien, Andrea Bohnert, Karl J. J. Lackner, Manfred E. E. Beutel, Matthias Michal, Thomas Muenzel, Philipp S. Wild, Norbert Pfeiffer, Andreas Schulz, Irene Schmidtmann, Christoph Matthias, Katharina Bahr
Summary: The aim of this study was to investigate the correlation between tinnitus, depression, anxiety, and somatic symptom disorders in a large population. The study found that participants with tinnitus had a higher prevalence of depression, anxiety, and somatic symptom disorders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jurgen H. Prochaska, Claus Junger, Andreas Schulz, Natalie Arnold, Felix Muller, Marc William Heidorn, Rieke Baumkotter, Daniela Zahn, Thomas Koeck, Sven-Oliver Trobs, Karl J. Lackner, Andreas Daiber, Harald Binder, Sanjiv J. Shah, Tommaso Gori, Thomas Muenzel, Philipp S. Wild
Summary: In the EmDia trial, researchers found that the sodium-glucose co-transporter 2 inhibitor empagliflozin has a positive effect on cardiovascular outcome in patients with type 2 diabetes mellitus and heart failure by improving left ventricular diastolic function.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas Muenzel, Mette Sorensen, Omar Hahad, Mark Nieuwenhuijsen, Andreas Daiber
Summary: Large epidemiological and health impact assessment studies indicate that chronic non-communicable diseases caused the majority of global deaths in 2020, with expectations for this number to increase by 2030. The exposome concept, established in 2005, focuses on the effects of various environmental exposures on health, such as pollution and climate change, and their contribution to adverse health effects and premature deaths. This Review discusses the exposome concept in relation to cardiovascular disease burden and highlights its relevance for future health research and preventive medicine.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lukas Hobohm, Karsten Keller, Stavros Konstantinides
Summary: Pulmonary embolism is a common cardiovascular disease with decreasing mortality but increasing incidence. Clinical probability scores and D-dimer test interpretation can avoid unnecessary computed tomography scans for excluding acute pulmonary embolism, even in pregnant women. The evaluation of the right ventricle contributes to risk-adapted treatment. Treatment includes anticoagulation alone or in combination with reperfusion treatment. Adequate aftercare is important for early detection of long-term sequelae.
ZEITSCHRIFT FUR HERZ THORAX UND GEFASSCHIRURGIE
(2023)
Article
Respiratory System
Lukas Hobohm, Karsten Keller, Stavros Konstantinides
Summary: Pulmonary embolism is a common cardiovascular disease with reduced mortality but increased incidence in recent years. Optimizing clinical probability scores and D-dimer test interpretation can help avoid unnecessary computed tomography examinations, including for pregnant women. The evaluation of the right ventricle contributes to tailored treatment. Treatment options include anticoagulation alone or in combination with reperfusion treatment, such as systemic thrombolysis and catheter-assisted or surgical treatment. Adequate aftercare is crucial for early detection of long-term sequelae.
ZEITSCHRIFT FUR PNEUMOLOGIE
(2023)
Article
Cardiac & Cardiovascular Systems
Sabrina Kopp, Marie-Kristin Tilch, Ingo Sagoschen, Joachim Kaes, Malte Kuniss, Thomas Neumann, Yang Yang, Katharina Schnitzler, Kai-Helge Schmidt, Thomas Rostock, Thomas Muenzel, Stavros Konstantinides, Johannes Wild, Lukas Hobohm
Summary: Pulmonary vein stenosis (PVS) is a serious complication after radiofrequency energy-mediated percutaneous pulmonary vein isolation for atrial fibrillation. It can result in nonspecific symptoms and may lead to pulmonary hypertension. We report a case of a 59-year-old female who developed progressive dyspnea after pulmonary vein ablation.
PULMONARY CIRCULATION
(2023)
Article
Medicine, General & Internal
Berit Hackenberg, Karoline O'Brien, Julia Doege, Karl J. J. Lackner, Manfred E. E. Beutel, Thomas Muenzel, Norbert Pfeiffer, Andreas Schulz, Irene Schmidtmann, Philipp S. S. Wild, Christoph Matthias, Katharina Bahr-Hamm
Summary: This study aimed to assess the prevalence of tinnitus in a large German cohort and determine its relationship with hearing impairment. The results showed that tinnitus is common in the German population, and its prevalence increases with age. Severe hearing loss was found to be associated with the occurrence of tinnitus.
MEDICINA-LITHUANIA
(2023)
Article
Cardiac & Cardiovascular Systems
Karsten Keller, Sebastian Goebel, Tommaso Gori, Thomas Muenzel, Philip Wenzel, Lukas Hobohm
Summary: This study analyzed the data of endomyocardial biopsy (EMB) from a nationwide German inpatient sample and found a significant increase in the number of EMB performed from 2005 to 2019. Patients who underwent EMB in recent years were older and had more severe comorbidity, but had fewer major complications, highlighting the safety of the procedure.
CLINICAL CARDIOLOGY
(2023)
