Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Hae Won Kim, Hyun Jung Kim
Summary: A 73-year-old woman diagnosed with pulmonary cement embolism after a chest radiography, underwent anticoagulation treatment and showed functional recovery through V/Q scan. The role of anticoagulation in the treatment of pulmonary cement embolism remains controversial.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pierre-Yves Le Roux, Pierre-Benoit Bonnefoy, Achraf Bahloul, Benoit Denizot, Bertrand Barres, Caroline Moreau-Triby, Astrid Girma, Amandine Pallardy, Quentin Ceyrat, Laure Sarda-Mantel, Micheline Razzouk-Cadet, Reka Zsigmond, Cachin Florent, Gilles Karcher, Pierre-Yves Salaun
Summary: This study assessed the role of ventilation imaging in COVID-19 patients undergoing lung scintigraphy for suspected pulmonary embolism (PE). The findings showed that in this population, only 57% of patients could confidently exclude PE without ventilation imaging, while 31% of patients required ventilation imaging to rule out PE. The study also revealed a low prevalence of PE (12%).
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Grace K. Grafham, Marie Bambrick, Christian Houbois, Sebastian Mafeld, Laura Donahoe, Marc de Perrot, Micheal C. Mcinnis
Summary: This study assessed interobserver agreement for quantification of thromboembolic lesions in chronic thromboembolic pulmonary hypertension (CTEPH) using a CTPA scoring index. The results showed moderate agreement among different observers for the level of disease, with substantial agreement at the main/lobar level and weaker agreement at the segmental and subsegmental levels.Occlusions were the most reliable sign of chronic thromboembolism, and CT level of disease demonstrated good agreement between radiologists and was highly predictive of the surgical level in CTEPH.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ghazaleh Mehdipoor, David Jimenez, Laurent Bertoletti, Jorge Del Toro, Carmen Fernandez-Capitan, Alessandra Bura-Riviere, Cristina Amado, Beatriz Valero, Angeles Blanco-Molina, Remedios Otero, Egidio Imbalzano, Ramin Khorasani, Martin R. Prince, Behnood Bikdeli, Manuel Monreal
Summary: The study found that CTPA was the primary modality for confirming PE in all trimesters of pregnancy, with a higher proportional use in later stages of pregnancy.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthew S. Lazarus, Yoel Kim, Bertin Mathai, Jeffrey M. Levsky, Leonard M. Freeman, Linda B. Haramati, Renee M. Moadel
Summary: For patients evaluated for PE, a history of asthma in the past 10 years does not affect the diagnostic performance of imaging techniques such as VQ or CTPA. Patients with asthma are not more likely to have inconclusive results, require repeat exams, or experience false negatives compared to patients without asthma.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Medicine, General & Internal
Samir Jawad, Peter Sommer Ulriksen, Anna Kalhauge, Kristoffer Lindskov Hansen
Summary: The study investigated the use of DECT software technique to assess the severity of acute PE, finding that perfusion defect volume assessed by DECT may be a helpful tool in comparison to other measures such as obstruction score and RV/LV diameter ratio.
Article
Radiology, Nuclear Medicine & Medical Imaging
Roman Johannes Gertz, Felix Gerhardt, Michael Pienn, Simon Lennartz, Jan Robert Kroeger, Liliana Caldeira, Lenhard Pennig, Thomas Henning Schoemig, Nils Grosse Hokamp, David Maintz, Stephan Rosenkranz, Alexander Christian Bunck
Summary: This study aimed to differentiate between acute pulmonary embolism (PE) and chronic thromboembolic pulmonary hypertension (CTEPH) using dual-layer dual-energy computed tomography (dlDECT)-derived pulmonary perfusion maps. The study found that patients with acute PE had higher iodine uptake in normal perfused lung areas compared to those with CTEPH. Additionally, after normalizing iodine density in perfusion defects, patients with acute PE had reduced average perfusion compared to both CTEPH patients and controls. dlDECT enables quantification and characterization of pulmonary perfusion patterns in acute PE and CTEPH and can enhance differentiation between the two diseases when combined with morphological CT parameters.
EUROPEAN RADIOLOGY
(2023)
Article
Hematology
Heleen Alblas, Coen van Kan, Suzanne C. van Het Westeinde, Jasper Emmering, Andre Niezen, Ibrahim A. M. al Butaihi, Anton Vonk Noordegraaf, Josien van Es
Summary: This study assessed the rate of persistent dyspnea and perfusion defects after acute pulmonary embolism (PE) and their association with long-term quality of life (QoL). The results showed that persistent dyspnea was associated with a lower QoL on the long term, however no relation was found between persistent perfusion defects and a lower QoL.
THROMBOSIS RESEARCH
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Thanuja Mahaletchumy, Maimanah Muhamad, Nur Ezzaty Mohammad Kazmin, Najma Kori, Petrick Periyasamy
Summary: This case emphasizes the risk of pulmonary embolism in COVID-19 patients with elevated d-dimer levels, even in the absence of symptoms. It also underscores the importance of performing a V/Q study when CTPA results are inconclusive or contraindications to iodinated contrast media exist.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Medicine, General & Internal
Shameek Gayen, Vruksha Upadhyay, Maruti Kumaran, Riyaz Bashir, Vladimir Lakhter, Joseph Panaro, Gerard Criner, Simin Dadparvar, Parth Rali
Summary: This study investigated the use of mechanical thrombectomy and lung perfusion scoring in treating patients with intermediate-risk pulmonary embolism. The results showed that mechanical thrombectomy improved lung perfusion and right ventricle size or function.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Hematology
Oyvind Jervan, Adam Dhayyat, Jostein Gleditsch, Stacey Haukeland-Parker, Mazdak Tavoly, Frederikus A. Klok, Diyar Rashid, Knut Stavem, Waleed Ghanima, Kjetil Steine
Summary: This study aimed to determine the prevalence of residual perfusion defects (RPD) in a cohort diagnosed with pulmonary embolism (PE) and the variables associated with RPD. The results showed that RPD were common in this group, and were associated with reduced pulmonary artery acceleration time, greater tricuspid annular plane systolic excursion (TAPSE), greater thrombotic burden, and unprovoked PE.
THROMBOSIS RESEARCH
(2023)
Article
Obstetrics & Gynecology
Terence T. Lao
Summary: The occurrence of pulmonary embolism in pregnant women is increasing, possibly due to improved healthcare and an increase in high-risk groups. Obstetricians should be vigilant for venous thrombosis and pulmonary embolism and provide preventive measures, early diagnosis, and prompt treatment. Postpartum management is also crucial to address subsequent health issues.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Article
Multidisciplinary Sciences
Florian Poschenrieder, Stefanie Meiler, Matthias Lubnow, Florian Zeman, Janine Rennert, Gregor Scharf, Jan Schaible, Christian Stroszczynski, Michael Pfeifer, Okka W. Hamer
Summary: In a cohort of 27 consecutive patients with severe COVID-19 pneumonia, dual-energy CT demonstrated that areas of ground-glass opacifications and consolidations in the lungs showed a wide range of iodine uptake, indicating hypo- and hyperperfusion compared to normal lung tissue. Vessel enlargement within opacifications correlated significantly with iodine uptake levels. These findings suggest that DECT may help tailor therapy to individual patients based on predominant pathophysiology.
Article
Hematology
Hanke M. G. Wiegers, Josien van Es, Akos F. Pap, Anthonie W. A. Lensing, Saskia Middeldorp, Luuk J. J. Scheres
Summary: The study found no significant differences in clot resolution and absolute reduction in pulmonary vascular obstruction between male and female patients receiving anticoagulant therapy, suggesting that the risk differences in recurrent VTE between genders may not be explained by clot resolution.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Turgut Bora Cengiz, Ahmed Abdelrahman, Scott A. Rohren, John Doucette, Munir Ghesani
Summary: This study aimed to assess the diagnostic accuracy of Q-only imaging in the pandemic era. The results showed that Q-only imaging provides clinically acceptable results, and its sensitivity is increased when coupled with SPECT/CT.
ANNALS OF THORACIC MEDICINE
(2023)
Article
Infectious Diseases
Sylvere Bastien, Severien Meyers, Wilmara Salgado-Pabon, Stefano G. Giulieri, Jean-Phillipe Rasigade, Laurens Liesenborghs, Kyle J. Kinney, Florence Couzon, Patricia Martins-Simoes, Vincent Le Moing, Xavier Duval, Natasha E. Holmes, Niels Eske Bruun, Robert Skov, Benjamin P. Howden, Vance G. Fowler, Peter Verhamme, Paal Skytt Andersen, Coralie Bouchiat, Karen Moreau, Francois Vandenesch
Summary: Through a genome-wide association study and experimental animal models, it was found that specific S. aureus strains causing bloodstream infection do not necessarily cause infective endocarditis. Therefore, all S. aureus strains isolated from patients with bloodstream infection should be considered capable of causing this common and deadly infection.
JOURNAL OF INFECTION
(2023)
Editorial Material
Obstetrics & Gynecology
Ingrid Bistervels, Andrea Buchmueller, Hanke M. G. Wiegers, Fionnuala Ni Ainle, Bernard Tardy, Jennifer Donnelly, Peter F. Verhamme, Anne T. Jacobsen, Anette A. Hansen, Marc T. Rodger, Maria G. DeSancho, Roman Shmakov, Nick van Es, Martin H. Prins, Celine Chauleur, Saskia Middeldorp
Summary: Venous thromboembolism (VTE) is a major concern during pregnancy and its prevention with medical thromboprophylaxis can cause bleeding complications. This study found that low-dose heparin is effective in preventing VTE recurrence in pregnant women with a history of VTE, with no significant difference in bleeding risk compared to intermediate-dose heparin.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2023)
Article
Oncology
Tzu-Fei Wang, Alok A. Khorana, Giancarlo Agnelli, Dan Bloomfield, Marc P. Bonaca, Harry R. Buller, Jean M. Connors, Shinya Goto, Zhi-Cheng Jing, Ajay K. Kakkar, Yasser Khder, Gary E. Raskob, Gerald A. Soff, Peter Verhamme, Jeffrey Weitz, Marc Carrier
Summary: Cancer-associated thrombosis, a condition with increasing incidence, has significant morbidity and mortality in cancer patients. Recent advances in its treatment include the use of direct oral anticoagulants (DOACs) which are more convenient and effective than low-molecular-weight heparin (LMWH). However, there are still unmet needs and concerns about bleeding risk, drug-drug interactions, and management of patients with severe renal impairment.
Article
Hematology
Asim Cengiz Akbulut, Ryanne A. Arisz, Constance C. F. M. J. Baaten, Gaukhar Baidildinova, Aarazo Barakzie, Rupert Bauersachs, Jur Ten Berg, Wout W. A. van den Broek, H. C. de Boer, Amandine Bonifay, Vanessa Broker, Richard J. Buka, Hugo ten Cate, Arina J. ten Cate-Hoek, S. Cointe, Ciro De Luca, Ilaria De Simone, Rocio Vacik Diaz, Francoise Dignat-George, Kathleen Freson, Giulia Gazzaniga, Eric C. M. van Gorp, Anxhela Habibi, Yvonne M. C. Henskens, Aaron F. J. Iding, Abdullah Khan, Gijsje H. Koenderink, Akhil Konkoth, Romaric Lacroix, Trisha Lahiri, Wilbur Lam, Rachel E. Lamerton, Roberto Lorusso, Qi Luo, Coen Maas, Owen J. T. McCarty, Paola E. J. van der Meijden, Joost C. M. Meijers, Adarsh K. Mohapatra, Neta Nevo, Alejandro Pallares Robles, Philippe Poncelet, Christoph Reinhardt, Wolfram Ruf, Ronald Saraswat, Claudia Schonichen, Roger Schutgens, Paolo Simioni, Stefano Spada, Henri M. H. Spronk, Karlygash Tazhibayeva, Jecko Thachil, Rocio Vacik Diaz, L. Vallier, Alicia Veninga, Peter Verhamme, Chantal Visser, Steve P. Watson, Philip Wenzel, Ruth A. L. Willems, Anne Willers, Pengyu Zhang, Konstantinos Zifkos, Anton Jan van Zonneveld
Summary: The Fourth Maastricht Consensus Conference on Thrombosis covered a wide range of topics, including the role of coagulation proteins in cardiovascular disease, novel mechanisms of thrombosis, strategies to limit bleeding risks, hemostasis in extracorporeal systems, and clinical dilemmas in thrombosis and antithrombotic management. The conference also revisited the coagulopathy associated with COVID-19.
THROMBOSIS AND HAEMOSTASIS
(2023)
Editorial Material
Pharmacology & Pharmacy
Lorenz Roger van der Linden, Jens Neefs, Thomas Vanassche, Robin Lemmens, Peter Verhamme
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Article
Hematology
Saartje Van de Vondel, Christophe Vandenbriele, Gerald Gheysens, Peter Verhamme, Ann Janssens
Summary: We report a case of a patient with chronic immune thrombocytopenia (ITP) who developed catastrophic antiphospholipid antibody syndrome (CAPS) following treatment with avatrombopag. The patient presented with symptoms including headache, nausea, and abdominal pain 3 weeks after initiation of avatrombopag, and diagnostic work-up revealed multiple microvascular thrombotic events. Laboratory tests showed positive antiphospholipid antibodies. The diagnosis of avatrombopag-associated CAPS was made.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biology
Caroline P. Martens, Marijke Peetermans, Thomas Vanassche, Peter Verhamme, Marc Jacquemin, Kimberly Martinod
Summary: Staphylococcus aureus infection is associated with increased levels of neutrophil extracellular traps (NETs) and von Willebrand factor (VWF), and with reduced activity of ADAMTS13. Peptidylarginine deiminase 4 (PAD4) contributes to NET formation and inactivates ADAMTS13 in vitro. The levels of PADs correlate with ADAMTS13 activity, with neutrophils as the likely source of PAD activity in S. aureus infection. NETs are positively correlated with PADs and negatively correlated with ADAMTS13 activity.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Hematology
Patricia Siguenza, Juan J. Lopez-Nunez, Conxita Falga, Covadonga Gomez-Cuervo, Antoni Riera-Mestre, Aida Gil-Diaz, Peter Verhamme, Ana Cristina Montenegro, Cristina Barbagelata, Egidio Imbalzano, Manuel Monreal
Summary: This study compared the effectiveness of enoxaparin monotherapy in cancer patients with renal insufficiency using the RIETE registry. The results showed that the incidence of fatal PE was higher than fatal bleeding in patients with severe renal insufficiency receiving recommended doses of enoxaparin.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Christine Van Laer, Marc Jacquemin, Sarissa Baert, Veerle Labarque, Chantal Thys, Thomas Vanassche, Chris Van Geet, Peter Verhamme, Karen Willekens, Anniek Corveleyn, Kathelijne Peerlinck, Kathleen Freson
Summary: This study focuses on the implementation of genetic testing for inherited bleeding, thrombotic, and platelet disorders in Belgian clinical practice. The results highlight the challenges in interpreting genetic results and suggest the need for continuous optimization of diagnostic outcomes. Variants were reclassified and submitted to the ISTH's GoldVariants database.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Clinical Neurology
Rebeca Alejandra Gavrila Laic, Peter Verhamme, Jos Vander Sloten, Bart Depreitere
Summary: Elderly patients receiving antithrombotic treatment have a higher risk of developing intracranial hemorrhage after traumatic brain injury (TBI), leading to higher mortality rates and worse outcomes. This study aims to investigate injury patterns and long-term outcomes in elderly patients treated with antithrombotic drugs.
ACTA NEUROCHIRURGICA
(2023)
Meeting Abstract
Peripheral Vascular Disease
Jesus D. Melgarejo, Jan Van Eijgen, Dongmei Wei, Gladys E. Maestre, Lama A. Al Aswad, Luis J. Mena, Thomas Vanassche, Stefan Janssens, Peter Verhamme, Karel V. Keer, Ingeborg Stalmans, ZhenYu Zhang
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Jesus D. Melgarejo, Jan Van Eijgen, Dongmei Wei, Gladys E. Maestre, Lama A. Al Aswad, Luis J. Mena, Thomas Vanassche, Stefan Janssens, Peter Verhamme, ZhenYu Zhang, Karel V. Keer, Ingeborg Stalmans
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Dongmei Wei, Vannina Gonzalez Marrachelli, Jesus Melgarejo, ChiaTe Liao, Stefan Janssens, Peter Verhamme, Daniel Monleon, Josep Redon, Lucas Van Aelst, Thomas Vanassche, ZhenYu Zhang
JOURNAL OF HYPERTENSION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
H. Verelst, L. Bonne, H. Mufty, E. Claus, S. Houthoofd, P. Verhamme, I. Fourneau, G. Maleux
Summary: This study compared the safety and effectiveness of percutaneous direct puncture approach and contralateral femoral native vessel approach for catheter-directed thrombolysis of occluded infra-inguinal bypass grafts. The results showed that the direct puncture approach is a safe and efficient method with comparable clinical outcomes to the native vessel approach. The rate of adverse events was slightly lower in the direct approach group, but without significance.
CLINICAL RADIOLOGY
(2023)
Article
Hematology
Thomas Vanassche, Rachel P. Rosovsky, Fares Moustafa, Harry R. Buller, Annelise Segers, Indu Patel, Minggao Shi, Naoki Miyoshi, Venkatesh Mani, Zahi Fayad, Dominique Stephan, Jeannot Schmidt, Michael A. Grosso, Victor F. Tapson, Peter Verhamme, M. Huisman
Summary: This study evaluated the tolerability and efficacy of adding DS-1040 in patients with intermediate-risk PE. The results showed that adding DS-1040 did not increase bleeding risk, but also did not improve thrombus resolution or right ventricular dilation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
