Response variability to clopidogrel: is tailored treatment, based on laboratory testing, the right solution?

Outcomes With Concurrent Use of Clopidogrel and Proton-Pump Inhibitors

(2013) Wayne A. Ray   ANNALS OF INTERNAL MEDICINE

A Meta-Analysis of Impact of Proton Pump Inhibitors on Antiplatelet Effect of Clopidogrel

(2011) Mao Chen et al.   Cardiovascular Therapeutics

Clinical Events as a Function of Proton Pump Inhibitor Use, Clopidogrel Use, and Cytochrome P450 2C19 Genotype in a Large Nationwide Cohort of Acute Myocardial Infarction

(2011) Tabassome Simon et al.   CIRCULATION

Platelet Reactivity and Cardiovascular Outcomes After Percutaneous Coronary Intervention

(2011) Matthew J. Price et al.   CIRCULATION

Paraoxonase-1 Q192R Polymorphism and Antiplatelet Effects of Clopidogrel in Patients Undergoing Elective Coronary Stent Placement

(2011) Dietmar Trenk et al.   Circulation-Cardiovascular Genetics

CYP2C19 But Not PON1 Genetic Variants Influence Clopidogrel Pharmacokinetics, Pharmacodynamics, and Clinical Efficacy in Post–Myocardial Infarction Patients

(2011) Jean-Sébastien Hulot et al.   Circulation-Cardiovascular Interventions

No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting

(2011) D. Sibbing et al.   EUROPEAN HEART JOURNAL

Variability in on-treatment platelet reactivity explained by CYP2C19*2 genotype is modest in clopidogrel pretreated patients undergoing coronary stenting

(2011) H. J. Bouman et al.   HEART

Meta-analyses of the association between cytochrome CYP2C19 loss- and gain-of-function polymorphisms and cardiovascular outcomes in patients with coronary artery disease treated with clopidogrel

(2011) Michel Zabalza et al.   HEART

Standard- vs High-Dose Clopidogrel Based on Platelet Function Testing After Percutaneous Coronary Intervention

(2011) Matthew J. Price   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High Residual Platelet Reactivity After Clopidogrel Loading and Long-term Cardiovascular Events Among Patients With Acute Coronary Syndromes Undergoing PCI

(2011) Guido Parodi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CYP2C19 Genotype, Clopidogrel Metabolism, Platelet Function, and Cardiovascular Events

(2011) Michael V. Holmes et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

An Initial Experiment With Personalized Antiplatelet Therapy

(2011) Paul A. Gurbel   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Correlation between Light Transmission Aggregometry, VerifyNow P2Y12, and VASP-P Platelet Reactivity Assays Following Percutaneous Coronary Intervention

(2011) MICHAEL A. GAGLIA et al.   JOURNAL OF INTERVENTIONAL CARDIOLOGY

Clopidogrel–Drug Interactions

(2011) Eric R. Bates et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impact of Platelet Reactivity on Clinical Outcomes After Percutaneous Coronary Intervention

(2011) Somjot S. Brar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

High On-Treatment Platelet Reactivity After Prasugrel Loading Dose and Cardiovascular Events After Percutaneous Coronary Intervention in Acute Coronary Syndromes

(2011) Laurent Bonello et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Prospective Evaluation of On-Clopidogrel Platelet Reactivity Over Time in Patients Treated With Percutaneous Coronary Intervention

(2011) Gianluca Campo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Relationship between paraoxonase-1 activity, its Q192R genetic variant and clopidogrel responsiveness in the ADRIE study

(2011) P. FONTANA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Paraoxonase-1 and clopidogrel efficacy

(2011) Thomas Cuisset et al.   NATURE MEDICINE

Reply to: "Paraoxonase-1 and clopidogrel efficacy"

(2011) Heleen J Bouman et al.   NATURE MEDICINE

Paraoxonase-1 and clopidogrel efficacy

(2011) Patrick M Dansette et al.   NATURE MEDICINE

Paraoxonase-1 and clopidogrel efficacy

(2011) Jordi Camps et al.   NATURE MEDICINE

Relationship between cardiovascular outcomes and proton pump inhibitor use in patients receiving dual antiplatelet therapy after acute coronary syndrome

(2011) Fei-Yuan Hsiao et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Diurnal variation in platelet inhibition by clopidogrel

(2011) Marek Kozinski et al.   PLATELETS

Development of North American Consensus Guidelines for Medical Laboratories That Perform and Interpret Platelet Function Testing Using Light Transmission Aggregometry

(2010) Catherine P.M. Hayward et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Clopidogrel response: Head-to-head comparison of different platelet assays to identify clopidogrel non responder patients after coronary stenting

(2010) Thomas Cuisset et al.   Archives of Cardiovascular Diseases

The platelet P2Y12 receptor for adenosine diphosphate: congenital and drug-induced defects

(2010) M. Cattaneo   BLOOD

New P2Y 12 Inhibitors

(2010) Marco Cattaneo   CIRCULATION

Response to Ticagrelor in Clopidogrel Nonresponders and Responders and Effect of Switching Therapies

(2010) Paul A. Gurbel et al.   CIRCULATION

ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use

(2010) et al.   CIRCULATION

Medication Adherence in Cardiovascular Disease

(2010) Steven Baroletti et al.   CIRCULATION

Long-Term Aspirin and Clopidogrel Response Evaluated by Light Transmission Aggregometry, VerifyNow, and Thrombelastography in Patients Undergoing Percutaneous Coronary Intervention

(2010) E. H. Madsen et al.   CLINICAL CHEMISTRY

Differential Effects of Omeprazole and Pantoprazole on the Pharmacodynamics and Pharmacokinetics of Clopidogrel in Healthy Subjects: Randomized, Placebo-Controlled, Crossover Comparison Studies

(2010) D J Angiolillo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)

(2010) et al.   EUROPEAN HEART JOURNAL

Reduced-Function CYP2C19 Genotype and Risk of Adverse Clinical Outcomes Among Patients Treated With Clopidogrel Predominantly for PCI

(2010) Jessica L. Mega et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Comparison of Platelet Function Tests in Predicting Clinical Outcome in Patients Undergoing Coronary Stent Implantation

(2010) Nicoline J. Breet   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Influence of Proton Pump Inhibitors on the Antiplatelet Potency of Clopidogrel Evaluated by 5 Different Platelet Function Tests

(2010) Thomas Gremmel et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

A Risk Score to Predict Bleeding in Patients With Acute Coronary Syndromes

(2010) Roxana Mehran et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Long-Term Clinical Outcome Based on Aspirin and Clopidogrel Responsiveness Status After Elective Percutaneous Coronary Intervention

(2010) Gianluca Campo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate

(2010) Laurent Bonello et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiovascular Risk in Clopidogrel-Treated Patients According to Cytochrome P450 2C19*2 Loss-of-Function Allele or Proton Pump Inhibitor Coadministration

(2010) Jean-Sébastien Hulot et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impact of Cytochrome P450 2C19 Loss-of-Function Polymorphism and of Major Demographic Characteristics on Residual Platelet Function After Loading and Maintenance Treatment With Clopidogrel in Patients Undergoing Elective Coronary Stent Placement

(2010) Willibald Hochholzer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

ACCF/AHA Clopidogrel Clinical Alert: Approaches to the FDA “Boxed Warning”

(2010) David R. Holmes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Platelet Aggregation and Its Association With Stent Thrombosis and Bleeding in Clopidogrel-Treated Patients

(2010) Dirk Sibbing et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of proton pump inhibitors on clinical outcome in patients treated with clopidogrel: a systematic review and meta-analysis

(2010) J. M. SILLER-MATULA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON–TIMI 38 trial: a pharmacogenetic analysis

(2010) Jessica L Mega et al.   LANCET

Paraoxonase-1 is a major determinant of clopidogrel efficacy

(2010) Heleen J Bouman et al.   NATURE MEDICINE

Clopidogrel with or without Omeprazole in Coronary Artery Disease

(2010) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects ofCYP2C19Genotype on Outcomes of Clopidogrel Treatment

(2010) Guillaume Paré et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparative Effectiveness Research and Personalized Medicine

(2010) Robert S. Epstein et al.   PHARMACOECONOMICS

Cytochrome P450 2C19*2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis

(2010) F Sofi et al.   PHARMACOGENOMICS JOURNAL

Intra-individual variability in clopidogrel responsiveness in coronary artery disease patients under long term therapy

(2010) Sébastien Arméro et al.   PLATELETS

Stability of the high on-treatment platelet reactivity phenotype over time in clopidogrel-treated patients

(2010) J. Jaitner et al.   THROMBOSIS AND HAEMOSTASIS

Comparison of methods for monitoring residual platelet reactivity after clopidogrel by point-of-care tests on whole blood in high-risk patients

(2010) Emilia Antonucci et al.   THROMBOSIS AND HAEMOSTASIS

Methods for the Measurement of Platelet Function

(2009) Alan D. Michelson   AMERICAN JOURNAL OF CARDIOLOGY

Assessment of platelet response to clopidogrel with multiple electrode aggregometry, the VerifyNow P2Y12 analyzer and platelet vasodilator-stimulated phosphoprotein flow cytometry

(2009) Nicolas von Beckerath et al.   BLOOD COAGULATION & FIBRINOLYSIS

Can We Override Clopidogrel Resistance?

(2009) Ana Pena et al.   CIRCULATION

Cardiovascular Outcomes and Mortality in Patients Using Clopidogrel With Proton Pump Inhibitors After Percutaneous Coronary Intervention or Acute Coronary Syndrome

(2009) Jeremy A. Rassen et al.   CIRCULATION

Prognostic Modeling of Individual Patient Risk and Mortality Impact of Ischemic and Hemorrhagic Complications

(2009) Stuart J. Pocock et al.   CIRCULATION

Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial

(2009) Alan D. Michelson et al.   EUROPEAN HEART JOURNAL

Risk of Adverse Outcomes Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Acute Coronary Syndrome

(2009) P. Michael Ho   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

(2009) Alan R. Shuldiner   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH

(2009) M. CATTANEO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

CYP2C19*2 polymorphism is not the sole determinant of the response to clopidogrel: implications for its monitoring

(2009) B. ALEIL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials

(2009) Michelle L O'Donoghue et al.   LANCET

Tailored Clopidogrel Loading Dose According to Platelet Reactivity Monitoring to Prevent Acute and Subacute Stent Thrombosis

(2008) Laurent Bonello et al.   AMERICAN JOURNAL OF CARDIOLOGY

Clopidogrel 150 mg/day to Overcome Low Responsiveness in Patients Undergoing Elective Percutaneous Coronary Intervention

(2008) Boris Aleil et al.   JACC-Cardiovascular Interventions

Adjusted Clopidogrel Loading Doses According to Vasodilator-Stimulated Phosphoprotein Phosphorylation Index Decrease Rate of Major Adverse Cardiovascular Events in Patients With Clopidogrel Resistance

(2008) Laurent Bonello et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Influence of Omeprazole on the Antiplatelet Action of Clopidogrel Associated With Aspirin

(2008) Martine Gilard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY