Article
Hematology
Helle Jorgensen, Erzsebet Horvath-Puho, Kristina Laugesen, Sigrid Braekkan, John-Bjarne Hansen, Henrik Toft Sorensen
Summary: The study found that individuals with higher levels of education, income, and employment status had a lower risk of incident VTE. A composite SES score was found to be superior to individual indicators in assessing VTE risk.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Ellen-Sofie Hansen, Fridtjof B. Rinde, Magnus S. Edvardsen, Kristian Hindberg, Nadezhda Latysheva, Pal Aukrust, Thor Ueland, Annika E. Michelsen, John-Bjarne Hansen, Sigrid K. Braekkan, Vania M. Morelli
Summary: The results of the study suggest that elevated plasma D-dimer levels are associated with an increased risk of incident VTE. However, the risk estimates were slightly attenuated after adjusting for body mass index and C-reactive protein, indicating that D-dimer may partly reflect underlying conditions related to obesity and inflammation.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Tobias Frischmuth, Kristian Hindberg, Pal Aukrust, Thor Ueland, Sigrid K. Braekkan, John-Bjarne Hansen, Vania M. Morelli
Summary: This study investigated the association between plasma leptin levels and the risk of incident VTE. Results suggest that the apparent association between leptin levels and VTE risk is confounded by BMI, and leptin is not a relevant mediator for VTE risk in obesity.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Nutrition & Dietetics
Shuai Yuan, Jie Chen, Tian Fu, Xue Li, Maria Bruzelius, Agneta Akesson, Susanna C. Larsson
Summary: This study aimed to investigate the association between ultra-processed food (UPF) intake and the risk of venous thromboembolism (VTE). After adjusting for covariates, higher UPF intake was moderately associated with an increased risk of VTE compared to the lowest intake quintile.
CLINICAL NUTRITION
(2023)
Article
Hematology
Tobias Frischmuth, Kristian Hindberg, Pal Aukrust, Thor Ueland, Sigrid K. Braekkan, John-Bjarne Hansen, Vania M. Morelli
Summary: This study aimed to investigate the association between plasma PAI-1 levels and the risk of future incident VTE, as well as to explore the potential mediation of PAI-1 on the VTE risk in obesity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Christabel Esi Damoah, Omri Snir, Kristian Hindberg, Peter Garred, Judith K. Ludviksen, Sigrid K. Braekkan, Vania M. Morelli, Tom Eirik Mollnes, John-Bjarne Hansen
Summary: This study investigated the association between plasma MASP-2 levels and future risk of VTE. The findings suggest that high plasma MASP-2 levels are causally associated with VTE risk. Genetic variants linked to MASP-2 levels were also identified.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Hematology
Samantha Swamy, Thor Ueland, John-Bjarne Hansen, Omri Snir, Sigrid K. Braekkan
Summary: This study found that elevated plasma levels of P-selectin are associated with an increased risk of future venous thromboembolism in women, but not in men.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Tobias Frischmuth, Birgitte G. Tondel, Sigrid K. Braekkan, John-Bjarne Hansen, Vania M. Morelli
Summary: This study examined the impact of overweight and obesity on venous thromboembolism (VTE) in a population from Norway. The results showed a strong association between overweight, obesity, and VTE, with almost 25% of all VTE events being attributed to these conditions.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Genetics & Heredity
Hossam Hodeib, Amira Youssef, Alzahraa A. Allam, Amal Selim, Mohamed A. Tawfik, Mohammed F. Abosamak, Ahmed Esam, Mohamed S. Abd Elghafar, Sameh Samir, Ola A. ELshora
Summary: The study found that patients with >= 3 risk alleles were associated with a higher risk of VTE recurrence compared to those with <= 2 risk alleles (the reference group) (HR 2.5, 95% CI 1.48-4.21) (p = 0.001). Patients with GRS >= 3 had a significantly shorter time recurrence free survival (43.07 months) compared to the low risk group of patients with GRS (0-2) (p < 0.001). The GRS model could be effective in risk stratification of VTE patients and genetic risk profiling could be used for predicting VTE recurrence.
Article
Hematology
Line H. Evensen, Aaron R. Folsom, James S. Pankow, John-Bjarne Hansen, Matthew A. Allison, Mary Cushman, Pamela L. Lutsey
Summary: The study confirmed associations between various biomarkers (such as D-dimer, factor VIII, and IL-6) and inflammatory markers (such as CRP, fibrinogen, and PAP) with the risk of venous thromboembolism (VTE). A novel association was also found between PAP levels and VTE risk.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Tobias Frischmuth, Kristian Hindberg, Maiken E. Gabrielsen, Ben Brumpton, Kristian Hveem, Sigrid K. Braekkan, John-Bjarne Hansen, Vania M. Morelli
Summary: The combination of obesity and multiple prothrombotic genotypes has an additive effect on overall venous thromboembolism (VTE) risk, but it may have a supra-additive effect on the risk of deep vein thrombosis (DVT) and unprovoked VTE.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Anne Gulbech Ording, Peter Bronnum Nielsen, Flemming Skjoth, Thure Filskov Overvad, Simon Noble, Timothy L. Lash, Samuel Zachery Goldhaber, Thomas Decker Christensen, Torben Bjerregaard Larsen, Mette Sogaard
Summary: This study describes the risk of recurrent venous thromboembolism in patients with active cancer and highlights the variations in recurrence risks based on cancer type and patient characteristics.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Hematology
Darae Ko, Sarah R. Preis, Andrew D. Johnson, Ramachandran S. Vasan, Emelia J. Benjamin, Naomi M. Hamburg, Gary F. Mitchell
Summary: The study did not find any significant association between arterial vascular function measures and the risk of VTE after multivariable adjustment in a comprehensive examination.
THROMBOSIS RESEARCH
(2021)
Article
Medicine, General & Internal
JunQing Xie, Albert Prats-Uribe, Qi Feng, YunHe Wang, Dipender Gill, Roger Paredes, Dani Prieto-Alhambra
Summary: This population-based cohort study found that ambulatory COVID-19 was associated with a substantially increased risk of incident VTE, but this risk was greatly reduced in fully vaccinated people with breakthrough infection. Older age, male sex, and obesity were clinical risk factors for post-COVID-19 VTE, and factor V Leiden thrombophilia was additionally associated with double the risk. These findings are important for emphasizing the need for vaccination, informing VTE risk stratification, and calling for targeted VTE prophylaxis strategies for unvaccinated outpatients with COVID-19.
JAMA INTERNAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Andrew S. Rifkin, Zhuqing Shi, Jun Wei, Siqun Lilly Zheng, Brian T. Helfand, Jonathan S. Cordova, Vincent F. Biank, Alfonso J. Tafur, Omar Khan, Jianfeng Xu
Summary: This study found that venous thromboembolism (VTE) complications are common in patients with inflammatory bowel disease (IBD) similar to cancer patients. The polygenic score (PGS) provides more informative risk information for personalized thromboprophylaxis compared to monogenic mutations (F5/F2).
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Letter
Public, Environmental & Occupational Health
Junichi Ishigami, Amy B. Karger, Pamela L. Lutsey, Josef Coresh, Kunihiro Matsushita
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Letter
Urology & Nephrology
Junichi Ishigami, Keiichi Sumida, Morgan E. Grams, Alexander R. Chang, Pamela L. Lutsey, Andrew S. Levey, Josef Coresh, David W. Dowdy, Kunihiro Matsushita
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Geriatrics & Gerontology
Kelsie M. Full, Snigdha Pusalavidyasagar, Priya Palta, Kevin J. Sullivan, Jung-Im Shin, Rebecca F. Gottesman, Adam P. Spira, Matthew P. Pase, Pamela L. Lutsey
Summary: This study aimed to examine the association between the use of sleep medications and incident dementia in a community-based cohort of older adults. The results showed that sleep medication use was associated with a 48% greater risk of dementia compared to nonuse.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Rebecca L. Molinsky, Melana Yuzefpolskaya, Faye L. Norby, Bing Yu, Amil M. Shah, James S. Pankow, Chiadi E. Ndumele, Pamela L. Lutsey, Panos N. Papapanou, James D. Beck, Palo C. Colombo, Ryan T. Demmer
Summary: Periodontal disease is associated with an increased risk of incident heart failure, both with reduced and preserved ejection fraction, while being completely edentulous is also linked to a higher risk. Additionally, periodontal disease is associated with unfavorable changes in biomarkers of inflammation and congestion.
JACC-HEART FAILURE
(2022)
Article
Clinical Neurology
Sanaz Sedaghat, Pamela L. Lutsey, Yuekai Ji, Jean-Philippe Empana, Farzaneh Sorond, Timothy M. Hughes, Thomas H. Mosley, Rebecca F. Gottesman, David S. Knopman, Keenan A. Walker, Vilmundur Gudnason, Lenore J. Launer, Thomas T. van Sloten
Summary: Better cardiovascular health at midlife and improvement of cardiovascular health within midlife are associated with lower dementia risk.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
Brian T. Steffen, Weihong Tang, Pamela L. Lutsey, Ryan T. Demmer, Elizabeth Selvin, Kunihiro Matsushita, Alanna C. Morrison, Weihua Guan, Mary R. Rooney, Faye L. Norby, Nathan Pankratz, David Couper, James S. Pankow
Summary: Proteomics analysis identified plasma proteins associated with the risk of type 2 diabetes. These proteins may serve as potential targets for intervention or pharmacological approaches to prevent, reverse, or slow down the progression of type 2 diabetes.
Review
Cardiac & Cardiovascular Systems
Pamela L. Lutsey, Neil A. Zakai
Summary: Venous thromboembolism is an under-appreciated vascular disease with significant health disparities in incidence and outcomes. In addition to understanding the epidemiological characteristics and risk factors of this disease, attention should also be given to prevention measures and reducing disparities.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Hematology
Brian T. Steffen, James S. Pankow, Faye L. Norby, Pamela L. Lutsey, Ryan T. Demmer, Weihua Guan, Nathan Pankratz, Aixin Li, Guning Liu, Kunihiro Matsushita, Adrienne Tin, Weihong Tang
Summary: This study identified proteomic signatures and pathways related to 23 gene loci associated with abdominal aortic aneurysm (AAA). The results suggest that low levels of neogenin and kit ligand may be novel risk factors for AAA development.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Arun Kumar, Pamela L. Lutsey, Wendy L. St. Peter, Jon C. Schommer, Jeremy R. Van't Hof, Abhijeet Rajpurohit, Joel F. Farley
Summary: In acute coronary syndrome following percutaneous coronary intervention, newer P2Y12 inhibitors (ticagrelor and prasugrel) reduce cardiovascular outcomes compared to clopidogrel, but have a higher bleeding risk. This study examines the safety of each inhibitor in a real-world population.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Arun Kumar, Pamela L. Lutsey, Wendy L. St Peter, Jon C. Schommer, Jeremy R. Van't Hof, Abhijeet Rajpurohit, Joel F. Farley
Summary: This study compared the effectiveness of newer P2Y12 inhibitors (prasugrel and ticagrelor) with clopidogrel in real-world US populations. The results showed that ticagrelor reduced the risk of cardiovascular events by 10% at 90 days compared to clopidogrel. There were no significant differences for other comparisons. This study provides valuable information for clinicians in selecting P2Y12 inhibitors after ACS.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemical Research Methods
Bruno Bohn, Pamela L. Lutsey, Weihong Tang, James S. Pankow, Faye L. Norby, Bing Yu, Christie M. Ballantyne, Eric A. Whitsel, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study compared the proteome of statin users and nonusers and found differences in proteins unrelated to lipid metabolism. Further investigation into these differences may help elucidate the pleiotropic effects of statins.
JOURNAL OF PROTEOMICS
(2023)
Article
Medicine, General & Internal
Bruno Bohn, Pamela L. Lutsey, Jeffrey R. Misialek, Keenan A. Walker, Charles H. Brown, Timothy M. Hughes, Junichi Ishigami, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study found an association between hospitalization with infection and incident dementia, suggesting that infections are risk factors for dementia.
Article
Nutrition & Dietetics
Linzi Li, Pamela L. Lutsey, Lin Yee Chen, Elsayed Z. Soliman, Mary R. Rooney, Alvaro Alonso
Summary: Higher serum magnesium is associated with a lower risk of cardiovascular events, especially myocardial infarction, in patients with atrial fibrillation.
Article
Hematology
Pamela L. Lutsey
Summary: The case-control design is an observational study design that compares the exposure prevalence between individuals with and without disease. Proper control selection is crucial for case-control study design, and optimizing control selection can maximize causal inference and enhance the scientific rigor of hematologic case-control studies.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Respiratory System
David M. MacDonald, Yuekai Ji, Selcuk Adabag, Alvaro Alonso, Lin Yee Chen, Benjamin E. Henkle, Stephen P. Juraschek, Faye L. Norby, Pamela L. Lutsey, Ken M. Kunisaki
Summary: This study found that better cardiovascular autonomic function was associated with a lower risk of COPD hospitalization, while worse autonomic function was associated with a higher risk of COPD hospitalization. This relationship was more significant in participants without airflow obstruction.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
