Tissue factor and cell signalling in cancer progression and thrombosis

Use of dabigatran etexilate to reduce breast cancer progression

(2011) Karen DeFeo et al.   CANCER BIOLOGY & THERAPY

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

(2011) Simona Frateschi et al.   Nature Communications

Kallikrein-Related Peptidase 4

(2010) Valérie Gratio et al.   AMERICAN JOURNAL OF PATHOLOGY

Oncogenic epidermal growth factor receptor up-regulates multiple elements of the tissue factor signaling pathway in human glioma cells

(2010) N. Magnus et al.   BLOOD

Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption

(2010) H. Kothari et al.   BLOOD

Tissue factor mutated at the allosteric Cys186-Cys209 disulfide bond is severely impaired in decrypted procoagulant activity

(2010) W. Ruf et al.   BLOOD

Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development

(2010) F. Schaffner et al.   BLOOD

Identification of a Metalloprotease-Chemokine Signaling System in the Ovarian Cancer Microenvironment: Implications for Antiangiogenic Therapy

(2010) A. Agarwal et al.   CANCER RESEARCH

Colitis-Associated Cancer Is Dependent on the Interplay between the Hemostatic and Inflammatory Systems and Supported by Integrin αMβ2Engagement of Fibrinogen

(2010) Kris A. Steinbrecher et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo

(2010) Eric Camerer et al.   DEVELOPMENTAL CELL

The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors

(2010) Jennifer Disse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering of Substrate Selectivity for Tissue Factor·Factor VIIa Complex Signaling through Protease-activated Receptor 2

(2010) Katrine S. Larsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype

(2010) G. J. Villares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue Factor and Its Measurement in Whole Blood, Plasma, and Microparticles

(2010) Nigel Key et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Modulation of the oncogene-dependent tissue factor expression by kinase suppressor of ras 1

(2010) Joanne L. Yu et al.   THROMBOSIS RESEARCH

Tissue Factor and PAR2 Signaling in the Tumor Microenvironment

(2009) Florence Schaffner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tissue Factor in Coagulation

(2009) Saulius Butenas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement

(2009) G. L. Van Sluis et al.   BLOOD

Role of activated protein C and its receptor in inhibition of tumor metastasis

(2009) M. Bezuhly et al.   BLOOD

Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells

(2009) N Yokota et al.   BRITISH JOURNAL OF CANCER

Epidermal Growth Factor Receptor and PTEN Modulate Tissue Factor Expression in Glioblastoma through JunD/Activator Protein-1 Transcriptional Activity

(2009) Y. Rong et al.   CANCER RESEARCH

Blockade of PAR1 Signaling with Cell-Penetrating Pepducins Inhibits Akt Survival Pathways in Breast Cancer Cells and Suppresses Tumor Survival and Metastasis

(2009) E. Yang et al.   CANCER RESEARCH

c-Met activation in medulloblastoma induces tissue factor expression and activity: effects on cell migration

(2009) M. Provencal et al.   CARCINOGENESIS

Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site

(2009) Vishal Trivedi et al.   CELL

Tumor-Derived Tissue Factor-Bearing Microparticles Are Associated With Venous Thromboembolic Events in Malignancy

(2009) J. I. Zwicker et al.   CLINICAL CANCER RESEARCH

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer cell–derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo

(2009) Grace M. Thomas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ixolaris, a tissue factor inhibitor, blocks primary tumor growth and angiogenesis in a glioblastoma model

(2009) T. C. CARNEIRO-LOBO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor

(2009) R. A. SCHUEPBACH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hepatocyte Nuclear Factor-4-Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases

(2009) S. Koizume et al.   MOLECULAR CANCER RESEARCH

Inhibition of tissue factor/protease-activated receptor-2 signaling limits proliferation, migration and invasion of malignant glioma cells

(2009) F. Gessler et al.   NEUROSCIENCE

Proteinase-activated receptor 2 expression in breast cancer and its role in breast cancer cell migration

(2009) S Su et al.   ONCOGENE

Multiple Lineages of Human Breast Cancer Stem/Progenitor Cells Identified by Profiling with Stem Cell Markers

(2009) Wendy W. Hwang-Verslues et al.   PLoS One

Alternatively spliced tissue factor induces angiogenesis through integrin ligation

(2009) Y. W. van den Berg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coagulation Factor Xa inhibits cancer cell migration via Protease-activated receptor-1 activation

(2009) Keren Borensztajn et al.   THROMBOSIS RESEARCH

Matrix Metalloproteinase-1 and Thrombin Differentially Activate Gene Expression in Endothelial Cells via PAR-1 and Promote Angiogenesis

(2008) Jessica S. Blackburn et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting Melanoma Growth and Metastasis with Systemic Delivery of Liposome-Incorporated Protease-Activated Receptor-1 Small Interfering RNA

(2008) Gabriel J. Villares et al.   CANCER RESEARCH

Protease-Activated Receptor (PAR) 2, but not PAR1, Signaling Promotes the Development of Mammary Adenocarcinoma in Polyoma Middle T Mice

(2008) H. H. Versteeg et al.   CANCER RESEARCH

Tissue Factor Regulation by Epidermal Growth Factor Receptor and Epithelial-to-Mesenchymal Transitions: Effect on Tumor Initiation and Angiogenesis

(2008) C. C. Milsom et al.   CANCER RESEARCH

G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFκB serine 536 phosphorylation in human keratinocytes

(2008) Fui Goon Goh et al.   CELLULAR SIGNALLING

rNAPc2 Inhibits Colorectal Cancer in Mice through Tissue Factor

(2008) J. Zhao et al.   CLINICAL CANCER RESEARCH

Hypercoagulability and Tissue Factor Gene Upregulation in Hematologic Malignancies

(2008) Anna Falanga et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Role of Alternatively Spliced Tissue Factor in Pancreatic Cancer Growth and Angiogenesis

(2008) Maxim Signaevsky et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS