Article
Multidisciplinary Sciences
Takashin Nakayama, Tatsuhiko Azegami, Maki Kiso, Masaki Imai, Ryuta Uraki, Kaori Hayashi, Akihito Hishikawa, Norifumi Yoshimoto, Ran Nakamichi, Erina Sugita-Nishimura, Eriko Yoshida-Hama, Yoshihiro Kawaoka, Hiroshi Itoh
Summary: COVID-19 is a global pandemic caused by SARS-CoV-2, and the efficacy of existing vaccines has been reduced due to mutations. This study developed a novel peptide vaccine targeting PAI-1 and evaluated its effects on sepsis and SARS-CoV-2 infection in mice. The vaccine showed promising results in reducing organ damage and thrombosis in sepsis, but did not significantly affect the severity of SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Fabiola Biasella, Tobias Strunz, Christina Kiel, Bernhard H. F. Weber, Ulrike Friedrich
Summary: The pathogenesis of age-related macular degeneration (AMD) remains unclear, but studies show a strong association between the polymorphism rs704 in the VTN gene and AMD susceptibility. The rs704 variant may influence vascular complications in AMD, particularly in neovascular AMD subtype.
Article
Biotechnology & Applied Microbiology
Orla M. McGee, David R. Nolan, Pattie S. Mathieu, Caitriona Lally
Summary: The orientation of vascular cells plays a crucial role in determining the mechanical properties and functionality of soft tissues. While cells align with structural cues like collagen fibers, they tend to align perpendicularly to mechanical stimuli, such as strain, on unstructured substrates. This interplay between structural cues and mechanical stimuli is not well understood, highlighting the need for further research in this area.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Teng-fei Zheng, Xiao-lin Liu, Xiao Li, Qian-qian Wang, Ya-chao Zhao, Xuan Li, Meng-meng Li, Yu Zhang, Meng Zhang, Wen-cheng Zhang, Cheng Zhang, Yun Zhang, Mei Zhang
Summary: The study reveals that DKK1 mediates the mechanical stretch regulation of smooth muscle cell function by modulating UHRF1 expression through the YAP-TEAD pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Hematology
Claire S. Whyte, Megan Simpson, Gael B. Morrow, Carol A. Wallace, Alexander J. Mentzer, Julian C. Knight, Susan Shapiro, Nicola Curry, Catherine N. Bagot, Henry Watson, Jamie G. Cooper, Nicola J. Mutch
Summary: This study investigates the dysregulation of the fibrinolytic system in COVID-19 disease and finds that elevated levels of PAI-1 suppress plasmin generation, leading to suboptimal fibrinolysis. These findings have important implications for the treatment and prognostic potential of COVID-19 disease.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia G. Hsu, Vyacheslav A. Korshunov, Xiaochun Long, Peter A. Knight, Bradford C. Berk, Chen Yan
Summary: The study revealed that PDE10A contributes to SMC proliferation and intimal hyperplasia by antagonizing the CNP/NPR2/cGMP/PKG1alpha signaling pathway, suggesting that PDE10A may be a novel drug target for treating vascular occlusive disease.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cell Biology
Ngoc Luu, Apratim Bajpai, Rui Li, Seojin Park, Mahad Noor, Xiao Ma, Weiqiang Chen
Summary: This study reveals the defective mechanosensation of vascular smooth muscle cells (VSMCs) during aging, leading to a decline in their ability to sense and adapt to mechanical perturbations. Aged VSMCs exhibit a relatively inert mechanobiological state with altered actin cytoskeletal integrity, resulting in impaired mechanosensitivity and dynamic mechanoresponse. This decline in mechanosensation is mediated by hyperactivity of Piezo1-dependent calcium signaling. Inhibition of Piezo1 can alleviate vascular aging and partially restore the loss in dynamic contractile properties in aged cells.
Article
Physiology
Julie M. M. Lade, Manuella R. R. Andrade, Clark Undem, Jasmine Walker, Haiyang Jiang, Xin Yun, Larissa A. A. Shimoda
Summary: Exposure to hypoxia leads to structural changes in pulmonary vascular wall, including hyperplasia and migration of pulmonary arterial smooth muscle cells (PASMCs). In this study, the interaction between ezrin and NHE1 was found to increase under hypoxic conditions, promoting SMA binding and enhancing PASMC migration and proliferation.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biophysics
Sheng-wen Zhou, Jing Wang, Sheng-yu Chen, Ke-feng Ren, You-xiang Wang, Jian Ji
Summary: Changes in cellular microenvironment stiffness play a crucial role in pathological processes of blood vessels. This study constructed hydrogel substrates with physiological stiffness and found that an increase in stiffness within the physiological range significantly enhanced cell adhesion and proliferation behaviors.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Cell Biology
Genmao Cao, Xuezhen Xuan, Jie Hu, Ruijing Zhang, Haijiang Jin, Honglin Dong
Summary: Vascular smooth muscle cells (VSMCs) are highly plastic and can switch into synthetic VSMCs to repair vascular injury. Multiple phenotypes of VSMCs have been discovered in vascular aging, atherosclerosis, and aortic aneurysm. The transformation of VSMCs is regulated by various factors such as transcription factors, growth factors, and non-coding RNAs.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Chihiro Sakai, Mei Mikawa, Takeshi Yamamoto, Tomoyuki Uchida, Yoshihide Nakamura, Hideaki Akase, Takeshi Suetomi, Naoomi Tominaga, Masako Inamitsu, Tetsuro Oda, Takayuki Okamura, Shigeki Kobayashi, Masafumi Yano
Summary: This study investigated the inhibitory effect of Dantrolene on smooth muscle cell proliferation and migration, and found that Dantrolene effectively suppressed vascular smooth muscle cell proliferation, migration, and neointimal formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Deborah D. Chin, Christopher Poon, Jonathan Wang, Johan Joo, Victor Ong, Zhangjingyi Jiang, Kayley Cheng, Anastasia Plotkin, Gregory A. Magee, Eun Ji Chung
Summary: The delivery of miR-145 micelles to VSMCs shows promise in mitigating atherosclerosis progression by altering cell phenotypes and reducing plaque growth. In mouse experiments, miR-145 micelles significantly inhibited the advancement of atherosclerosis.
Review
Biochemistry & Molecular Biology
Yu Jiang, Hai-Yan Qian
Summary: Atherosclerosis (AS) is the accumulation of lipids and inflammatory debris in the arterial wall, leading to gradual occlusion of the arterial lumen. Despite therapeutic advances, AS remains the most common cause of cardiovascular diseases and the main mechanism of death and disability worldwide. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, with remarkable plasticity and involvement in various processes such as phenotypic transformation, proliferation, migration, calcification, and apoptosis. Transcription factors and complex interactions of conserved cis-regulatory elements are key in the transcriptional regulation of VSMC genes, and manipulating transcription factors can regulate the development of atherosclerotic lesions.
MOLECULAR MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Christine Veith, Ipek Varturk-Ozcan, Magdalena Wujak, Stefan Hadzic, Cheng-Yu Wu, Fenja Knoepp, Simone Kraut, Aleksandar Petrovic, Marija Gredic, Oleg Pak, Monika Brosien, Marie Heimbrodt, Jochen Wilhelm, Friederike C. Weisel, Kathrin Malkmus, Katharina Schaefer, Henning Gall, Khodr Tello, Djuro Kosanovic, Akylbek Sydykov, Akpay Sarybaev, Andreas Guenther, Ralf P. Brandes, Werner Seeger, Friedrich Grimminger, Hossein A. Ghofrani, Ralph T. Schermuly, Grazyna Kwapiszewska, Natascha Sommer, Norbert Weissmann
Summary: This study provides evidence for the involvement of SPARC in the pathogenesis of human PH and chronic hypoxia-induced PH in mice, most likely by affecting vascular cell function.
Article
Pathology
Asmita Pant, Anna K. Kopec, Kevin S. Baker, Holly Cline-Fedewa, Daniel A. Lawrence, James P. Luyendyk
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Multidisciplinary Sciences
Jintao Wang, Enming Su, Hui Wang, Chiao Guo, Daniel A. Lawrence, Daniel T. Eitzman
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Ashley A. Reinke, Shih-Hon Li, Mark Warnock, Maxim E. Shaydakov, Naga Sandhya Guntaka, Enming J. Su, Jose A. Diaz, Cory D. Emal, Daniel A. Lawrence
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Cell Biology
Gerard E. Kaiko, Feidi Chen, Chin-Wen Lai, I-Ling Chiang, Jacqueline Perrigoue, Aleksandar Stojmirovic, Katherine Li, Brian D. Muegge, Umang Jain, Kelli L. VanDussen, Bridie J. Goggins, Simon Keely, Jessica Weaver, Paul S. Foster, Daniel A. Lawrence, Ta-Chiang Liu, Thaddeus S. Stappenbeck
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Hematology
Adam Miszta, Anna K. Kopec, Asmita Pant, Lori A. Holle, James R. Byrnes, Daniel A. Lawrence, Kirk C. Hansen, Matthew J. Flick, James P. Luyendyk, Bas de laat, Alisa S. Wolberg
Article
Biochemistry & Molecular Biology
Mary Migliorini, Shih-Hon Li, Anqi Zhou, Cory D. Emal, Daniel A. Lawrence, Dudley K. Strickland
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Hematology
Hekmat B. Khoukaz, Yan Ji, Drew J. Braet, Manisha Vadali, Ahmed A. Abdelhamid, Cory D. Emal, Daniel A. Lawrence, William P. Fay
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Meeting Abstract
Hematology
Kelly L. Schoenbeck, Anand Dhruva, Albert Lee, Neha G. Goyal, Adrienne K. Yang, Sa Ra Park, Catherine C. Smith, Neil P. Shah, Chloe E. Atreya
Article
Oncology
Neha Goyal, Beverly J. Levine, Sybil L. Crawford, Nancy E. Avis
Summary: The study found no significant difference in sleep problems between breast cancer survivors and women without cancer before and after diagnosis, but identified three distinct sleep trajectories among BCS and found that sleep issues were influenced by pre-diagnosis vasomotor symptoms, anxiety, depressive symptoms, and smoking.
JOURNAL OF CANCER SURVIVORSHIP
(2022)
Article
Cardiac & Cardiovascular Systems
Hannah K. Tandon, Kara Stout, David T. Shin, Muaaz Almerstani, Ahmad Aroudaky, Jason P. Payne, Neha Goyal, Shane F. Tsai, Arthur Easley, Faris Khan, John R. Windle, Daniel R. Anderson, John William Schleifer, Niyada Naksuk
Summary: Interatrial block (IAB) has predictive value for atrial fibrillation (AF) ablation outcomes in obese patients. Partial IAB and advanced IAB are independently associated with increased risk of recurrent arrhythmia after ablation, regardless of other risk factors.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Neha Goyal, Yahiya Hussain, Gianna G. Yang, Daniel Haehn
Summary: In Connectomics, researchers are creating the brain's wiring diagram at nanometer resolution. They propose a new alignment method called MITO that uses mitochondria as landmark points to improve and accelerate the alignment procedure. The experiments show promising results, with a decrease in alignment time and faster throughput compared to existing methods.
BIOMEDICAL IMAGE REGISTRATION (WBIR 2022)
(2022)
Article
Medicine, General & Internal
Neha Goyal, Vaishali Chaudhary
Summary: Muscle tightness in the iliopsoas was compared between students engaged in prolonged sitting due to online classes with higher BMI and students with normal BMI. The study found that students with higher BMI had significantly greater iliopsoas muscle tightness compared to students with normal BMI.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2022)
Review
Business
Komal Goyal, Ashutosh Nigam, Neha Goyal
Summary: This study investigates the antecedents of employee loyalty, finding that job satisfaction is closely related to employee loyalty, and theoretically, organizational commitment is regarded as the behavioral outcome of employee loyalty.
PACIFIC BUSINESS REVIEW INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Radhika Sharma, Neha Goyal, Mandakini Singla, Vijay Lakshmi Sharma
JOURNAL OF DIETARY SUPPLEMENTS
(2019)
Article
Neurosciences
Tamara K. Stevenson, Daniel A. Lawrence