Article
Oncology
Xu-Heng Chiang, Tzu-Pin Lu, Min-Shu Hsieh, Tung-Ming Tsai, Hsien-Chi Liao, Tzu-Ning Kao, Chia-Hong Chang, Mong-Wei Lin, Hsao-Hsun Hsu, Jin-Shing Chen
Summary: Based on a comparison study of wedge resection and segmentectomy in patients with cT1N0 lung adenocarcinoma, segmentectomy showed better DFS in certain patients. However, in other cases, wedge resection may be a safe and feasible option.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Weijian Song, Yucheng Hou, Jianfeng Zhang, Qianjun Zhou
Summary: The study analyzed the prognostic significance of lung adenocarcinoma classification and investigated the optimal surgical procedure for patients with pathological N0 lung invasive adenocarcinomas ≤1 cm who underwent surgical resection. The results showed that anatomical resection had better survival outcomes compared to wedge resection. Additionally, wedge resection could provide similar oncological effect when the tumor was lepidic predominant or acinar predominant.
Article
Oncology
Hongdou Ding, Nan Song, Peng Zhang, Gening Jiang, Haifeng Wang
Summary: This study aimed to investigate whether wedge resection plus adequate lymph nodes resection conferred comparable survival to lobectomy for small non-small cell lung cancer (NSCLC). The results showed that wedge resection was inferior to lobectomy for NSCLC smaller than 1 cm and 1-2 cm. For lesions 1-2 cm, more lymph nodes resected during lobectomy were associated with a statistically significant increase in survival, with six nodes being the optimal number. Lymph nodes resection had no impact on survival for lesions smaller than or equal to 1 cm. Wedge resection and lobectomy were comparable when one or more nodes were resected for lesions smaller than or equal to 1 cm, and six or more nodes were resected for lesions 1-2 cm. Therefore, wedge resection plus adequate lymph nodes resection could be considered as an alternative to lobectomy for selected NSCLC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Masaya Yotsukura, Yuji Muraoka, Yukihiro Yoshida, Kazuo Nakagawa, Kouya Shiraishi, Takashi Kohno, Yasushi Yatabe, Shun-ichi Watanabe
Summary: This study found that the prognosis and survival of lung cancer patients after 5 years of surgery were associated with age rather than stage classification. It suggests that the long-term follow-up strategy does not need to be modified based on stage classification, and screening for secondary primary lung cancer should be considered.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Congkuan Song, Zilong Lu, Donghang Li, Shize Pan, Ning Li, Qing Geng
Summary: This study compared the survival outcomes of wedge resection and lobectomy in patients with early-stage second primary non-small cell lung cancer (SP-NSCLC) who had previous lung cancer-directed surgery. The results showed that wedge resection was comparable to lobectomy in overall survival, indicating that wedge resection may be sufficient for these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mirza Zain Baig, Syed S. Razi, Stephanie Stroever, Joanna F. Weber, Cliff P. Connery, Faiz Y. Bhora
Summary: The study found that anatomic lung resections may provide better long-term survival than wedge resections for early-stage peripheral SPLC in patients previously undergoing lobectomy. Additionally, improvement in survival was observed with wedge resection when lymph node sampling was done.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Oncology
Takahiro Mimae, Hisashi Saji, Hiroshige Nakamura, Norihito Okumura, Masanori Tsuchida, Makoto Sonobe, Takuro Miyazaki, Keiju Aokage, Masayuki Nakao, Tomohiro Haruki, Morihito Okada, Kenji Suzuki, Masayuki Chida
Summary: The study suggests that wedge resection may be equivalent to lobectomy or segmentectomy for early-stage NSCLC patients aged 80 or older who can tolerate lobectomy. The surgical procedure is not an independent prognostic predictor.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Meredith A. Ray, Olawale Akinbobola, Carrie Fehnel, Andrea Saulsberry, Kourtney Dortch, Bradley Wolf, Ganpat Valaulikar, Hetal D. Patel, Thomas Ng, Todd Robbins, Matthew P. Smeltzer, Nicholas R. Faris, Raymond U. Osarogiagbon
Summary: This study examines the association between surgeon-level intermediate outcomes differences and patient survival differences. It finds that surgeon performance is associated with patient outcomes and that adjustment for specific processes can mitigate survival differences among surgeons.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Guoshu Li, Shuanshuan Xie, Feng Hu, Min Tan, Lihong Fan, Changhui Wang
Summary: This study compared the survival outcomes of segmentectomy and wedge resection in stage IA lung squamous cell carcinoma and lung adenocarcinoma patients. The results suggest that segmentectomy may yield superior survival outcomes compared to wedge resection in squamous cell carcinoma patients, but the survival outcomes of the two procedures are generally equivalent in adenocarcinoma patients.
Review
Medicine, General & Internal
Peiyu Wang, Shaodong Wang, Zheng Liu, Xizhao Sui, Xun Wang, Xiao Li, Mantang Qiu, Fan Yang
Summary: Segmentectomy is a promising treatment for elderly patients with early-stage NSCLC, while wedge resection should be limited. Sublobar resections have a lower risk of perioperative complications compared to lobectomy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Nasser Altorki, Xiaofei Wang, David Kozono, Colleen Watt, Rodney Landrenau, Dennis Wigle, Jeffrey Port, David R. Jones, Massimo Conti, Ahmad S. Ashrafi, Moishe Liberman, Kazuhiro Yasufuku, Stephen Yang, John D. Mitchell, Harvey Pass, Robert Keenan, Thomas Bauer, Daniel Miller, Leslie J. Kohman, Thomas E. Stinchcombe, Everett Vokes
Summary: This study compared lobectomy and sublobar resection in lung cancer patients. The results showed that in patients with tumors sized 2 cm or less and negative lymph nodes, sublobar resection was not inferior to lobectomy in terms of disease-free survival, and overall survival was similar between the two procedures.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Harry B. Lengel, Brooke Mastrogiacomo, James G. Connolly, Kay See Tan, Yuan Liu, Cameron N. Fick, Elizabeth G. Dunne, Di He, Manendra B. Lankadasari, Baby Anusha Satravada, Yichao Sun, Ritika Kundra, Chris Fong, Shaleigh Smith, Gregory J. Riely, Charles M. Rudin, Daniel R. Gomez, David B. Solit, Michael F. Berger, Bob T. Li, Marty W. Mayo, Irina Matei, David C. Lyden, Prasad S. Adusumilli, Nikolaus Schultz, Francisco Sanchez-Vega, David R. Jones
Summary: We analyzed a large cohort of lung adenocarcinomas to study the clinicopathological and genomic features associated with metastasis and organotropism. We found that patients with metastasis were younger, male, and had specific histological subtypes and genomic alterations. Certain genes were correlated with a shorter time to metastasis in specific sites. Our findings also revealed common and unique genetic alterations between primary tumors and metastases. Only a small percentage of metastases had therapeutically actionable alterations not found in the primary tumors. Overall, our analysis highlights the complexity of clinicopathological features and tumor genomics in lung adenocarcinoma organotropism.
Article
Surgery
Yu Asakura, Hirochika Toyama, Jun Ishida, Sadaki Asari, Sachio Terai, Sachiyo Shirakawa, Hironori Yamashita, Takashi Shimizu, Yuta Ogura, Ippei Matsumoto, Hidetoshi Gon, Daisuke Tsugawa, Shohei Komatsu, Kaori Kuramitsu, Hiroaki Yanagimoto, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto
Summary: This study investigated the clinicopathological features and risk factors for lung recurrence after pancreatectomy for PDAC. The results showed that lung recurrence has better outcomes than other recurrences, and para-aortic lymph node metastasis and female sex are independent risk factors for lung recurrence.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Christopher W. Seder, Forough Farrokhyar, Rahul Nayak, Jean-Marc Baste, Yogita Patel, John Agzarian, Christian J. Finley, Yaron Shargall, Pascal-Alexandre Thomas, Marcel Dahan, Jean-Philippe Verhoye, Frankie Mbadinga, Wael C. Hanna
Summary: In obese patients, robotic surgery (RTS) for lung resection is associated with a lower rate of conversion to thoracotomy compared to video-assisted thoracoscopic surgery (VATS). RTS patients have longer hospital stays, higher rates of respiratory failure, and are less likely to be discharged to their home compared to VATS patients.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Long Xu, Hang Su, Shengnan Zhao, Haojie Si, Huikang Xie, Yijiu Ren, Jiani Gao, Fang Wang, Xiaofeng Xie, Chenyang Dai, Chunyan Wu, Deping Zhao, Chang Chen
Summary: A new method using semi-dry dot-blot (SDB) to detect micropapillary (MIP) component in lung adenocarcinoma (LUAD) surgery was developed. Differential protein expression analysis identified cellular retinoic acid-binding protein 2 (CRABP2) as significantly upregulated in MIP-positive LUAD. The SDB method accurately detected MIP component using CRABP2 visualization, comparable to a pathologist's performance.
BRITISH JOURNAL OF CANCER
(2023)
Article
Cardiac & Cardiovascular Systems
Neel P. Chudgar, Shi Yan, Meier Hsu, Kay See Tan, Katherine D. Gray, Daniela Molena, Tamar Nobel, Prasad S. Adusumilli, Manjit Bains, Robert J. Downey, James Huang, Bernard J. Park, Gaetano Rocco, Valerie W. Rusch, Smita Sihag, David R. Jones, James M. Isbell
Summary: The study compared the observed and predicted outcomes after pulmonary resections between SURPAS and NSQIP SRC. Results showed no significant differences in discrimination performance between the two models for most complications, except for renal failure. The NSQIP SRC performed better in discriminating the risk of renal failure compared to SURPAS.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Raul Caso, Gregory D. Jones, Kay See Tan, George J. Bosl, Samuel A. Funt, Joel Sheinfeld, Victor E. Reuter, David Amar, Gregory Fischer, Daniela Molena, Gaetano Rocco, Manjit S. Bains, Darren R. Feldman, David R. Jones
Summary: This study explored the outcomes of thoracic metastasectomy in GCT patients who received first-line chemotherapy alone versus salvage chemotherapy. Patients treated with salvage chemotherapy had more aggressive disease and worse PFS, but achieved encouraging OS. Aggressive thoracic metastasectomy plays an integral role in treating GCT patients with residual thoracic disease after chemotherapy.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Shunichiro Matsuoka, Takashi Eguchi, Tetsu Takeda, Kentaro Miura, Kazutoshi Hamanaka, Kimihiro Shimizu
Summary: Using a combination of 3D-CT imaging and ICG fluorescence navigation, lung resection in patients with pulmonary sequestration can safely and effectively identify and divide aberrant arteries, draining veins, and resection margins intraoperatively.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Neel Chudgar, Shi Yan, Meier Hsu, Kay See Tan, Katherine D. Gray, Daniela Molena, David R. Jones, Valerie W. Rusch, Gaetano Rocco, James M. Isbell
Summary: The NSQIP SRC can reasonably predict postoperative complications in patients undergoing pulmonary resection, except for certain calibration issues.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Surgery
Gregory D. Jones, Whitney S. Brandt, Ronglai Shen, Francisco Sanchez-Vega, Kay See Tan, Axel Martin, Jian Zhou, Michael Berger, David B. Solit, Nikolaus Schultz, Hira Rizvi, Yuan Liu, Ariana Adamski, Jamie E. Chaft, Gregory J. Riely, Gaetano Rocco, Matthew J. Bott, Daniela Molena, Marc Ladanyi, William D. Travis, Natasha Rekhtman, Bernard J. Park, Prasad S. Adusumilli, David Lyden, Marcin Imielinski, Marty W. Mayo, Bob T. Li, David R. Jones
Summary: The integration of genomic and clinicopathologic features can better predict recurrence in early-stage LUAD patients after surgical resection, potentially enhancing accrual to clinical trials.
Article
Cardiac & Cardiovascular Systems
Nicolas Zhou, Matthew Bott, Bernard J. Park, Eric Vallieres, Candice L. Wilshire, Kazuhiro Yasufuku, Jonathan D. Spicer, David R. Jones, Boris Sepesi
Summary: The study highlights the survival benefit of adjuvant chemotherapy in limited-stage SCLC, but did not find a statistically significant influence from mediastinal PORT or PCI in the cohort. Larger prospective studies are needed to determine the benefits of PORT or PCI in a surgically resected limited-stage SCLC population.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Takashi Eguchi, Kazutoshi Hamanaka, Kimihiro Shimizu
ANNALS OF THORACIC SURGERY
(2021)
Article
Pathology
Kentaro Miura, Kimihiro Shimizu, Takashi Eguchi, Sachie Koike, Shunichiro Matsuoka, Tetsu Takeda, Kazutoshi Hamanaka, Takeshi Uehara
Summary: The study demonstrated the high sensitivity and specificity of SS18-SSX antibody in diagnosing pulmonary metastatic SS. The positive results in 100% of metastatic SS cases and 0% of clinical and histologic mimics suggest its potential application in clinical practice. This simple and reliable immunohistochemistry method may serve as a substitute for traditional genomic tests.
DIAGNOSTIC PATHOLOGY
(2021)
Review
Oncology
Takashi Eguchi, Toshihiko Sato, Kimihiro Shimizu
Summary: By discussing and summarizing key issues related to minimally invasive segmentectomy, including preoperative planning and intraoperative tumor localization, we can help overcome the technical challenges associated with this procedure.
Article
Cardiac & Cardiovascular Systems
Tetsu Takeda, Shunichiro Matsuoka, Kentaro Miura, Kazutoshi Hamanaka, Kimihiro Shimizu, Takashi Eguchi
Summary: This study investigated predictors of PA-adherent lymph nodes and conversion/PA injury during minimally invasive surgery. Bronchoscopy and CT were found to be independent predictors, with the combination of dark pigmentation and LN size useful in stratifying patients' risk of PA-adherent LNs. The presence of PA-adherent LNs was associated with a higher risk of conversion and PA injury during MIS.
ANNALS OF THORACIC SURGERY
(2022)
Review
Medicine, General & Internal
Kentaro Miura, Kimihiro Shimizu, Shogo Ide, Shuji Mishima, Shunichiro Matsuoka, Tetsu Takeda, Takashi Eguchi, Kazutoshi Hamanaka, Takeshi Uehara
Summary: Accurately diagnosing the histologic type of lung cancer is crucial for determining the appropriate treatment. Immunostaining is commonly used for diagnosing high-grade neuroendocrine tumors, with Stathmin-1 immunostaining proving to be a useful tool in this process.
Review
Health Care Sciences & Services
Takashi Eguchi, Kentaro Miura, Kazutoshi Hamanaka, Kimihiro Shimizu
Summary: This article discusses the key issues related to robotic lung segmentectomy, with a focus on the technical features under difficult conditions. It also introduces our preferred surgical strategy and specific maneuvers for robotic lung segmentectomy.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
Noriaki Sakakura, Takashi Eguchi
Summary: This narrative review summarizes the variations in approaches and port placements used for robotic lung resections. The four-arm, look-up-view method is considered the mainstream approach worldwide. Several variations have been devised, including horizontal open-thoracotomy-view techniques and fewer port and incision techniques. Familiarity with these variations allows thoracic surgeons to choose the optimal procedure for each patient.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Editorial Material
Health Care Sciences & Services
Takashi Eguchi
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Oncology
Kazutoshi Hamanaka, Kentaro Miura, Takashi Eguchi, Kimihiro Shimizu
Summary: With the increasing incidence of early-stage lung cancer and the demand for less invasive surgeries, sublobar resections are becoming more common. Three-dimensional imaging technology and software solutions have been developed for precise lung segmentectomy simulations. In the future, artificial intelligence technology and immersive technology such as extended reality can further enhance anatomical recognition and visualization, facilitating high-quality tailor-made sublobar resections for lung cancer.