Review
Genetics & Heredity
Mikhlid Almutairi, Mahmoud Rouabhia, Mohammed Sahab Almutairi, Mohammed Al-Zahrani, Nouf S. Al-Numair, Abdullah Mohammad Alhadeq, Narasimha Reddy Parine, Abdelhabib Semlali
Summary: The study investigated the genotype and allele distributions of four TDG SNPs in relation to smoking behavior in a Saudi population. The results suggested that certain SNPs may increase the risk of developing smoking-related diseases in smokers, especially in long-term smokers and those under 29 years old. Additionally, the allele distributions of TDG SNPs in the Saudi population were found to differ from other ethnicities represented in the HapMap project.
Article
Multidisciplinary Sciences
Haojian Li, Yue Liu, Yunjie Xiao, Crystal N. Wilson, Hui Jen Bai, Maxwell D. Jones, Shihchun Wang, Jennie E. DeVore, Esther Y. Maier, Stephen T. Durant, Myriem Boufraqech, Urbain Weyemi
Summary: Cancer treatments targeting DNA repair deficiencies often encounter drug resistance, likely due to alternative metabolic pathways that counteract the most damaging effects. In this study, we identified KEAP1 as a key factor that desensitizes cancer cells to ATM inhibition, leading to increased sensitivity to DNA damage. Moreover, we found a negative correlation between ATM levels and KEAP1 levels in multiple solid malignancies, suggesting the potential of targeting ATM and KEAP1 as vulnerabilities in solid tumors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Rhys Gillman, Kylie Lopes Floro, Miriam Wankell, Lionel Hebbard
Summary: Hepatocellular carcinoma is rapidly becoming a major cause of global mortality due to the increasing prevalence of obesity. DNA damage and repair pathways play important roles in the initiation of liver cancer, yet many contemporary reports neglect the individual pathways in their hypotheses.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Biochemistry & Molecular Biology
Alexandra Wagner, Helena Kosnacova, Miroslav Chovanec, Dana Jurkovicova
Summary: Mitochondria play a crucial role in cellular metabolism and bioenergetics, and are involved in cancer development and treatment response. Studying the genetic and epigenetic control of mitochondria can provide insights into cancer therapy response and aid in the development of new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Seo-Young Koo, Eun-Ji Park, Hyun-Ji Noh, Su-Mi Jo, Bo-Kyoung Ko, Hyun-Jin Shin, Chang-Woo Lee
Summary: Changes in DNA damage response and cellular metabolism enable cancer cells to proliferate. Dysregulation of the DNA damage response and ubiquitination of associated enzymes are common in cancer. Additionally, upregulation of glycolysis and ubiquitination of enzymes in this pathway occur in cancer cells. E3 ligases with high substrate specificity are considered potential therapeutic targets for cancer treatment, and small molecule inhibitors targeting the ubiquitin-proteasome system have been developed and tested in clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dimitra T. Stefanou, Marousa Kouvela, Dimitris Stellas, Konstantinos Voutetakis, Olga Papadodima, Konstantinos Syrigos, Vassilis L. Souliotis
Summary: The deregulated DNA damage response network is associated with the onset and progression of lung cancer. This study found that lung cancer patients have higher levels of endogenous DNA damage, which may be caused by oxidative stress and defective DNA repair mechanisms. The findings suggest that oxidative stress and DDR-related aberrations contribute to the accumulation of endogenous DNA damage in lung cancer patients.
Article
Biology
Alvaro Gonzalez Rajal, Kamila A. Marzec, Rachael A. McCloy, Max Nobis, Venessa Chin, Jordan F. Hastings, Kaitao Lai, Marina Kennerson, William E. Hughes, Vijesh Vaghjiani, Paul Timpson, Jason E. Cain, D. Neil Watkins, David R. Croucher, Andrew Burgess
Summary: The study identified a non-genetic mechanism of resistance in human lung adenocarcinoma that is dependent on the cell cycle stage at the time of cisplatin exposure, using RNA sequencing and biosensors to track single-cell fates.
Article
Oncology
Minghui Chang, Shanshan Ding, Xiaohan Dong, Xiaoling Shang, Yang Li, Li Xie, Xingguo Song, Xianrang Song
Summary: This study demonstrates the potential anti-tumor property of liensinine in non-small cell lung cancer (NSCLC) and its ability to inhibit the growth of NSCLC both in vitro and in vivo. Additionally, liensinine blocks autophagic flux and impairs the function of mitochondria and lysosomes.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Michael S. S. May, Jacob K. K. Jamison, Winston Wong, Alissa Michel, Alexander G. G. Raufi, Alfred I. I. Neugut, Gulam A. A. Manji
Summary: This study found no association between smoking and the risk of pulmonary metastasis in resectable pancreatic ductal adenocarcinoma (PDAC) through a retrospective case-control study.
CANCER INVESTIGATION
(2023)
Review
Genetics & Heredity
Hossein Ghaderi-Zefrehi, Maryam Rezaei, Farzin Sadeghi, Mohammad Heiat
Summary: Hepatocellular carcinoma (HCC) is closely related to risk factors such as chronic hepatitis B or C infections and alcohol addiction. Defects in DNA repair systems can increase susceptibility to cancer, and genetic polymorphisms in DNA repair genes may affect DNA repair capacity and modulate cancer risk. Identifying these polymorphisms and their association with HCC risk can help improve prevention and treatment strategies.
Article
Obstetrics & Gynecology
Jingli Wang, Chengcheng Guan, Jing Sui, Yucui Zang, Yuwen Wu, Ru Zhang, Xiaoying Qi, Shunfu Piao
Summary: This study suggests that the genetic variant rs2228000 in XPC may be associated with PE risk in Chinese Han women, and pregnant women carrying the TT genotype have a reduced risk of developing PE. Further research is needed to confirm these findings in other populations.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Review
Cell Biology
Danilo Cucchi, Amy Gibson, Sarah A. Martin
Summary: The DNA damage response (DDR) and cellular metabolism are closely related, with metabolic pathways influencing DDR repair process and DDR proteins regulating metabolic flux. This connection holds great importance in cancer biology.
Article
Oncology
Kimiko L. Krieger, Jie H. Gohlke, Kevin J. Lee, Danthasinghe Waduge Badrajee Piyarathna, Patricia D. Castro, Jeffrey A. Jones, Michael M. Ittmann, Natalie R. Gassman, Arun Sreekumar
Summary: This study found that prostate cancer in African American patients has more severe DNA damage, indicating dysfunction in the base excision repair pathway and metabolic rewiring, which can explain the poorer outcomes in African American men compared to European American men with prostate cancer.
Review
Oncology
Janina Janetzko, Sebastian Oeck, Alexander Schramm
Summary: Lamins, as nuclear proteins, were previously thought to primarily have structural functions. However, recent reports suggest that they also play a broader role in cancer development and progression. These reports indicate that changes in lamin subtype composition can affect various cell processes, such as cellular stiffness and chromatin condensation, which have implications for cancer metastasis. Additionally, studies suggest that cancer cells can manipulate lamin functions to modify chromatin accessibility, cell cycle regulation, and DNA damage response. This comprehensive overview focuses on the role of lamins in lung cancer and the DNA damage response, providing insights into their sometimes-conflicting functions in cancer.
Review
Immunology
Hirva Mamdani, Sandro Matosevic, Ahmed Bilal Khalid, Gregory Durm, Shadia I. Jalal
Summary: Lung cancer treatment has undergone major changes with the development of targeted therapies and immunotherapy. However, predicting response and overcoming resistance to immune checkpoint inhibitors remains challenging, necessitating the discovery of new predictive biomarkers. Additionally, exploring additional targets is important for maximizing the benefits of immunotherapy in lung cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Keiichi Sasaki, Toshikazu Tsuji, Yasutaka Kimoto, Yuki Yanagihara, Ken Masuguchi, Ayako Chikamori, Hiroyuki Watanabe, Tesshin Murakami, Daisuke Oryoji, Masafumi Hashimoto, Takahiko Horiuchi, Nobuaki Egashira
Summary: Switching from weekly 5 mg folic acid supplementation to daily 1.25 mg in Japanese RA patients can reduce MTX toxicity without affecting efficacy. Significant improvements in liver function markers were observed, while other clinical indicators remained stable.
MODERN RHEUMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Toyoki Maeda, Takahiko Horiuchi, Naoki Makino
Summary: Research indicates that regular use of hypnotics may be associated with somatic telomere shortening and aging, and this effect may be gender-related in patients.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Rheumatology
Yukiko Takeyama, Nobuyuki Ono, Yuri Shirahama, Yasushi Inoue, Atsushi Tanaka, Naoyasu Ueda, Naoya Nishimura, Shuji Nagano, Ayumi Uchino, Tomoya Miyamura, Kensuke Oryoji, Hisako Inoue, Akihito Maruyama, Shun-ichiro Ota, Seiji Yoshizawa, Takuya Sawabe, Naoko Himuro, Katsuhisa Miyake, Yasutaka Kimoto, Takahiko Horiuchi, Hiroki Mitoma, Hiroaki Niiro, Ayako Takamori, Yoshifumi Tada
Summary: The study found that rituximab maintenance therapy may be effective and safe for Japanese patients with granulomatosis with polyangiitis, with comparable relapse-free survival rates and incidence of severe adverse events compared to other treatment options.
MODERN RHEUMATOLOGY
(2021)
Article
Materials Science, Textiles
Shuhei Watanabe, Takahiko Horiuchi
Summary: This study focused on the texture of genuine leather and artificial leather, examining various impressions of genuine leather through a perception model and developing a method to quantify the texture. Through multiple measurement experiments and subjective evaluation experiments, the texture of genuine leather was ultimately quantified based on impressions.
TEXTILE RESEARCH JOURNAL
(2021)
Article
Cell Biology
Toyoki Maeda, Takahiko Horiuchi, Naoki Makino
Summary: The study found a correlation between the length of telomeres and methylated subtelomeres with an increase in bacterial species and certain strains in feces, suggesting an influence of intestinal conditions on the proportion of the intestinal microbial population. Shortened telomeres and demethylation status are considered to represent the degree and acceleration of aging, respectively, with biased microbial status associated with advanced stages or acceleration phases of biological aging.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Allergy
Michihiro Hide, Takahiko Horiuchi, Isao Ohsawa, Irmgard Andresen, Atsushi Fukunaga
Summary: Hereditary angioedema (HAE) is characterized by unpredictable and painful swelling episodes, with increasing awareness worldwide but low recognition in Japan. Challenges in diagnosis and treatment exist, highlighting the need for greater awareness and solutions in the country.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Computer Science, Hardware & Architecture
Shiori Yamaguchi, Keita Hirai, Takahiko Horiuchi
Summary: This study proposes a novel method for removing smoke from videos based on a single image sequence, involving the development of a smoke imaging model and smoke removal through spatio-temporal pixel compensation. The experimental results demonstrate the effectiveness of the method in removing smoke from dynamic scenes, and quantitative assessment is conducted based on a temporal coherence measure.
IEICE TRANSACTIONS ON FUNDAMENTALS OF ELECTRONICS COMMUNICATIONS AND COMPUTER SCIENCES
(2021)
Article
Immunology
Keisuke Imabayashi, Masahiro Ayano, Kazuhiko Higashioka, Kana Yokoyama, Ken Yamamoto, Koji Takayama, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: This study reported a case of a NBD patient presenting with acute onset dementia, who responded well to treatment with infliximab. Analysis showed that IP-10 levels in the cerebrospinal fluid were higher than in peripheral blood, and both decreased after treatment. It is crucial to consider introducing infliximab in glucocorticoid-resistant patients to prevent irreversible brain dysfunction.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Rheumatology
Kensuke Irino, Yojiro Arinobu, Masahiro Ayano, Shotaro Kawano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: The study retrospectively analyzed 64 pregnancies in 39 cases of lupus patients at Kyushu University Hospital from October 2002 to July 2018. The results showed that 29.7% of patients experienced lupus flare during pregnancy, with discontinuation of immunosuppressants being a significant risk factor. Additionally, fetal stillbirth rates were significantly higher in cases with lower C3 levels at 12 weeks of gestation compared to before conception.
Article
Multidisciplinary Sciences
Miki Nakano, Masahiro Ayano, Kazuo Kushimoto, Shotaro Kawano, Kazuhiko Higashioka, Shoichiro Inokuchi, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: Serum sCD226 levels are associated with disease activity and flares of SLE, with high levels significantly correlated with clinical symptoms and antibody titers. Serum sCD226 may be a useful biomarker for SLE, aiding in more precise management of the disease.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Yusuke Kashiwado, Yasutaka Kimoto, Kenji Oku, Mari Yamamoto, Shiro Ohshima, Satoshi Ito, Takahiko Horiuchi, Tsutomu Takeuchi
Summary: This study evaluated the treatment and prognosis of COVID-19 in patients with rheumatic diseases based on the time of onset and dominant strain. Data from a nationwide COVID-19 registry in Japan were analyzed, and the primary endpoints were hypoxemia incidence and mortality. The study found that the prognosis of COVID-19 improved over time in patients with rheumatic diseases, particularly during the Omicron BA.5-dominant period. Vaccination history and onset during the Omicron BA.5-dominant period were negatively associated with hypoxemia.
MODERN RHEUMATOLOGY
(2023)
Article
Rheumatology
Sho Fujimoto, Yojiro Arinobu, Kohta Miyawaki, Masahiro Ayano, Hiroki Mitoma, Yasutaka Kimoto, Nobuyuki Ono, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: This study examined the role of basophils and anti-double-stranded DNA (dsDNA) IgE in the pathogenesis of SLE using human samples. The results showed that the serum levels of anti-dsDNA IgE in SLE patients were correlated with disease activity. Basophils were found to promote B cell differentiation through dsDNA-specific IgE, similar to the process observed in mouse models.
Article
Rheumatology
Yusuke Kashiwado, Chikako Kiyohara, Yasutaka Kimoto, Shuji Nagano, Takuya Sawabe, Kensuke Oryoji, Shinichi Mizuki, Hiroaki Nishizaka, Seiji Yoshizawa, Shigeru Yoshizawa, Tomomi Tsuru, Yasushi Inoue, Naoyasu Ueda, Shun-ichiro Ota, Yasuo Suenaga, Tomoya Miyamura, Yoshifumi Tada, Hiroaki Niiro, Koichi Akashi, Takahiko Horiuchi
Summary: Discontinuation of biologic therapy after hospitalization for infections may lead to flares in rheumatoid arthritis. Continuing biologic therapy reduces the risk of rheumatoid arthritis flares, especially in patients without immunodeficiency.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Rheumatology
Kazuo Kushimoto, Masahiro Ayano, Keisuke Nishimura, Miki Nakano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: This study aimed to identify new characteristics of elderly onset large-vessel vasculitis (EOLVV), focusing on human leucocyte antigen (HLA) genotype, polymyalgia rheumatica (PMR), and affected vascular lesions observed on positron emission tomography/computed tomography (PET/CT) imaging. The study identified a cluster of LVV with GCA features, particularly in HLA-B52-positive patients, suggesting HLA-B52-positive patients with LVV and GCA features may comprise a core population of Japanese patients with EOLVV. The findings of HLA-B52 positivity and diffusely affected vessels in patients with EOLVV can be considered suspicious findings of LV-GCA.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Cell Biology
Joon-Cheol Kwon, O. Hwan Kwon, Rae Ung Jeong, Nayoun Kim, Seonah Song, Ilsub Choi, Juneok Lee, Takahiko Horiuchi
Summary: The comprehensive comparison assessment of physicochemical and biological attributes between LBAL and Humira (R) demonstrated their structural and functional similarity, supporting the biosimilarity of LBAL to Humira (R) in terms of clinical efficacy and safety.
ANIMAL CELLS AND SYSTEMS
(2021)
