Article
Cardiac & Cardiovascular Systems
Yoshito Yamada, Tosiya Sato, Norio Harada, Hidenao Kayawake, Satona Tanaka, Yojiro Yutaka, Masatsugu Hamaji, Daisuke Nakajima, Akihiro Ohsumi, Hiroshi Date
Summary: The study found that perioperative diabetes mellitus (DM) is an independent adverse factor for overall survival (OS) and CLAD-free survival after lung transplantation. The management of perioperative DM should be emphasized in clinical practice.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Yoshito Yamada, Tosiya Sato, Norio Harada, Hidenao Kayawake, Satona Tanaka, Yojiro Yutaka, Masatsugu Hamaji, Daisuke Nakajima, Akihiro Ohsumi, Hiroshi Date
Summary: This study found that perioperative diabetes mellitus is an independent adverse factor for overall survival and CLAD-free survival after lung transplantation, with diabetic patients having lower survival rates and CLAD-free survival rates compared to non-diabetic patients at the 6-month landmark point post-transplantation.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Oncology
Yasmin Leshem, Yardenna Dolev, Nava Siegelmann-Danieli, Sarah Sharman Moser, Lior Apter, Gabriel Chodick, Alla Nikolaevski-Berlin, Sivan Shamai, Ofer Merimsky, Ido Wolf
Summary: This study evaluated the impact of diabetes mellitus (DM) on the efficacy of pembrolizumab in treating metastatic non-small cell lung cancer (NSCLC). The results showed that patients with DM had shorter progression-free survival and overall survival, especially when treated with pembrolizumab alone. The study suggests that immunotherapy may be less beneficial in NSCLC patients with diabetes.
Article
Medicine, General & Internal
Hristo Kirov, Alexandros Moschovas, Tulio Caldonazo, Imke Schwan, Gloria Faerber, Tim Sandhaus, Thomas Lehmann, Torsten Doenst
Summary: This study found that pre-transplant diabetes mellitus increases the risk of cancer after heart and/or lung transplantation. However, new-onset diabetes after transplantation is associated with a much greater cancer risk. These findings are relevant for screening during follow-up.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Kelechi Njoku, Heather J. Agnew, Emma J. Crosbie
Summary: This study aimed to investigate the impact of pre-existing type 2 diabetes mellitus (T2DM) on survival outcomes in endometrial cancer. The results showed that women with T2DM had an increased risk of overall mortality, cancer-specific mortality, and recurrence rates compared to those without T2DM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jing de Haan-Du, Klaas H. Groenier, Brendy Wauben-Spaetgens, Mathilde Jalving, Nanne Kleefstra, Gijs W. D. Landman, Geertruida H. de Bock
Summary: This study investigated the association between pre-diagnosis glycemic control and all-cause mortality in patients with type 2 diabetes (T2DM) who develop cancer. The results showed that among T2DM patients in the Netherlands, poor glycemic control before diagnosis with breast and colorectal cancer can increase mortality compared with good control.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Review
Endocrinology & Metabolism
Hua Fan, Shikun Bai, Xin Guan, Wen Ma, Yu Fu, Xuan Zhang, Lili Deng, Jing Tian
Summary: A systematic literature search found that patients with concurrent SCLC and DM using metformin had significantly longer overall survival (OS) and disease-free survival (DFS) compared to those without metformin usage.
MINERVA ENDOCRINOLOGY
(2023)
Article
Oncology
Dong Peng, Xiao-Yu Liu, Yu-Xi Cheng, Wei Tao, Yong Cheng
Summary: The study evaluated the impact of CRC surgery on T2DM and analyzed the change in T2DM on overall survival. Remission of T2DM was 12.8% one year after CRC surgery, with weight loss and shorter T2DM duration as predictive factors for remission. Lower TNM stage and T2DM remission were predictive factors for better overall survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jing Ding, Xudong Li, Jun Ge, Yuanqian Gong, Ya Zhou, Juan Xiao, Qin Yang, Jing Chen, Mian Mao
Summary: This study aimed to investigate the clinicopathological characteristics and survival risk factors in small cell lung cancer (SCLC) patients with preexisting type 2 diabetes mellitus (preDM). The results showed that preDM may increase the risk of distant metastasis in SCLC, while insulin therapy may have an adverse effect on the prognosis of patients. The findings suggest that improving blood glucose control and reducing the use of insulin analogs are essential for the long-term survival of diabetic patients with SCLC.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Medicine, General & Internal
Yiting Li, Shinong Gu, Xuanwen Li, Qing Huang
Summary: This study used bioinformatic analysis to identify biomarkers associated with the development and metastasis of diabetes and cancer. The findings validate the association of these genes with patients' conditions and emphasize the importance of gene expression and survival prognosis.
Article
Endocrinology & Metabolism
Daryl J. Selen, Tanayott Thaweethai, Carolin C. M. Schulte, Sarah Hsu, Wei He, Kaitlyn James, Anjali Kaimal, James B. Meigs, Camille E. Powe
Summary: Gestational glucose intolerance (GGI), an abnormal initial gestational diabetes mellitus (GDM) screening test without a GDM diagnosis, is associated with an increased risk of future diabetes. Individuals with GGI have a higher risk of developing diabetes compared to those with normal glucose tolerance during pregnancy. Routine clinical data can be used to identify this unrecognized group who may benefit from enhanced diabetes screening and prevention.
Article
Oncology
Xuejiao Li, Haiyan Fang, Dongwei Zhang, Liming Xia, Xiang Wang, Jingping Yang, Shaohu Zhang, Ya Su, Yongfu Zhu
Summary: This study investigated the impact of type 2 diabetes mellitus on the overall survival of patients with stage IIIB-IV non-small cell lung cancer. The results showed that patients without diabetes had a higher overall survival compared to those with diabetes.
Article
Medicine, General & Internal
Nam Eun Kim, Eun-Hwa Kang, Eunhee Ha, Ji-Young Lee, Jin Hwa Lee
Summary: Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of developing lung cancer, and type 2 diabetes mellitus (T2DM) may also increase this risk.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Fouad Chouairi, Clancy W. Mullan, Ahmed Ahmed, Jasjit Bhinder, Avirup Guha, P. Elliott Miller, Ania M. Jastreboff, Michael Fuery, Maya Rose Chiravuri, Arnar Geirsson, Nihar R. Cesar, Christopher Maulion, Sounok Sen, Tariq Ahmad, Muhammad Anwer
Summary: This study examined the demographics and outcomes of heart transplant recipients with type 2 diabetes. The proportion of patients with type 2 diabetes undergoing heart transplantation has increased in the past ten years, but they have a lower likelihood of transplantation and a higher likelihood of post-transplant mortality.
Article
Oncology
Kaoru Kaseda, Tomoyuki Hishida, Kyohei Masai, Keisuke Asakura, Yuichiro Hayashi, Hisao Asamura
Summary: The study aimed to investigate the clinicopathological and prognostic features of NSCLC patients with DM. Patients with DM showed distinct clinicopathological features and worse overall survival. The presence and control status of diabetes were important predictors of postoperative complications and overall survival.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Bjorn H. Gronberg, Bjorg Sjoblom, Tore Wentzel-Larsen, Vickie E. Baracos, Marianne J. Hjermstad, Nina Aass, Roy M. Bremnes, Oystein Flotten, Asta Bye, Marit Jordhoy
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Oncology
Magnus Harneshaug, Lene Kirkhus, Jurate Saltyte Benth, Bjorn Henning Gronberg, Sverre Bergh, Jon Elling Whist, Siri Rostoft, Marit S. Jordhoy
JOURNAL OF GERIATRIC ONCOLOGY
(2019)
Article
Oncology
Lene Kirkhus, Magnus Harneshaug, Jurate Saltyte Benth, Bjorn Henning Gronberg, Siri Rostoft, Sverre Bergh, Marianne J. Hjermstad, Geir Selbaek, Torgeir Bruun Wyller, Oyvind Kirkevold, Tom Borza, Ingvild Saltvedt, Marit S. Jordhoy
JOURNAL OF GERIATRIC ONCOLOGY
(2019)
Article
Geriatrics & Gerontology
Kristine Pettersen, Sonja Andersen, Anna van der Veen, Unni Nonstad, Shinji Hatakeyama, Christian Lambert, Estelle Lach-Trifilieff, Siver Moestue, Jana Kim, Bjorn Henning Gronberg, Alain Schilb, Carsten Jacobi, Geir Bjorkoy
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2020)
Article
Geriatrics & Gerontology
Bjorn H. Gronberg, Christine Damgaard Valan, Tarje Halvorsen, Bjorg Sjoblom, Marit S. Jordhoy
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2019)
Letter
Health Care Sciences & Services
Lene Kirkhus, Jurate Saltyte Benth, Bjorn Henning Gronberg, Marianne J. Hjermstad, Siri Rostoft, Magnus Harneshaug, Geir Selbaek, Torgeir Bruun Wyller, Marit Slaaen
PALLIATIVE MEDICINE
(2020)
Article
Pathology
Anine Larsen Ottestad, Sissel G. F. Wahl, Bjorn Henning Gronberg, Frank Skorpen, Hong Yan Dai
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2020)
Article
Oncology
Inger Johanne Zwicky Eide, Aslaug Helland, Simon Ekman, Anders Mellemgaard, Karin Holmskov Hansen, Saulius Cicenas, Jussi Koivunen, Bjorn Henning Gronberg, Odd Terje Brustugun
Article
Oncology
Tarje O. Halvorsen, Kristin Stokke, Kristin T. Killingberg, Sunil X. Raj, Sveinung Sorhaug, Odd Terje Brustugun, Oystein Flotten, Nina Helbekkmo, Kjersti Hornslien, Tesfaye Madebo, Sverre Fluge, Bjorn Henning Gronberg
Article
Geriatrics & Gerontology
Tarje Onsoien Halvorsen, Christine Damgaard Valan, Marit Slaaen, Bjorn Henning Gronberg
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2020)
Article
Oncology
Inger Johanne Zwicky Eide, Harald Grut, Aslaug Helland, Simon Ekman, Jens Benn Sorensen, Karin Holmskov Hansen, Bjorn Henning Gronberg, Saulius Cicenas, Jussi Pekka Koivunen, Anders Mellemgaard, Odd Terje Brustugun
Summary: The study confirmed the CNS efficacy of osimertinib in patients with the T790M resistance mutation. Other treatment options should be considered for T790M-negative patients with brain metastases.
Article
Oncology
Guro Falk Eriksen, Jurate Saltyte Benth, Bjorn Henning Gronberg, Siri Rostoft, Lene Kirkhus, Oyvind Kirkevold, Anne Hjelstuen, Marit Slaaen
Summary: This study revealed that geriatric impairments were common in older cancer patients receiving radiotherapy, with nutritional status and IADL function being independent predictors of survival. As the number of impairments increased, overall survival significantly decreased. Targeted interventions to address modifiable impairments may improve patient outcomes.
Article
Oncology
Henrik Horndalsveen, Tine Norman Alver, Astrid Marie Dalsgaard, Lotte Victoria Rogg, Nina Helbekkmo, Bjorn Henning Gronberg, Tarje Onsoien Halvorsen, Christina Ramberg, Vilde Drageset Haakensen, Asa Kristina Ooejlert, Maria Moksnes Bjaanaes, Aslaug Helland
Summary: In this phase II trial, the combination of atezolizumab and stereotactic body radiotherapy was found to be safe and effective in treating advanced non-small-cell lung cancer patients. The study also highlighted the potential of circulating tumor DNA (ctDNA) as a biomarker for monitoring treatment response.
MOLECULAR ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Inga Marie Royset, Guro Falk Eriksen, Jurate Saltyte Benth, Ingvild Saltvedt, Bjorn Henning Gronberg, Siri Rostoft, Oyvind Kirkevold, Darryl Rolfson, Marit Slaaen
Summary: This study found that Edmonton Frail Scale (EFS) score predicts mortality in older patients with cancer receiving radiotherapy, and EFS is a quick and sensitive screening tool to identify patients who may benefit from a geriatric assessment.
Article
Health Care Sciences & Services
Kristin Stokke, Tarje Onsoien Halvorsen, Bjorn Henning Gronberg, Ingvild Saltvedt, Marit Slaaen, Oyvind Kirkevold, Kristin Toftaker Killingberg, Marie Softeland Sandvei
Summary: In patients with advanced non-small-cell lung cancer receiving platinum-doublet chemotherapy, patient-reported physical function is an independent prognostic factor for survival, while measured physical performance does not have the same impact.