Article
Biochemical Research Methods
Yiyi Pu, Chao Li, Haining Yuan, Xiaoju Wang
Summary: This study identified and validated a panel of prostate cancer specific DNA methylation biomarkers with diagnostic value using multi-cancer data from TCGA and GEO. The biomarkers were able to differentiate between non-aggressive and aggressive prostate cancer, as well as distinguish between PRAD and normal prostate tissues and other urinary samples.
BMC BIOINFORMATICS
(2021)
Article
Oncology
Yifei Fang, Yunhui Qu, Longtao Ji, Hao Sun, Jiaqi Li, Yutong Zhao, Feifei Liang, Zhi Wang, Jiao Su, Jingjing Liu, Liping Dai, Songyun Ouyang
Summary: The study reveals an association between hypomethylation of the FUT7 gene and lung cancer, especially for LUSC. This provides novel support for the use of blood-based methylation markers in assessing lung cancer risk.
CLINICAL EPIGENETICS
(2022)
Article
Cell Biology
Yu-Chan Chang, Ming-Hsien Chan, Chien-Hsiu Li, Chih-Jen Yang, Yu-Wen Tseng, Hsing-Fang Tsai, Jean Chiou, Michael Hsiao
Summary: Phosphoglycerate kinase (PGK) plays a crucial role in tumorigenesis, especially PGK1 which is associated with metastasis and negatively correlated with survival rate. The study found a significant increase of PGK1 in adenocarcinoma, and suggested a functional control of cancer metastasis by PGK1 binding to HTATSF1. Additionally, a nonenzymatic function of PGK1 was also demonstrated.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Takahiro Ebata, Satoshi Yamashita, Hideyuki Takeshima, Hiroshi Yoshida, Yoshiko Kawata, Nao Kino, Toshiharu Yasugi, Yasuhisa Terao, Kan Yonemori, Tomoyasu Kato, Toshikazu Ushijima
Summary: This study aimed to identify markers for evaluating ovarian cancer cell fraction. Using genome-wide DNA methylation data, SIM1 and ZNF154 were found to be highly correlated with pathological cancer cell fractions. Pyrosequencing primers were successfully designed for cost-effective analysis. In an independent validation cohort, ZNF154 methylation showed a significant correlation with the pathological cancer cell fraction.
Article
Medicine, General & Internal
Karina Biskup, Caroline Stellmach, Elena Ioana Braicu, Jalid Sehouli, Veronique Blanchard
Summary: The modification of glycosaminoglycans in tissues surrounding malignant cells may contribute to tumor progression and metastasis in various types of cancers. A novel GAG-based score, CS-bio, was proposed as a potential biomarker for primary epithelial ovarian cancer, showing better sensitivity and specificity than the clinically used CA125 in identifying early-stage patients.
Article
Medical Laboratory Technology
Peikun Ding, Bin Peng, Guofeng Li, Xuefeng Sun, Guangsuo Wang
Summary: GNPNAT1 and methylated GNPNAT1 are biomarkers for the diagnosis and prognosis of lung cancer.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Agnieszka Maria Jelen, Bartlomiej Strehl, Dagmara Szmajda-Krygier, Milena Pazik, Ewa Balcerczak
Summary: P-glycoprotein (P-gp) plays a role in lung cancer development, progression, and patient survival. Changes in ABCB1 expression level may be related to tumorigenesis and multidrug resistance (MDR). Epigenetic modifications, such as DNA methylation, also regulate the gene's activity. Our analysis found downregulated ABCB1 expression and associated methylation changes in lung cancer cells, with variations based on age, gender, ethnicity, and smoking cessation. Decreased transcript levels were linked to advanced cancer stage and lower survival probability. Notably, ABCB1 expression changes were often unique to specific tumor subtypes. Methylation promoter was identified as a cause of decreased gene expression in lung cancer cells. These findings establish ABCB1 as an important prognostic factor in lung cancer.
APPLIED SCIENCES-BASEL
(2023)
Article
Oncology
Yujin Kim, Bo Bin Lee, Dongho Kim, Sang-Won Um, Joungho Han, Young Mog Shim, Duk-Hwan Kim
Summary: This study analyzed samples from lung cancer patients and cancer-free patients, and found that SLIT2 gene showed aberrant methylation in tumor tissues and plasma, which could serve as a biomarker for the early detection and prognosis prediction of non-small cell lung cancer.
Article
Genetics & Heredity
Lei Zhang, Dapeng Li, Lijing Gao, Jinming Fu, Simin Sun, Hao Huang, Ding Zhang, Chenyang Jia, Ting Zheng, Binbin Cui, Yanlong Liu, Yashuang Zhao
Summary: Early and specific detection of cancer is crucial for appropriate treatment. This study reveals that QKI methylation can serve as a diagnostic marker for colorectal cancer. By integrating methylation data from various cancer types, the researchers demonstrate the specific and high diagnostic ability of QKI promoter methylation in colorectal cancer.
FRONTIERS IN GENETICS
(2022)
Article
Biology
Jeremias Ivan, Gabriella Patricia, David Agustriawan
Summary: This study analyzed the methylation pattern of White breast cancer patients across different cancer stages using the TCGA dataset, identifying three potential stage-specific detection biomarkers. These findings suggest ABCC9, SHISA3, and POU4F1 as promising biomarkers for early detection and monitoring of breast cancer in White individuals. Further research is needed to investigate their roles in other racial groups.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Runzhang Liang, Xiaosong Li, Weiquan Li, Xiao Zhu, Chen Li
Summary: DNA methylation, catalyzed by DNMT, plays a role in lung cancer pathogenesis and progression, with smoking influencing gene methylation status and increasing the risk of central lung cancer. It is crucial in the mechanisms of lung cancer, early diagnosis, and treatment, but faces challenges in clinical application due to limitations in methylation markers and sample tests. The future development of DNA methylation may need to focus on improving efficiency and sensitivity in liquid biopsy for lung cancer diagnosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Giulia Cantini, Laura Fei, Letizia Canu, Giuseppina De Filpo, Tonino Ercolino, Gabriella Nesi, Massimo Mannelli, Michaela Luconi
Summary: Fascin-1 (FSCN1) is associated with an invasive phenotype of solid carcinomas and has been identified in the bloodstream of adrenocortical carcinoma (ACC) patients. Circulating levels of FSCN1 may serve as a new minimally-invasive prognostic marker for advanced ACC, particularly when measured before surgery for histological diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Mengxia Li, Rong Qiao, Runbo Zhong, Yujie Wei, Jun Wang, Zheng Zhang, Ling Wang, Tian Xu, Yue Wang, Liping Dai, Wanjian Gu, Baohui Han, Rongxi Yang
Summary: This study identified a potential association between hypomethylation of the FYB gene and early-stage lung cancer, particularly in males over the age of 55. Additionally, gender differences may play a role in DNA methylation levels.
Article
Chemistry, Multidisciplinary
Yang Zhao, Christine M. O'Keefe, Kuangwen Hsieh, Leslie Cope, Sonali C. Joyce, Thomas R. Pisanic, James G. Herman, Tza-Huei Wang
Summary: There is a strong interest in developing liquid biopsy assays for detecting cancer-specific alterations in circulating tumor DNA obtained from noninvasive blood draws. This paper describes the development and validation of a multiplex digital methylation-specific PCR platform for the detection of non-small cell lung cancer (NSCLC) in liquid biopsy samples. The platform demonstrates high analytical sensitivity and superior clinical performance compared to traditional MSP assays.
Article
Oncology
Wu-Hao Lin, Jian Xiao, Zi-Yi Ye, Da-Liang Wei, Xiao-Hui Zhai, Rui-Hua Xu, Zhao-Lei Zeng, Hui-Yan Luo
Summary: This study validated the potential of MYO1-G as a biomarker for diagnosis and monitoring of CRC, showing high accuracy in discriminating CRC patients and association with tumor burden and treatment response.
CLINICAL EPIGENETICS
(2021)