Article
Oncology
David Fielding, Andrew J. Dalley, Mahendra Singh, Lakshmy Nandakumar, Vanessa Lakis, Haarika Chittoory, David Fairbairn, Ann-Marie Patch, Stephen H. Kazakoff, Kaltin Ferguson, Farzad Bashirzadeh, Michael Bint, Carl Pahoff, Jung Hwa Son, Kimberley Ryan, Alan Hodgson, Sowmya Sharma, John V. Pearson, Nicola Waddell, Sunil R. Lakhani, Gunter Hartel, Peter T. Simpson, Katia Nones
Summary: Tumour Mutation Burden (TMB) is a potential biomarker for immune cancer therapies, and this study investigated parameters affecting TMB using duplicate cytology smears obtained from malignant lymph nodes sampled by EBUS TBNA. The results showed minimal variation in TMB in most cases with repeated samples of a lymph node station.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Wei Liu, Yongxue Wang, Weidong Zhang, Huaiqiu Wu, Zhiguang Liu
Summary: This case report describes a 28-year-old male with mediastinal cyst diagnosed as lymphangioma through EBUS examination, with subsequent infection after the procedure and recovery following treatment. EBUS-TBNA is a useful tool for mediastinal cyst management but requires careful execution to avoid complications.
Review
Respiratory System
Jose Sanz-Santos, Pere Almagro, Komal Malik, Pablo Martinez-Camblor, Conxi Caro, Ramon Rami-Porta
Summary: The current guidelines recommend invasive staging for non-small cell lung cancer (NSCLC) with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). However, the indication for confirming a negative EBUS-TBNA result with video-assisted mediastinoscopy (VAM) before resection varies in different guidelines. This study evaluates the evidence for the added value of confirmatory VAM after a negative EBUS-TBNA result in NSCLC mediastinal staging, and finds that confirmatory VAM can reduce the rate of unforeseen N2/3 disease, but with a high number needed to treat (NNT), and should be recommended only for specific cases yet to be defined.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Cardiac & Cardiovascular Systems
Maribel Botana-Rial, Irene Lojo-Rodriguez, Virginia Leiro-Fernandez, Cristina Ramos-Hernandez, Almudena Gonzalez-Montaos, Luis Pazos-Area, Manuel Nunez-Delgado, Alberto Fernandez-Villar
Summary: CryoEBUS has shown higher diagnostic usefulness compared to EBUS-TBNA for mediastinal and hilar involvement, especially in cases of benign pathologies and other tumor types such as lymphomas. Samples obtained by cryoEBUS also allow for better histological subtyping of lymphoma and complete molecular characterization in cases of lung cancer.
RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Huzaifa A. Jaliawala, Samid M. Farooqui, Kassem Harris, Tony Abdo, Jean I. Keddissi, Houssein A. Youness
Summary: EBUS-TBNA, as the procedure of choice for sampling hilar and mediastinal adenopathy, has been studied extensively in the last two decades. New ultrasound scanning modes and tools have been introduced to optimize target lymph node selection and sampling, potentially reducing passes, procedure time, and increasing diagnostic yield.
Article
Oncology
Tetsuya Sakai, Hibiki Udagawa, Keisuke Kirita, Shogo Nomura, Ryo Itotani, Yutaro Tamiya, Akira Sugimoto, Takahiro Ota, Tomoyuki Naito, Hiroki Izumi, Kaname Nosaki, Takaya Ikeda, Yoshitaka Zenke, Shingo Matsumoto, Kiyotaka Yoh, Seiji Niho, Tokiko Nakai, Genichiro Ishii, Koichi Goto
Summary: This study compared the diagnostic yield of using 22G and 25G needles for EBUS-TBNA in diagnosing lymph node metastasis of lung cancer. The results showed no significant difference in the malignant cell detection rate between the two needle gauges, but the 22G needle provided larger tissue samples and specimens with more malignant cells.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Respiratory System
Yu Okubo, Yuji Matsumoto, Midori Tanaka, Tatsuya Imabayashi, Yasuhito Uezono, Shun-ichi Watanabe, Takaaki Tsuchida
Summary: The use of a 25-gauge needle for endobronchial ultrasound-guided transbronchial needle aspiration in LN staging of lung cancer provides a high sampling rate and diagnostic accuracy, covers multiple stations, and provides enough tissue for genetic testing.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Medicine, General & Internal
Ching-Wei Wang, Muhammad-Adil Khalil, Yi-Jia Lin, Yu-Ching Lee, Tsai-Wang Huang, Tai-Kuang Chao
Summary: Lung cancer is the leading cause of cancer deaths worldwide, and accurate nodal staging is crucial for determining treatment strategies. This paper proposes a fast, efficient, and fully automatic deep convolutional neural network system for advanced lung cancer staging using EBUS-TBNA cytological WSIs. The method achieves high precision and sensitivity in experiments, outperforming state-of-the-art models and reducing computational time compared to other methods.
Article
Oncology
Duilio Divisi, Gabriella Di Leonardo, Massimiliano Venturino, Elisa Scarnecchia, Alessandro Gonfiotti, Domenico Viggiano, Marco Lucchi, Alessandro Bertani, Maria Giovanna Mastromarino, Roberto Crisci
Summary: This study analyzed the role of endobronchial ultrasound (EBUS) in the preoperative staging of non-small cell lung cancer (NSCLC) and found that it has high sensitivity, specificity, and accuracy. EBUS is a minimally invasive and easy procedure that ensures patient safety.
Article
Cardiac & Cardiovascular Systems
Terunaga Inage, Kosuke Fujino, Yamato Motooka, Tsukasa Ishiwata, Hideki Ujiie, Nicholas Bernards, Alexander Gregor, Zhenchian Chen, Masato Aragaki, Tomonari Kinoshita, Ichiro Yoshino, Kazuhiro Yasufuku
Summary: The study demonstrated the feasibility of using EBUS-TBNI for thrombolysis of pulmonary emboli, showing promising results in clot dissolution without complications in experimental pig models.
ANNALS OF THORACIC SURGERY
(2021)
Article
Pathology
Atsuko Seki, Deborah J. Chute
Summary: This study investigated the use of EBUS-TBNA in young adults. The procedure was most commonly performed to evaluate lymphadenopathy and lung nodules in this population, with granulomatous disease being the most common benign finding. Although rare, primary lung cancer and metastasis from other sites do occur in young adults, with sarcoma being the most common pathology.
Article
Medicine, General & Internal
Wei Liu, Yun Li, Lingjia Chen, Zhiguang Liu, Weidong Zhang
Summary: This article presents a case of right upper mediastinal schwannoma, including its diagnosis, treatment, and outcome. The patient underwent EBUS-TBNA, which provided cell blocks for pathological examination, confirming the diagnosis of schwannoma. Surgical excision was performed based on the EBUS-TBNA and postsurgical pathology results. The patient had an uneventful recovery and remained symptom-free during the 4-year follow-up period.
Article
Respiratory System
Jing Zhang, Jie-Ru Guo, Zan-Sheng Huang, Wan-Lei Fu, Xian-Li Wu, Na Wu, Wolfgang M. Kuebler, Felix J. F. Herth, Ye Fan
Summary: This study demonstrated that transbronchial mediastinal cryobiopsy monitored by endosonography is a safe and effective approach for diagnosing mediastinal lesions, with higher diagnostic yield compared to traditional needle aspiration techniques.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Surgery
Taiki Fujiwara, Takahiro Nakajima, Terunaga Inage, Yuki Sata, Takayoshi Yamamoto, Yuichi Sakairi, Hironobu Wada, Hidemi Suzuki, Masako Chiyo, Ichiro Yoshino
Summary: This study retrospectively evaluated the feasibility of using EBUS-TBNA for lymph node examination in patients previously treated for lung cancer, demonstrating high diagnostic accuracy in both detecting recurrence and nodal metastasis.
Article
Oncology
Mari Tone, Minoru Inomata, Nobuyasu Awano, Naoyuki Kuse, Kohei Takada, Jonsu Minami, Yutaka Muto, Kazushi Fujimoto, Toshio Kumasaka, Takehiro Izumo
Summary: This study compared the adequacy of TBLC and EBUS-TBNA samples for NGS analysis, and found that TBLC samples had significantly fewer genes that could not be evaluated and a greater total area of tumor cells. In the TBNA group, there were two fully inadequate samples for NGS analysis, while there were none in the TBLC group. Therefore, TBLC is more effective in obtaining adequate samples for NGS analysis in lung cancer patients.
Article
Cardiac & Cardiovascular Systems
Clara Marquina, Stella Talic, Sandra Vargas-Torres, Marjana Petrova, Dina Abushanab, Alice Owen, Sean Lybrand, David Thomson, Danny Liew, Ella Zomer, Zanfina Ademi
Summary: The study estimated the health and economic burden of cardiovascular disease in Australia from 2020 to 2029, finding a significant impact in terms of morbidity, mortality, healthcare costs, and productivity losses. The model projected a high number of fatal and non-fatal cardiovascular events, with a substantial number of Australians expected to have prevalent cardiovascular disease by 2029. The total cost of cardiovascular disease, including healthcare costs and productivity losses, was projected to exceed a significant amount in Australian dollars.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dina Abushanab, Daoud Al-Badriyeh, Danny Liew, Zanfina Ademi
Summary: This study evaluated the cost-effectiveness of first-line empagliflozin plus standard care for patients with newly diagnosed type 2 diabetes and existing cardiovascular disease. The results indicate that adding empagliflozin to standard care can provide additional years of life and quality-adjusted life years for patients at a reasonable cost.
CURRENT PROBLEMS IN CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Ruth S. Martin, Barbara J. Hayes, Anastasia Hutchinson, Paul Yates, Wen Kwang Lim
Summary: This study introduced GOPC medical treatment orders in three residential aged care facilities to improve healthcare decision-making for residents. The healthcare providers identified ACP and GOPC as positive tools for assisting with medical decision-making, despite some barriers.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Nursing
Fazila Aloweni, Stephane L. Bouchoucha, Ana Hutchinson, Shin Yuh Ang, Hui Xian Toh, Nur' Azzah Bte Suhari, Raden Nurheryany Bte Sunari, Siew Hoon Lim
Summary: This study explored the experiences and concerns of healthcare workers regarding the prolonged use of personal protective equipment (PPE) in clinical settings. The results showed that PPE-related side effects were common, with the majority of them being reported by nurses and those working in high-risk areas. The study also found that while most participants believed PPE supplies were readily available and training was sufficient, only a small percentage reported feeling highly confident in overall PPE protection.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Nursing
Mirella Keast, Anastasia F. Hutchinson, Damien Khaw, Joanne McDonall
Summary: This study aimed to explore patient perceptions of postoperative pain impact on acute recovery following Total Knee Arthroplasty (TKA), and barriers and facilitators to participating in pain management. The majority of patients experienced severe pain on postoperative Day 3, but their participation in pain management was limited due to factors such as reliance on prior instruction, limited knowledge, inconsistent promotion of non-pharmacologic strategies, and suboptimal clinician-patient communication. Regular analgesia was identified as a facilitator for patient participation.
PAIN MANAGEMENT NURSING
(2022)
Article
Geriatrics & Gerontology
Joanne Tropea, Debra Nestel, Christina Johnson, Barbara J. Hayes, Anastasia F. Hutchinson, Caroline Brand, Brian H. Le, Irene Blackberry, Gideon A. Caplan, Ross Bicknell, Graham Hepworth, Wen K. Lim
Summary: People with dementia living in nursing homes often have suboptimal access to quality palliative and end-of-life care. This study evaluated the effectiveness of a simulation training intervention for nursing home staff in reducing unplanned hospital transfers and deaths among residents with dementia. The results showed no significant difference in these outcomes between the intervention and control groups.
Review
Cardiac & Cardiovascular Systems
Benjamen Wang, Justin Verrocchi, Danny Liew, Dominica Zentner
Summary: This study aims to compare the long-term outcomes after cardiac surgery in adults with and without Down syndrome (DS). The meta-analysis showed that DS does not affect long-term survival after congenital cardiac surgery in adulthood, but individuals with DS have a lower risk of cardiac reoperation. The study is limited by limited sample sizes and clinical heterogeneity.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Psychology, Multidisciplinary
Mataya Kilpatrick, Ana Hutchinson, Elizabeth Manias, Stephane L. Bouchoucha
Summary: This article aims to explore how Terror Management Theory (TMT) is used to explain children's, adolescents', and parents' behavior in situations that increase mortality salience through a systematic review. The findings indicate that adolescents comprehend death and exhibit mortality salience reactions similar to adults, highlighting the potential for TMT to explain children's and adolescents' social behavior in high-stress situations.
Article
Endocrinology & Metabolism
Jedidiah Morton, Clara Marquina, Jonathan E. Shaw, Danny Liew, Kevan R. Polkinghorne, Zanfina Ademi, Dianna J. Magliano
Summary: The use of SGLT2i is cost-effective based on cardiovascular and kidney benefits for people with type 2 diabetes, while the use of GLP-1 RA is not.
Review
Health Care Sciences & Services
David Glanville, Anastasia Hutchinson, Damien Khaw
Summary: This study reviewed the use of mobile health apps in nursing clinical decision-making. The findings suggest that mobile health apps have a positive impact on nursing decisions, care quality, and acceptance. However, more research is needed to determine the true potential of these apps in optimizing acute nursing care.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Emergency Medicine
Megan Hayes, Ana Hutchinson, Debra Kerr
Summary: The study found gender-based differences in the pharmacological management of acute abdominal pain in the emergency department. Men were more likely to receive combined opioid and non-opioid medication as first-line analgesia, while women were more likely to receive their first analgesic after 90 minutes from ED presentation and waited longer before receiving the second analgesia.
AUSTRALASIAN EMERGENCY CARE
(2023)
Article
Public, Environmental & Occupational Health
M. Kilpatrick, A. Hutchinson, E. Manias, S. L. Bouchoucha
Summary: This study aimed to explore nurses' understanding of antimicrobial stewardship and infection prevention and control practices. Through interviews and analysis of 43 nurses, the study found that nurses had some understanding of preventable infections, protecting patients based on guidelines, and their role in antimicrobial stewardship. However, there was a lack of understanding of pediatric COVID-19 transmission and presentations. The study highlighted the importance of educating nurses and parents on best practices in infection prevention and antimicrobial stewardship.
JOURNAL OF HOSPITAL INFECTION
(2023)
Review
Rehabilitation
Elyse Ladbrook, Stephane Bouchoucha, Ana Hutchinson
Summary: This scoping review synthesized the evidence on medical complications in adult patients in subacute inpatient rehabilitation and their impact on length of stay and readmission. The findings revealed that patients admitted for inpatient rehabilitation are at a high risk of medical complications and may require ongoing management by clinicians with expertise in functional rehabilitation and a multidisciplinary team.
JOURNAL OF REHABILITATION MEDICINE
(2022)
Article
Endocrinology & Metabolism
Anthony Pease, Emily Callander, Ella Zomer, Mary B. Abraham, Elizabeth A. Davis, Timothy W. Jones, Danny Liew, Sophia Zoungas
Summary: The study found that HCL therapy was more cost-effective than current care for young people with type 1 diabetes in Australia. The incremental cost-effectiveness ratio was AUD $32,789 per QALY gained, with the majority of simulations falling below the willingness-to-pay threshold of AUD $50,000 per QALY gained. Sensitivity analyses indicated that the results were robust.
Article
Health Care Sciences & Services
Jo McDonall, Bernice Redley, Patricia Livingston, Ana Hutchinson, Richard de Steiger, Mari Botti
Summary: This paper describes an implementation strategy and evaluation to examine the contextual factors for successful adoption of new technology by nurses in acute postoperative care. The results show positive outcomes in terms of patient participation and acceptance, but difficulties in assessing nurse engagement with the program.
JMIR HUMAN FACTORS
(2022)