Article
Oncology
Konstantinos Grapatsas, Fabian Doerr, Hruy Menghesha, Martin Schuler, Viktor Gruenwald, Sebastian Bauer, Hartmut H. -J. Schmidt, Stephan Lang, Rainer Kimmig, Stefan Kasper, Natalie Baldes, Servet Boeluekbas
Summary: This study investigates the morbidity and mortality after pulmonary metastasectomy (PM) and develops a score to predict high-risk patients. Preoperative cardiovascular comorbidities, major lung resections, repeated pulmonary metastasectomy, and open thoracotomy are identified as independent factors for postoperative complications. The developed Essen score can accurately predict the occurrence of postoperative complications.
Article
Oncology
Theresa Stork, Rebecca Boemans, Jendrik Hardes, Arne Streitburger, Uta Dirksen, Christoph Poettgen, Hans-Ulrich Schildhaus, Sebastian Bauer, Stephane Collaud, Clemens Aigner
Summary: PM is a safe procedure with encouraging long-term outcomes. Patients with more than three metastases and progression under chemotherapy had significantly worse OS.
Article
Oncology
Fumiaki Takatsu, Hiromasa Yamamoto, Yasuaki Tomioka, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Katsuhito Takahashi, Shinichi Toyooka
Summary: This study retrospectively analyzed patients with retroperitoneal sarcoma metastasized to the lungs and found that age, disease-free interval, and size of metastasis were associated with prognosis. Pulmonary metastasectomy can be an effective management strategy for these patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Mohamed Hassan, Benjamin Ehle, Bernward Passlick, Konstantinos Grapatsas
Summary: This study investigated the feasibility and survival rate of pulmonary metastasectomy (PM) in elderly patients. The results showed no significant difference in the rate of postoperative complications and length of hospital stay between the elderly group and the non-elderly group. Although the 5-year survival rate was slightly lower in the elderly group compared to the non-elderly group, the difference was not statistically significant. COPD was associated with poor survival in the elderly group.
Article
Surgery
Byung Min Lee, Jee Suk Chang, Woong Sub Koom, Hwa Kyung Byun, Han Sang Kim, Seung-Hoon Beom, Caleb Oh, Young Joo Suh, Joong Bae Ahn, Sang Joon Shin, Byung Jo Park, Seong Yong Park
Summary: This study aimed to assess the effect of local ablative therapy (LAT) on overall survival in patients with lung metastases from colorectal cancer (CRC). The results showed that patients treated with LAT had significantly higher survival rates compared to those treated with systemic therapy alone.
Article
Oncology
Pina Ziranu, Paolo Albino Ferrari, Francesco Guerrera, Pietro Bertoglio, Alessandro Tamburrini, Andrea Pretta, Paraskevas Lyberis, Giulia Grimaldi, Eleonora Lai, Massimiliano Santoru, Fabio Bardanzellu, Laura Riva, Francesca Balconi, Eleonora Della Beffa, Marco Dubois, Matteo Pinna-Susnik, Clelia Donisi, Enrico Capozzi, Valeria Pusceddu, Alessandro Murenu, Marco Puzzoni, Federico Mathieu, Sabrina Sarais, Aiman Alzetani, Luca Luzzi, Piergiorgio Solli, Piero Paladini, Enrico Ruffini, Roberto Cherchi, Mario Scartozzi
Summary: This study analyzed the data of 260 colorectal cancer patients with lung metastases and established the Meta-Lung Score, which can provide valuable prognostic information and guide surgical selection and prognosis assessment.
Article
Oncology
Halla Vidarsdottir, Christina Siesing, Bjorn Nodin, Per Jonsson, Jakob Eberhard, Karin Jirstrom, Hans Brunnstrom
Summary: This study investigated prognostic factors in CRC patients treated with pulmonary metastasectomy, including the expression of RBM3. The research found that factors such as age, number of metastases, size of metastasis, disease-free interval, RBM3 score in lung metastasis, and adjuvant chemotherapy were associated with overall survival in these patients.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Nagore Garcia-Exposito, Ricard Ramos, Valentin Navarro-Perez, Kevin Molina, Maria Dolores Arnaiz, Susana Padrones, Jose Carlos Ruffinelli, Cristina Santos, Ferran Guedea, Arturo Navarro-Martin
Summary: Colorectal cancer is a common malignancy and lung and liver are the most common sites of metastasis. Surgery has been the traditional treatment for lung metastases, but stereotactic body radiotherapy (SBRT) is becoming increasingly favored. This study aimed to compare the local control rates of SBRT and surgery in patients with colorectal cancer lung metastases.
Article
Oncology
Michel Gonzalez, Marcello Migliore
Summary: This study updates a previously proposed classification system for pulmonary metastases in order to explore predictive and survival prognostic factors, as well as to differentiate patients who will benefit from lung metastasectomy. The secondary objective is to provide a common language for physicians, oncologists, and surgeons to compare data and evaluate treatment results for lung metastases.
Review
Surgery
Giuseppe Mangiameli, Ugo Cioffi, Marco Alloisio, Alberto Testori
Summary: Pulmonary metastasectomy is an established treatment option for patients with lung metastases, providing improved long-term survival. This mini-review discusses the current state and future perspectives of thoracic surgery in the surgical management of lung metastases, emphasizing the principles of surgical therapy and reporting on surgical indications and oncological results.
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Hope A. Feldman, Nicolas Zhou, Mara B. Antonoff, Wayne L. Hofstetter, Ravi Rajaram, David C. Rice, Boris Sepesi, Ara A. Vaporciyan, Andres Zorrilla-Vaca, Reza J. Mehran
Summary: In carefully selected patients, simultaneous bilateral metastasectomy is a safe option that offers advantages such as shorter length of stay and shorter operative time compared to staged procedures.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Filippo Tommaso Gallina, Enrico Melis, Luca Bertolaccini, Lorenzo Spaggiari, Michele Rocca, Davide Maria Donati, Marco Chiappetta, Stefano Margaritora, Pietro Bertoglio, Piergiorgio Solli, Marco Mammana, Federico Rea, Elisa Concetta Onesti, Virginia Ferraresi, Isabella Sperduti, Gennaro Ciliberto, Francesco Facciolo
Summary: This study aimed to construct a composite prognostic score for patients with metachronous oligometastatic sarcoma. Through a retrospective analysis of patients who underwent radical surgery, it was found that a longer disease-free interval and a lower neutrophil-to-lymphocytes ratio were predictive of better survival. A prognostic score was developed based on these factors, which effectively predicted outcomes for surgically treated patients with lung metastases from sarcoma.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Takaaki Hasegawa, Hiroaki Kuroda, Noriaki Sakakura, Yozo Sato, Shohei Chatani, Shinichi Murata, Hidekazu Yamaura, Takeo Nakada, Yuko Oya, Yoshitaka Inaba
Summary: The hybrid treatment involving surgery and radiofrequency ablation showed promising outcomes for patients with multiple lung metastases. However, complications such as empyema, pneumothorax, and lung abscess were observed. During follow-up, 59% of patients developed new metastases, with a 5-year disease-free survival rate of 32%. Factors such as having four or fewer lung metastases and metastases from colorectal carcinoma significantly influenced disease-free survival.
Article
Oncology
Pierina Navarria, Davide Baldaccini, Elena Clerici, Beatrice Marini, Luca Cozzi, Davide Franceschini, Alexia Francesca Bertuzzi, Vittorio Quagliuolo, Valter Torri, Piergiuseppe Colombo, Ciro Franzese, Luisa Bellu, Marta Scorsetti
Summary: This study aimed to assess the role of SBRT in patients with lung metastases. The results showed that SBRT can effectively control lung metastases with minimal toxicity, and the overall survival rate was satisfactory.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Rachel M. Lee, Cecilia G. Ethun, Adriana C. Gamboa, Michael K. Turgeon, Thuy Tran, George Poultsides, Valerie Grignol, Meena Bedi, Harveshp Mogal, Callisia N. Clarke, Jennifer Tseng, Kevin K. Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A. Krasnick, Ryan C. Fields, Shervin Oskouei, David K. Monson, Nickolas B. Reimer, Shishir K. Maithel, Allan Pickens, Kenneth Cardona
Summary: Surgical resection for sarcoma lung metastases is associated with improved overall survival. Patients with certain characteristics, such as older age, retroperitoneal primary tumor, R1 resection of primary tumor, and multiple lung metastases, have decreased overall survival. A risk score was developed to stratify patients into low-risk and high-risk groups, with significantly better 5-year overall survival in low-risk patients. This risk score may be an important tool for preoperative counseling and consideration for multimodal therapy.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Summary: This study aimed to compare the postoperative and pathological outcomes between CROSS and FLOT in EAC patients. The study found that CROSS had a higher 90-day mortality rate compared to FLOT, mainly due to cardio-pulmonary complications. Additionally, CROSS had higher rates of pathologic complete response and margin-negative resections compared to FLOT. Further research is needed to understand the causes and mechanisms of the higher mortality rate with CROSS and its impact on long-term survival.
Editorial Material
Cardiac & Cardiovascular Systems
Dirk Van Raemdonck, Laurens J. Ceulemans, Dieter Van Beersel, Arne Neyrinck
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Dirk Van Raemdonck, Laurens J. Ceulemans, Robin Vos, Geert M. Verleden
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Editorial Material
Surgery
Michaela Orlitova, Marc Gewillig, Jan Van Slambrouck, Dirk Vlasselaers, Bart Jacobs, Arne P. Neyrinck, Lieven Depypere, Laurent Godinas, Robin Vos, Geert M. Verleden, Dirk E. Van Raemdonck, Laurens J. Ceulemans
Summary: Pulmonary vein stenosis (PVS) and pulmonary vein occlusion (PVO) are rare complications after lung transplantation (LTx) with limited treatment options and a high risk of graft loss. We describe two cases of successful endovascular transatrial stenting following double LTx. Both patients, one with chronic obstructive pulmonary disease and the other with idiopathic pulmonary arterial hypertension, underwent endovascular transatrial dilatation and stenting to treat PVS and PVO respectively, avoiding the need for surgical reintervention. This treatment option appears to be effective and safe for these life-threatening complications after LTx.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Oncology
Tom Vandaele, Jan Van Slambrouck, Viktor Proesmans, Paul Clement, Maarten Lambrecht, Philippe Nafteux, Dirk Van Raemdonck, Laurens J. Ceulemans
Summary: This review provides an overview of the current literature on hyperthermic intrathoracic chemotherapy (HITHOC) for thymoma with pleural dissemination (TPD). The results suggest that combining cytoreductive surgery and HITHOC is feasible and safe for TPD, but there is significant heterogeneity in the literature, calling for further research to better understand the additional benefit of HITHOC in TPD treatment.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Alessio Vagliasindi, Filippo Di Franco, Maurizio Degiuli, Davide Papis, Marcello Migliore
Summary: The role of two- or three-field nodal dissection in the surgical treatment of esophageal and gastroesophageal junction cancer in the minimally invasive era is still controversial. This review aims to clarify the extension of nodal dissection in esophageal and gastroesophageal junctional cancer. Three-field lymph node dissection improves staging accuracy, enhances locoregional disease control and might improve survival in the group of patients with cervical and upper mediastinal metastatic lymph nodal involvement from middle and proximal-third esophageal cancer.
Article
Medicine, General & Internal
Jan Van Slambrouck, Mona Khan, Erik Verbeken, Sumin Choi, Vincent Geudens, Cedric Vanluyten, Simon Feys, Emiel Vanhulle, Elke Wollants, Kurt Vermeire, Charlotte De Fays, Lucia Aversa, Janne Kaes, Dirk Van Raemdonck, Robin Vos, Bart Vanaudenaerde, Gert De Hertogh, Els Wauters, Joost Wauters, Laurens J. Ceulemans, Peter Mombaerts
Summary: A study introduces a methodology for visualizing the replication of SARS-CoV-2 in the lungs at single-cell resolution. The method utilizes fluorescence staining and confocal imaging to observe viral replication in histological sections. This technique can be valuable for studying SARS-CoV-2 variants and other respiratory viruses.
Review
Oncology
Erik Claes, Reinier Wener, Arne P. Neyrinck, Axelle Coppens, Paul E. Van Schil, Annelies Janssens, Therese S. Lapperre, Annemiek Snoeckx, Wen Wen, Hanne Voet, Stijn E. Verleden, Jeroen M. H. Hendriks
Summary: Lung cancer is the leading cause of cancer-related deaths, and surgery is the preferred treatment for early-stage cancer. However, for more advanced stages, a multimodal treatment approach consisting of chemotherapy, radiotherapy, and/or immunotherapy is recommended. Loco-regional techniques have gained interest due to their potential advantages over current therapies. This article provides an overview of established and promising invasive loco-regional techniques categorized by route of administration (endobronchial, endovascular, and transthoracic), along with their implementation and effectiveness. Further clinical studies are needed to ensure the efficacy and safety of these techniques before they can be widely used.
Editorial Material
Surgery
Marcello Migliore
WORLD JOURNAL OF SURGERY
(2023)
Review
Oncology
Lawek Berzenji, Wen Wen, Stijn Verleden, Erik Claes, Suresh Krishan Yogeswaran, Patrick Lauwers, Paul Van Schil, Jeroen M. H. Hendriks
Summary: In the last twenty years, minimally invasive surgery (MIS) has revolutionized surgical procedures. In thoracic surgery, video-assisted thoracoscopic surgery (VATS) and robotic-assisted thoracoscopic surgery (RATS) have become the new standards, especially for early-stage lung cancer. However, there is a lack of concrete data comparing the outcomes of these minimally invasive approaches to traditional open surgery. As lung cancer screening programs lead to the detection of more early-stage lung cancer, data on the effectiveness of VATS and RATS in treating it is needed.
Review
Surgery
Adewale Adisa
Summary: This study aims to prioritize feasible interventions to reduce the environmental impact of operating theatres. Through a four-phase Delphi consensus methodology, the results suggest that actionable interventions applicable to both high- and low-middle-income countries can be taken to achieve environmentally sustainable operating environments.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Oncology
Shao-Jun Xu, Rui-Qin Chen, Jia-Hua Tu, Cheng-Xiong You, Chao Chen, Zhi-Fan Zhang, Duilio Divisi, Marcello Migliore, Stefano Bongiolatti, Marion Durand, Masaaki Sato, Hiroaki Kuroda, Chao-Fu Yang, Shao-Bin Yu, Shu-Chen Chen
Summary: This study aimed to evaluate the effect of a radiographically manifested ground-glass opacity (GGO) component on the prognosis of patients with pathological stage IA3 lung adenocarcinoma. The presence of a GGO component was associated with lower rates of recurrence and death, and better tumor-specific survival. Therefore, different treatment and follow-up strategies should be developed based on the presence or absence of GGO components.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Surgery
Hanne Beeckmans, Elfri Van Roy, Janne Kaes, Annelore Sacreas, Vincent Geudens, Astrid Vermaut, Lynn Willems, Xin Jin, Saskia Bos, Arno Vanstapel, Jan Van Slambrouck, Michaela Orlitova, Bart Vanaudenaerde, Laurens J. J. Ceulemans, Dirk Van Raemdonck, Arne P. P. Neyrinck, Laurent Godinas, Lieven J. J. Dupont, Geert M. M. Verleden, Robin Vos
Summary: Fungal exposure and sensitization negatively impact respiratory diseases, including lung transplant recipients. This study examines the correlation between fungal-specific antibodies, fungal isolation, chronic lung allograft dysfunction (CLAD), and overall survival in 311 lung transplant patients. The results show that elevated levels of Aspergillus fumigatus or Aspergillus flavus IgG are associated with more fungal isolation and CLAD. However, IgE levels and fungal isolation are not correlated with CLAD or death. Mold and Aspergillus species isolation are associated with CLAD occurrence, while Aspergillus species isolation is also linked to impaired survival. Fungus-specific IgG could serve as a non-invasive marker for fungal exposure and a diagnostic tool for identifying high-risk patients in long-term follow-up post-lung transplant.
TRANSPLANT INTERNATIONAL
(2023)
Article
Surgery
Matteo Marro, Miguel M. Leiva-Juarez, Frank D'Ovidio, Justin Chan, Dirk Van Raemdonck, Laurens Joseph Ceulemans, Paula Moreno, Antonio Alvarez Kindelan, Thorsten Krueger, Angela Koutsokera, Jonas Peter Ehrsam, Ilhan Inci, Alkin Yazicioglu, Erdal Yekeler, Massimo Boffini, Geoffrey Brioude, Pascal Alexandre Thomas, Nikolaus Pizanis, Clemens Aigner, Marco Schiavon, Federico Rea, Marco Anile, Federico Venuta, Shaf Keshavjee
Summary: This study describes the outcomes of lung transplantation in the largest population of PCD patients, including those with situs abnormalities. It found that lung transplantation is an acceptable treatment option for PCD, with no significant differences in survival or freedom from chronic lung allograft dysfunction between PCD patients with and without situs abnormalities.
TRANSPLANT INTERNATIONAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Ding, Jingyu Zhang, Weitao Zhuang, Zhen Gao, Kaiming Kuang, Dan Tian, Cheng Deng, Hansheng Wu, Rixin Chen, Guojie Lu, Gang Chen, Paolo Mendogni, Marcello Migliore, Min-Woong Kang, Ryu Kanzaki, Yong Tang, Jiancheng Yang, Qiuling Shi, Guibin Qiao
Summary: A new pulmonary nodule diagnostic model was constructed in this study, which showed high diagnostic efficiency, non-invasiveness, and simplicity in measurement. By combining the 7-AAB panel, AI diagnostic system, and other clinical features, the model demonstrated good diagnostic performance in distinguishing lung nodules, especially those with diameters ≤ 2 cm.
EUROPEAN RADIOLOGY
(2023)