Article
Medicine, General & Internal
Huzaifa A. Jaliawala, Samid M. Farooqui, Kassem Harris, Tony Abdo, Jean I. Keddissi, Houssein A. Youness
Summary: EBUS-TBNA, as the procedure of choice for sampling hilar and mediastinal adenopathy, has been studied extensively in the last two decades. New ultrasound scanning modes and tools have been introduced to optimize target lymph node selection and sampling, potentially reducing passes, procedure time, and increasing diagnostic yield.
Review
Respiratory System
Jose Sanz-Santos, Pere Almagro, Komal Malik, Pablo Martinez-Camblor, Conxi Caro, Ramon Rami-Porta
Summary: The current guidelines recommend invasive staging for non-small cell lung cancer (NSCLC) with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). However, the indication for confirming a negative EBUS-TBNA result with video-assisted mediastinoscopy (VAM) before resection varies in different guidelines. This study evaluates the evidence for the added value of confirmatory VAM after a negative EBUS-TBNA result in NSCLC mediastinal staging, and finds that confirmatory VAM can reduce the rate of unforeseen N2/3 disease, but with a high number needed to treat (NNT), and should be recommended only for specific cases yet to be defined.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Oncology
Clara So, Yuji Matsumoto, Tatsuya Imabayashi, Keigo Uchimura, Yuichiro Ohe, Hideaki Furuse, Takaaki Tsuchida
Summary: This study retrospectively investigated the factors causing failure of nodal staging by EBUS-TBNA in NSCLC. The results showed that false positives with ROSE and the involvement of driver oncogenes were associated with nodal staging failure, in addition to limitations of the procedure itself. Especially in adenocarcinoma patients with driver oncogenes, their nodal staging results should be interpreted cautiously.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Terunaga Inage, Kosuke Fujino, Yamato Motooka, Tsukasa Ishiwata, Hideki Ujiie, Nicholas Bernards, Alexander Gregor, Zhenchian Chen, Masato Aragaki, Tomonari Kinoshita, Ichiro Yoshino, Kazuhiro Yasufuku
Summary: The study demonstrated the feasibility of using EBUS-TBNI for thrombolysis of pulmonary emboli, showing promising results in clot dissolution without complications in experimental pig models.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Wei Liu, Yun Li, Lingjia Chen, Zhiguang Liu, Weidong Zhang
Summary: This article presents a case of right upper mediastinal schwannoma, including its diagnosis, treatment, and outcome. The patient underwent EBUS-TBNA, which provided cell blocks for pathological examination, confirming the diagnosis of schwannoma. Surgical excision was performed based on the EBUS-TBNA and postsurgical pathology results. The patient had an uneventful recovery and remained symptom-free during the 4-year follow-up period.
Review
Gastroenterology & Hepatology
Zhiwang Li, Wei Liu, Xiaoda Xu, Peiyu Li
Summary: This study compared the diagnostic value and safety of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) in sampling solid lesions, showing that FNB has better diagnostic accuracy and tissue core rates in solid gastrointestinal lesions, with fewer needle passes, but no difference in solid pancreatic disease.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Surgery
Taiki Fujiwara, Takahiro Nakajima, Terunaga Inage, Yuki Sata, Takayoshi Yamamoto, Yuichi Sakairi, Hironobu Wada, Hidemi Suzuki, Masako Chiyo, Ichiro Yoshino
Summary: This study retrospectively evaluated the feasibility of using EBUS-TBNA for lymph node examination in patients previously treated for lung cancer, demonstrating high diagnostic accuracy in both detecting recurrence and nodal metastasis.
Article
Medicine, General & Internal
Hyun Seok Lee, Eaum-Seok Lee
Summary: This article reports a case of an unexpected catecholamine crisis that occurred after EUS-FNB. Despite being considered relatively safe, careful evaluation is required when performing biopsy of lesions around the aorta.
Article
Medicine, General & Internal
Roberto Piro, Matteo Fontana, Eleonora Casalini, Laura Rossi, Maria Serena Simeone, Federica Ghinassi, Patrizia Ruggiero, Chiara Pollorsi, Sofia Taddei, Bianca Beghe', Nicola Cosimo Facciolongo
Summary: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a safe and accurate diagnostic procedure for investigating mediastinal pathologies. This study compared the accuracy and safety of EBUS-TBNA through the nasal route with the oral route, and found that the nasal route is a valid alternative with similar outcomes.
Article
Medicine, General & Internal
Filiz Oezkan, Woo Yul Byun, Clemens Loeffler, Udo Siebolts, Linda Diessel, Nina Lambrecht, Stephan Eisenmann
Summary: Advancements in personalized medicine have increased the demand for tissue preservation and quantity in EBUS-TBNA samples. This study compared the characteristics, diagnostic accuracy, and patient safety of the SonoTip TopGain(R) and ViziShot 2(R) needles. The results showed that when cartilage penetration was avoided, the SonoTip TopGain(R) needle allowed for sampling of more material.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Xuefeng Sun, Ting Zhang, Chi Shao, Ping Wang, Minjiang Chen, Jing Zhao, Mengzhao Wang
Summary: A retrospective analysis was conducted to evaluate the diagnostic value of all-shot aspirations and no-tissue-core aspirations in endobronchial ultrasound-guided transbronchial needle aspiration procedures. The results showed that patients with all-shot aspirations were more likely to have a pathologic and clinical diagnosis of malignancy compared to patients with no-tissue-core aspirations. It is important to take additional measures to exclude malignancy in all-shot patients when the endobronchial ultrasound-guided transbronchial needle aspiration was nondiagnostic.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Respiratory System
Yu Okubo, Yuji Matsumoto, Midori Tanaka, Tatsuya Imabayashi, Yasuhito Uezono, Shun-ichi Watanabe, Takaaki Tsuchida
Summary: The use of a 25-gauge needle for endobronchial ultrasound-guided transbronchial needle aspiration in LN staging of lung cancer provides a high sampling rate and diagnostic accuracy, covers multiple stations, and provides enough tissue for genetic testing.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Medicine, General & Internal
Shi-Jie Li, Qi Wu
Summary: This study evaluated the value of EBUS-TBNA in diagnosing intrathoracic lymphadenopathy in patients with extrathoracic malignancies. The results showed that EBUS-TBNA has high sensitivity and accuracy, making it a simple and effective diagnostic method for patients with extrathoracic malignancies.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Medicine, General & Internal
Wei Liu, Yongxue Wang, Weidong Zhang, Huaiqiu Wu, Zhiguang Liu
Summary: This case report describes a 28-year-old male with mediastinal cyst diagnosed as lymphangioma through EBUS examination, with subsequent infection after the procedure and recovery following treatment. EBUS-TBNA is a useful tool for mediastinal cyst management but requires careful execution to avoid complications.
Article
Oncology
Tsukasa Ishiwata, Terunaga Inage, Alexander Gregor, Yamato Motooka, Harley H. L. Chan, Nicholas Bernards, Masato Aragaki, Zhenchian Chen, Hideki Ujiie, Tomonari Kinoshita, Andrew Effat, Kazuhiro Yasufuku
Summary: A thin convex probe endobronchial ultrasound bronchoscope (TCP-EBUS) has the potential to improve the diagnostic yield for intrapulmonary lesions over conventional bronchoscopes, with greater reach and real-time sampling under ultrasound guidance.
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Lyndon V. Hernandez, Michael B. Wallace, Deborah E. Bowman, Stephanie Kinnan, Dominic Klyve, Amandeep K. Shergill
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Do Han Kim, Somashekar G. Krishna, Emmanuel Coronel, Paul T. Kroner, Herbert C. Wolfsen, Michael B. Wallace, Juan E. Corral
Summary: Confocal laser endomicroscopy (CLE) is a useful tool for real-time diagnosis of pancreatobiliary disorders, with high sensitivity and specificity in distinguishing tumors, cysts, and other diseases. However, challenges such as cost, technical training, and image interpretation still need to be overcome for routine utilization.
CLINICAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Michael B. Wallace, Prateek Sharma, Pradeep Bhandari, James East, Giulio Antonelli, Roberto Lorenzetti, Micheal Vieth, Ilaria Speranza, Marco Spadaccini, Madhav Desai, Frank J. Lukens, Genci Babameto, Daisy Batista, Davinder Singh, William Palmer, Francisco Ramirez, Rebecca Palmer, Tisha Lunsford, Kevin Ruff, Elizabeth Bird-Liebermann, Victor Ciofoaia, Sophie Arndtz, David Cangemi, Kirsty Puddick, Gregory Derfus, Amitpal S. Johal, Mohammed Barawi, Luigi Longo, Luigi Moro, Alessandro Repici, Cesare Hassan
Summary: This study demonstrates that the use of artificial intelligence can significantly reduce the miss rate of colorectal neoplasia, especially for small and subtle lesions. This is of great importance in improving the prevention of colorectal cancer.
Article
Gastroenterology & Hepatology
Ji Young Lee, Audrey H. Calderwood, William Karnes, James Requa, Brian C. Jacobson, Michael B. Wallace
Summary: This study demonstrates the objective assessment of bowel preparation adequacy using an AI/CNN algorithm developed from colonoscopy videos, showing good performance and agreement with experts.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Kasper A. Overbeek, Nikki van Leeuwen, Matteo Tacelli, Muhammad S. Anwar, Muhammad N. Yousaf, Ankit Chhoda, Paolo Giorgio Arcidiacono, Tamas A. Gonda, Michael B. Wallace, Gabriele Capurso, James J. Farrell, Djuna L. Cahen, Marco J. Bruno
Summary: The study validated the performance of DART-1 in predicting the development of WFs or HRS in BD-IPMN, with risk estimations most accurate for patients in the middle risk quintile and slightly underestimated in the lowest quintiles.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Review
Gastroenterology & Hepatology
Pujan Kandel, Murtaza Hussain, Deepesh Yadav, Santosh K. Dhungana, Bhaumik Brahmbhatt, Massimo Raimondo, Frank J. Lukens, Ghassan Bachuwa, Michael B. Wallace
Summary: The application of snare tip soft coagulation (STSC) at the margins of mucosal defects can significantly reduce adenoma recurrence at the first surveillance colonoscopy and decrease the risk of bleeding complications, according to the findings of a systematic review and meta-analysis.
ENDOSCOPY INTERNATIONAL OPEN
(2022)
Editorial Material
Gastroenterology & Hepatology
Michael B. Wallace, Stephanie Kinnan
Review
Oncology
Raefa Abou Khouzam, Jean-Marie Lehn, Hemma Mayr, Pierre-Alain Clavien, Michael Bradley Wallace, Michel Ducreux, Perparim Limani, Salem Chouaib
Summary: Hypoxia is a crucial characteristic of the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) and plays a significant role in its pathogenesis. This review focuses on the impact of hypoxia on genomic instability and the tumor immune microenvironment in PDAC. Strategies for alleviating hypoxia and their potential applications for diagnosis and therapy in PDAC patients will also be discussed.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sanne A. Hoogenboom, Megan M. L. Engels, Anthony Chuprin, Jeanin E. van Hooft, Jordan D. LeGout, Michael B. Wallace, Candice W. Bolan
Summary: This study aims to characterize the prevalence of missed pancreatic masses and PDAC-related findings on CT and MRI scans among pre-diagnostic patients and healthy individuals. The results show that radiological features such as pancreatic duct dilation and interruption, and focal atrophy are common first signs of PDAC and are often missed or unrecognized. Therefore, further investigation with dedicated pancreas imaging is recommended for patients with PDAC-related radiological findings.
ABDOMINAL RADIOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Marc Monachese, Jennifer M. Kolb, Kenneth J. Chang, Alyssa Y. Choi, Sagar Shah, Thomas J. Wang, Ahmad Bazarbashi, Ali Zakaria, Pushpak Taunk, Ali M. Abbas, Pedro Cortes, Michael B. Wallace, Bhaumik Brahmbhatt, Natalie D. Cosgrove, Wenjing Cai, David P. Lee, Prashant Kedia, Marvin Ryou, Jason B. Samarasena
Meeting Abstract
Gastroenterology & Hepatology
Megan M. Engels, Sanne A. Hoogenboom, Derk Klatte, Anthony Chuprin, Ahmed Ouni, Jason Klug, Panagiotis Korfiatis, Alexander D. Weston, Jeanin E. Van Hooft, Michael B. Wallace, Candice W. Bolan, Yan Bi
Meeting Abstract
Gastroenterology & Hepatology
Megan M. Engels, Sanne Hoogenboom, Ugur Demir, Tara Pattilachan, Jeanin E. Van Hooft, Yan Bi, Candice W. Bolan, Michael B. Wallace, Ulas Bagci
Article
Gastroenterology & Hepatology
Karthik Ravi, William Ross, Ara Sahakian, Brian Weston, Prasad G. Iyer, Amit Rastogi, Michael B. Wallace
GASTROINTESTINAL ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Babu P. Mohan, Antonio Facciorusso, Shahab R. Khan, Deepak Madhu, Lena L. Kassab, Suresh Ponnada, Saurabh Chandan, Stefano F. Crino, Gursimran S. Kochhar, Douglas G. Adler, Michael B. Wallace
Summary: Based on rigorous systematic review and meta-analysis, this study found that artificial intelligence performs well in the analysis of EUS-images of pancreatic lesions, with good accuracy, sensitivity, and specificity.
ENDOSCOPIC ULTRASOUND
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Marco Spadaccini, Ludovico Alfarone, Leonardo Da Rio, Roberta Maselli, Silvia Carrara, Piera Alessia Galtieri, Gaia Pellegatta, Alessandro Fugazza, Glenn Koleth, James Emmanuel, Andrea A. Anderloni, Yuichi Mori, Michael B. Wallace, Prateek Sharma, Alessandro Repici, Cesare Hassan
GASTROINTESTINAL ENDOSCOPY
(2022)