Article
Cardiac & Cardiovascular Systems
Alexander H. J. Staal, Kimberley R. G. Cortenbach, Mark A. J. Gorris, Lieke L. van der Woude, Mangala Srinivas, Robin H. Heijmen, Guillaume S. C. Geuzebroek, Nimrat Grewal, Konnie M. Hebeda, I. Jolanda M. de Vries, Marco C. DeRuiter, Roland R. J. van Kimmenade
Summary: This study reveals a significant presence of immune cells in dilating aortas of patients with bicuspid aortic valve (BAV). These findings raise the question of whether immune cells in BAV aortopathy are innocent bystanders or contribute to the deterioration of the aortic wall.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ari Mennander, Ivana Kholova, Saku Pelttari, Timo Paavonen
Summary: This study finds that the degeneration of the ascending aortic wall is less prominent in patients with bicuspid aortic valves (BAV) compared to tricuspid aortic valves (TAV), indicating that histopathology alone may not support the need for surgery of the dilated ascending aorta in BAV patients.
JOURNAL OF CARDIOTHORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Siavash Zamirpour, Yue Xuan, Zhongjie Wang, Axel Gomez, Joseph Leach, Dimitrios Mitsouras, David A. Saloner, Julius M. Guccione, Liang Ge, Elaine E. Tseng
Summary: This study evaluated the association between aortic area/height and peak aneurysm wall stresses, valve morphology, and 3-year all-cause mortality. The results showed that the aortic area/height ratio was more predictive of high circumferential stresses in bicuspid valve aneurysms, while peak longitudinal stress independently predicted all-cause mortality.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Mi Chen, Wangli Xu, Yan Ding, Honglei Zhao, Pei Wang, Bo Yang, Huanyu Qiao, Wei Zhang, Chenyang Zhou, Junnan Jia, Tao Bai, Jinrong Xue, Junming Zhu, Yongmin Liu, Weimin Li, Lizhong Sun
Summary: Long-term mortality and reoperation benefits associated with integrated aortic-valve and ascending-aortic replacement (IR) compared to partial replacement (PR) were found to be significant for patients with bicuspid aortic valve (BAV)-related aortopathy, with differences seen for different aortic diameter groups based on valve or aorta type.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Pediatrics
Emma C. Dunne, Ronald V. Lacro, Jonathan N. Flyer
Summary: The purpose of this review is to summarize and critically evaluate recent clinical and research advancements in pediatric BAV and its associated aortopathy. Recent findings show that progressive aortic dilation is commonly present in pediatric patients with BAV and is associated with increased risk for aortic aneurysm, dissection, and surgery in adulthood. Ongoing research aims to explore the cause, incidence, and progression of bicuspid aortopathy to improve early diagnosis and preventive management.
CURRENT OPINION IN PEDIATRICS
(2023)
Article
Oncology
Calogera Pisano, Antonella Marino Gammazza, Francesca Rappa, Rosario Barone, Rosalinda Allegro, Alessandro Pitruzzella, Alessia Tagliavia, Virginia Agostara, Giovanni Ruvolo, Francesco Cappello, Vincenzo Argano
Summary: The study found a correlation between ascending aortic wall degeneration in patients with aortic valve disease and the expression levels of miRNAs, especially miR-486, suggesting that it may be a non-invasive biomarker associated with the risk of dissection and rupture in BAV patients.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Medicine, General & Internal
Charles Cheng, Yohann Bohbot, Hector Michelena, Dan Rusinaru, Floriane Fay, Frederic Elmkies, Maurice Enriquez Sarano, Christophe Tribouilloy
Summary: This study describes the clinical history of patients with BAV across different age groups and evaluates the long-term outcomes of patients referred for surgery. The results showed high survival rates in both the surveillance and surgical groups, with low incidences of complications.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Multidisciplinary Sciences
Shuofang Ren, Yulin Wen, Guotao Ma, Qi Miao
Summary: Thrombus formation on a native bicuspid aortic valve without calcification or stenosis is rare. In this case, the thrombus was located at the orifice of the left coronary artery and caused symptoms similar to atherosclerosis. The patient is in excellent condition after surgery, with no apparent predisposing causes of thrombosis.
Article
Cardiac & Cardiovascular Systems
Pasquale Totaro, Simone Morganti, Ferdinando Auricchio, Stefano Pelenghi
Summary: This study found differences in the adaptability of the aortic wall to dilatation mechanism between patients with bicuspid aortic valve (BAV) and those with tricuspid aortic valve (TAV). The aortic wall thickness was thinner in BAV patients, and dilatation > 51 mm was a significant predictor of severely reduced aortic wall thickness in BAV patients.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Jose M. Siurana, Anna Sabate-Rotes, Ariadna Ayerza, Lorenzo Jimenez, Marc Figueras-Coll, Maria Aranzazu Gonzalez
Summary: This study aimed to find the best reference tool to define dilation of the aortic root and the ascending aorta in BAV adolescents with an adult body surface area (BSA). The results indicate that in the ascending aorta, it is advisable to switch to BSA-IV when children are older than 10 years old and have a BSA >= 1.5 m2.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Cardiac & Cardiovascular Systems
Yi-Jia Li, Wei-Guo Ma, Yue Qi, Jun-Ming Zhu, Ya Yang, Li-Zhong Sun
Summary: This study demonstrates that adherence to the 45mm size criterion for preemptive AAR during AVR in BAV patients is not associated with increased risk of adverse events, and may actually improve early surgical outcomes.
THORACIC AND CARDIOVASCULAR SURGEON
(2022)
Article
Physiology
Guillaume Goudot, Charles Cheng, Alexis F. Guedon, Tristan Mirault, Olivier Pedreira, Alexandre Dahan, Louise Z. Wang, Mathieu Pernot, Emmanuel Messas
Summary: This study developed an automated method for aortic data acquisition using ultrafast ultrasound imaging (UUI) to assess the aortic maximal rate of systolic distention (MRSD). The results showed that UUI technology can accurately track the aortic diameter and calculate the MRSD value, which is important for evaluating aortic diseases associated with bicuspid aortic valve.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bo Hwa Choi, Sung Min Ko, Je Kyoun Shin, Hyun Keun Chee, Jun Seok Kim
Summary: The study found that the morphological characteristics of BAV did not determine aortic dilatation, but age, sex, and severity of aortic stenosis were predictors of bicuspid aortopathy. This suggests that treatment planning for BAV patients should focus on age, sex, and aortic stenosis severity rather than valve morphology.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Olivier Milleron, Paul Masi, Ludivine Eliahou, Jean-Francois Paul, Florence Arnoult, Nadia Ould Ouali, Emmanuel Lansac, Richard Raffoul, Quentin Pellenc, Phalla Ou, Guillaume Jondeau
Summary: This study describes the asymmetry of bicuspid aortic valve (BAV) and its impact on aortic root diameter measurements obtained using transthoracic echocardiography. The study found that the orientation of the valve opening differed from the orientation of the largest root diameter in both groups of BAV. The parasternal long-axis view on transthoracic echocardiography significantly underestimated the maximal aortic root diameter in one group and modestly underestimated it in the other group.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)