Article
Oncology
Hansheng Wu, Weitao Zhuang, Shujie Huang, Xueting Guan, Yuju Zheng, Zefeng Xie, Gang Chen, Jiming Tang, Haiyu Zhou, Liang Xie, Xiaosong Ben, Zihao Zhou, Zijun Li, Rixin Chen, Guibin Qiao
Summary: For ESCC patients undergoing radical esophagectomy, the optimal extent of lymphadenectomy is 15-25 for pT1Nany disease and 24-37 for pT2Nany disease. Resection of extra lymph nodes beyond this appropriate range is not helpful to improve the probability of finding positive lymph nodes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Yu-Jie Zhou, Qi-Wen Wang, Qing-Wei Zhang, Jin-Nan Chen, Xin-Yuan Wang, Yun-Jie Gao, Xiao-Bo Li
Summary: Guidelines on endoscopic resection of gastric-neuroendocrine neoplasms (g-NENs) and duodenal-NENs (d-NENs) have varied. This study found tumor size, depth of invasion, and differentiation to be independently associated with lymph node metastasis. Patients with d-NENs had a higher risk of LNM than those with g-NETs, suggesting that endoscopic resection may be appropriate for small lesions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Dong-lin Li, Lin Zhang, Hao-ji Yan, Yin-bin Zheng, Xiao-guang Guo, Sheng-jie Tang, Hai-yang Hu, Hang Yan, Chao Qin, Jun Zhang, Hai-yang Guo, Hai-ning Zhou, Dong Tian
Summary: This study investigates the performance of machine learning models in predicting lymph node metastasis (LNM) in patients with T1-T2 esophageal squamous cell carcinoma (ESCC). The study finds that ML models provide good predictive value for LNM in these patients, with the naive Bayes algorithm and determination coefficient for feature selection performing the best.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xavier Serra-Aracil, Noemi Montes, Laura Mora-Lopez, Anna Serracant, Carles Pericay, Pere Rebasa, Salvador Navarro-Soto
Summary: For cases of diagnostic uncertainty in rectal adenomas and adenocarcinomas, the observational study recommends transanal endoscopic surgery (TES) as the initial indication based on the finding that it may help differentiate and treat higher stages of adenocarcinomas effectively.
Article
Gastroenterology & Hepatology
Allon Kahn, Kevin Song, Lovekirat Dhaliwal, Shivani Thanawala, Catherine E. Hagen, Siddharth Agarwal, Nicholas M. Mcdonald, Joel T. Gabre, Gary W. Falk, Gregory G. Ginsberg, Herbert C. Wolfsen, Francisco C. Ramirez, Cadman L. Leggett, Kenneth K. Wang, Prasad G. Iyer
Summary: The aim of this study is to evaluate the incidence and predictors of long-term recurrence in patients with T1 esophageal adenocarcinoma treated with endoscopic eradication therapy (EET). The results show that 8.3% of patients experienced tumor recurrence after 5 years of successful EET. Complete eradication of intestinal metaplasia is associated with reduced recurrence.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Steffi E. M. van de Ven, Manon C. W. Spaander, Roos E. Pouw, Thjon J. Tang, Martin H. M. G. Houben, Erik J. Schoon, Pieter J. F. de Jonge, Marco J. Bruno, Arjun D. Koch
Summary: This study found that experienced interventional endoscopists were able to downstage approximately 60% of cT2 EACs to cT1 after endoscopic reassessment, with some patients successfully undergoing endoscopic resection, effectively preventing overtreatment in 40% of patients.
Article
Cardiac & Cardiovascular Systems
Jae Kwang Yun, Hyeong Ryul Kim, Seung Il Park, Yong-Hee Kim
Summary: This study aimed to investigate long-term survival outcomes and develop a risk model for occult lymph node metastasis (LNM) in patients with clinical T1 through T2 N0 esophageal squamous cell carcinoma. Results showed that occult LNM was associated with worse prognosis and had similar outcomes to clinical T1 through T2 N+ cancer. According to the risk model, tumor maximum standardized uptake, histological differentiation grade, tumor length, and advanced clinical T stage were independent risk factors for occult LNM in clinical T1 through T2 N0 cancer. The risk scoring system based on this model exhibited high accuracy and good discriminant ability.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Surgery
Si-yuan Xia, Qing Lu, Zi-jing Wang, Tao Gan, Jin-lin Yang, Zhu Wang
Summary: This study analyzed the possible risk factors for esophageal strictures after endoscopic submucosal dissection (ESD) and developed a risk-scoring model to predict the progression of postoperative esophageal strictures. Factors such as operating time, circumferential range, lesion location, depth of infiltration, and R0 resection were found to be independent risk factors for esophageal strictures after ESD.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Xiaoyu Xiong, Chao Wang, Bo Wang, Zhanlong Shen, Kewei Jiang, Zhidong Gao, Yingjiang Ye
Summary: A meta-analysis of 12 studies involving 3526 patients showed that compared to radical surgery (RS), transanal endoscopic microsurgery (TEM) has advantages in terms of operative time, intraoperative blood loss, perioperative mortality, and postoperative surgical complications. However, TEM is associated with higher risks of positive margin, local recurrence, and overall recurrence.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Gastroenterology & Hepatology
Meng Qian, Shuo Feng, Hangcheng Zhou, Lijie Chen, Song Wang, Kaiguang Zhang
Summary: This study compared the outcomes of endoscopic submucosal dissection (ESD) and esophagectomy in the treatment of superficial esophageal squamous cell carcinoma (SESCC). The results showed that the ESD group had significantly higher overall survival and disease-specific survival compared to the esophagectomy group. The ESD group also had less blood loss, shorter procedure duration and hospital stay, lower hospital cost, and fewer adverse events. However, the ESD group had a lower R0 resection rate compared to the esophagectomy group.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Sho Shiroma, Toshiyuki Yoshio, Yusuke Kato, Yoshimasa Horie, Ken Namikawa, Yoshitaka Tokai, Shoichi Yoshimizu, Natsuko Yoshizawa, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiaki Hirasawa, Tomohiro Tsuchida, Naoki Akazawa, Junichi Akiyama, Tomohiro Tada, Junko Fujisaki
Summary: The study demonstrated that using artificial intelligence with deep learning for diagnosis could be beneficial in endoscopic examinations. The AI system showed high accuracy in detecting superficial esophageal squamous cell carcinoma from esophagogastroduodenoscopy videos, and the sensitivity of endoscopists was improved with AI real-time support.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Tomoyuki Nishimura, Shiro Oka, Shinji Tanaka, Naoki Asayama, Shinji Nagata, Yuzuru Tamaru, Toshio Kuwai, Ken Yamashita, Yuki Ninomiya, Yasuhiko Kitadai, Koji Arihiro, Kazuya Kuraoka, Mayumi Kaneko, Fumio Shimamoto, Kazuaki Chayama
Summary: This study showed that immunohistochemical lymphovascular evaluation is important for indicating additional surgery for T1 CRC patients after ESD, and can predict lymph node metastasis. Preoperative immunohistochemical testing has clinical significance in determining the presence of lymphovascular invasion.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Review
Oncology
Sofian Benkhaled, Cedric Peters, Nicolas Jullian, Tatjana Arsenijevic, Julie Navez, Dirk Van Gestel, Luigi Moretti, Jean-Luc Van Laethem, Christelle Bouchart
Summary: Pancreatic ductal adenocarcinoma cancer (PDAC) has a unique and complex tumor microenvironment (TME) that hinders effective treatment. Radiotherapy (RT) has the potential to modulate the TME and improve the efficacy of targeted therapies. Understanding the complex TME and therapy associations, including RT, is crucial for future clinical trials.
Article
Surgery
Kang Xu, Yulin Liu, Peng Yu, Wei Shang, Yongbo Zhang, Mingwen Jiao, Zhonghui Cui, Lijian Xia, Jingbo Chen
Summary: Adjuvant chemoradiotherapy after TEM may be an alternative for high-risk pT1 and T2 rectal cancer patients who are not suitable or unwilling to undergo salvage radical surgery, as suggested by our study.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2021)
Article
Surgery
Neizekhotuo Brian Shunyu, Zareen Lynrah, Jayanta Medhi, Hanifa Aktar, Judita Syiemlieh, Nari Lyngdoh
Summary: This retrospective study evaluated the efficacy of salvage endoscopic nasopharyngectomy in 10 patients with recurrent nasopharyngeal carcinoma (rNPC). The results demonstrated a local disease-free rate of 40% and an overall survival rate of 50%. Regular endoscopic follow-up is crucial for early detection of recurrence and improving survival.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2023)
Article
Surgery
Daniel B. Larach, Michael J. Sahara, Sawsan As-Sanie, Stephanie E. Moser, Andrew G. Urquhart, Jules Lin, Afton L. Hassett, Joseph A. Wakeford, Daniel J. Clauw, Jennifer F. Waljee, Chad M. Brummett
Summary: This study identified characteristics associated with greater opioid use in the first month after surgery among opioid-naive patients undergoing major surgery. Future studies should focus on the use of non-opioid medications and behavioral therapies for these higher risk patients in the perioperative period.
Article
Oncology
Salma K. Jabbour, Terence M. Williams, Mutlay Sayan, Eric D. Miller, Jaffer A. Ajani, Andrew C. Chang, Norman Coleman, Wael El-Rifai, Michael Haddock, David Ilson, Daniel Jamorabo, Charles Kunos, Steven Lin, Geoffrey Liu, Pataje G. Prasanna, Anil K. Rustgi, Rosemary Wong, Bhadrasain Vikram, Mansoor M. Ahmed
Summary: Although effective combined chemoradiation regimens have shown survival benefits in esophageal cancers, the majority of patients treated with curative intent still experience relapse. Further improvements in disease control and survival will require individualized therapy based on host and tumor genomics, and potentially utilizing the host immune system. While there are gene targets and overexpressed proteins in esophageal cancers, targeting them has not been successful in unselected patients, leading to the need for further research and exploration of novel treatment combinations.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Jules Lin
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, Research & Experimental
Kiran H. Lagisetty, Dyke P. McEwen, Derek J. Nancarrow, Johnathon G. Schiebel, Daysha Ferrer-Torres, Dipankar Ray, Timothy L. Frankel, Jules Lin, Andrew C. Chang, Laura A. Kresty, David G. Beer
Summary: The study identified immune microenvironment changes during Barrett's esophagus progression to esophageal adenocarcinoma, characterized by increased chemokines and cytokines expression and alterations in immune cell populations. Esophageal adenocarcinoma microenvironment was found to have poor cytotoxic effector cell infiltration and increased immune inhibitory signaling, suggesting a potential immunosuppressive environment requiring further exploration for immune modulatory therapy.
Article
Anesthesiology
Douglas A. Colquhoun, Aleda M. Leis, Amy M. Shanks, Michael R. Mathis, Bhiken I. Naik, Marcel E. Durieux, Sachin Kheterpal, Nathan L. Pace, Wanda M. Popescu, Robert B. Schonberger, Benjamin D. Kozower, Dustin M. Walters, Justin D. Blasberg, Andrew C. Chang, Michael F. Aziz, Izumi Harukuni, Brandon H. Tieu, Randal S. Blank
Summary: The study did not find an independent association between a low tidal volume lung-protective ventilation regimen and a composite of postoperative pulmonary complications in patients undergoing one-lung ventilation during thoracic surgery.
Review
Oncology
Caitlin T. Demarest, Andrew C. Chang
Summary: Esophagectomy is the main treatment for resectable esophageal cancer, with chemotherapy and chemoradiation as essential adjunct therapies. The optimal perioperative therapy remains controversial. Three landmark trials have established chemotherapy and chemoradiotherapy as standard care, with ongoing research aiming to clarify the roles of different regimens in esophageal cancer treatment.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Aaron M. Williams, Ranganath G. Kathawate, Lili Zhao, Tyler R. Grenda, Curtis S. Bergquist, Alexander A. Brescia, Keara Kilbane, Emily Barrett, Andrew C. Chang, William Lynch, Jules Lin, Elliot Wakeam, Kiran H. Lagisetty, Mark B. Orringer, Rishindra M. Reddy
Summary: The study found that there were no clear patient-reported benefits of transhiatal robotic-assisted MIE (Th-RAMIE) over open transhiatal esophagectomy (THE) for esophageal cancer patients, although Th-RAMIE conferred some perioperative benefits.
ANNALS OF THORACIC SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Jules Lin
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Jules Lin, William B. Weir, Tyler Grenda, Peng Zhang, Brian A. Derstine, Binu Enchakalody, Joshua Underhill, Rishindra M. Reddy, Andrew C. Chang, Stewart C. Wang
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Editorial Material
Oncology
Bryan J. Schneider, Andrew C. Chang
Summary: This article reviews the findings of a randomized clinical trial evaluating adjuvant nivolumab in esophageal or gastroesophageal junction carcinoma. The study suggests that postoperative immunotherapy represents a significant treatment option for these aggressive malignancies.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Jules Lin
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Surgery
Sunil Agarwal, Anuj Shah, Vidhya Gunaseelan, Catherine Sulich, Jenna McAfee, Andrew G. Urquhart, Sawsan As-Sanie, Jules Lin, Jennifer F. Waljee, Chad M. Brummett
Summary: The study found that among patients not using opioids preoperatively, a history of opioid use was independently associated with new persistent opioid use after surgery, especially those with a history of continuous opioid use.
Review
Cardiac & Cardiovascular Systems
Basheer Elsolh, Zubair Bayat, Dennis Lyu, Jules Lin, Elliot Wakeam
Summary: Through a review and pooled analysis, it was found that patients with incidentally removed NSCLC with earlier stage disease have better survival outcomes following LTx, especially for those with stage I disease.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Sen Yan, Xianben Liu, Wenqun Xing, Duo Jiang, Shao-Kang Feng, Andrew C. Chang, Hai-Bo Sun
Summary: This study evaluated the relationship between tumor length and prognosis in patients with pathological stage IA-IC esophageal adenocarcinoma. Patients from a US database were analyzed and it was found that patients with tumor lengths over 20 millimeters had worse prognosis. Multivariable Cox regression analysis showed that tumor length was an independent risk factor. Tumor length has an impact on the prognosis of patients with pathological stage IA-IC esophageal adenocarcinoma who undergo surgery alone.
DISEASES OF THE ESOPHAGUS
(2023)