Article
Critical Care Medicine
Karan R. Kumar, Antonina Flair, Elizabeth J. Thompson, Kanecia O. Zimmerman, Nicholas D. Andersen, Kevin D. Hill, Christoph P. Hornik
Summary: This study aimed to examine the association between digoxin use and cardiac function in infants with single-ventricle congenital heart disease during the interstage period. The results showed that infants discharged home on digoxin had smaller changes in cardiac function during the interstage period compared to those without digoxin. This suggests that digoxin may partially mitigate the expected decrease in cardiac function during this period through its positive inotropic effects.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sudeep D. Sunthankar, Juan Zhao, Wei-Qi Wei, Garick D. Hill, David A. Parra, Karen Kohl, Allison McCoy, Natalie M. Jayaram, Justin Godown
Summary: This study aimed to optimize risk-prediction models using advanced machine learning algorithms and identify features most predictive of interstage mortality in single ventricle heart disease. The study utilized retrospective data from a national collaborative and evaluated multiple machine learning models. The findings highlighted modifiable and non-modifiable risk factors for interstage mortality, but the model performance remained modest, suggesting the presence of unmeasured confounders.
PEDIATRIC CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Janez Vodiskar, Takashi Kido, Martina Strbad, Julie Cleuziou, Alfred Hager, Peter Ewert, Juergen Hoerer, Masamichi Ono
Summary: This study retrospectively analyzed the clinical data of patients with heterotaxy born between 2001 and 2019, and found that restrictive pulmonary blood flow and greater than mild atrioventricular valve regurgitation are independent risk factors for mortality.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Rachel E. Klausner, David Parra, Karen Kohl, Tyler Brown, Garick D. Hill, LuAnn Minich, Justin Godown
Summary: This study found that digoxin is independently associated with lower interstage mortality and greater freedom from unplanned readmission in the current era. The lack of improvement in overall interstage mortality may be due to a higher proportion of high-risk patients and/or disproportionately higher digoxin use in lower risk patients who may not derive the same benefit.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Humera Ahmed, Jeffrey B. Anderson, Katherine E. Bates, Shobha Natarajan, Nancy S. Ghanayem, Carole M. Lannon, David W. Brown
Summary: This study investigated interstage mortality (IM) in patients with single-ventricle congenital heart disease between Stage 1 Palliation and Glenn operation, finding that most deaths occurred at home or in the emergency department with unknown causes of death. The data suggests a need for further research to identify occult causes of death, including arrhythmia.
PEDIATRIC CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Raina Sinha, Peter Chen, Rebecca Sam, Ali Dodge-Khatami, Jorge D. Salazar
Summary: This study compared early outcomes of neonatal palliation in SV patients using less than 5-mm versus 5-mm RV-PA conduits, finding statistical differences in some indicators but no significant differences in others. The results support further exploration into tailoring RV-PA conduit size based on individual patient characteristics.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Conall T. Morgan, Devin Chetan, Jaymie Varenbut, Christoph Haller, Mike Seed, Luc L. Mertens, Osami Honjo
Summary: Atrioventricular valve replacement in patients with single-ventricle circulations carries significant surgical risks and is associated with high morbidity and mortality. Mechanical valve replacement has a relatively low transplant-free survival rate.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Review
Biochemistry & Molecular Biology
David Renaud, Sabine Scholl-Buergi, Daniela Karall, Miriam Michel
Summary: Most studies on single ventricle (SV) circulation focus on physiological or anatomical aspects, while the metabolic perspective is relatively new. Early evidence suggests that SV circulation is associated with major metabolic disturbances, including impaired glucose and fatty acid oxidation. Fontan patients also exhibit systemic metabolic abnormalities. Comparisons between SV and healthy biventricular (BV) or failing BV heart metabolism reveal similarities, indicating the importance of addressing metabolic issues in SV patients. Therapeutic ketosis, such as through ketogenic diet or SGLT2 inhibitors, shows promise in improving Fontan patients' outcomes.
Article
Cardiac & Cardiovascular Systems
Catherine C. Allen, Karoline Canada, Sarah Schlueter, Xiao Zhang, Heather Bartlett
Summary: Visceral hyperalgesia is common among children with complex medical conditions, with infants with complex congenital heart disease, specifically single ventricle interstage patients, often experiencing feeding intolerance and irritability. Treatment with gabapentin has shown promise for symptomatic improvement in some patients, based on a case series presented, but future multi-center prospective studies are needed for further evaluation.
PEDIATRIC CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Raina Sinha, Husnu Firat Altin, Courtney McCracken, Andrew Well, Joshua Rosenblum, Kirk Kanter, Brian Kogon, Bahaaldin Alsoufi
Summary: This study reviewed the outcomes of atrioventricular valve (AVV) repair in infants undergoing single-ventricle (SV) palliative surgery, indicating that AVV repair is associated with transplant-free survival, mortality, and reoperation rates. Early repair and reduced systemic ventricle function are linked with poor outcomes. Different approaches may be needed for high-risk patients to improve outcomes.
ANNALS OF THORACIC SURGERY
(2021)
Article
Computer Science, Artificial Intelligence
Bin Yang, Jun Chen, Xianzheng Ma, Mang Ye
Summary: This paper focuses on the task of unsupervised domain adaptive visible infrared person re-identification (UDA-VI-ReID) without relying on cross-modality annotation. The proposed Translation, Association and Augmentation (TAA) framework transfers knowledge from the labeled visible source domain to the unlabeled visible-infrared target domain. It performs modality translation, association and augmentation to improve the performance of cross-modality person re-identification. Experimental results show that the proposed method outperforms current state-of-the-art unsupervised methods and even some supervised counterparts.
IEEE TRANSACTIONS ON IMAGE PROCESSING
(2023)
Article
Cardiac & Cardiovascular Systems
Jennifer L. Smerling, Andrew B. Goldstone, Emile A. Bacha, Leonardo Liberman
Summary: The study aims to evaluate the long-term outcomes after tricuspid valve intervention during stage 2 palliation in patients with right ventricular dominant circulation in a multicenter study.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Ari J. Gartenberg, Oluwatimilehin Okunowo, Yoav Dori, Christopher L. Smith, J. William Gaynor, Christopher E. Mascio, Jonathan J. Rome, Matthew J. Gillespie, Andrew C. Glatz, Michael L. O'Byrne
Summary: Intensive monitoring during the interstage period can reduce the death rate and prevent lasting harm in neonates undergoing the Norwood operation. It is associated with a lower likelihood of ventricular dysfunction in patients with recoarctation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Engineering, Biomedical
Anna Joong, Katsuhide Maeda, David M. Peng
Summary: Data on the outcomes of ventricular assist device (VAD) in infants with stage 1 single ventricle (SV) palliation are limited. This study examined the outcomes of SV patients undergoing VAD implantation between March 2018 and October 2020. The results showed that stage 1 SV patients have high preimplant illness severity and experience significant morbidity and mortality postimplant.
Article
Cardiac & Cardiovascular Systems
Syed Shahyan Bakhtiyar, Sara Sakowitz, Konmal Ali, Nikhil L. Chervu, Arjun Verma, Ming-Sing Si, David D'Alessandro, Peyman Benharash
Summary: The study evaluates the survival rate after heart transplantation in adults with single and biventricular CHD and compares it to that of non-CHD transplant recipients. Single-ventricle physiology is associated with higher short-term mortality, but 10-year conditional survival is similar for biventricular CHD patients and most single-ventricle CHD patients, and notably better for biventricular CHD patients compared to non-CHD heart transplant recipients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)