Article
Gastroenterology & Hepatology
Branden D. Tarlow, W. Ray Kim, Ajitha Mannalithara, Paul Y. Kwo, C. Andrew Bonham, Allison Kwong
Summary: This study found that MELD 3.0 scores beyond 40 are associated with increasing waitlist mortality without adversely affecting posttransplant outcomes. Uncapping the MELD score for waitlist candidates may lead to greater survival benefits from liver transplantation.
Article
Cardiac & Cardiovascular Systems
Oliver K. Jawitz, Vignesh Raman, David Becerra, Jacob Klapper, Matthew G. Hartwig
Summary: This study aimed to identify factors associated with survival beyond a decade after lung transplant. The results showed that approximately one-quarter of lung transplant recipients survived 10 years post-transplant. There were different factors associated with 1-year and 10-year survival, and the Lung Allocation Score did not impact long-term survival. Further research is needed to improve patient selection and management strategies to increase long-term survival.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Respiratory System
Adele Coriati, Jenna Sykes, Lydie Lemonnier, Xiayi Ma, Sanja Stanojevic, Clemence Dehillotte, Nicolas Carlier, Anne L. Stephenson, Pierre-Regis Burgel
Summary: After the implementation of the BELT programme, CF patients in France were more likely to receive lung transplants than die. Post-transplant survival in France did not change significantly in the post-HELT period compared with the pre-HELT period, and was similar to outcomes in Canada.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Jay M. Brahmbhatt, Travis Hee Wai, Christopher H. Goss, Erika D. Lease, Christian A. Merlo, Siddhartha G. Kapnadak, Kathleen J. Ramos
Summary: Improved predictive models are needed for lung transplantation in the United States to accurately predict long-term post-transplant survival and fairly allocate organs. The existing models show poor accuracy in predicting 1-year and 3-year post-transplant mortality, and tend to overestimate the risk of death in patients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Selena S. Li, Asishana Osho, Philicia Moonsamy, Stanley Wolfe, Mauricio A. Villavicencio, Nathaniel Langer, Thoralf M. Sundt, Masaki Funamoto
Summary: Short-term outcomes of lung transplantation from HCV viremic donors are promising, with no difference in early complications or survival. The effects of seroconversion and long-term outcomes including chronic rejection and infection need to be further explored.
ANNALS OF THORACIC SURGERY
(2022)
Article
Critical Care Medicine
Nicholas A. Kolaitis, Hubert Chen, Daniel R. Calabrese, Kerry Kumar, Jill Obata, Carrie Bach, Jeffrey A. Golden, Marc A. Simon, Jasleen Kukreja, Steven R. Hays, Lorriana E. Leard, Jonathan P. Singer, Teresa De Marco
Summary: The 2015 revision of the lung allocation score (LAS) aimed to improve waiting list mortality and transplant rates for patients with pulmonary arterial hypertension (PAH). A study comparing the pre- and post-revision eras found that the revision did achieve its intended goals, providing better transplantation opportunities and reducing the risk of death on the waiting list for patients with PAH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Ben F. J. Goudsmit, Ilaria Prosepe, Maarten E. Tushuizen, Vincenzo Mazzaferro, Ian P. J. Alwayn, Bart van Hoek, Andries E. Braat, Hein Putter
Summary: In this study, the bias-corrected LT survival benefit for patients with(out) HCC who underwent a transplant was calculated using longitudinal data. The results showed that performing a transplant in patients with HCC resulted in individual survival benefit, but on a population level, patients without HCC gained more survival benefit from transplantation.
Editorial Material
Multidisciplinary Sciences
Jonathan M. Henshaw, Adam G. Jones, Lukas Scharer
Summary: A new study shows the evolutionary link between gamete size dimorphism and the 'Bateman gradients', explaining why males usually compete more intensely for mating opportunities.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Travis D. Hull, Gregory A. Leya, Andrea L. Axtell, Philicia Moonsamy, Asishana Osho, David C. Chang, Thoralf M. Sundt, Mauricio A. Villavicencio
Summary: Restricted listing preference is associated with increased waitlist mortality, but DLT recipients have superior posttransplant survival.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Multidisciplinary Sciences
David Guijo-Rubio, Javier Briceno, Pedro Antonio Gutierrez, Maria Dolores Ayllon, Ruben Ciria, Cesar Hervas-Martinez
Summary: This study investigated Donor-Recipient matching using the United Network for Organ Sharing database and found that the traditional statistical method LR outperformed multiple machine learning techniques and standard scores at the 5-year endpoint, suggesting limitations of machine learning methods in improving liver allocation performance.
Article
Cardiac & Cardiovascular Systems
Jerome Le Pavec, Feuillet Severine, Mercier Olaf, Pradere Pauline, Dauriat Gaelle, Crutu Adrian, Florea Valentina, Savale Laurent, Levy Marilyne, Laverdure Florent, Stephan Francois, Fabre Dominique, Mitilian Delphine, Boulate David, Mussot Sacha, Hascoet Sebastien, Bonnet Damien, Humbert Marc, Fadel Elie
Summary: This study investigated the survival of children with PAH listed for transplantation when using a high-priority allocation program (HPAP). Implementing HPAP was associated with significant improvements in waitlist mortality, transplantation rates, and survival after listing.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Carli J. Lehr, Andrew Wey, Melissa A. Skeans, Erika D. Lease, Maryam Valapour
Summary: This study evaluated the factors impacting lung transplant allocation, including queue updates, post-transplant survival time, time-varying effects for non-proportional hazards, and different weights for waitlist and post-transplant area under the curve. The findings suggest that incorporating equally weighted models using 5-year posttransplant survival can improve transplant outcomes under the continuous distribution system.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Carli J. Lehr, Jarrod E. Dalton, Paul R. Gunsalus, Douglas D. Gunzler, Maryam Valapour
Summary: A clinically intuitive indexing system was developed to simplify mortality risk assessment of lung transplant candidates, offering the opportunity to identify more nuanced and interpretable clinical phenotypes by reducing the dimensionality of waitlist mortality risk.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Rohit Gupta, Matthew Zheng, Andrew J. Gangemi, Huaqing Zhao, Francis C. Cordova, Gerard J. Criner, Albert J. Mamary, Sameep Sehgal
Summary: In patients with sarcoidosis on the lung transplant waitlist, female gender and severe pulmonary hypertension are associated with a higher likelihood of death, while taller minimum donor height and blood type B are protective factors against death on the waitlist. Earlier referral for transplantation should be considered for patients with these characteristics.
RESPIRATORY MEDICINE
(2022)
Article
Surgery
M. Valapour, C. J. Lehr, M. A. Skeans, J. M. Smith, E. Miller, R. Goff, J. Foutz, A. K. Israni, J. J. Snyder, B. L. Kasiske
Summary: The number of lung transplants performed is increasing annually with decreasing waitlist mortality, attributed to more candidates listed for transplant and increasing number of donors. Despite these favorable trends, a small percentage of recovered lungs were not transplanted in 2019. Posttransplant survival rates have shown slight gains, but regional heterogeneity still exists.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Mark J. Russo, James M. McCabe, Vinod H. Thourani, Mayra Guerrero, Philippe Genereux, Tom Nguyen, Kimberly N. Hong, Susheel Kodali, Martin B. Leon
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Letter
Cardiac & Cardiovascular Systems
Quan M. Bui, Kimberly N. Hong, Megan Kraushaar, Gary S. Ma, Michela Brambatti, Andrew M. Kahn, Chrystelle Bougault, Kylie Boynton, Luisa Mestroni, Matthew R. G. Taylor, Eric Adler
JACC-CARDIOVASCULAR IMAGING
(2020)
Article
Cardiac & Cardiovascular Systems
Enrico Ammirati, Michela Brambatti, Oscar O. Braun, Palak Shah, Manlio Cipriani, Quan M. Bui, Jesse Veenis, Euyhyun Lee, Ronghui Xu, Kimberly N. Hong, Caroline M. Van de Heyning, Enrico Perna, Philippe Timmermans, Maja Cikes, Jasper J. Brugts, Giacomo Veronese, Jonathan Minto, Saige Smith, Grunde Gjesdal, Yan K. Gernhofer, Cynthia Partida, Luciano Potena, Marco Masetti, Silvia Boschi, Antonio Loforte, Nina Jakus, Davor Milicic, Johan Nilsson, Dina De Bock, Caroline Sterken, Klaartje Van den Bossche, Filip Rega, Hao Tran, Ramesh Singh, Jonathan Montomoli, Michele Mondino, Barry Greenberg, Claudio F. Russo, Victor Pretorius, Klein Liviu, Maria Frigerio, Eric D. Adler
Summary: There are geographic variations in the management and outcomes of CF-LVAD patients between the US and Europe, but overall survival rates are similar. Disparities in donor characteristics, duration of support, and adverse events between the US and Europe may explain differences in the utilization of mechanical bridging strategies.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Kimberly N. Hong, Michela Brambatti, Sonya John, Quan M. Bui, Marzia Rigolli, Matthew Taylor, Eric D. Adler
Summary: Danon disease is a rare X-linked dominant cardioskeletal myopathy with varied phenotypic expression by sex. It is characterized by severe cardiomyopathy, skeletal myopathy, cognitive impairment, and other potential manifestations. Research focuses on genetics, pathophysiologic mechanisms, clinical characteristics, diagnostics, and management of the disease.
EXPERT OPINION ON ORPHAN DRUGS
(2021)
Letter
Cardiac & Cardiovascular Systems
Kathryn F. Larson, Enrico Ammirati, Eric D. Adler, Leslie T. Cooper, Kimberly N. Hong, Gianluigi Saponara, Daniel Couri, Alberto Cereda, Antonio Procopio, Cristina Cavalotti, Fabrizio Oliva, Tommaso Sanna, Vincenzo Antonio Ciconte, George Onyango, David R. Holmes, Daniel D. Borgeson
Article
Cardiac & Cardiovascular Systems
Douglas Darden, Enrico Ammirati, Michela Brambatti, Andrew Lin, Jonathan C. Hsu, Palak Shah, Enrico Perna, Maja Cikes, Grunde Gjesdal, Luciano Potena, Marco Masetti, Nina Jakus, Caroline Van De Heyning, Dina De Bock, Jasper J. Brugts, Claudio F. Russo, Jesse F. Veenis, Filip Rega, Manlio Cipriani, Maria Frigerio, Klein Liviu, Kimberly N. Hong, Eric Adler, Oscar O. Braun
Summary: Observational data from a multinational registry of LVAD patients showed that different types of CIED did not have a significant impact on survival rates, but patients with a pre-existing CRT-D had a higher risk of late right ventricular failure.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kimberly N. Hong, Carol Battikha, Sonya John, Andrew Lin, Quan M. Bui, Michela Brambatti, Garrett Storm, Kylie Boynton, Danielle Medina-Hernandez, Ana Garcia-Alvarez, Maria Angeles Castel, Luis Garcia-Guereta, Carles Diez Lopez, Laura Perez-Gomez, Daniela Miani, John D. Symanski, Matthew R. Taylor, Pablo Garcia-Pavia, Eric D. Adler
Summary: This study analyzed the outcomes of cardiac transplantation in patients with Danon disease (DD) and found that there was no difference in 5-year graft survival between males and females. These results suggest that cardiac transplantation is an effective treatment option for DD patients.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Quan M. Bui, Kimberly N. Hong, Megan Kraushaar, Gary S. Ma, Michela Brambatti, Andrew M. Kahn, Carol Elias Battiha, Kylie Boynton, Garrett Storm, Luisa Mestroni, Matthew R. G. Taylor, Anthony N. DeMaria, Eric A. Adler
Summary: In this study, global longitudinal strain may be a useful assessment of myocardial function and predict clinical outcomes in patients with Danon disease. This highlights the potential use of myocardial strain phenotyping to monitor disease progression and predict clinical outcomes in genetic cardiomyopathies.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Meeting Abstract
Biotechnology & Applied Microbiology
Barry Greenberg, Joseph Rossano, Shilpi Epstein, Pavan Battiprolu, Marcus A. Urey, Kimberly N. Hong, Andrew M. Kahn, Abigail Waldron, David Ricks, Paul Yarabe, Kinnari Patel, Jonathan Schwartz, Gaurav Shah, Jose Trevejo
Meeting Abstract
Cardiac & Cardiovascular Systems
E. A. Margolin, A. Lin, F. Han, M. Kearns, V. Pretorius, E. D. Adler, G. K. Feld, J. C. Hsu, K. N. Hong
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Emily Margolin, Kimberly N. Hong, Emily Eshraghian, Jennifer Attias, Marcus Anthony Urey, Eric Adler
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kimberly N. Hong, Galilea Macias, Nyah Rodman, Jade Kozuch, Victor Pretorius, Eric Adler
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
K. N. Hong, C. Battikha, A. Lin, S. John, M. Brambatti, A. Garcia-Alvarez, L. Garcia-Guereta, C. Diez, L. Perez-Gomez, P. Garcia-Pavia, M. Taylor, E. Adler
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mary Brooks, Gary Ma, Douglas Darden, Kimberly N. Hong, Victor Escobedo, Boss Le, Michela Brambatti, Chrystelle Bougalt, Eric Adler
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Quan Bui, Gary Ma, Megan Kraushaar, Victor Escobedo, Boss Le, Liz Covarrubias, Michela Brambatti, Andrew Kahn, Chrystelle Bougault, Kimberly N. Hong, Matthew R. Taylor, Eric Adler
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)