Article
Health Care Sciences & Services
Giuseppe Facondo, Gianluca Vullo, Vitaliana De Sanctis, Margherita Rotondi, Riccardo Carlo Sigillo, Maurizio Valeriani, Mattia Falchetto Osti
Summary: This study retrospectively analyzed the clinical outcomes of stereotactic body radiation therapy (SBRT) for lymph node metastases from gynecological cancers. The results showed that SBRT achieved excellent tumor control with low toxicities.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Analytical
Wei Liu, Shengyan Yin, Yingcai Hu, Ting Deng, Jishan Li
Summary: A pH-responsive T2-T1 switchable MRI nanoprobe was constructed by combining the microemulsion method with the biomineralization principle, which can achieve T1-weighted imaging in tumor environments.
ANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Petr Burkon, Jan Trna, Marek Slavik, Radim Nemecek, Tomas Kazda, Petr Pospisil, Milan Dastych, Michal Eid, Ivo Novotny, Tomas Prochazka, Miroslav Vrzal
Summary: Pancreatic cancer is the third leading cause of cancer death in the developed world. Surgical resection is the only cure, but for advanced cases, neoadjuvant therapy and stereotactic body radiotherapy (SBRT) may improve treatment outcomes and offer convenience and tolerability.
Article
Oncology
P. Boisselier, A. Coutte, E. Martin, Y. Pointreau
Summary: This article presents the data and future perspectives on the historical treatment methods and future development of early-stage non-small cell lung cancer, including surgery and stereotactic radiotherapy.
CANCER RADIOTHERAPIE
(2022)
Article
Oncology
Nikhil T. Sebastian, Amy Webb, Konstantin Shilo, Ryan Robb, Meng Xu-Welliver, Karl Haglund, Jeremy Brownstein, Gina M. DeNicola, Changxian Shen, Terence M. Williams
Summary: This study validates the association between higher PI3K activity and local recurrence and worse disease-free survival in early-stage NSCLC patients treated with SBRT.
Article
Medicine, General & Internal
Gyujae Choi, George Chen, Weiyuan Mai, Albert Chen, Angela Zhu
Summary: This study retrospectively examined the outcomes of patients with early-stage MPLC treated with SBRT. The results showed high control rates and limited toxicity for early-stage MPLC treated with SBRT. Therefore, SBRT should be considered for MPLC patients who are unfit for surgery.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Oncology
Janita E. van Timmeren, Mischa S. Hoogeman, Stefanie Ehrbar, Michael Mayinger, Nicolaus Andratschke, Matthias Guckenberger, Stephanie Tanadini-Lang
Summary: Relative inter-lesion position variation in single-isocenter SBRT is influenced by inter-target distance and location, and can be compensated with additional safety margins of less than 1 mm.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Gang Liu, Lewei Zhao, An Qin, Inga Grills, Rohan Deraniyagala, Craig Stevens, Sheng Zhang, Di Yan, Xiaoqiang Li, Xuanfeng Ding
Summary: The study developed a 4D interplay effect model to evaluate the effectiveness of using spot-scanning proton arc (SPArc) therapy for hypo-fractionated lung SBRT. Results showed that SPArc was more effective in mitigating interplay effects and sparing normal tissue compared to other proton therapy techniques. The study concluded that SPArc may make proton SBRT delivery more feasible and less complex.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Tomoki Kimura, Toshiki Fujiwara, Tsubasa Kameoka, Yoshinori Adachi, Shinji Kariya
Summary: SBRT plays a crucial role in the treatment of early-stage HCC, portal vein or inferior vena cava thrombi, and may have potential in pre-transplantation and the treatment of oligometastases. Further research is needed to establish the rationale for utilizing SBRT in different scenarios.
Article
Oncology
Hendrick Tan, Patrick Cheung, Alexander V. Louie, Sten Myrehaug, Mark Niglas, Eshetu G. Atenafu, William Chu, Hans T. Chung, Ian Poon, Arjun Sahgal, Hany Soliman
Summary: SBRT treatment for metastatic breast cancer patients showed good overall survival and progression-free survival rates. SBRT can delay the start of systemic therapy for these patients.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Guillaume Virbel, David G. Cox, Anne Olland, Pierre-Emmanuel Falcoz, Clara Le Fevre, Roland Schott, Delphine Antoni, Georges Noel
Summary: Stereotactic body radiotherapy (SBRT) with a 60-Gy schedule in 8 fractions is an effective and well-tolerated treatment for patients with lung oligometastases from any solid primary tumor. It provides favorable clinical outcomes in terms of local control, progression-free survival, overall survival, and toxicity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Rashid Al-Umairi, Usman Tarique, Rahim Moineddin, Laura Jimenez-Juan, Lan Chau Kha, Patrick Cheung, Anastasia Oikonomou
Summary: This study evaluated CT patterns of lung injury post-SBRT and identified predictable time points and durations. Familiarity with these patterns and timeframes aids in distinguishing them from local recurrence.
Review
Oncology
Barbara A. Jereczek-Fossa, Giulia Marvaso, Mattia Zaffaroni, Simone Giovanni Gugliandolo, Dario Zerini, Federica Corso, Sara Gandini, Filippo Alongi, Alberto Bossi, Philip Cornford, Berardino De Bari, Valerie Fonteyne, Peter Hoskin, Bradley R. Pieters, Alison C. Tree, Stefano Arcangeli, Donald B. Fuller, Ciro Franzese, Jean-Michel Hannoun-Levi, Guillaume Janoray, Linda Kerkmeijer, Young Kwok, Lorenzo Livi, Mauro Loi, Raymond Miralbell, David Pasquier, Michael Pinkawa, Nathaliel Scher, Marta Scorsetti, Mohamed Shelan, Alain Toledano, Nicholas van As, Andrea Vavassori, Thomas Zilli, Matteo Pepa, Piet Ost
Summary: This study investigated expert opinions on salvage SBRT for intraprostatic relapse after RT. Through three rounds of Delphi consensus, experts reached a certain level of consensus on selection criteria, diagnostic procedures, and therapeutic approaches.
CANCER TREATMENT REVIEWS
(2021)
Article
Geochemistry & Geophysics
Olabode Ijasan
Summary: This paper presents a data-driven workflow for estimating surface relaxivities and bulk relaxation times in borehole nuclear magnetic resonance (NMR) logging of unconventional reservoirs. The workflow involves petrophysical multimodal analysis and derives key relaxation effects for different pore and fluid types. The results obtained in an unconventional field are within the range of published experiments, highlighting the potential of this approach for estimating NMR-based pore-size distributions and permeability in subsurface.
Article
Oncology
Bichun Xu, Xianzhi Zhao, Di Chen, Wenjuan Zhao, Xiaoyan Wang, Changhua Ding, Zhiyong Yuan, Huojun Zhang
Summary: This study reports the feasibility and effectiveness of stereotactic body radiation therapy (SBRT) in the treatment of adrenal gland metastases (AGMs) from liver cancer. The results suggest that SBRT is a safe and effective technique for treating AGMs, especially in patients with smaller tumors.
Article
Cardiac & Cardiovascular Systems
Neel Chudgar, Shi Yan, Meier Hsu, Kay See Tan, Katherine D. Gray, Daniela Molena, David R. Jones, Valerie W. Rusch, Gaetano Rocco, James M. Isbell
Summary: The NSQIP SRC can reasonably predict postoperative complications in patients undergoing pulmonary resection, except for certain calibration issues.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Oncology
Yi Lao, Dan Ruan, April Vassantachart, Zhaoyang Fan, Jason C. Ye, Eric L. Chang, Robert Chin, Tania Kaprealian, Gabriel Zada, Mark S. Shiroishi, Ke Sheng, Wensha Yang
Summary: This study introduces a novel postsurgery multiparametric magnetic resonance-based support vector machine (SVM) method coupled with stem cell niche (SCN) proximity estimation for early and localized glioblastoma (GBM) recurrence prediction. The SVMPE classifier achieved promising results in localizing subclinical traces of recurrence 2 months ahead of clinical diagnosis, providing potential guidance for more effective personalized early salvage therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pavitra Ramesh, Qihui Lyu, Wenbo Gu, Dan Ruan, Ke Sheng
Summary: The reformulated McNamara RBE model can effectively minimize biological dose to organs at risk in proton therapy, improving both dose distribution and treatment planning flexibility. Comparing different optimization techniques, McNam-FISTA and McNam-CP show significant improvements in organ-at-risk doses and robustness, suggesting the potential benefits of directly incorporating McNamara RBE in proton treatment planning.
Article
Oncology
Ting Martin Ma, Jack Neylon, Maria Casado, Sahil Sharma, Ke Sheng, Daniel Low, Yingli Yang, Michael L. Steinberg, James Lamb, Minsong Cao, Amar U. Kishan
Summary: During MRI-guided prostate SBRT treatment, prostate volume consistently increases while there are considerable variations in rotation angles of the proximal SV. Most patients have favorable prostate dosimetry, but occasionally online adaptive therapy may be needed to account for treatment plan adjustments.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Kaley E. Woods, Ting Martin Ma, Kiri A. Cook, Eric D. Morris, Yu Gao, Ke Sheng, Amar U. Kishan, John V. Hegde, Carol Felix, Vincent Basehart, Kelsey Narahara, Zhouhuizi Shen, Stephen Tenn, Michael L. Steinberg, Robert K. Chin, Minsong Cao
Summary: HyperArc technique shows significant advantages in head and neck cancer treatment, with improved dose conformity and target dose escalation. The treatment delivery is feasible and safe, and patients have favorable quality of life.
Article
Radiology, Nuclear Medicine & Medical Imaging
Pavitra Ramesh, Hengjie Liu, Wenbo Gu, Ke Sheng
Summary: A major obstacle for heavy ion therapy is the cost and technical difficulties. We propose to mitigate this by optimizing the treatment couch angle. Through mathematical modeling and algorithms, the optimization of integrated beam orientation on fixed beamlines can help reduce dosimetric limitations.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2022)
Article
Oncology
Amr M. H. Abdelhamid, Lu Jiang, Darren Zuro, An Liu, Srideshikan Sargur Madabushi, Hemendra Ghimire, Jeffrey Y. C. Wong, Simonetta Saldi, Christian Fulcheri, Claudio Zucchetti, Antonio Pierini, Ke Sheng, Cynthia Aristei, Susanta K. Hui
Summary: Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation, but preclinical TMI treatment lacks the ability to reduce radiation doses to critical organs close to the skeletal system. A novel Sparse Orthogonal Collimator (SOC)-based TMI with dose modulation technique is introduced to enhance dosimetric conformality and bridge the gap between preclinical and clinical TMI.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Di Xu, Ting Martin Ma, Ricky Savjani, Jonathan Pham, Minsong Cao, Yingli Yang, Amar U. Kishan, Fabien Scalzo, Ke Sheng
Summary: This study presents a fully automatic MRgRT-based prostatic urethra segmentation framework, using 3D nnU-Net as the base model and innovatively combining data and radial distance map during training. The experimental results show improved segmentation precision with the use of a post-processing step.
Article
Engineering, Biomedical
Lu Jiang, Qihui Lyu, Amr M. H. Abdelhamid, Susanta Hui, Ke Sheng
Summary: This study investigates and evaluates a significantly improved optimization method for small animal intensity-modulated radiotherapy (IMRT) using sparse orthogonal collimators (SOC). The results show that this method can achieve comparable dosimetry to idealistic IMRT and has better performance for complex total marrow irradiation (TMI) cases.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Engineering, Biomedical
Qihui Lyu, Ryan Neph, Ke Sheng
Summary: This article presents a technique for tomographic reconstruction to measure the radiation dose reaching a patient's body. Through simulations, it is shown that this imaging modality, named "pair-production tomography", can be used for monitoring radiotherapy dosing and other applications such as element mapping and soft-tissue differentiation.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Medicine, General & Internal
Di Xu, Qifan Xu, Kevin Nhieu, Dan Ruan, Ke Sheng
Summary: To improve bone shadow suppression in chest X-rays, a generalizable yet efficient workflow combining physical and machine learning methods is proposed. Visually, the proposed SADXNet can suppress rib edges near the lung wall/vertebra without compromising vessel/abnormality conspicuity. Quantitatively, it achieves promising results in lung nodule detection and common lung disease localization tasks.
Review
Biology
Francois Trompier, Larry A. Dewerd, Yannick Poirier, Morgane Dos Santos, Ke Sheng, Keith A. Kunugi, Thomas A. Winters, Andrea L. Dicarlo, Merriline Satyamitra
Summary: The cornerstones of science advancement are rigor, reproducibility, and unbiased reporting in scientific research. For radiation research, it is important to accurately describe experimental details and irradiation protocols for precise and reproducible dosimetry. However, many institutions conducting radiation biology research lack sufficient details in reporting their protocols, hindering balanced review and replication of experiments. To address this, experts have outlined minimum reporting standards for preclinical irradiators and dosimetry.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jiayi Du, Yu Zhou, Lihua Jin, Ke Sheng
Summary: As a powerful computational method, hybrid computational models study multicellular systems' dynamics. However, increasing computational cost limits large-scale simulations. To address this, we develop Gell, a GPU-based platform that enables large-scale system modeling. By fully parallelizing simulations on the GPU and introducing a voxel sorting method, Gell efficiently handles simulations with millions of cells. Comparisons with a CPU-based simulator show that Gell achieves 150X acceleration with lower memory requirements.
Article
Oncology
Jonathan Pham, Ricky R. Savjani, Stephanie M. Yoon, Tiffany Yang, Yu Gao, Minsong Cao, Peng Hu, Ke Sheng, Daniel A. Low, Michael Steinberg, Amar U. Kishan, Yingli Yang
Summary: We retrospectively analyzed urethral interfractional geometric and dosimetric variations in prostate cancer patients treated on an MR-guided radiotherapy system. The visualization of the prostatic urethra on onboard MRIs was evaluated for urethra-focused online adaptive RT.
FRONTIERS IN ONCOLOGY
(2022)
Proceedings Paper
Engineering, Biomedical
Qifan Xu, Qihui Lyu, Dan Ruan, Ke Sheng
Summary: This study proposes an improved Plug-and-Play (PnP) framework for low-dose CT reconstruction and evaluates the results using clinical-relevant segmentation metrics. Compared to using deep learning methods alone, the PnP framework performs slightly worse in some evaluation metrics but shows better image spectrum and accuracy.
2022 IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (IEEE ISBI 2022)
(2022)