Editorial Material
Multidisciplinary Sciences
Tikvah K. K. Hayes, Matthew Meyerson
Summary: Assessing genetic and cellular changes in human lung cancer during its progression can contribute to the development of treatments, as reported by the TRACERx project.
Article
Oncology
Hongchen Cai, Su Kit Chew, Chuan Li, Min K. Tsai, Laura Andrejka, Christopher W. Murray, Nicholas W. Hughes, Emily G. Shuldiner, Emily L. Ashkin, Rui Tang, King L. Hung, Leo C. Chen, Shi Ya C. Lee, Maryam Yousefi, Wen-Yang Lin, Christian A. Kunder, Le Cong, Christopher D. McFarland, Dmitri A. Petrov, Charles Swanton, Monte M. Winslow
Summary: The study utilized a multiplexed mouse model to quantify the impact of 48 putative tumor suppressor genes on carcinogenesis at an unprecedented scale and resolution. It uncovered novel functional tumor suppressors that control cancer growth in vivo and revealed a complex landscape of tumor suppression. The findings have implications for understanding cancer evolution, interpreting clinical cancer genome sequencing data, and directing approaches to limit tumor initiation and progression.
Article
Multidisciplinary Sciences
Daniel Deluiz, Gaetan J. -R. Delcroix, Samira R. G. Fraga, Gianluca D'Ippolito, Cristina Grau-Monge, Andrea Bonnin-Marquez, Teresita Reiner, Thais Amadeu, Eduardo M. B. Tinoco, Paul Christian Schiller
Summary: This study aimed to evaluate the osteogenic ability of a viable cryopreserved human bone graft (VC-HBG) in mandibular augmentation in rats. The results showed that the VC-HBG had better outcomes in enhancing mandibular bone volume and promoting bone remodeling and formation compared to the acellular graft.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Xiaojun Zhang, Mazharul Karim, Farzana Alam, Faleh Alqahtani, Sireesha Y. Reddy, In-San Kim, Taslim A. Al-Hilal, Youngro Byun, Jeong Uk Choi, Md Mahedi Hasan, Seung Woo Chung
Summary: Growth factors play a crucial role in regulating normal development to cancer progression. Biomaterials that modulate GF activity by mimicking interactions observed in the native ECM could be designed as an effective treatment strategy. GAG-based materials can be designed to imitate and leverage bio-inspired interactions to control the tumor microenvironment.
Article
Food Science & Technology
Rulan Jiang, Miller Tran, Bo Lonnerdal
Summary: The study shows that recombinant bovine OPN and recombinant human OPN exhibit similar effects to bovine milk OPN and mouse milk OPN on stimulating infant development.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Editorial Material
Oncology
Kristopher K. Frese, Kathryn L. Simpson, Caroline Dive
Summary: Gay et al. present a molecular classification of small cell lung cancers in Cancer Cell, extending previous studies on personalized treatments. Their identification of an "inflamed" subtype suggests potential susceptibility to immunotherapy after acquired chemoresistance.
Review
Biochemistry & Molecular Biology
Amanda Louise White, Gregory Jaye Bix
Summary: Therapeutic angiogenesis, using VEGFA, has shown promising results in animal models for vasculature disruptions, such as cerebral vasculature diseases. However, clinical trials using VEGFA have not been successful in replicating these results in humans, potentially due to administration methods and VEGFA's ability to increase vascular permeability. Alternative splicing of VEGFA isoforms may offer a solution to mitigate side effects and provide a potential therapeutic approach for cerebrovascular diseases.
Article
Oncology
Giuseppe Giaccone, Yongfeng He
Summary: Lung cancer is the leading cause of cancer related death, with two major histological subtypes, NSCLC and SCLC. Transformation from NSCLC to SCLC can cause treatment resistance, potentially due to therapy-induced changes or clonal selection. This article discusses the potential mechanisms, cell of origin, and genomic alterations in both de novo and transformed SCLC, as well as treatment options including chemotherapy, radiotherapy, TKIs, immunotherapy, and antiangiogenic agents.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Oncology
Krisztina Jambor, Viktoria Koroknai, Timea Kiss, Istvan Szasz, Peter Piko, Margit Balazs
Summary: Osteopontin (OPN) is a multifunctional glycoprotein that interacts with integrins and may serve as a prognostic biomarker in melanoma. This study found that the relative expression of OPNa, OPNb, and OPNc was higher in metastatic melanomas compared to primary lesions, while OPN4 and OPN5 expression was low. Nodular melanomas had higher expression levels and thicker tumors (>4 mm) had significantly higher expression of OPNc. High expression of OPNa, OPNb, OPNc, and low expression of OPN4 and ITGA2 were associated with advanced tumor progression and poor prognosis in melanoma.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Multidisciplinary Sciences
David B. Jaffe, Payam Shahi, Bruce A. Adams, Ashley M. Chrisman, Peter M. Finnegan, Nandhini Raman, Ariel E. Royall, FuNien Tsai, Thomas Vollbrecht, Daniel S. Reyes, N. Lance Hepler, Wyatt J. McDonnell
Summary: Research shows that for naive antibodies, the probability of using the same light chain V gene is around 10%, while for memory (functional) antibodies, even if only one cell per clonotype is used, this probability can reach up to 80%. This property of functional antibodies is referred to as light chain coherence.
Article
Immunology
Michael Hiltensperger, Eduardo Beltran, Ravi Kant, Sofia Tyystjarvi, Gildas Lepennetier, Helena Dominguez Moreno, Isabel J. Bauer, Simon Grassmann, Sebastian Jarosch, Kilian Schober, Veit R. Buchholz, Selin Kenet, Christiane Gasperi, Rupert Ollinger, Roland Rad, Andreas Muschaweckh, Christopher Sie, Lilian Aly, Benjamin Knier, Garima Garg, Ali M. Afzali, Lisa Ann Gerdes, Tania Kumpfel, Soren Franzenburg, Naoto Kawakami, Bernhard Hemmer, Dirk H. Busch, Thomas Misgeld, Klaus Dornmair, Thomas Korn
Summary: The location of T cell priming plays a crucial role in determining their effector phenotypes and migration to distal sites of immunopathology. This study suggests that defining helper T cell subsets by their priming site can provide advanced insights into helper T cell biology in both health and disease.
Review
Medicine, Research & Experimental
Julie Ko, Monte M. Winslow, Julien Sage
Summary: Metastasis is a major cause of morbidity and mortality in cancer patients, especially with small cell lung cancer (SCLC) known for its remarkable metastatic proclivity. Recent advances in research, such as using circulating tumor cells and genetically engineered mouse models, are helping to overcome limitations in studying SCLC metastasis. New insights into cellular mechanisms associated with increased metastatic ability offer promise for future therapeutic options.
EMBO MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Shuye Lin, Hanli Xu, Lin Qin, Mengdi Pang, Ziyu Wang, Meng Gu, Lishu Zhang, Cong Zhao, Xuefeng Hao, Zhiyun Zhang, Weimin Ding, Jianke Ren, Jiaqiang Huang
Summary: This study found that PRSS3 transcripts and their isoforms were divergently expressed in lung cancer, exhibiting opposing functions and clinical outcomes. Epigenetic silencing of PRSS3-V3 through site-specific iCpGI methylation was associated with early clinical progression in lung cancer. This research provides new theoretical basis for early detection and targeted therapy of lung cancer.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Multidisciplinary Sciences
Dhruba Deb, Yangfan Wu, Courtney Coker, Tetsuhiro Harimoto, Ruoqi Huang, Tal Danino
Summary: The study found that using synthetic biology to engineer bacteria for cancer therapy can effectively deliver drugs to tumors, and when combined with current targeted therapies, can improve treatment efficacy.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Xiaodi Lv, Zixian Mao, Xianjun Sun, Baojun Liu
Summary: The diagnosis and treatment of lung cancer is challenging due to intratumoral heterogeneity. While previous research has revealed various mechanisms and characteristics of intratumoral heterogeneity in lung cancer, a comprehensive discussion on the topic is still lacking. This review provides an overview of how intratumoral heterogeneity develops over space and time in lung cancer. It discusses the intricate details and impacts of each aspect of intratumoral heterogeneity and explores their relationships. Based on these findings, a more accurate multidisciplinary therapeutic strategy and potential approach for lung cancer therapy are proposed.
Article
Oncology
Andrew G. Nicholson, Jennifer L. Sauter, Anna K. Nowak, Hedy L. Kindler, Ritu R. Gill, Martine Remy-Jardin, Samuel G. Armato, Lynnette Fernandez-Cuesta, Raphael Bueno, Nicolas Alcala, Matthieu Foll, Harvey Pass, Richard Attanoos, Paul Baas, Mary Beth Beasley, Luka Brcic, Kelly J. Butnor, Lucian R. Chirieac, Andrew Churg, Pierre Courtiol, Sanja Dacic, Marc De Perrot, Thomas Frauenfelder, Allen Gibbs, Fred R. Hirsch, Kenzo Hiroshima, Aliya Husain, Sonja Klebe, Sylvie Lantuejoul, Andre Moreira, Isabelle Opitz, Maurice Perol, Anja Roden, Victor Roggli, Arnaud Scherpereel, Frank Tirode, Henry Tazelaar, William D. Travis, Ming-Sound Tsao, Paul van Schil, Jean Michel Vignaud, Birgit Weynand, Loic Lang-Lazdunski, Ian Cree, Valerie W. Rusch, Nicolas Girard, Francoise Galateau-Salle
JOURNAL OF THORACIC ONCOLOGY
(2020)
Expression of Concern
Oncology
Andrea Napolitano, Daniel J. Antoine, Laura Pellegrini, Francine Baumann, Ian Pagano, Sandra Pastorino, Chandra M. Goparaju, Kirill Prokrym, Claudia Canino, Harvey I. Pass, Michele Carbone, Haining Yang
CLINICAL CANCER RESEARCH
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Harvey I. Pass
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Editorial Material
Oncology
Harvey Pass
Editorial Material
Cardiac & Cardiovascular Systems
Harvey I. Pass
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Multidisciplinary Sciences
Xin Hu, Marcos R. Estecio, Runzhe Chen, Alexandre Reuben, Linghua Wang, Junya Fujimoto, Jian Carrot-Zhang, Nicholas McGranahan, Lisha Ying, Junya Fukuoka, Chi-Wan Chow, Hoa H. N. Pham, Myrna C. B. Godoy, Brett W. Carter, Carmen Behrens, Jianhua Zhang, Mara B. Antonoff, Boris Sepesi, Yue Lu, Harvey Pass, Humam Kadara, Paul Scheet, Ara A. Vaporciyan, John Heymach, Ignacio I. Wistuba, J. Jack Lee, P. Andrew Futreal, Dan Su, Jean-Pierre J. Issa, Jianjun Zhang
Summary: This study reveals that DNA methylation alterations accompany the evolution of pre-cancerous lesions in early carcinogenesis of lung adenocarcinomas, with global hypomethylation correlating with immune infiltration, mutational burden, and copy number alterations.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Hitoshi Dejima, Xin Hu, Runzhe Chen, Jiexin Zhang, Junya Fujimoto, Edwin R. Parra, Cara Haymaker, Shawna M. Hubert, Dzifa Duose, Luisa M. Solis, Dan Su, Junya Fukuoka, Kazuhiro Tabata, Hoa H. N. Pham, Nicholas Mcgranahan, Baili Zhang, Jie Ye, Lisha Ying, Latasha Little, Curtis Gumbs, Chi-Wan Chow, Marcos Roberto Estecio, Myrna C. B. Godoy, Mara B. Antonoff, Boris Sepesi, Harvey Pass, Carmen Behrens, Jianhua Zhang, Ara A. Vaporciyan, John Heymach, Paul Scheet, J. Jack Lee, Jia Wu, P. Andrew Futreal, Alexandre Reuben, Humam Kadara, Ignacio I. Wistuba, Jianjun Zhang
Summary: The evolution of immune landscape in lung adenocarcinoma involves a gradual increase of immunosuppression and decrease of anti-tumor response associated with specific genomic and epigenetic features, influencing the progression from preneoplasia to invasive ADC.
NATURE COMMUNICATIONS
(2021)
Correction
Multidisciplinary Sciences
Xin Hu, Junya Fujimoto, Lisha Ying, Junya Fukuoka, Kazuto Ashizawa, Wenyong Sun, Alexandre Reuben, Chi-Wan Chow, Nicholas McGranahan, Runzhe Chen, Jinlin Hu, Myrna C. Godoy, Kazuhiro Tabata, Kishio Kuroda, Lei Shi, Jun Li, Carmen Behrens, Edwin Roger Parra, Latasha D. Little, Curtis Gumbs, Xizeng Mao, Xingzhi Song, Samantha Tippen, Rebecca L. Thornton, Humam Kadara, Paul Scheet, Emily Roarty, Edwin Justin Ostrin, Xu Wang, Brett W. Carter, Mara B. Antonoff, Jianhua Zhang, Ara A. Vaporciyan, Harvey Pass, Stephen G. Swisher, John V. Heymach, J. Jack Lee, Ignacio I. Wistuba, Waun Ki Hong, P. Andrew Futreal, Dan Su, Jianjun Zhang
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Travis C. Geraci, Zachary N. Kon, Nader Moazami, Stephanie H. Chang, Julius Carillo, Stacey Chen, Anthony Fargnoli, Marjan Alimi, Harvey Pass, Aubrey Galloway, Deane E. Smith
Summary: The study showed that adding hemoadsorption to VV-ECMO in patients with severe COVID-19 is feasible and reduces measured cytokine levels. However, the precise impact on the overall clinical course and survival benefit remains unknown and needs further research.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Multidisciplinary Sciences
Jonas Meinel, Vadim Vorobyov, Boris Yavkin, Durga Dasari, Hitoshi Sumiya, Shinobu Onoda, Junichi Isoya, Joerg Wrachtrup
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Jun-Chieh J. Tsay, Benjamin G. Wu, Imran Sulaiman, Katherine Gershner, Rosemary Schluger, Yonghua Li, Ting-An Yie, Peter Meyn, Evan Olsen, Luisannay Perez, Brendan Franca, Joseph Carpenito, Tadasu Iizumi, Mariam El-Ashmawy, Michelle Badri, James T. Morton, Nan Shen, Linchen He, Gaetane Michaud, Samaan Rafeq, Jamie L. Bessich, Robert L. Smith, Harald Sauthoff, Kevin Felner, Ray Pillai, Anastasia-Maria Zavitsanou, Sergei B. Koralov, Valeria Mezzano, Cynthia A. Loomis, Andre L. Moreira, William Moore, Aristotelis Tsirigos, Adriana Heguy, William N. Rom, Daniel H. Sterman, Harvey Pass, Jose C. Clemente, Huilin Li, Richard Bonneau, Kwok-Kin Wong, Thales Papagiannakopoulos, Leopoldo N. Segal
Summary: In lung cancer patients, dysbiosis of the lower airway microbiota is more prevalent in advanced stages and associated with poor prognosis, upregulation of IL17, PI3K pathways, etc. in the airway transcriptome. The dysbiosis with V. parvula in the lower airway of the KP lung cancer model leads to decreased survival and tumor progression.
Review
Cell Biology
Jiaming Xue, Joelle S. Suarez, Michael Minaai, Shuangjing Li, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
Summary: HMGB1 has been reassessed as a damage-associated molecular pattern protein with crucial roles in the extracellular matrix; Different isoforms of HMGB1 present distinctive physiological functions in diseases; Targeting HMGB1 as a therapeutic strategy involves antagonists interfering with its activity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medical Laboratory Technology
Joanna Roder, Lelia Net, Carlos Oliveira, Krista Meyer, Senait Asmellash, Sabine Kasimir-Bauer, Harvey Pass, Jeffrey Weber, Heinrich Roder, Julia Grigorieva
CLINICAL MASS SPECTROMETRY
(2020)
Article
Respiratory System
Harvey Pass, Marjan Alimi, Michele Carbone, Haining Yang, Chandra M. Goparaju
THORACIC SURGERY CLINICS
(2020)
Review
Oncology
Michele Carbone, Sarah T. Arron, Bruce Beutler, Angela Bononi, Webster Cavenee, James E. Cleaver, Carlo M. Croce, Alan D'Andrea, William D. Foulke, Giovanni Gaudino, Joanna L. Groden, Elizabeth P. Henske, Ian D. Hickson, Paul M. Hwang, Richard D. Kolodner, Tak W. Mak, David Malkin, Raymond J. Jr Jr Monnat, Flavia Novelli, Harvey Pass, John H. Petrini, Laura S. Schmidt, Haining Yang
NATURE REVIEWS CANCER
(2020)