Article
Cardiac & Cardiovascular Systems
William R. Miranda, Patrick S. Kamath, C. Charles Jain, Heidi C. Connolly, Alexander C. Egbe
Summary: This study found that APRI and Fib-4 scores were positively correlated with resting and exercise Fontan pressure and PAWP, and negatively correlated with arterial O2 saturation. These results support the role of hepatic venous hypertension and reduced oxygen supply in patients with FALD.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, Research & Experimental
Yunqiang Nie, Li Sun, Wei Long, Xin LV, Cuiyun Li, Hui Wang, Xing Li, Ping Han, Miao Guo
Summary: The clinical study found that patients with mixed-type pulmonary embolisms are more susceptible to pulmonary hypertension, enlarged right ventricles, and have shorter disease durations compared to those with distal-type pulmonary embolisms. The distribution of pulmonary artery embolism in acute pulmonary embolism can provide valuable clinical reference.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Rola Khedraki, Jacob Abraham, Orvar Jonsson, Kunjan Bhatt, Hesham R. R. Omar, Mosi Bennett, Arvind Bhimaraj, Ashrith Guha, Patrick McCann, Evan D. D. Muse, Monique Robinson, Andrew J. J. Sauer, Andrew Cheng, Samantha Bagsic, Marat Fudim, J. Thomas Heywood, Maya Guglin
Summary: In this multicenter study, we investigated the relationship between pulmonary artery pressure (PAP) at rest and post-exercise in heart failure patients with a CardioMEMS sensor. The results showed a significant increase in PAP after exercise, especially in patients with higher baseline pressures.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Akash Gupta, Chris Gillett, Patrick Gerard, Michael M. H. Cheung, Jonathan P. Mynard, Ethan Kung
Summary: The study showed strong positive correlations between PA size in Fontan patients and BSA and age, with predicted PA size consistently smaller than in the control group. These models can be useful references for clinicians and utilized to construct 3D anatomic models corresponding to patient body size or age.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Zachary M. Hong, Julio Garcia
Summary: This study compared pulmonary artery remodeling and hemodynamic changes in patients with pulmonary hypertension and a control group, and found that these changes may serve as potential biomarkers for pulmonary hypertension in clinical applications.
APPLIED SCIENCES-BASEL
(2022)
Article
Physiology
Zan Ahmad, Lynn H. Jin, Daniel J. Penny, Craig G. Rusin, Charles S. Peskin, Charles Puelz
Summary: This paper develops a model to explore the effects of a fenestration added to the Fontan circulation. The fenestration increases cardiac output and decreases systemic venous pressure, but reduces arterial oxygen saturation. The study demonstrates that there is a range of fenestration sizes in certain high-risk Fontan physiologies that can maintain relatively constant systemic oxygen availability while decreasing systemic venous pressure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Freja Pust, Tania Deis, Johan Larsson, Benjamin Lautrup Hansen, Kasper Rossing, Mads Ersboll, Soren Lund Kristensen, Finn Gustafsson
Summary: The study aimed to investigate the association between the duration of advanced heart failure (HF) and pulmonary vascular resistance (PVR). It was found that there is a positive correlation between the duration of HF and PVR. However, this association disappeared in multivariate analysis. Therefore, the duration of HF per se is unlikely to cause elevated PVR and should not discourage evaluation for heart transplantation.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Takashi Kido, Christoph Stern, Paul Philipp Heinisch, Melchior Burri, Janez Vodiskar, Martina Strbad, Julie Cleuziou, Bettina Ruf, Peter Ewert, Alfred Hager, Juergen Hoerer, Masamichi Ono
Summary: This study aimed to investigate the impact of pulmonary artery size on outcomes after nonfenestrated total cavopulmonary connection. The individual impact of each branch pulmonary artery size was determined in a subgroup of patients with right-sided bidirectional cavopulmonary shunt. The results showed that the pulmonary artery index was significantly associated with the occurrence of chylothorax, and the left pulmonary artery index had a significant predictive value for longer stay in the intensive care unit and adverse events in patients with right-sided bidirectional cavopulmonary shunt.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Abdulaziz Al-Khaldi, Atif Alsahari, Abdulmajeed Alotay, Tarek Momenah, Juan J. Alfonso
Summary: This study retrospectively reviewed 22 patients with single-ventricle physiology who underwent surgical reconstruction for peripheral pulmonary artery stenosis (PPAS). The surgical approach was either single stage or two stage depending on the presence or absence of PA hypoplasia distal to the PPAS.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Eiri Kisamori, Yasuhiro Kotani, Hiroyuki Suzuki, Junko Kobayashi, Takuya Kawabata, Yosuke Kuroko, Shingo Kasahara
Summary: Pulmonary artery coarctation (PACoA) was diagnosed in 45.2% of the patients, and an uneven pulmonary artery branching was strongly associated with PACoA development, rather than the size of the ductus arteriosus. Therefore, morphologic assessment using contrast-enhanced computed tomography should be considered for patients with pulmonary atresia.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
Shijia Zhao, Wei Wu, Saurabhi Samant, Behram Khan, Ghassan S. Kassab, Yusuke Watanabe, Yoshinobu Murasato, Mohammadali Sharzehee, Janaki Makadia, Daniel Zolty, Anastasios Panagopoulos, Francesco Burzotta, Francesco Migliavacca, Thomas W. Johnson, Thierry Lefevre, Jens Flensted Lassen, Emmanouil S. Brilakis, Deepak L. Bhatt, George Dangas, Claudio Chiastra, Goran Stankovic, Yves Louvard, Yiannis S. Chatzizisis
Summary: Patient-specific and lesion-specific computational simulation of bifurcation stenting is an effective approach for individualized pre-procedural planning and improving outcomes. The study demonstrated high agreement between computational stent simulation and clinical cases in terms of lumen diameter and stent size, suggesting the feasibility and accuracy of patient-specific computational stenting for coronary bifurcations. Future clinical studies are needed to further explore the potential of computational stenting simulations in guiding decision-making and enhancing clinical outcomes in cardiac catheterization labs.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Makiko Nakamura, Teruhiko Imamura, Yuki Hida, Koichiro Kinugawa
Summary: This study aimed to investigate the relationship between hemodynamics, especially right ventricular function, and the occurrence of hemolysis during Impella-incorporated mechanical circulatory support. The study found that patients with lower pulmonary artery pulsatility index (PAPi) following Impella insertion had a higher risk of hemolysis and lower survival rate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
John C. Dykes, David N. Rosenthal, Daniel Bernstein, Doff B. McElhinney, Maryanne R. K. Chrisant, Kevin P. Daly, Rebecca K. Ameduri, Kenneth Knecht, Marc E. Richmond, Kimberly Y. Lin, Simon Urschel, Jacob Simmonds, Kathleen E. Simpson, Erin L. Albers, Asma Khan, Kurt Schumacher, Christopher S. Almond, Sharon Chen
Summary: This study aimed to describe the clinical and hemodynamic characteristics of Fontan failure in children listed for heart transplant. The results showed that elevated Fontan pressure is more common than low cardiac output in pediatric failing Fontan patients, and there are subtle hemodynamic differences between the various phenotypes of Fontan failure in children. Additionally, waitlist and post-transplant mortality risks differ by phenotype.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Nirav Y. Raval, Ali Valika, Philip B. Adamson, Christopher Williams, Marie-Elena Brett, Maria Rosa Costanzo
Summary: Hemodynamic-guided heart failure management is an effective strategy to prevent hospitalization and preserve renal function across severities of comorbid renal insufficiency. This strategy involves remotely obtaining pulmonary artery pressures to guide treatment.
CIRCULATION-HEART FAILURE
(2023)
Article
Pediatrics
Elizabeth K. Weiss, Joshua D. Robinson, Aparna Sodhi, Michael Markl, Cynthia K. Rigsby
Summary: In this study, we found that unequal flow distribution from the IVC may lead to increased peak velocities and viscous energy losses, which are associated with worse clinical outcomes. Therefore, changes in peak velocity can serve as a surrogate measure for changes in viscous energy loss.
PEDIATRIC RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Merve Celik, Selda Goktas, Cansu Karakaya, Ayse Idil Cakiroglu, Sercin Karahuseyinoglu, S. Samaneh Lashkarinia, Erhan Ermek, Kerem Pekkan
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Urology & Nephrology
Canberk Yildirim, Hakan Erturk, Kerem Pekkan, Sinan Deniz, Ege Can Serefoglu
Summary: Measurement of blood flow velocity through penile color Doppler ultrasound is commonly used for assessing erectile function, but invasive intracavernosal pressure measurement may be needed in some cases. This study developed a lumped parameter model of the penile circulation mechanism to estimate intracavernosal pressure values non-invasively. The model was validated using PDUS data and showed promising results for predicting intracavernosal pressure and changes in penile size during erection.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Mohammad Rezaeimoghaddam, Gokce Nur Oguz, Mehmet Sanser Ates, Tijen Alkan Bozkaya, Senol Piskin, S. Samaneh Lashkarinia, Erhan Tenekecioglu, Haldun Karagoz, Kerem Pekkan
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2020)
Article
Biophysics
S. Samaneh Lashkarinia, Gursan Coban, Banu Kose, Ece Salihoglu, Kerem Pekkan
Summary: Recent progress in vascular growth mechanics utilizes computational algorithms to study the volumetric growth of pulmonary arterial tissue following complex cardiovascular patch surgeries. The study reveals that arterial tissue growth leads to tissue stiffening to limit elastic deformations, while high stress and strain during patch reconstruction are compensated by tissue growth.
JOURNAL OF BIOMECHANICS
(2021)
Article
Nanoscience & Nanotechnology
Reza Rasooli, Onur Dur, Kerem Pekkan
Summary: This study characterizes the effect of inflow pulsatility on hydrodynamic power loss inside intersecting DIPI with cross-flow mixing using CFD simulations. Three easy-to-calculate pulsatility indices were proposed to predict pulsatile flow performance, and results showed strong correlations between inflow pulsatility, total inflow pulsatility, inflow frequency content, and power loss. The analytical expression provided by the study can predict pulsatile power loss inside DIPI geometry with high accuracy and is a valuable predictive tool for estimating energy dissipation in complex junctions with minimal CFD computations.
Article
Biophysics
Reza Rasooli, Muhammad Jamil, Mohammad Rezaeimoghaddam, Yahya Yildiz, Ece Salihoglu, Kerem Pekkan
Summary: VV-ECMO is the preferred surgical intervention for severe cardiorespiratory failure, also used in SARS-Cov-2 management. The Avalon DLC outperformed the Origen DLC in neonatal patients, capturing venous blood with an efficiency of over 85%.
JOURNAL OF BIOMECHANICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Okan Yildiz, Banu Kose, I. Cansaran Tanidir, Kerem Pekkan, Alper Guzeltas, Sertac Haydin
Summary: This study assessed the application of 3D cardiac modeling in preoperative evaluation for complex congenital heart surgeries and demonstrated its importance for clinical operations. The use of 3D cardiac models allows clinicians to more accurately evaluate patient's cardiac anatomy and provide additional information for surgical decision-making.
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kerem Pekkan, John N. Oshinski
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Syed Murfad Peer, Canberk Yildirim, Manan Desai, Karthik Ramakrishnan, Pranava Sinha, Richard Jonas, Can Yerebakan, Kerem Pekkan
Summary: This study compares the haemodynamics of a mechanically assisted pulmonary flow-based Norwood circulation with a standard Norwood Blalock-Taussig shunt circulation using a computational model. The results show that the assisted Norwood circulation has higher systemic flow and oxygen delivery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Biophysics
Reza Rasooli, Banu Kose, S. Samaneh Lashkarinia, Ahmet Sasmazel, Kerem Pekkan
Summary: This study provides a performance assessment of low-cost steady RANS k-epsilon turbulent models in simulating Fontan hemodynamics, showing that these models can estimate important hemodynamic indices with low error.
JOURNAL OF BIOMECHANICS
(2022)
Article
Engineering, Electrical & Electronic
Easa AliAbbasi, Anil Akseki, Azmat Ullah, Kerem Pekkan
Summary: This article presents a hollow-fiber assembly system for manufacturing research-grade extracorporeal blood oxygenator mandrels. The system can wind fibers at different layout dimensions to evaluate different configurations for mass transfer capacity and blood damage. It consists of three main units - unwinding, accumulator, and winding systems - integrated together via control software.
Article
Engineering, Biomedical
Emrah Sisli, Canberk Yildirim, Ibrahim Basar Aka, Osman Nuri Tuncer, Yuksel Atay, Mustafa Ozbaran, Kerem Pekkan
Summary: This paper proposes a novel bi-ventricle mechanical circulatory support configuration for failing Fontan patients, with the systemic circulation maintained by a conventional mechanical ventricle assist device while the venous circulation is delegated to the native single ventricle. Experimental validation and model studies show promising feasibility and performance in various failure modes.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Sercan Altundemir, S. Samaneh Lashkarinia, Kerem Pekkan, A. Kerem Uguz
Summary: This paper develops a biphasic multilayer model to study the effects of age-related arterial thickening and stiffening on arterial deformation and interstitial flow. The results show that with aging, the circumferential residual stress shifts outward and its gradient increases up to 6 times. Age-related changes in the arterial wall reduce the hydraulic conductivity and increase the interstitial flow, leading to more significant flow shear stress on vascular smooth muscle cells (VSMCs) in the aged arteries compared to the young arteries, which may accelerate cardiovascular disease progression.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Pediatrics
Sercin Ozkok, Hatice Ozge Ciftci, Kevser Banu Kose, Ilker Kemal Yucel, Ahmet Sasmazel, Ahmet Celebi, Kerem Pekkan
Summary: Preprocedural MRI characteristics, such as strain, flow distribution, and morphology of the right ventricular outflow tract and branch pulmonary arteries, differ significantly between patients undergoing surgical and transcatheter pulmonary valve replacement.
PEDIATRIC RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hummaira Banu Siddiqui, Sedat Dogru, Seyedeh Samaneh Lashkarinia, Kerem Pekkan
Summary: Changes in cardiovascular microstructure and material properties during embryonic development are crucial for understanding biomechanics. The interaction between mechanical loading modes and microstructural changes has been studied in animal models, but characterizing the mechanical properties of embryonic cardiovascular tissue is challenging. This review focuses on material characterization of developing cardiovascular systems and introduces novel measurement methods.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)