Article
Peripheral Vascular Disease
Katarzyna Hackert, Susanne Homann, Shakila Mir, Arne Beran, Simone Gorressen, Florian Funk, Jens W. Fischer, Maria Grandoch, Joachim P. Schmitt
Summary: 4-MU can attenuate inflammation and extracellular matrix remodeling in pressure-overloaded myocardium by reducing both resident and invading cardiac macrophages, leading to reduced myocardial fibrosis. Additionally, 4-MU also reduces left ventricular hypertrophy and increases cardiac output after TAC surgery.
Article
Medicine, Research & Experimental
Weiji Lin, Yaqin Song, Tingting Li, Jiahui Yan, Ruiyuan Zhang, Liang Han, Xin Ba, Yao Huang, Kai Qin, Zhe Chen, Yu Wang, Shenghao Tu, Ying Huang
Summary: Triptolide effectively alleviated bleomycin-induced pulmonary fibrosis by inhibiting various key aspects of fibrotic ECM remodeling, including gene expression, signaling pathways, and enzyme activities. Triptolide also regulated the biomechanical stress transduction pathway and attenuated the pro-fibrotic feedback of fibrotic ECM on fibroblasts. These findings suggest that triptolide has therapeutic potential for pulmonary fibrosis by targeting multiple linkages of fibrotic ECM remodeling.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Victor Alfonso Solarte David, Viviana Raquel Guiza-Argueello, Martha L. Arango-Rodriguez, Claudia L. Sossa, Silvia M. Becerra-Bayona
Summary: The absence or damage of tissue is a major cause of diseases, and novel therapeutic alternatives aim to recover lost functions through tissue regeneration. Chronic cutaneous lesions are common wounds that require regenerative medicine and tissue engineering interventions to develop bioactive medical products for proper healing and prevention of complications. The coordination of cells, extracellular matrix (ECM), and biomolecules is crucial in tissue repair and regeneration, with ECM acting as a biological platform for their interactions. Tissue engineering utilizes synthetic polymers and decellularized tissues to mimic native ECM and provide necessary functionalities for cell differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marina Marozzi, Arianna Parnigoni, Aide Negri, Manuela Viola, Davide Vigetti, Alberto Passi, Evgenia Karousou, Federica Rizzi
Summary: Cancer is a complex pathology characterized by uncontrolled cell proliferation and decreased apoptosis, often in an inflammatory environment. Changes in the extracellular matrix (ECM) and signaling pathways play crucial roles in tumor growth and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Kun Wang, Yu Qi, Rong Gu, Qing Dai, Anqi Shan, Zhu Li, Chenyi Gong, Lei Chang, Han Hao, Junfeng Duan, Jiamin Xu, Jiaxin Hu, Dan Mu, Ning Zhang, Jianrong Lu, Lian Wang, Han Wu, Lixin Li, Lina Kang, Biao Xu
Summary: RDN is an effective therapeutic strategy for counteracting postreperfusion myocardial injury and dysfunction, and the application of RDN holds promising prospects in clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ane Charlotte Christensen, Kristian Kinden Lensjo, Mikkel Elle Lepperod, Svenn-Arne Dragly, Halvard Sutterud, Jan Sigurd Blackstad, Marianne Fyhn, Torkel Hafting
Summary: Perineuronal nets are suggested to stabilize synaptic connections and long-term memories. The removal of perineuronal nets disrupts the temporal and spatial organization of grid cell firing, impacting the stability of representations in both novel and familiar environments. This work indicates that perineuronal nets provide a key stabilizing element for the grid cell network.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Elke Pach, Maike Kuemper, Julia E. Fromme, Jan Zamek, Fabian Metzen, Manuel Koch, Cornelia Mauch, Paola Zigrino
Summary: The deletion of MMP14 in dermal fibroblasts leads to the deposition of an extracellular matrix that inhibits melanoma growth, with collagen XIV identified as a key regulator in melanoma progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Ana Rubina Perestrelo, Ana Catarina Silva, Jorge Oliver-De La Cruz, Fabiana Martino, Vladimir Horvath, Guido Caluori, Ondrej Polansky, Vladimir Vinarsky, Giulia Azzato, Giuseppe de Marco, Vita Zampachova, Petr Skladal, Stefania Pagliari, Alberto Rainer, Perpetua Pinto-do-O, Alessio Caravella, Kamila Koci, Diana S. Nascimento, Giancarlo Forte
Summary: The study reveals that the remodeling of cardiac extracellular matrix (ECM) during heart failure (HF) leads to cardiac fibroblast activation and focal adhesion protein expression through hyperactivated YAP signaling, impacting cell homing.
CIRCULATION RESEARCH
(2021)
Article
Chemistry, Physical
Xiaoqian Ge, Xueqi Xu, Qi Cai, Hejian Xiong, Chen Xie, Yi Hong, Xiaofei Gao, Yao Yao, Robert Bachoo, Zhenpeng Qin
Summary: The pan-ECM method enables live imaging of the entire brain extracellular matrix, providing insights into its heterogeneity and changes in neurological disorders. This novel approach has the potential to advance our understanding of brain function and neurological diseases.
Review
Oncology
Zoi Piperigkou, Konstantina Kyriakopoulou, Christos Koutsakis, Stylianos Mastronikolis, Nikos K. Karamanos
Summary: Proteolytic enzymes and non-proteolytic enzymatic partners play crucial roles in cancer cell propagation and metastatic potential. This article revisits the functions of major matrix remodeling molecules and discusses their epigenetic regulation mechanisms, pharmacological targeting, and ongoing clinical trials. The importance of targeting matrix remodeling partners for cancer management is explored in relation to tissue homeostasis and ECM turnover.
Article
Biochemistry & Molecular Biology
Zeyu Cai, Ze Gong, Zhiqing Li, Li Li, Wei Kong
Summary: The article summarizes the dynamic changes of ECM during hypertension and after treatment, as well as the unclear mechanism by which ECM remodeling initiates the development of hypertension. Further research on matridomic and degradomic approaches is needed for a more comprehensive understanding of ECM remodeling in hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Engineering, Biomedical
Mimi Xu, Ting Su, Xiaoxuan Jin, Yibao Li, Yao Yao, Kaiyang Liu, Kaiqi Chen, Feng Lu, Yunfan He
Summary: Extracellular matrix (ECM)-mimicking biomaterials are considered effective scaffolds for tissue engineering and regenerative medicine. However, dysregulation of matrix remodeling can lead to various pathological conditions. This review summarizes the characteristics of inflammatory responses in matrix remodeling after transplantation of ECM-mimicking biomaterials and discusses the intrinsic linkages between matrix remodeling and tissue regeneration. Understanding host immune responses to matrix remodeling is crucial for directing effective tissue regeneration. Further studies on the effects of clinical characteristics on matrix remodeling are needed.
ACTA BIOMATERIALIA
(2022)
Article
Cardiac & Cardiovascular Systems
Javier Barallobre-Barreiro, Tamas Radovits, Marika Fava, Ursula Mayr, Wen-Yu Lin, Elizaveta Ermolaeva, Diego Martinez-Lopez, Eric L. Lindberg, Elisa Duregotti, Laszlo Daroczi, Maria Hasman, Lukas E. Schmidt, Bhawana Singh, Ruifang Lu, Ferheen Baig, Aleksandra Malgorzata Siedlar, Friederike Cuello, Norman Catibog, Konstantinos Theofilatos, Ajay M. Shah, Maria G. Crespo-Leiro, Nieves Domenech, Norbert Hubner, Bela Merkely, Manuel Mayr
Summary: The study identified ADAMTS5 protease as critical for versican degradation in the heart and found that versican accumulation is associated with impaired cardiac function in heart failure patients and animal models. Versikine, an ADAMTS-specific cleavage product, accumulated in ischemic heart failure patients and following cardiac ischemia/reperfusion injury in animal models. The use of beta-blockers in heart failure patients was associated with a reduction in ECM deposition, particularly in the levels of versican, indicating a potential beneficial effect on cardiac chondroitin sulfate proteoglycan content.
Article
Biochemical Research Methods
Marina Trombetta-Lima, Livia Rosa-Fernandes, Claudia B. Angeli, Isabele F. Moretti, Yollanda M. Franco, Adaliana S. Mousessian, Alda Wakamatsu, Antonio M. Lerario, Sueli M. Oba-Shinjo, Carlos A. Pasqualucci, Suely K. N. Marie, Giuseppe Palmisano
Summary: Differences in the extracellular matrix signatures of medulloblastomas (MBs) and glioblastomas (GBMs) have been identified, including differential expression of ECM proteins, a shift towards a denser fibrillary ECM, and alterations in glycoprotein signatures, all of which influence tumor pathophysiology.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biology
Hui Wang, Wenrui Zhang, Rujiao Liu, Jiaoyun Zheng, Xueping Yao, Hui Chen, Jie Wang, Horst Christian Weber, Xiaoqun Qin, Yang Xiang, Chi Liu, Huijun Liu, Lang Pan, Xiangping Qu
Summary: BC004004(-/-) mice exhibit attenuated pulmonary injury and less pulmonary fibrosis after bleomycin induction, with lower fibroblast proliferation and collagen production. BRAP homologous protein plays an important role in pulmonary fibrosis, possibly by regulating fibroblast function through inhibition of autophagy activity.
LIFE SCIENCE ALLIANCE
(2022)