Letter
Gastroenterology & Hepatology
Magdy El-Salhy, Odd Helge Gilja, Jan Gunnar Hatlebakk
Summary: This article is linked to the paper by Yau et al. Click the link to view the article.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Yong Xie, Xiaoyan Wang, Zhonghui Wang, Jianyang Feng, Dongsheng Li
Summary: This study aimed to investigate the effects of Fe3O4@ MSC-exo on PC12 cells and found that they can promote cell proliferation, migration, and neural differentiation.
Review
Medicine, Research & Experimental
Qi-Ming Pang, Kua-Qian Deng, Meng Zhang, Xiang-Chong Wu, Rui-Lin Yang, Sheng-Ping Fu, Feng-Qin Lin, Qian Zhang, Jun Ao, Tao Zhang
Summary: Spinal cord injury (SCI) is a serious complication that affects the central nervous system (CNS) after spine injury, resulting in sensory, motor, and autonomic dysfunction. Stem cell therapy, specifically the use of mesenchymal stem cells (MSCs), has shown promise in SCI treatment due to their immunomodulatory, neuroprotective, and angiogenic properties. However, the complex pathophysiological environment following SCI limits the therapeutic effect of MSCs. This review discusses the specific mechanisms of MSCs in promoting SCI repair and explores the use of pluripotent stem cells in combination with other therapeutic approaches for anatomical and functional recovery post-SCI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Melissa Alvarado-Velez, Syed Faaiz Enam, Nalini Mehta, Johnathan G. Lyon, Michelle C. LaPlaca, Ravi V. Bellamkonda
Summary: The development of immunosuppressive hydrogels for stem cell delivery, such as the agarose-FasL hydrogel in this study, has shown promising results in enhancing the benefits of stem cell therapy for traumatic brain injury. By reducing host cytotoxic CD8(+) T cell populations, increasing the survival of transplanted allogeneic MSCs, and elevating the expression of neurotrophic factors in the injury penumbra, this approach holds potential for improving therapeutic outcomes in TBI cases.
Article
Cell & Tissue Engineering
Chun-Wei Li, Tai-Horng Young, Mu-Hui Wang, Ming-Ying Pei, Tsung-Yu Hsieh, Chia-Lang Hsu, Nai-Chen Cheng
Summary: Our study demonstrates that a diabetic environment has an adverse effect on ASCs, and adopting a low glucose culture condition is a simple and effective way to enhance the wound healing capabilities of diabetic ASCs. This finding is valuable for the clinical application of autologous ASCs from diabetic patients.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Hua Shen, Ryan A. Lane
Summary: Achilles tendon rupture, a common sports-related injury, often leads to long-term pain and functional deficits. Previous studies have shown that extracellular vesicles from inflammation-primed adipose-derived stem cells (iEVs) can alleviate the early inflammatory response to tendon injury. This study aimed to investigate the mechanistic roles of iEVs in regulating the injury response of tendons and promoting regeneration.
Review
Biotechnology & Applied Microbiology
Tara Murty, Crystal L. Mackall
Summary: Gene editing platforms are being explored to enhance the potency of adoptive T cell therapies by knocking out molecules that inhibit immune responses and improving gene expression profiles. These approaches also aim to create off-the-shelf therapies that can prevent immune rejection, thus increasing the effectiveness and ease of use of these treatments.
Review
Immunology
Sikemi Ibikunle, Dolores Grosso, Usama Gergis
Summary: Allogeneic hematopoietic stem cell transplantation (HSCT) is the only potentially curative option for multiple hematological conditions. The two-step approach to HSCT, described here, aims to achieve an optimal balance in immune recovery, graft-versus-host disease control, and disease control. This review highlights key results from studies over the past two decades and discusses current strategies to optimize graft-versus-tumor effect and limit transplant-related toxicities.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Ecology
Coralie Fritsch, Sylvain Billiard, Nicolas Champagnat
Summary: Body size or mass plays a crucial role in shaping food web structure, and the consideration of biomass conversion efficiency dependent on species size is essential for the adaptive evolution of food webs. The study questions the robustness of evolutionary models for the study of food webs and emphasizes the importance of paying attention to how biomass flows into food webs in models.
Review
Multidisciplinary Sciences
Meng-yun Zhang, Peng Zhao, Yan Zhang, Ji-shi Wang
Summary: Our systematic review and meta-analysis indicates that Ruxolitinib therapy may be an effective and safe treatment for patients with steroid-refractory GVHD.
Article
Medicine, Research & Experimental
Hyun Jik Lee, Chang Woo Chae, Ho Jae Han
Summary: Mesenchymal stem cell (MSC) transplantation has potential for treating diabetes mellitus (DM) and its complications. However, hyperglycemia can cause senescence and dysfunction in transplanted and resident MSCs due to mitochondrial dysfunction. Improving mitochondrial function could enhance the therapeutic efficacy of MSC transplantation in DM.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Obada T. Alhalabi, Michael N. C. Fletcher, Thomas Hielscher, Tobias Kessler, Tolga Lokumcu, Ulrich Baumgartner, Elena Wittmann, Silja Schlue, Mona Goettmann, Shaman Rahman, Ling Hai, Lea Hansen-Palmus, Laura Puccio, Ichiro Nakano, Christel Herold-Mende, Bryan W. Day, Wolfgang Wick, Felix Sahm, Emma Phillips, Violaine Goidts
Summary: The mesenchymal subtype of glioblastoma showed higher sensitivity to dasatinib due to increased SRC pathway activation, with SERPINH1 suggesting a potential predictive marker. Stratification based on gene expression subtyping should be considered in future dasatinib trials for better patient selection strategies.
Article
Biochemistry & Molecular Biology
So Yoon Ahn, Dong Kyung Sung, Yun Sil Chang, Se In Sung, Young Eun Kim, Hyo-Jin Kim, Soon Min Lee, Won Soon Park
Summary: The study suggests that irradiated BDNF-eMSCs outperform naive MSCs in attenuating severe hypoxic ischemic brain injury, showing better paracrine potency and therapeutic efficacy by reducing cytotoxicity, oxidative stress, cell death, brain injury progression, apoptotic cell death, astrogliosis, inflammatory responses, and impaired motor function. The findings indicate that BDNF gene-transfected MSCs may offer a more effective therapeutic strategy against severe neonatal HI brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Electrical & Electronic
Kuo-Ching Tseng, Hao-Shiang Huang, Chun-An Cheng
Summary: An isolated high step-up converter has been proposed for low voltage renewable energy sources, such as photovoltaic cells and fuel cells, to achieve high voltage levels. The integrated IBFFC combines a boost converter, a forward-flyback converter, and a voltage doubler, with a maximum efficiency of approximately 94%.
IET POWER ELECTRONICS
(2021)
Article
Multidisciplinary Sciences
Yasunori Yoshida, Yuki Takeda, Kenichi Yamahara, Hanae Yamamoto, Toshinori Takagi, Yoji Kuramoto, Akiko Nakano-Doi, Takayuki Nakagomi, Toshihiro Soma, Tomohiro Matsuyama, Nobutaka Doe, Shinichi Yoshimura
Summary: By co-culturing with OP9, we can enhance the M2, tissue-protecting, and pro-angiogenic features of umbilical cord blood cells, which leads to amelioration of symptoms in mouse models of cerebral infarction.
SCIENTIFIC REPORTS
(2023)
