Article
Medicine, Research & Experimental
Huan Ji, Haiyang Song, Zeyu Wang, Pengfei Jiao, Jiani Xu, Xuan Li, Hongming Du, Heming Wu, Yi Zhong
Summary: This study identifies FAM83A as an oncogene of HNSCC with overexpression significantly associated with tumor size, lymph node status, and clinical tumor stages. FAM83A promotes HNSCC cell growth and metastasis by inducing EMT through activation of the Wnt/beta-catenin signaling pathway. Knockdown of FAM83A suppresses tumor growth and distant metastasis in xenograft animal models of HNSCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Pathology
Jia-Cheng Liu, Ling Gao, Shao-Ming Li, Jing-Jing Zheng, Da-Gang Li, Ke-Qian Zhi, Wen-Hao Ren
Summary: The study revealed that XRN2 is significantly overexpressed in oral squamous cell carcinoma (OSCC) and closely associated with tumor differentiation, prognosis, and metastasis. Functional assays in vitro showed that down-regulation of XRN2 inhibited cell proliferation, migration, and invasion while promoting apoptosis, and also affected the epithelial-mesenchymal transition (EMT) characteristics of OSCC cells.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Multidisciplinary Sciences
Qingyun Liao, Jing Yang, Zhaoyi Lu, Qingshan Jiang, Yongqian Gong, Lijun Liu, Hong Peng, Qin Wang, Xin Zhang, Zhifeng Liu
Summary: FTH1 plays a critical role in the progression and metastasis of head and neck squamous cell carcinoma and can serve as a promising prognostic factor and therapeutic target.
Article
Biochemistry & Molecular Biology
Olga Kovaleva, Polina Podlesnaya, Madina Rashidova, Daria Samoilova, Anatoly Petrenko, Valeria Mochalnikova, Vladimir Kataev, Yuri Khlopko, Andrey Plotnikov, Alexei Gratchev
Summary: Esophageal cancer, especially squamous cell carcinoma, shows significant correlations between microbiome composition and tumor infiltrating phenotypes. Specific types of tumors have higher bacterial burdens, with different microbial components associated with disease prognosis.
Article
Oncology
Shuang Liu, Zheng Lin, Wenqing Rao, Jing Zheng, Qianwen Xie, Yulan Lin, Xi Lin, Huilin Chen, Yuanmei Chen, Zhijian Hu
Summary: The study identified that the expression levels of serum exosomal hsa_circ_0026611 are related to lymph node metastasis in ESCC, and can serve as a prognostic predictor for ESCC patients.
Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Junni Chen, Shuai Zhang, Jiawei Chen
Summary: Esophageal cancer can metastasize to distant sites, leading to poor prognosis. Intestinal metastasis is extremely rare with atypical clinical presentations. We present a case of rectal metastasis after surgery for esophageal squamous cell carcinoma. The patient achieved good short-term efficacy with adjuvant chemoradiotherapy and carrelizumab immunotherapy, and is currently in tumor-free survival. This case report aims to deepen our understanding of rare metastasis in esophageal squamous cell carcinoma and promote the use of local radiotherapy, chemotherapy, and immunotherapy to improve survival.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Qiu-Yun Luo, Tian Di, Miao-Zhen Qiu, Zeng-Fei Xia, Yong Du, Run-Duan Lin, Li-Qiong Yang, Yu-Ting Sun, Da-Jun Yang, Jian Sun, Lin Zhang
Summary: High expression of AKAP8L is associated with poor prognosis of ESCC and can be considered an independent risk factor for ESCC.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Zui Chen, Di Che, Xiaoqiong Gu, Jiamin Lin, Jing Deng, Ping Jiang, Kaixiong Xu, Banglao Xu, Ting Zhang
Summary: PEDF is significantly correlated with tumor cell invasion and metastasis in ESCC, and its overexpression serves as an independent unfavorable prognostic factor for overall survival in ESCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Liang Ma, Wenyue Yan, Xingwei Sun, Ping Chen
Summary: The study demonstrates that VPS9D1-AS1 is significantly upregulated in esophageal squamous cell carcinoma (ESCC), correlating with poor prognosis in patients. VPS9D1-AS1 can promote tumor progression and may serve as a potential biomarker for ESCC diagnosis.
Article
Oncology
Nan Chen, Jieqing Wang, Lei Zhou, Baiqiang Hu, Yinzhong Chen, Zhuangchen Zhu
Summary: This study investigated the expression of GPBAR1 in HCC tissues and tumor-adjacent tissues and found that GPBAR1 was highly expressed in HCC tissues. GPBAR1 expression was significantly associated with poor prognosis in HCC and served as an independent prognostic biomarker. Additionally, GPBAR1 expression was significantly correlated with asynchronous bone metastasis but not liver or lung metastases. These findings provide new insights into HCC metastasis and improve prognostic assessment of HCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Yixuan Li, Tong Wu, Zan Jiao, Ankui Yang
Summary: This study investigated the relationship between the expression of BASP1 in TSCC tissue and the clinicopathological characteristics and prognosis of TSCC patients. The results suggest that overexpression of BASP1 is associated with distant lymph node metastasis and a poor prognosis in patients with TSCC.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Oncology
Seung-hwan Jeong, Jang Hee Han, Chang Wook Jeong, Hyeon Hoe Kim, Cheol Kwak, Hyeong Dong Yuk, Ja Hyeon Ku
Summary: This study retrospectively examined prospective patients enrolled in the registry of Seoul National University to determine the clinical significance of CA 19-9 in UTUC, finding that high serum CA 19-9 levels are associated with poor prognosis in UTUC, particularly in patients with high T and N stages.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Xiaotao Geng, Jie Liu, Huimin Sun, Zhenguo Song, Shaoyong Qin, Yang Li, Yanan Zhang, Furong Hao, Yuanyuan Cai
Summary: This case report presents a rare case of metastatic esophageal squamous cell carcinoma, highlighting the diagnosis and treatment process. The authors hope to provide insights for clinical practice through their experience.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dermatology
Neha Gupta, Rachel E. Weitzman, Fadi Murad, Shlomo A. Koyfman, Timothy D. Smile, Michael S. Chang, Jacqueline M. Maher, Chrysalyne D. Schmults, Allison T. Vidimos, Emily S. Ruiz
Summary: This study aimed to determine the risk factors associated with poor outcomes in BWH T2a tumors. The presence of certain criteria was found to be predictive of poor outcomes, with an 8% incidence rate in these tumors.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Oncology
I-Ying Kuo, Danping Liu, Wu-Wei Lai, Yi-Ching Wang, Y. Peng Loh
Summary: This study evaluates the efficacy of CPE/CPE-Delta N mRNA as a biomarker for predicting recurrence in lung adenocarcinoma patients. The results show that CPE/CPE-Delta N copy number is associated with recurrence and death, and it performs better in predicting recurrence in stage I and II patients.
Article
Medicine, Research & Experimental
Pei-Shan Yang, Min-Hua Yu, Ya-Chin Hou, Chih-Peng Chang, Shao-Chieh Lin, I-Ying Kuo, Pei-Chia Su, Hung-Chi Cheng, Wu-Chou Su, Yan-Shen Shan, Yi-Ching Wang
Summary: This study provides the first evidence that Rab37 mediates CHI3L1 secretion in immune cells and highlights the dual properties of CHI3L1 nAbs that can target both cancer cells and the tumor microenvironment.
Article
Oncology
Hsueh-Chien Chiang, Meng-Ying Lin, Forn-Chia Lin, Nai-Jung Chiang, Yi-Ching Wang, Wu-Wei Lai, Wei-Lun Chang, Bor-Shyang Sheu
Summary: This study aimed to compare the sensitivity of serum prealbumin, transferrin, and albumin in detecting malnutrition and predicting survival in esophageal cancer patients. The results showed that prealbumin and transferrin outperformed albumin in identifying malnutrition and poor prognosis.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Oncology
Yung-Ching Chen, Ming-Jer Young, Hui-Ping Chang, Chia-Yu Liu, Chia-Chi Lee, Yau-Lin Tseng, Yi-Ching Wang, Wen-Chang Chang, Jan-Jong Hung
Summary: This study reveals that estrogen negatively regulates DNMT1 and p53 expression in female lung cancer, which not only affects tumor cells but also modulates the tumor microenvironment, leading to a poor prognosis.
Review
Medicine, Research & Experimental
Chih-Hsiung Hsieh, Yi-Ching Wang
Summary: The protein gelsolin plays a significant role in controlling cytoskeletal remodeling, cell morphology, differentiation, movement, and apoptosis. Its expression has been found to be decreased in various pathological conditions and it has emerged as a potential diagnostic biomarker for early disease detection. Gelsolin can function as either an oncoprotein or a tumor suppressor depending on the type of carcinoma. This review discusses the roles of gelsolin in inflammation and wound healing, cancers, and tumor microenvironment, as well as future prospects for related studies and clinical application.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Yi-Zih Kuo, Ya-Rong Kang, Wei-Lun Chang, Lydia Chin-Ling Sim, Tzu-Chin Hsieh, Chu-Han Chang, Yi-Ching Wang, Ching-Jung Tsai, Li-Chun Huang, Sen-Tien Tsai, Li-Wha Wu
Summary: YAP1 acts as a tumor suppressor in esophageal cancer, while TAZ plays a pro-tumor role. YAP1 negatively regulates the expression of TAZ through transcriptional and translational control.
Article
Cell Biology
Shan-Ying Wu, Hung-Tsung Wu, Yi-Ching Wang, Chih-Jen Chang, Yan-Shen Shan, Shang-Rung Wu, Yen-Chi Chiu, Chia-Lang Hsu, Hsueh-Fen Juan, Kai-Ying Lan, Chi-Wen Chu, Ying-Ray Lee, Sheng-Hui Lan, Hsiao-Sheng Liu
Summary: This study reveals that secretory autophagy promotes RAB37-mediated insulin secretion to maintain the homeostasis of insulin and glucose.
Correction
Oncology
Yi-Zih Kuo, Ya-Rong Kang, Wei-Lun Chang, Lydia Chin Ling Sim, Tzu-Chin Hsieh, Chu-Han Chang, Yi-Ching Wang, Ching-Jung Tsai, Li-Chun Huang, Sen-Tien Tsai, Li-Wha Wu
Article
Biochemistry & Molecular Biology
Wei-Lun Chang, Chih-Hsiung Hsieh, I-Ying Kuo, Chien-Hsun Lin, Yu-Lin Huang, Yi-Ching Wang
Summary: A novel therapeutic agent, Nutlin-3, has been proposed to enhance the treatment efficacy of chemoradiation-resistant ESCC by regulating the expression of transcription factor proteins p53 and RB and downregulating the level of DNA methyltransferase. It has the potential for clinical application.
MOLECULAR CARCINOGENESIS
(2022)
Editorial Material
Cell Biology
Shan-Ying Wu, Yi-Ching Wang, Roberto Zuchini, Kai-Ying Lan, Hsiao-Sheng Liu, Sheng-Hui Lan
Summary: RAB37 GTPase regulates cargo exocytosis by cycling between GDP-bound and GTP-bound forms. It also simultaneously regulates autophagy activation and TIMP1 secretion in lung cancer cells under starvation conditions. Secretory autophagy participates in TIMP1 secretion in a RAB37- and Sec22b-dependent manner. Autophagy induction facilitates TIMP1 secretion and suppresses the motility and metastasis of lung cancer cells in a RAB37-dependent manner in a lung-to-lung mouse model.
Article
Cell Biology
Shaifali Singh, Nai Yang Yeat, Ya-Ting Wang, Shu-Yu Lin, I-Ying Kuo, Kuen-Phon Wu, Won-Jing Wang, Wen-Ching Wang, Wu-Chou Su, Yi-Ching Wang, Ruey-Hwa Chen
Summary: WDR4/PTPN23 axis plays a central role in the trafficking of EGFR and c-MET in non-small cell lung cancer (NSCLC). WDR4-mediated PTPN23 ubiquitination inhibits lysosome trafficking and degradation, sustaining EGFR and c-MET signaling and promoting NSCLC proliferation, migration, and metastasis. Clinical studies show that low expression of PTPN23 is associated with high expression of WDR4 and poor prognosis in lung cancer. Targeting WDR4-mediated PTPN23 ubiquitination may be a potential therapeutic strategy for EGFR TKI-resistant NSCLC.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Shan-Ying Wu, Jia-Wen Chen, Hsi-Yu Liu, Yi-Ching Wang, Yeh-Shiu Chu, Chi-Ying Huang, Kai-Ying Lan, Hsiao-Sheng Liu, Sheng-Hui Lan
Summary: This study is the first to report that autophagy promotes the secretion and metastasis of TIMP1 in a Rab37-dependent manner in lung cancer cells and a lung-to-lung mouse model.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Cell Biology
Chih-Hsiung Hsieh, Wen-Hui Kuan, Wei-Lun Chang, I-Ying Kuo, Hsun Liu, Dar-Bin Shieh, Hsuan Liu, Bertrand Tan, Yi-Ching Wang
Summary: This study identifies a novel SOX17(low)/NRF2(high) signature in ESCC patients with poor prognosis, recognizes SOX17 as a transcriptional repressor of NRF2, and provides a promising strategy targeting SOX17/NRF2 axis to overcome resistance.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Cell Biology
I. -Ying Kuo, Chih-Hsiung Hsieh, Wan-Ting Kuo, Chih-Peng Chang, Yi-Ching Wang
Summary: Cells in the tumor microenvironment require a class of checkpoints to regulate various secretion and transport processes. Recent studies have shown that Rab proteins mediate communication between diverse cargoes and substrates through vesicular trafficking and secretion pathways in the tumor microenvironment. This review focuses on the role and regulation of vesicular secretion pathways in the tumor microenvironment, and describes the latest research advances and future directions.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Cell Biology
Ming-Jer Young, Yung-Ching Chen, Shao-An Wang, Hui-Ping Chang, Wen-Bin Yang, Chia-Chi Lee, Chia-Yu Liu, Yau-Lin Tseng, Yi-Ching Wang, H. Sunny Sun, Wen-Chang Chang, Jan-Jong Hung
Summary: Decreased Sp1 levels in lung cancer are associated with poor prognosis and are related to estrogen. It has been found that E2 can decrease Sp1 levels by increasing the expression of RNF4, and ultimately lead to malignancy in lung cancer.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
