Article
Mathematics
Maria Jose Cervantes, Lucas O. Basiuk, Ana Gonzalez-Suarez, C. Manuel Carlevaro, Ramiro M. Irastorza
Summary: This study investigated the relationship between the electrical conductivity of trabecular bone and the conductivity of its constituents, including free water content. Computer simulations using microCT images of bovine trabecular samples were conducted to build realistic geometries. The results showed that the conductivity of bone marrow needs to be higher in order to match experimental data, and anisotropy cannot be detected in small trabecular samples. The simulations also demonstrated good fitting of the Bruggeman mixture model, which could be useful for whole-bone electrical simulations.
Article
Engineering, Biomedical
Jenny Carlsson, Anna Braesch-Andersen, Stephen J. Ferguson, Per Isaksson
Summary: A dynamic phase-field fracture finite element model is used to investigate rapid bone fracture in human trabecular bone based on high-resolution three-dimensional computed tomography images. The model is compared to quasi-static experimental results and a quasi-static phase-field finite element model. The experiment shows complex crack evolution with multiple crack fronts and crack arrests, while the quasi-static phase-field fracture model can reasonably capture the fractures in the experiment. At higher load rates, inertia effects significantly contribute to increased stiffness, higher peak forces, and more cracks spread over a larger volume. The study concludes that dynamic fracture models are necessary for simulating rapid bone fracture.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Nuclear Science & Technology
Bohyun Yoon, Kunok Chang
Summary: The thermal conductivity of uranium oxide (UO2) with pores and grain boundaries is investigated using simulations based on the finite-difference method. The study quantifies the effects of porosity, pore size, and grain size on the thermal conductivity of UO2. A new empirical model is developed to predict the thermal conductivity of porous polycrystalline UO2 fuel.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Peng Gao, Xihao Chen, Ning Wang, Jiwen Li, Hua Tang, Zonghang Liu, Fuqiang Zhai
Summary: With the rapid development of material preparation and quantum computation technologies, the discovery of superior electronic devices in the nanoscale has been widely facilitated. For materials for application in thermoelectric and thermal conductivity devices, their overall performance can be demonstrated by their inner heat transport efficiency. The study focuses on a novel carbon monolayer (net-Y) and assesses its practical applicability in electronic device design using first-principles calculations. Through a comparative study with graphene, the heat transport mechanism of net-Y was successfully summarized.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Review
Engineering, Multidisciplinary
Xin Zhang, ZhongShan Deng
Summary: As electronic devices become smaller and more integrated, traditional thermal interface materials (TIMs) are not sufficient for thermal management challenges. Liquid metals, with their high conductivity and conformability, have potential for advanced thermal management and are being developed as next-generation TIMs. This review classifies and evaluates liquid metal TIMs, discusses material innovation and heat transfer enhancement mechanisms, predicts the limits of their conductivity, and outlines a roadmap and strategy for developing high-performance liquid metal TIMs.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Stephan Skornitzke, Neha Vats, Taisiya Kopytova, Elizabeth Wai Yee Tong, Tobias Hofbauer, Tim Frederik Weber, Christoph Rehnitz, Oyunbileg von Stackelberg, Klaus Maier-Hein, Wolfram Stiller, Juergen Biederer, Hans-Ulrich Kauczor, Claus-Peter Heussel, Mark Wielpuetz, Viktoria Palm
Summary: Asynchronous calibration is found to be feasible for opportunistic screening of osteoporosis using routine CT scans. The study shows that using different CT scanners and adjusting image reconstruction settings can accurately estimate bone mineral density (BMD), with a strong correlation to the ground truth values.
SCIENTIFIC REPORTS
(2022)
Article
Soil Science
Lin Liu, Weiliu Li, Yili Lu, Tusheng Ren, Robert Horton
Summary: Soil thermal conductivity (λ) and electrical conductivity (σ) are influenced by soil water content (θ), texture, bulk density (ρb), temperature, structure, and organic matter content. The quantitative relationship between λ and σ, as well as how soil texture and ρb modify this relationship, is not well understood. In this study, a new model for normalized σ curves of soils with a unimodal pore size distribution is developed, and the correlation between λ(θ) and σ(θ) curves is examined. Measurements of θ, λ, and σ on two soils confirm the model's performance.
Article
Multidisciplinary Sciences
Eva C. Herbst, Alessandro A. Felder, Lucinda A. E. Evans, Sara Ajami, Behzad Javaheri, Andrew A. Pitsillides
Summary: This study developed a semi-automated protocol for separating trabecular and cortical compartments in bone images obtained through X-ray micro-CT scans. The method eliminates user bias, is user-friendly across various datasets, and has been validated for use in complex bone analyses, making it a widely applicable tool in the field of skeletal research.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Multidisciplinary Sciences
Jaap P. P. Saers, Adam D. Gordon, Timothy M. Ryan, Jay T. Stock
Summary: This paper shows that the trabecular bone structure provides insights into ontogenetic variation in locomotor loading conditions, as the product of interactions between increases in body mass and neuromuscular maturation. The age-related changes in trabecular bone volume fraction (BV/TV) are strongly associated with ontogenetic changes in locomotor kinetics, which are in turn associated with brain and body size growth in all species. These findings imply that trabecular structure can be a proxy for the rate of neuromuscular maturation and major life history events in fossil subadults.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Physical
Anthony Yu-Tung Wang, Steven K. Kauwe, Ryan J. Murdock, Taylor D. Sparks
Summary: In this paper, we demonstrated the application of the Transformer self-attention mechanism in materials science through CrabNet. CrabNet shows promising performance in structure-agnostic materials property predictions when only a chemical formula is provided, outperforming current best-practice methods on 28 benchmark datasets and offering model interpretability through its architecture. CrabNet and its attention-based framework are expected to spark interest among future materials informatics researchers.
NPJ COMPUTATIONAL MATERIALS
(2021)
Letter
Materials Science, Multidisciplinary
Guangxin Lv, Elynn Jensen, Christopher M. Evans, David G. Cahill
Summary: Polymer materials with enhanced thermal conductivity are highly sought after for thermal management of electronic devices. This study successfully developed epoxy resins with a thermal conductivity of 0.52 W/(m K), which is 2.5 times higher than common polymers. It was found that the thermal conductivity and density of these epoxy resins have a positive correlation with crystallinity.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Guangxin Lv, Elynn Jensen, Chengtian Shen, Kexin Yang, Christopher M. Evans, David G. Cahill
Summary: The study investigated the thermal conductivity of seven thermosets and found that variations in the molecular structure of phenylenediamine hardeners significantly affect the cured resin's thermal conductivity, with the highest being 0.27 W/(m K) and the lowest being 0.14 W/(m K). The thermal conductivities of these epoxy resins are 10-40% lower than the prediction of the minimum thermal conductivity model.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Engineering, Biomedical
Bingyang Dai, Xu Li, Jiankun Xu, Yuwei Zhu, Le Huang, Wenxue Tong, Hao Yao, Dick Ho-kiu Chow, Ling Qin
Summary: The combination of magnesium and simvastatin showed synergistic effects in attenuating high-fat diet-induced bone loss in mice by inhibiting osteoclast formation and bone resorption, reducing hepatic cholesterol synthesis, and inhibiting matrix metallopeptidase 13 (Mmp13) expression in pre-osteoclasts. This combination therapy may be a cost-effective alternative treatment for obesity-related bone loss.
BIOACTIVE MATERIALS
(2021)
Article
Endocrinology & Metabolism
Karin H. Nilsson, Jianyao Wu, Karin L. Gustafsson, Maha El Shahawy, Antti Koskela, Juha Tuukkanen, Jan Tuckermann, Petra Henning, Ulf H. Lerner, Claes Ohlsson, Sofia Moverare-Skrtic
Summary: Osteoblast-derived RSPO3 is a crucial regulator of vertebral trabecular bone. Our findings show that RSPO3 and estrogen regulate trabecular bone independent of each other, but that RSPO3 is necessary for a complete estrogenic effect on cortical bone.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Agronomy
Tianyue Zhao, Shuchao Liu, Jia Xu, Hailong He, Dong Wang, Robert Horton, Gang Liu
Summary: Soil thermal conductivity is an important property for surface energy balance and water balance studies. This study evaluated five empirical models and seven machine learning algorithms to estimate soil thermal conductivity. The results showed that machine learning algorithms performed better than empirical models, with GBDT, NN, and RF being the top performers. Soil moisture content and soil bulk density were found to be the most critical factors affecting soil thermal conductivity.
AGRICULTURAL AND FOREST METEOROLOGY
(2022)
Article
Oncology
Maria Villamonte, Fernando Burdio, Eva Pueyo, Ana Andaluz, Xavier Moll, Enrique Berjano, Aleksander Radosevic, Luis Grande, Miguel Pera, Benedetto Ielpo, Patricia Sanchez-Velazquez
Summary: The study aimed to compare the impact of an additional application of RF energy on the top of the resection surface on local recurrence in liver surgery. The results showed that additional margin coagulation (AMC) was associated with lower local recurrence, and the use of RF applicator was significantly related to reduced local recurrence. The Control group had smaller coagulation widths compared to the AMC group.
Article
Computer Science, Interdisciplinary Applications
Ana Gonzalez-Suarez, Juan J. Perez, Ramiro M. Irastorza, Andre D'Avila, Enrique Berjano
Summary: This article discusses the importance of theoretical, mathematical and computational models for radiofrequency catheter ablation (RFCA) and reviews the progress in computer modeling research. It also discusses the implementation details of mathematical models, the use of lumped element models, computer model verification and validation, as well as current limitations and future work.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Claudio Tucci, Macarena Trujillo, Enrique Berjano, Marcello Iasiello, Assunta Andreozzi, Giuseppe Peter Vanoli
Summary: This study aims to develop a more realistic mathematical model based on porous media to simulate microwave thermal ablation of liver tumors. The model takes into account the vascularization of the tumor and shows good agreement with clinical studies. It provides a more accurate prediction of the ablation zone and reduces the risk of tumor recurrence.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Juan J. Perez, Robert d'Angelo, Ana Gonzalez-Suarez, Hiroshi Nakagawa, Enrique Berjano, Andre d'Avila
Summary: This study compares the temperature dynamics and lesion size at different power-duration settings for the delivery of equivalent total energy. The results show that in homogeneous tissue, high power-short duration and moderate power-short duration produce similar lesion sizes, slightly larger than moderate power-long duration. In heterogeneous tissue, these differences are smaller. Additionally, high power-short duration leads to higher absolute tissue temperature, which may increase the risk of collateral tissue injury and steam pops.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ramiro M. Irastorza, Timothy Maher, Michael Barkagan, Rokas Liubasuskas, Enrique Berjano, Andre d'Avila
Summary: The study aimed to investigate the impact of dispersive patch (DP) location on radiofrequency catheter ablation (RFCA) and lesion size. The results showed that DP location does not significantly affect RFCA in the posterior left atrium but may have a slight effect on anterior right ventricular ablation, leading to slightly larger lesions.
Article
Oncology
Juan J. Perez, Enrique Berjano, Ana Gonzalez-Suarez
Summary: This study used computer modeling to estimate the size of the zone of heat-induced transient block during radiofrequency catheter ablation (RFCA). The results showed that the depth of this zone could extend beyond the lesion limit by up to 2 mm, and the maximum width could exceed the lesion limit by approximately 2.5 mm.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Biochemical Research Methods
Luciana Melina Luque, Carlos Manuel Carlevaro, Camilo Julio Llamoza Torres, Enrique Lomba
Summary: This study presents a multiagent-based model that captures the interactions between different types of cells with their microenvironment, and enables the analysis of the emergent global behavior during tissue regeneration and tumor development. By tuning the system with the characteristics of the individual patients, the model reproduces a variety of spatial patterns of tissue regeneration and tumor growth, resembling those found in clinical imaging or biopsies. In the clinical context, the model is able to predict the recurrence of a hepatocellular carcinoma after a 70% partial hepatectomy.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Engineering, Chemical
Luis Cuenca-Dacal, Enrique Berjano, Ana Gonzalez-Suarez, Juan J. Perez
Summary: By simulating radiofrequency cardiac ablation, it was found that temperature sensors inserted into the tissue may affect the measured temperature value, but it does not substantially alter the shape and size of the thermal lesion.
Editorial Material
Physics, Condensed Matter
Marcia C. Barbosa, Ana Laura Benavides, Manuel Carlevaro, Gerhard Kahl, Enrique Lomba
JOURNAL OF PHYSICS-CONDENSED MATTER
(2023)
Article
Biochemistry & Molecular Biology
H. Ariel Alvarez, Alexandra Cousido-Siah, Yanis R. Espinosa, Alberto Podjarny, C. Manuel Carlevaro, Eduardo Howard
Summary: Fatty acid binding proteins (FABPs) are responsible for the transport of long-chain fatty acids (FAs) inside cells, but there is no definitive answer about the stages of the lipid entry-exit mechanism. The structure of FABPs consists of a β-barrel with 10 anti-parallel strands and a helix-turn-helix motif. The portal region, which involves certain helices and turns, is believed to play a role in FAs exchange. Through experiments and simulations, researchers have gained insight into the mechanistic view of the exchange process.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2023)
Article
Mathematics
Maria Jose Cervantes, Lucas O. Basiuk, Ana Gonzalez-Suarez, C. Manuel Carlevaro, Ramiro M. Irastorza
Summary: This study investigated the relationship between the electrical conductivity of trabecular bone and the conductivity of its constituents, including free water content. Computer simulations using microCT images of bovine trabecular samples were conducted to build realistic geometries. The results showed that the conductivity of bone marrow needs to be higher in order to match experimental data, and anisotropy cannot be detected in small trabecular samples. The simulations also demonstrated good fitting of the Bruggeman mixture model, which could be useful for whole-bone electrical simulations.
Article
Mathematics
Ricardo Romero-Mendez, Enrique Berjano
Summary: This study aims to compare the differences in electric field values between finite and infinite length electrode cases, and evaluate the adequacy of the simplification to infinite length models. The research found substantial differences in electric field distribution between the two cases, not only near the edges and close locations, but also in the central area and at greater distances.
Article
Cardiac & Cardiovascular Systems
Ramiro M. Irastorza, Timothy Maher, Michael Barkagan, Rokas Liubasuskas, Juan J. Perez, Enrique Berjano, Andre d'Avila
Summary: This study simulated left atrial radiofrequency catheter ablation to investigate the contributions of local and remote impedance to the electrical circuit and found that identical baseline impedance and RF current can result in significantly different lesion sizes with different relative contributions of local and remote impedances.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Juan J. Perez, Enrique Berjano, Ana Gonzalez-Suarez
Summary: This study used computer modeling to investigate the differences in lesion sizes created by radiofrequency catheters in cardiac ablation between two pre-clinical models. The results showed that the thermal lesions in the thigh muscle model were slightly larger than in the heart model, possibly due to the higher electrical conductivity of striated muscle.
BIOENGINEERING-BASEL
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Marcela Mercado-Montoya, Tatiana Gomez-Bustamante, Enrique Berjano, James Daniels, Steven Mickelsen, Pablo Hernandez-Arango, Jay Schieber, Erik Kulstad
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Biology
Aref Maddahi, Adel Saberivand, Hossein Hamali, Farnoosh Jafarpour, Maryam Saberivand
Summary: Heat stress affects the fertility of dairy cattle, but supplementing vitamins E and coenzyme Q10 can alleviate its adverse effects on oocyte maturation and embryo development. Vitamin E was found to be more effective than vitamin C and coenzyme Q10 in improving maturation and cleavage rates, as well as increasing the count of blastocyst cells.
JOURNAL OF THERMAL BIOLOGY
(2024)