Article
Biology
Anusha Shankar, Isabelle N. H. Cisneros, Sarah Thompson, Catherine H. Graham, Donald R. Powers
Summary: Many endotherms use torpor to save energy, but deep torpor in mammals may have potential costs. Deep torpor also occurs in birds, but the trade-offs are unknown. This study found that some hummingbird species are capable of both deep and shallow torpor, indicating a fine-scale regulation of avian torpid metabolism.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna Fosch, Maria Rodriguez-Garcia, Cristina Miralpeix, Sebastian Zagmutt, Maite Larranaga, Ana Cristina Reguera, Jesus Garcia-Chica, Laura Herrero, Dolors Serra, Nuria Casals, Rosalia Rodriguez-Rodriguez
Summary: Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance and disruption leads to obesity. The effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and underlying mechanisms were investigated. Unsaturated LCFA increased BAT thermogenesis through CPT1C-mediated FA metabolism shift, while saturated LCFA did not. These findings provide new insight into neuronal circuitries activated by LCFA to drive thermogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jesus Fernandez-Felipe, Adrian Plaza, Gema Dominguez, Javier Perez-Castells, Victoria Cano, Francesco Cioni, Nuria Del Olmo, Mariano Ruiz-Gayo, Beatriz Merino
Summary: High-fat diets enriched with lauric acid do not increase leptin production and reduce the effect of leptin on kinase phosphorylation. Both high-fat diets affect adipocyte-size distribution and gene expression related to adipogenesis and inflammation. The composition of white adipose tissue is different between the two diets, which may impact the biophysical properties and signaling of leptin receptor.
Article
Endocrinology & Metabolism
Chao Cao, Han-Chow E. Koh, Stephan Van Vliet, Bruce W. Patterson, Dominic N. Reeds, Richard Laforest, Robert J. Gropler, Bettina Mittendorfer
Summary: This study found that enhanced FFA clearance in people with obesity is negatively correlated with muscle insulin sensitivity, and the stimulatory effect of insulin on FFA clearance is more significant in obese individuals.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Chemistry, Medicinal
Long Cheng, Lu Shi, Changhao He, Chen Wang, Yinglan Lv, Huimin Li, Yongcheng An, Hongyu Dai, Yuhui Duan, Huilin Zhang, Yan Huang, Wanxin Fu, Yanyan Meng, Baosheng Zhao
Summary: The study found that rutin can activate thermogenesis in brown and white adipose tissue by increasing the concentration of short-chain fatty acids, thereby improving obesity and diabetes.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Debora Maria Soares de Souza, Maria Claudia Silva, Silvia Elvira Barros Farias, Ana Paula de J. Menezes, Cristiane Maria Milanezi, Karine de P. Lucio, Nivia Carolina N. Paiva, Paula Melo de Abreu, Daniela Caldeira Costa, Kelerson Mauro de Castro Pinto, Guilherme de Paula Costa, Joao Santana Silva, Andre Talvani
Summary: The study showed that tissue from mice subjected to a lard diet was more favorable for the growth of T. cruzi parasites, supporting the hypothesis of a relationship between the source of dietary lipids and parasite-induced immunopathology.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Dongli Li, Zhaonan Xu, Yuanyuan Li, Lishe Gan, Panpan Wu, Rihui Wu, Jingwei Jin, Xi Zheng, Kun Zhang, Hang Ma, Liya Li
Summary: This study investigated the anti-obesity effects of a crude extract of Callerya speciosa polysaccharides (NP) and its underlying mechanisms in a mouse model. The results demonstrated that NP supplementation alleviated HFD-induced diabetic biomarkers, liver steatosis, and adipocyte hypertrophy. NP also improved gut dysbiosis induced by a high-fat diet, suggesting its potential as a functional food for obesity management.
Article
Agronomy
Qixiu Huang, Lijun Xiang, Li Zhang, Yushanjiang Maimaiti, Wenfang Luo, Zhonghua Lei
Summary: This study analyzed the fatty acid content of five varieties of oilseed sunflower and sequenced the transcriptome of seed embryos from one high oleic acid variety at different stages. The results showed that oleic acid synthesis dominated the pathways of unsaturated fatty acid synthesis in seed embryos. Differential expression genes were detected at various post-flowering stages, with the highest number of up-regulated genes at 10 days after flowering and most genes being down-regulated at 20 days after flowering. The enriched genes were consistent with the FAD2 gene in almost all experimental groups. The expression of FAD2 was negatively correlated with the expressions of FAD6, FAD3, and FAD7. The expression level of FAD2 was highly negatively correlated with the final oleic acid content and highly positively correlated with the final linoleic acid content during seed embryo development, suggesting that FAD2 is a key enzyme catalyzing the conversion of oleic acid to linoleic acid.
Article
Agriculture, Dairy & Animal Science
Piotr Domaradzki, Bozena Nowakowicz-Debek, Lukasz Wlazlo, Mateusz Ossowski, Malgorzata Dmoch, Mariusz Florek
Summary: This study investigated the effect of adding natural sorbents to pig feed on the fatty acid content of pig meat and fat. The results showed that the sorbents had limited effects on muscle tissue but had significant effects on kidney fat. The impact of different sorbents varied, but overall, they did not have a negative effect on the nutritional and pro-health quality of pig adipose tissue during fattening.
Article
Biochemistry & Molecular Biology
Petra Roskaric, Marcela Speranda, Tomislav Masek, Donatella Verbanac, Kristina Starcevic
Summary: The study shows that fructose intake leads to increased blood lipids, insulin resistance, and oxidative stress, as well as elevated monounsaturated fatty acid levels in adipose tissue. However, supplementation with DHA can reduce oxidative stress and improve adiponectin levels.
Article
Agriculture, Multidisciplinary
Yu Wang, Aiqing Zhao, Haiping Du, Yueyue Liu, Bangran Qi, Xingbin Yang
Summary: The study indicates that theabrownin can enhance BAT activity and promote WAT browning by activating the AMPK-PGC la pathway and modulating SCFAs, thereby improving inflammatory disorder in HFD-fed mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Alessandra Feraco, Stefania Gorini, Andrea Armani, Elisabetta Camajani, Manfredi Rizzo, Massimiliano Caprio
Summary: Skeletal muscle, beyond its role in movement, is now recognized as an endocrine organ that releases factors regulating physiological processes. It plays a crucial role in maintaining body homeostasis and insulin-mediated glucose disposal. Alterations in skeletal muscle differentiation and function are closely linked to the pathogenesis of metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Jussara J. Simao, Maysa M. Cruz, Fernanda M. Abdala, Andressa Bolsoni-Lopes, Lucia Armelin-Correa, Maria Isabel C. Alonso-Vale
Summary: The study demonstrates that palmitoleic acid (n7) can alleviate or prevent low-grade chronic inflammation caused by obesity by inducing adipocyte differentiation and reducing the expression of inflammatory cytokines.
Article
Biochemistry & Molecular Biology
Susana Castelo Branco Ramos Nakandakari, Rafael Calais Gaspar, Gabriel Keine Kuga, Camila de Oliveira Ramos, Renan Fudoli Vieira, Thaiane da Silva Rios, Vitor Rosetto Munoz, Marcella Ramos Sant'ana, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Leandro Pereira Moura, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Dennys Esper Cintra
Summary: Long-term high-fat diet affects adipose tissue and leads to metabolic disorders. Short-term high-fat diet affects neuronal signaling pathways. Flaxseed oil containing omega-3 fatty acids protects against increased food intake and fasting glucose, but not inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Marine & Freshwater Biology
Gilles Tinant, Melusine Van Larebekea, Benjamin Lemaire, Marine Courteille, Cecile Gardin, Ineke Neefs, Krishna Das, Melissa M. Page, Jean-Francois Rees, Yvan Larondelle, Cathy Debier
Summary: This study investigated the impacts of dietary MeHg and fatty acids on lipid metabolism in rainbow trout. The results showed that a diet enriched in linoleic acid (LA) increased the overall lipid content, while the addition of MeHg significantly reduced the lipid content. The size of adipocytes was influenced by both LA and MeHg. The fatty acid composition of adipose tissue and liver was significantly altered by the dietary fatty acids. Exposure to MeHg led to a release of n-6 PUFA from the hepatic membranes. This study highlights the important impact of MeHg exposure and dietary fatty acids on lipid metabolism in fish.
AQUATIC TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hanane Hadj-Moussa, Jing Zhang, Fabien Pifferi, Martine Perret, Kenneth B. Storey
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2020)
Article
Ecology
Olivier Boissier, Francois Feer, Pierre-Yves Henry, Pierre-Michel Forget
ECOLOGICAL APPLICATIONS
(2020)
Review
Nutrition & Dietetics
Fabien Pifferi, Stephen C. Cunnane, Philippe Guesnet
Article
Biology
Clara Hozer, Fabien Pifferi
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Article
Physiology
Julie Landes, Samuel Pavard, Pierre-Yves Henry, Jeremy Terrien
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Ecology
Pauline Vuarin, Loic Lesobre, Gwenaelle Leveque, Michel Saint Jalme, Frederic Lacroix, Yves Hingrat, Gabriele Sorci
Summary: Research shows that paternal age can affect offspring sperm production, ultimately reducing their reproductive success. Offspring sired by old fathers exhibit different age-dependent trajectories of sperm production compared to offspring sired by young fathers, producing less sperm throughout their lifetime. The strongest effect was observed for paternal age, with weaker evidence for the effects of grandpaternal or great grandpaternal age.
Article
Paleontology
Romain Jattiot, Jens Lehmann, Benjamin Latutrie, Pauline Vuarin, Amane Tajika, Emmanuelle Vennin
Summary: This study focuses on the cephalopod fauna in the Salazac locality of southeastern France, revealing a high diversity of ammonites and conducting extensive morphological and biometric analyses on a variety of species. Additionally, it challenges the diagnostic value of certain shell characters commonly used to characterize ammonite species.
Article
Biodiversity Conservation
Ilke Geladi, Pierre-Yves Henry, Andre Mauchamp, Paulina Couenberg, Birgit Fessl
Summary: Habitat loss due to land conversion for agriculture is a main driver of biodiversity loss. In the agricultural zone of the Galapagos, bird populations have been declining, with ten out of eleven monitored landbird species showing reduced relative abundance since 2010. Forest and coffee sites had the highest landbird diversity, while pasture sites had the least diversity. Main predictors of higher landbird diversity were the presence of forest patches, abundance of native vegetation, and lower elevations.
BIODIVERSITY AND CONSERVATION
(2021)
Review
Infectious Diseases
Amalia Rataud, Pierre-Yves Henry, Sara Moutailler, Maud Marsot
Summary: Understanding the role of hosts in the production of infected ticks is crucial for designing effective measures to reduce exposure to infectious tick bites. Research efforts on the reservoir host potential of wild birds in Lyme borreliosis circulation have focused more on tick production than on realized reservoir competence and bird density. More interdisciplinary research is needed to gain a comprehensive understanding of pathogen-tick-host systems at a local scale.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Zoology
Yohann Chaudron, Fabien Pifferi, Fabienne Aujard
Summary: Gray mouse lemur, a species with relatively slow aging, presents similarities to human pathological aging in terms of cognitive decline, brain atrophy, amyloidosis, and glucoregulatory imbalance. Studying aging in mouse lemurs offers promising insights for understanding, preventing, and treating pathological aging in humans, with potential focus on nutrition as a nonpharmacological antiaging strategy.
AMERICAN JOURNAL OF PRIMATOLOGY
(2021)
Article
Biology
Clara Hozer, Fabien Pifferi
Summary: This study examined the relationship between endogenous period and biomarkers of aging, finding that a deviation of endogenous period from 24 h led to increased oxidative stress, decreased IGF-1 concentrations, and impaired learning performances. These results support the circadian resonance theory, demonstrating a connection between endogenous period and lifespan, aging, and biological performance.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Evolutionary Biology
Gabriele Sorci, Loic Lesobre, Pauline Vuarin, Gwenaelle Leveque, Michel Saint Jalme, Frederic Lacroix, Yves Hingrat
Summary: Research has shown that in captive populations of endangered species, females in a polyandrous mating system invest more in reproduction, and removing sexual selection can alter reproductive investment, potentially impacting population fitness and the success of conservation breeding programs.
EVOLUTIONARY APPLICATIONS
(2021)
Article
Agriculture, Multidisciplinary
Ilke Geladi, Pierre-Yves Henry, Paulina Couenberg, Rick Welsh, Birgit Fessl
Summary: Conservation practices in agricultural landscapes are crucial for mitigating biodiversity loss. This study examined the farmers' perception of landbirds in the agricultural zone of Santa Cruz in the Galapagos Islands. The majority of farmers had a positive or neutral perception of birds, but some found them bothersome. Farmers employed various techniques to deter birds from damaging their crops.
RENEWABLE AGRICULTURE AND FOOD SYSTEMS
(2022)
Article
Microbiology
Amalia Rataud, Clemence Galon, Laure Bournez, Pierre-Yves Henry, Maud Marsot, Sara Moutailler
Summary: Birds contribute to the multiplication of ticks and pathogens during their breeding season, playing a role in the maintenance of tick-borne diseases. A study in France found that Ixodes ricinus was the most prevalent tick species, while Borrelia burgdorferi sensu lato was the most prevalent pathogen genus in bird-feeding ticks. Certain bird species, such as Turdidae birds, Troglodytes troglodytes, and Anthus trivialis, had a higher prevalence of B. burgdorferi s.l.-infected bird-feeding ticks, indicating their potential role as reservoir hosts for this pathogen during their breeding season.
Article
Evolutionary Biology
Margaux Bieuville, Tazzio Tissot, Alexandre Robert, Pierre-Yves Henry, Samuel Pavard
Summary: Tumors originate from cell lineages with accumulating mutations, but current theories struggle to explain age-specific cancer incidence and interspecies cancer prevalence. This study proposes that cellular senescence can explain these patterns, suggesting a trade-off between dying of cancer or other aging-related causes. By integrating cellular biology and eco-evolutionary principles, the study demonstrates the importance of understanding the role of senescence in solving the cancer puzzle.
EVOLUTIONARY APPLICATIONS
(2023)
Article
Biology
Aref Maddahi, Adel Saberivand, Hossein Hamali, Farnoosh Jafarpour, Maryam Saberivand
Summary: Heat stress affects the fertility of dairy cattle, but supplementing vitamins E and coenzyme Q10 can alleviate its adverse effects on oocyte maturation and embryo development. Vitamin E was found to be more effective than vitamin C and coenzyme Q10 in improving maturation and cleavage rates, as well as increasing the count of blastocyst cells.
JOURNAL OF THERMAL BIOLOGY
(2024)