Journal
JOURNAL OF THERMAL BIOLOGY
Volume 35, Issue 8, Pages 406-410Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtherbio.2010.08.006
Keywords
Whole-body cryotherapy; Oxidative stress; Multiple sclerosis
Ask authors/readers for more resources
There is strong evidence that multiple sclerosis (MS) is characterized not only by immune mediated inflammatory reactions but also by neurodegenerative processes. Accumulated data indicate that oxidative stress (OS) plays a major role in this process. Generated in excess, reactive oxygen species (ROS) lead to oxidative stress and are involved in demyelination and axonal damage in MS. ROS generation may be inhibited partly by hypothermia, which is known as a potent putative neuroprotectant and may inhibit generating free radicals and oxidative stress. Whole-body cryotherapy (WBCT) treatment may improve both survival and neurological outcome in MS patients. The aim of the study was to determine the effects of WBCT on oxidative stress by the level of total antioxidative status (TAS) in plasma and the activity of antioxidative enzymes: superoxide dismutase (SOD) and catalase (CAT) in the erythrocytes from MS patients. Moreover, we measured the combined effects of WBCT and melatonin on TAS and activity of antioxidative enzymes in MS patients. Sixteen MS patients were treated with 3 cycles of 10 exposures in a cryogenic chamber. The last cycle was accompanied by a 14-day-long supplementation of melatonin (10 mg daily). Healthy subjects as a control group had 1 cycle of WBCT. Our preliminary results for the first time showed that WBCT treatment of MS patients resulted in the increase of TAS but had no effects on activity of antioxidative enzymes: SOD and CAT. Supplementation of melatonin and the treatment along with WBCT significantly increased the activity of SOD and CAT in erythrocytes of MS patients. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available