Journal
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
Volume 97, Issue 2, Pages 741-745Publisher
SPRINGER
DOI: 10.1007/s10973-009-0347-2
Keywords
Norfloxacin; Thermal characterization; Kinetic studies; Compatibility studies
Funding
- CNPq
- CAPES
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Norfloxacin (NFX) is a synthetic antibacterial drug. The development of extended release tablets improves the patients' comfort and compliance, resulting in lower discontinuation of the therapy; with consequently decrease in bacterial resistance. In the present work, the thermal behavior of NFX was investigated using TG and DSC techniques. Isothermal and non-isothermal methods were employed to determine kinetic data of decomposition process. Compatibility studies between NFX and pharmaceutical excipients, including three hydrophilic polymers were carried out in order to develop a new formulation of NFX to obtain extended release tablets with an approved quality.
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