Journal
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
Volume 93, Issue 1, Pages 289-294Publisher
SPRINGER
DOI: 10.1007/s10973-007-8836-7
Keywords
antipyrine; atropine sulfate; caffeine; crystallinity; drug release; DSC; glycine; phenobarbital; PLLA polymer-drug interaction; sulfacetamide sodium; TG; XRD
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This project investigated the interaction between poly-L-lactic acid (PLLA) and several therapeutic agents. Low percentage crystallinity PLLA (melt-pressed, molded and drawn) was studied. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) were used to characterize the crystallinity and thermal properties in a thermal cycling process. Repeatable melting and crystallization events were observed. The thermal properties of a drug-polymer combination using PLLA and an acidic, basic, neutral and zwitterionic material were investigated. A sufficient quantity of the drug must be present in the polymer to be observed thermally. Release of atropine sulfate from a PLLA tablet showed a two-phase process.
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